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The map label for this gene is mdtA [H]

Identifier: 157961605

GI number: 157961605

Start: 2175365

End: 2176471

Strand: Reverse

Name: mdtA [H]

Synonym: Spea_1781

Alternate gene names: 157961605

Gene position: 2176471-2175365 (Counterclockwise)

Preceding gene: 157961606

Following gene: 157961604

Centisome position: 42.06

GC content: 44.99

Gene sequence:

>1107_bases
ATGCTTTATCAGGCCTATCGGAAAATTGATTTAAGGTCTGCTTACATGGAAGCGTTAAATAAGAAAGTCATCATCCTATC
TATACTGCTAGCAACACTATTAACAGCCTGTAGCGAAGAAGAACAAGCCAAAGAGGAAGAGAAGTATGCCGTCCCCGTAG
AAACAGCCACTGTAATACAAGGTGATGTGTCCTCTTTCTATAGCACCACAGCCACACTTGAAGCCCCTCAAGAAGCCAAA
GTCGTTACCCGCGTCGCAGGGCTCATCCGATCAATTGAGGTTGAAGAAGGTGACAGAGTTAAAAAAGGTCAGCTATTGGC
TGTAATTGACTCAAAAAGGCAGAAATTTGATTTAGACCGCTCTCAAGCCGAAGTCGAAATCATTGAGCAAGAATTAAATC
GCCTTAAGAAAATTAGTAATAAAGAGTTTTTCAGTGCCGACTCGATGGCAAAGCTTGAATACAACCTACAGGCTGCCATG
GCAAAACGCGATTTAGCCGCATTATATGTCCAAGAAAGCATGATCCGCTCGCCTATCGACGGCATAGTGGCTACCCGCTT
TGTGAAGTCTGGCAATATGGCCAAAGAGTTTGATGAGCTATTTTATGTGGTCAATCAAGACGAGCTCTACGGCATTGTGC
ATCTGCCAGAGCAGCAACTTCAGCACCTGCGTCTAGGACAAGACGCCGAGATCTACGCTAATAAACATATCCAACAAACT
ACACACGCCAGCGTATTACGCATCAGCCCGATTGTTGACTCACAAAGTGGCACCTTTAAAGTTACCCTTTCAGTCCCTAA
TCAAAACGCGACATTAAAAGCCGGCATGTTTACCCGTGTAGAGCTTAAGTACGATACCCACAACAATGTCATTACCGTGC
CTTATAACGCAGTGATCAATCAAGACAATGAGTTTGCCCTCTACGTTATTGATGGTGACAACGCTAATCGACGCAGCGTC
TCTCTTGGCTATCGTGAAGCCGATACCGTTGAAGTCGTCGCGGGGATCGAACCGGGTGAGCAGATTGTGATCCGCGGTCA
GCAAAACCTAAAAGATAAATCATTAGTTGAAGTGATCAATTCTGTCGACATAGCGTCAGCTAAATAG

Upstream 100 bases:

>100_bases
TTGTACCTTTTCGCTACATTTATCACAAATAATACATACGCAAAAACACCAGTAGAACTAAGCTGTTGAATTTCATAACC
TTTAAAGGTTGGCACAGTTA

Downstream 100 bases:

>100_bases
ATAAGGCTCTCACCATGTCTACTATCAAAGATATCGACGCTATATCAGCCATTGAACTAAGTACTTTTTCAGATCTAGCG
CTAACTAAAAAAATGGGGAA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLYQAYRKIDLRSAYMEALNKKVIILSILLATLLTACSEEEQAKEEEKYAVPVETATVIQGDVSSFYSTTATLEAPQEAK
VVTRVAGLIRSIEVEEGDRVKKGQLLAVIDSKRQKFDLDRSQAEVEIIEQELNRLKKISNKEFFSADSMAKLEYNLQAAM
AKRDLAALYVQESMIRSPIDGIVATRFVKSGNMAKEFDELFYVVNQDELYGIVHLPEQQLQHLRLGQDAEIYANKHIQQT
THASVLRISPIVDSQSGTFKVTLSVPNQNATLKAGMFTRVELKYDTHNNVITVPYNAVINQDNEFALYVIDGDNANRRSV
SLGYREADTVEVVAGIEPGEQIVIRGQQNLKDKSLVEVINSVDIASAK

Sequences:

>Translated_368_residues
MLYQAYRKIDLRSAYMEALNKKVIILSILLATLLTACSEEEQAKEEEKYAVPVETATVIQGDVSSFYSTTATLEAPQEAK
VVTRVAGLIRSIEVEEGDRVKKGQLLAVIDSKRQKFDLDRSQAEVEIIEQELNRLKKISNKEFFSADSMAKLEYNLQAAM
AKRDLAALYVQESMIRSPIDGIVATRFVKSGNMAKEFDELFYVVNQDELYGIVHLPEQQLQHLRLGQDAEIYANKHIQQT
THASVLRISPIVDSQSGTFKVTLSVPNQNATLKAGMFTRVELKYDTHNNVITVPYNAVINQDNEFALYVIDGDNANRRSV
SLGYREADTVEVVAGIEPGEQIVIRGQQNLKDKSLVEVINSVDIASAK
>Mature_368_residues
MLYQAYRKIDLRSAYMEALNKKVIILSILLATLLTACSEEEQAKEEEKYAVPVETATVIQGDVSSFYSTTATLEAPQEAK
VVTRVAGLIRSIEVEEGDRVKKGQLLAVIDSKRQKFDLDRSQAEVEIIEQELNRLKKISNKEFFSADSMAKLEYNLQAAM
AKRDLAALYVQESMIRSPIDGIVATRFVKSGNMAKEFDELFYVVNQDELYGIVHLPEQQLQHLRLGQDAEIYANKHIQQT
THASVLRISPIVDSQSGTFKVTLSVPNQNATLKAGMFTRVELKYDTHNNVITVPYNAVINQDNEFALYVIDGDNANRRSV
SLGYREADTVEVVAGIEPGEQIVIRGQQNLKDKSLVEVINSVDIASAK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=331, Percent_Identity=24.773413897281, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081796, Length=358, Percent_Identity=23.1843575418994, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789929, Length=364, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789637, Length=160, Percent_Identity=32.5, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41180; Mature: 41180

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQAYRKIDLRSAYMEALNKKVIILSILLATLLTACSEEEQAKEEEKYAVPVETATVIQ
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCEECCCCEEEEEE
GDVSSFYSTTATLEAPQEAKVVTRVAGLIRSIEVEEGDRVKKGQLLAVIDSKRQKFDLDR
CCHHHHHHCCEEECCCHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCCHHCCCCC
SQAEVEIIEQELNRLKKISNKEFFSADSMAKLEYNLQAAMAKRDLAALYVQESMIRSPID
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GIVATRFVKSGNMAKEFDELFYVVNQDELYGIVHLPEQQLQHLRLGQDAEIYANKHIQQT
HHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEECCHHHHHHHCCCCCCHHHHCCCHHHH
THASVLRISPIVDSQSGTFKVTLSVPNQNATLKAGMFTRVELKYDTHNNVITVPYNAVIN
HCCCEEEEEEEEECCCCEEEEEEEECCCCCEEEECCEEEEEEEEECCCCEEEEECHHEEC
QDNEFALYVIDGDNANRRSVSLGYREADTVEVVAGIEPGEQIVIRGQQNLKDKSLVEVIN
CCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHH
SVDIASAK
CCCCCCCC
>Mature Secondary Structure
MLYQAYRKIDLRSAYMEALNKKVIILSILLATLLTACSEEEQAKEEEKYAVPVETATVIQ
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCEECCCCEEEEEE
GDVSSFYSTTATLEAPQEAKVVTRVAGLIRSIEVEEGDRVKKGQLLAVIDSKRQKFDLDR
CCHHHHHHCCEEECCCHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCCHHCCCCC
SQAEVEIIEQELNRLKKISNKEFFSADSMAKLEYNLQAAMAKRDLAALYVQESMIRSPID
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GIVATRFVKSGNMAKEFDELFYVVNQDELYGIVHLPEQQLQHLRLGQDAEIYANKHIQQT
HHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEECCHHHHHHHCCCCCCHHHHCCCHHHH
THASVLRISPIVDSQSGTFKVTLSVPNQNATLKAGMFTRVELKYDTHNNVITVPYNAVIN
HCCCEEEEEEEEECCCCEEEEEEEECCCCCEEEECCEEEEEEEEECCCCEEEEECHHEEC
QDNEFALYVIDGDNANRRSVSLGYREADTVEVVAGIEPGEQIVIRGQQNLKDKSLVEVIN
CCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHH
SVDIASAK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]