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The map label for this gene is ggt [H]

Identifier: 157961688

GI number: 157961688

Start: 2272206

End: 2274005

Strand: Reverse

Name: ggt [H]

Synonym: Spea_1864

Alternate gene names: 157961688

Gene position: 2274005-2272206 (Counterclockwise)

Preceding gene: 157961690

Following gene: 157961687

Centisome position: 43.95

GC content: 49.56

Gene sequence:

>1800_bases
ATGCGCGCTTTTAAGACACCCTTGTCTAATTCTAGGTCTAGGTCTCATTCGCTTAAGCCTTATTCGTTTAAAGCTTTGGC
CTTCGCCATTTCAATGGCTATTCCCCTAACGCTTTCGGCCATAACTCCGCTTACCGCAACCGCTAAAGAAACCTCTATTT
ACAGCCATATTGCTACGGCCCAACCTATCTGGGCTAAATACGGTATGGTGTCTAGCCAAGAAGCGCTCGCTACACAAGCA
GGAGTTGAGATCCTAAAACAAGGCGGCAACGCGGTCGATGCCGCGGTTGCAGTCGGCTTTAGTTTGGCCGTTACCCTACC
AAGAGCAGGTAATATTGGTGGCGGTGGATTTATGCTGGTTCACCTAAGTGAGCCCAATAAAACTATCGCTATCGATTACC
GTGAAATGGCGCCAGCCAAAGCCCATCGTGATATTTTTCTCGATGAGGATGGCAACCCCGTTAATAAACTAAGCCGCGAA
CACGGATTAGCCGTCGGCGTGCCTGGCACGGTAATGGGCATGGAATTGGCATTAGAAAAGTACGGCACCATGACCATGAA
GCAAGTAACCGATGCCGCTATCAAGATGGCGAAAGACGGCATTGTCGTGACTCCGGATCTGCAAGCCTCATTATCAGGAC
TTAAGAGACGTATCGCCCAATGGCCAAGCTCTGCCGAAATATTTTATAAAGCCGATGGCAGTGACTACCAAAGTGGTGAG
TTGCTGAAACAGCCTGAACTCGCCCATTCACTATCACTTATTGCCAAGCACGGTAGCAAAGGCTTCTATCAGGGCGAAAC
CGCAGAAAAGCTGGTCAATGCCATTCAAGATGCCGGCGGCATCATGACCTTGGCCGATCTTAAAAACTATAAGGTCGTTG
AGCGTGAGCCTGTTGTCGGCGAATATCGGGGTTATCAAGTGGTCTCTATGCCGCCGCCATCATCGGGCGGGATACATATT
ATCGAGATGCTCAATATTCTAGAAGGCTATCCAATTAAGGAGCTAGGCCTTAATACCGCAGCCACACTGCACTTAATGAC
GGAAGCGATGAAACGCGCCTACGCCGATCGCAGCGAATATTTGGGCGATCCAGACTTTTTTGATGTACCTGTCAACTCGC
TGCTCAGTAAAGAGTATGCCAAGCAACTTGCTAAACAGATCGCTCCAGATAAGGCGACCCCAAGCAGTGAAATTAAGCCA
GGTAAGCTCGCCCCTTATGAGAGCAATCAAACCACCCATTACTCTGTGGTTGATAAATGGGGTAACGCCGTATCTAACAC
TTATACCCTCAACTTCAGCTATGGTTCAGGACTTGTAGCAAAAGGCACAGGTATTTTACTCAACAATGAGATGGATGACT
TTTCAGCCAAACCCGGCACCCCGAACGGTTATGGTTTAGTCGGCGGCGAAGCCAATGCTGTTGAGGCCAATAAGCGGCCA
CTAAGCTCAATGAGCCCAACCATAGTGATGAAGGACTCCAAGCCCTATATTGTGACAGGTAGTCCAGGCGGTTCGCGCAT
CATCACCACTACCATGCAGATCATCATGAATGTCATCGACCACGACTTAAACATTGCCGAAGCCACTTATGCACCACGTG
TTCACCATCAGTGGTTACCGGACGTACTGCGCGTTGAGCATACCCTCAACCGTGACACCCAAAGCTTACTCAAAGCCAAA
GGTCACGAGGTGAAAGTCAATAATGCCATGGGATCGACTCAATCGATTATGGTGACTGAGCAAGGCATATTTGGCGCCAG
CGATCCGCGCCGTGCGGGCAGTGAAACAGCGGGTTACTAG

Upstream 100 bases:

>100_bases
TAAACGTCACATTGCACATAGCTAAACAGTCACAATACTATAACCATTTAGCCTCATGCTATAACAGTCAAACTAAAACA
ATAATCATGAAGGATGTAAA

Downstream 100 bases:

>100_bases
CCGCTTCAGCAAATAAACAACTGCAATTGGATATCTTCTATAAGCCCTCGCCCTTAGGTTTTGCCTAAGGGCGATTTTGT
TTTTATACAAACGCGTCGCC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MRAFKTPLSNSRSRSHSLKPYSFKALAFAISMAIPLTLSAITPLTATAKETSIYSHIATAQPIWAKYGMVSSQEALATQA
GVEILKQGGNAVDAAVAVGFSLAVTLPRAGNIGGGGFMLVHLSEPNKTIAIDYREMAPAKAHRDIFLDEDGNPVNKLSRE
HGLAVGVPGTVMGMELALEKYGTMTMKQVTDAAIKMAKDGIVVTPDLQASLSGLKRRIAQWPSSAEIFYKADGSDYQSGE
LLKQPELAHSLSLIAKHGSKGFYQGETAEKLVNAIQDAGGIMTLADLKNYKVVEREPVVGEYRGYQVVSMPPPSSGGIHI
IEMLNILEGYPIKELGLNTAATLHLMTEAMKRAYADRSEYLGDPDFFDVPVNSLLSKEYAKQLAKQIAPDKATPSSEIKP
GKLAPYESNQTTHYSVVDKWGNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGTPNGYGLVGGEANAVEANKRP
LSSMSPTIVMKDSKPYIVTGSPGGSRIITTTMQIIMNVIDHDLNIAEATYAPRVHHQWLPDVLRVEHTLNRDTQSLLKAK
GHEVKVNNAMGSTQSIMVTEQGIFGASDPRRAGSETAGY

Sequences:

>Translated_599_residues
MRAFKTPLSNSRSRSHSLKPYSFKALAFAISMAIPLTLSAITPLTATAKETSIYSHIATAQPIWAKYGMVSSQEALATQA
GVEILKQGGNAVDAAVAVGFSLAVTLPRAGNIGGGGFMLVHLSEPNKTIAIDYREMAPAKAHRDIFLDEDGNPVNKLSRE
HGLAVGVPGTVMGMELALEKYGTMTMKQVTDAAIKMAKDGIVVTPDLQASLSGLKRRIAQWPSSAEIFYKADGSDYQSGE
LLKQPELAHSLSLIAKHGSKGFYQGETAEKLVNAIQDAGGIMTLADLKNYKVVEREPVVGEYRGYQVVSMPPPSSGGIHI
IEMLNILEGYPIKELGLNTAATLHLMTEAMKRAYADRSEYLGDPDFFDVPVNSLLSKEYAKQLAKQIAPDKATPSSEIKP
GKLAPYESNQTTHYSVVDKWGNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGTPNGYGLVGGEANAVEANKRP
LSSMSPTIVMKDSKPYIVTGSPGGSRIITTTMQIIMNVIDHDLNIAEATYAPRVHHQWLPDVLRVEHTLNRDTQSLLKAK
GHEVKVNNAMGSTQSIMVTEQGIFGASDPRRAGSETAGY
>Mature_599_residues
MRAFKTPLSNSRSRSHSLKPYSFKALAFAISMAIPLTLSAITPLTATAKETSIYSHIATAQPIWAKYGMVSSQEALATQA
GVEILKQGGNAVDAAVAVGFSLAVTLPRAGNIGGGGFMLVHLSEPNKTIAIDYREMAPAKAHRDIFLDEDGNPVNKLSRE
HGLAVGVPGTVMGMELALEKYGTMTMKQVTDAAIKMAKDGIVVTPDLQASLSGLKRRIAQWPSSAEIFYKADGSDYQSGE
LLKQPELAHSLSLIAKHGSKGFYQGETAEKLVNAIQDAGGIMTLADLKNYKVVEREPVVGEYRGYQVVSMPPPSSGGIHI
IEMLNILEGYPIKELGLNTAATLHLMTEAMKRAYADRSEYLGDPDFFDVPVNSLLSKEYAKQLAKQIAPDKATPSSEIKP
GKLAPYESNQTTHYSVVDKWGNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGTPNGYGLVGGEANAVEANKRP
LSSMSPTIVMKDSKPYIVTGSPGGSRIITTTMQIIMNVIDHDLNIAEATYAPRVHHQWLPDVLRVEHTLNRDTQSLLKAK
GHEVKVNNAMGSTQSIMVTEQGIFGASDPRRAGSETAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=538, Percent_Identity=34.5724907063197, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI73915090, Length=538, Percent_Identity=34.5724907063197, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI73915096, Length=538, Percent_Identity=34.5724907063197, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI73915094, Length=538, Percent_Identity=34.5724907063197, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI113429324, Length=529, Percent_Identity=33.4593572778828, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI113429326, Length=534, Percent_Identity=33.1460674157303, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI109148539, Length=572, Percent_Identity=31.8181818181818, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI153266885, Length=553, Percent_Identity=26.7631103074141, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI153266901, Length=554, Percent_Identity=26.7148014440433, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI30581157, Length=227, Percent_Identity=35.2422907488987, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI30581155, Length=227, Percent_Identity=35.2422907488987, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=25.4083484573503, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI218505805, Length=227, Percent_Identity=34.8017621145374, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI310124095, Length=227, Percent_Identity=32.5991189427313, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI1789856, Length=541, Percent_Identity=60.4436229205176, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=548, Percent_Identity=35.2189781021898, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI72000294, Length=546, Percent_Identity=34.981684981685, Blast_Score=268, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17506189, Length=594, Percent_Identity=30.8080808080808, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17542894, Length=543, Percent_Identity=32.4125230202578, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193208245, Length=562, Percent_Identity=30.2491103202847, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193208247, Length=562, Percent_Identity=30.2491103202847, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17564448, Length=431, Percent_Identity=29.0023201856148, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI72001497, Length=283, Percent_Identity=23.321554770318, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=283, Percent_Identity=23.321554770318, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=528, Percent_Identity=30.1136363636364, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161077496, Length=544, Percent_Identity=32.1691176470588, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI18859893, Length=531, Percent_Identity=32.015065913371, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI45551474, Length=547, Percent_Identity=31.4442413162706, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642670, Length=547, Percent_Identity=31.4442413162706, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24642666, Length=547, Percent_Identity=31.4442413162706, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161077880, Length=547, Percent_Identity=31.4442413162706, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161077878, Length=547, Percent_Identity=31.4442413162706, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI18859741, Length=550, Percent_Identity=28.5454545454545, Blast_Score=186, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64406; Mature: 64406

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFKTPLSNSRSRSHSLKPYSFKALAFAISMAIPLTLSAITPLTATAKETSIYSHIATA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
QPIWAKYGMVSSQEALATQAGVEILKQGGNAVDAAVAVGFSLAVTLPRAGNIGGGGFMLV
CCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEEECCCCCCCCCCEEEEE
HLSEPNKTIAIDYREMAPAKAHRDIFLDEDGNPVNKLSREHGLAVGVPGTVMGMELALEK
EECCCCCEEEEEHHHCCCCHHCCCEEECCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHH
YGTMTMKQVTDAAIKMAKDGIVVTPDLQASLSGLKRRIAQWPSSAEIFYKADGSDYQSGE
HCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
LLKQPELAHSLSLIAKHGSKGFYQGETAEKLVNAIQDAGGIMTLADLKNYKVVEREPVVG
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCC
EYRGYQVVSMPPPSSGGIHIIEMLNILEGYPIKELGLNTAATLHLMTEAMKRAYADRSEY
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHH
LGDPDFFDVPVNSLLSKEYAKQLAKQIAPDKATPSSEIKPGKLAPYESNQTTHYSVVDKW
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHH
GNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGTPNGYGLVGGEANAVEANKRP
CCCCCCEEEEEEECCCCEEECCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
LSSMSPTIVMKDSKPYIVTGSPGGSRIITTTMQIIMNVIDHDLNIAEATYAPRVHHQWLP
CCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHH
DVLRVEHTLNRDTQSLLKAKGHEVKVNNAMGSTQSIMVTEQGIFGASDPRRAGSETAGY
HHHHHHHHHCCCHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAFKTPLSNSRSRSHSLKPYSFKALAFAISMAIPLTLSAITPLTATAKETSIYSHIATA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
QPIWAKYGMVSSQEALATQAGVEILKQGGNAVDAAVAVGFSLAVTLPRAGNIGGGGFMLV
CCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEEECCCCCCCCCCEEEEE
HLSEPNKTIAIDYREMAPAKAHRDIFLDEDGNPVNKLSREHGLAVGVPGTVMGMELALEK
EECCCCCEEEEEHHHCCCCHHCCCEEECCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHH
YGTMTMKQVTDAAIKMAKDGIVVTPDLQASLSGLKRRIAQWPSSAEIFYKADGSDYQSGE
HCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
LLKQPELAHSLSLIAKHGSKGFYQGETAEKLVNAIQDAGGIMTLADLKNYKVVEREPVVG
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCC
EYRGYQVVSMPPPSSGGIHIIEMLNILEGYPIKELGLNTAATLHLMTEAMKRAYADRSEY
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHH
LGDPDFFDVPVNSLLSKEYAKQLAKQIAPDKATPSSEIKPGKLAPYESNQTTHYSVVDKW
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHH
GNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGTPNGYGLVGGEANAVEANKRP
CCCCCCEEEEEEECCCCEEECCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
LSSMSPTIVMKDSKPYIVTGSPGGSRIITTTMQIIMNVIDHDLNIAEATYAPRVHHQWLP
CCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHH
DVLRVEHTLNRDTQSLLKAKGHEVKVNNAMGSTQSIMVTEQGIFGASDPRRAGSETAGY
HHHHHHHHHCCCHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]