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The map label for this gene is gltA [H]

Identifier: 157961607

GI number: 157961607

Start: 2177495

End: 2178784

Strand: Reverse

Name: gltA [H]

Synonym: Spea_1783

Alternate gene names: 157961607

Gene position: 2178784-2177495 (Counterclockwise)

Preceding gene: 157961618

Following gene: 157961606

Centisome position: 42.11

GC content: 44.96

Gene sequence:

>1290_bases
ATGGCTGATAATATAGCCACATTAGAACTACCAGGGAATGATTCAATCGAACTGCCTATTAAAGAAGGTACGGCAGGATT
TGATGTAATCGACATCAGTAAGCTAGGTAGCAAAGGTTACTTTACTTTCGATCCAGGATTTCTAGCGACCGGATCTTGTG
AATCTGCAATTACTTATATCGACGGAGAGCAAGGAATACTGCTACACCGTGGTTACCCTATCGACCAGTTGGCAGTAGAA
TCTAATTACTTAGATTTATGTTATTTATTGCTTTATGGTGAGCTTCCAAATAAAGCACAATACGACGAATTCGTATACAC
AGTAAAAACGCACACCATGGTGAATGAGCAGTTGTCTGCTTTCTTTGCAGGTTTCAGACCTGATGCTCATCCTATGGCAA
TGCTATGTGGTGTAACAGGTGCTTTATCGGCATTTTACCAAGACTCTTTGGATGTAAATGACGAGCGTCACCGTGAGATT
GCGGCCTATCGTTTGGTGTCAAAAATGCCAACGATTGCAGCAATGTGTTACAAGTATTCAATCGGTCAACCGTTTGTATA
CCCACGCAACGACTTAAGCTATGCGGGTAACTTCTTAAGCATGATGTTTGCTGTACCATGTGAAGAATACAAGGTTAACC
CAATCGTAGAACGCGCAATGGATCGTATCTTTATCCTACACGCGGATCACGAGCAAAATGCATCGACTTCTACCGTTCGT
CTAGCAGGCTCTTCAGGTGCTAACCCATTTGCATGTATTGCTGCGGGTATCGCATCACTATGGGGACCGGCTCACGGCGG
CGCTAACGAAGCATGTCTGAATATGCTGGAAGAGATTGGCACTGTCGATCGTATTCCAGAGTTCATTGCACGTGCTAAAG
ACAAAGAAGATCCATTCCGTCTAATGGGCTTCGGTCACCGTGTTTACAAGAACTTCGACCCTCGCGCTAAAGTCATGCGT
GAAACGTGTCATGAAGTCCTTGCCGAACTTAAAGTGAACGATCCGCTTCTAGATGTGGCAATGGAACTTGAGCGTATTGC
ACTAGAAGACGAGTATTTCGTGTCTAAGAAGCTTTATCCAAATGTTGATTTCTACTCAGGGATCATCATGAAGGCGATTG
GCATTCCGACAAGTATGTTCACCGTGCTGTTCGCGTTAGCGCGTACTGTCGGCTGGATTGCTCACTGGAAAGAGATGCTA
GATCAGCCAGGTCATAAGATCAGCCGTCCTCGCCAGCTTTATACCGGTGATGCGAAGCGTGACTTTGTTGACTTAGCTAA
ACGGGATTAA

Upstream 100 bases:

>100_bases
TTTAAACGCTTATTTAAATTGAAATGTGATCTAGATTCACTGTAAAGTATTCACGTTTGATAAGCCGCACTCAATAAGAA
TGAAGTAAGGAGAATGGGGT

Downstream 100 bases:

>100_bases
TCGCTTGTTGATGTCTAATTTAAACTCGTCACTTAAATTAAGACATGAATATTTGACTTAACAGAGCTAGATTAAACAAA
GTTAAGTAAAGCTTAAAGGC

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MADNIATLELPGNDSIELPIKEGTAGFDVIDISKLGSKGYFTFDPGFLATGSCESAITYIDGEQGILLHRGYPIDQLAVE
SNYLDLCYLLLYGELPNKAQYDEFVYTVKTHTMVNEQLSAFFAGFRPDAHPMAMLCGVTGALSAFYQDSLDVNDERHREI
AAYRLVSKMPTIAAMCYKYSIGQPFVYPRNDLSYAGNFLSMMFAVPCEEYKVNPIVERAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGTVDRIPEFIARAKDKEDPFRLMGFGHRVYKNFDPRAKVMR
ETCHEVLAELKVNDPLLDVAMELERIALEDEYFVSKKLYPNVDFYSGIIMKAIGIPTSMFTVLFALARTVGWIAHWKEML
DQPGHKISRPRQLYTGDAKRDFVDLAKRD

Sequences:

>Translated_429_residues
MADNIATLELPGNDSIELPIKEGTAGFDVIDISKLGSKGYFTFDPGFLATGSCESAITYIDGEQGILLHRGYPIDQLAVE
SNYLDLCYLLLYGELPNKAQYDEFVYTVKTHTMVNEQLSAFFAGFRPDAHPMAMLCGVTGALSAFYQDSLDVNDERHREI
AAYRLVSKMPTIAAMCYKYSIGQPFVYPRNDLSYAGNFLSMMFAVPCEEYKVNPIVERAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGTVDRIPEFIARAKDKEDPFRLMGFGHRVYKNFDPRAKVMR
ETCHEVLAELKVNDPLLDVAMELERIALEDEYFVSKKLYPNVDFYSGIIMKAIGIPTSMFTVLFALARTVGWIAHWKEML
DQPGHKISRPRQLYTGDAKRDFVDLAKRD
>Mature_428_residues
ADNIATLELPGNDSIELPIKEGTAGFDVIDISKLGSKGYFTFDPGFLATGSCESAITYIDGEQGILLHRGYPIDQLAVES
NYLDLCYLLLYGELPNKAQYDEFVYTVKTHTMVNEQLSAFFAGFRPDAHPMAMLCGVTGALSAFYQDSLDVNDERHREIA
AYRLVSKMPTIAAMCYKYSIGQPFVYPRNDLSYAGNFLSMMFAVPCEEYKVNPIVERAMDRIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGTVDRIPEFIARAKDKEDPFRLMGFGHRVYKNFDPRAKVMRE
TCHEVLAELKVNDPLLDVAMELERIALEDEYFVSKKLYPNVDFYSGIIMKAIGIPTSMFTVLFALARTVGWIAHWKEMLD
QPGHKISRPRQLYTGDAKRDFVDLAKRD

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=376, Percent_Identity=26.063829787234, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786939, Length=428, Percent_Identity=74.5327102803738, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=371, Percent_Identity=31.5363881401617, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17555174, Length=404, Percent_Identity=27.2277227722772, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=376, Percent_Identity=26.5957446808511, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=398, Percent_Identity=25.8793969849246, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=377, Percent_Identity=25.1989389920424, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640126, Length=352, Percent_Identity=27.5568181818182, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24640124, Length=352, Percent_Identity=27.5568181818182, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21356863, Length=352, Percent_Identity=25.5681818181818, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47921; Mature: 47790

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNIATLELPGNDSIELPIKEGTAGFDVIDISKLGSKGYFTFDPGFLATGSCESAITYI
CCCCEEEEEECCCCCEEEEECCCCCCCCEEEHHHCCCCCEEEECCCEEECCCCCCCEEEE
DGEQGILLHRGYPIDQLAVESNYLDLCYLLLYGELPNKAQYDEFVYTVKTHTMVNEQLSA
ECCCCEEEECCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHH
FFAGFRPDAHPMAMLCGVTGALSAFYQDSLDVNDERHREIAAYRLVSKMPTIAAMCYKYS
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHC
IGQPFVYPRNDLSYAGNFLSMMFAVPCEEYKVNPIVERAMDRIFILHADHEQNASTSTVR
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGTVDRIPEFIARAKDKEDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHH
LMGFGHRVYKNFDPRAKVMRETCHEVLAELKVNDPLLDVAMELERIALEDEYFVSKKLYP
HHHCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
NVDFYSGIIMKAIGIPTSMFTVLFALARTVGWIAHWKEMLDQPGHKISRPRQLYTGDAKR
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHH
DFVDLAKRD
HHHHHHCCC
>Mature Secondary Structure 
ADNIATLELPGNDSIELPIKEGTAGFDVIDISKLGSKGYFTFDPGFLATGSCESAITYI
CCCEEEEEECCCCCEEEEECCCCCCCCEEEHHHCCCCCEEEECCCEEECCCCCCCEEEE
DGEQGILLHRGYPIDQLAVESNYLDLCYLLLYGELPNKAQYDEFVYTVKTHTMVNEQLSA
ECCCCEEEECCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHH
FFAGFRPDAHPMAMLCGVTGALSAFYQDSLDVNDERHREIAAYRLVSKMPTIAAMCYKYS
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHC
IGQPFVYPRNDLSYAGNFLSMMFAVPCEEYKVNPIVERAMDRIFILHADHEQNASTSTVR
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGTVDRIPEFIARAKDKEDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHH
LMGFGHRVYKNFDPRAKVMRETCHEVLAELKVNDPLLDVAMELERIALEDEYFVSKKLYP
HHHCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
NVDFYSGIIMKAIGIPTSMFTVLFALARTVGWIAHWKEMLDQPGHKISRPRQLYTGDAKR
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHH
DFVDLAKRD
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]