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The map label for this gene is xapR [H]

Identifier: 157961543

GI number: 157961543

Start: 2090944

End: 2091921

Strand: Direct

Name: xapR [H]

Synonym: Spea_1719

Alternate gene names: 157961543

Gene position: 2090944-2091921 (Clockwise)

Preceding gene: 157961537

Following gene: 157961545

Centisome position: 40.41

GC content: 42.84

Gene sequence:

>978_bases
ATGGATACAAAATTTGTGAACAATGACCATAGCGTAATACCGCTAGATTTAAAGAGTCTTTATTGGGCTGAGCGTATTAG
CATGAAAATGCTGAGGTATTTTTATGTGGCCAGCCATAGTAAAACCTTAACTCAAGCCGCGCAGCGGCTACACATATCAA
AGTCTCCCTTGAGTGCTCAGATGCGAGAACTTGAAGCGATTCTAGGAGTGAAGTTATTTAACCGTGAACAAAGAAGTATT
CAACTGACATCGACAGGGTTGATGTTGCGCCATGAGTGTCAGTCGATTTTTAGCGTGATGGAAACCTCAGTAAATAAAGT
GACCCAATACGCGAGAGAAACCCAAGGGCATCTACGTTTGGGGATTGTGAGTTCAGTATTTTGGGCCGGGTTTGGCTATG
CCTGTCAGCAGTTGAAAACTCAATATCCAAGTATTCAATTTGAGTTTTTGGAATTATCGCCACAAGAGCAGAAAGTCGCA
CTGTTTAATAATGAAATTGATATCGGCTTTGTTCGCTACGCGGATACGTTGGATATCACGCCGTTAGAGTCCTGCAATTT
ATATTGTGAGTCGATGGTGATTGCGTTATCGGATAAGCATGAGCTTAGTAAAAGAGCCCAACTTTGTTTGTCTGAACTTG
CCACTGAAAAGTTTGTCATTATGAGTCAGAAAAACTCAGCATCTGCGCAATTAGTGGTTAATCACTGCATCAAGGAAGGC
TTTTTACCGCAGATAACTCAAGAGGTGGTAGAGCCGATGACATTAATGAATGTGATTGAAAGTCATGCTGGGATCTCCGT
TGTTCCCCACAGTTTTAGTCGTCAGAGCTGGAAGCATGTTCGCTTCGTATCGCTTGAGCAGGAGATCATTGCCAATATTT
GCGCTGTGTACAACCCGCAAAAAATGACCGCAGAAAAGCAGGCGCTTATTCAGTCGCTACATCAGTTTATGAACCTAGAG
GCCTCCAAACAAGTCTAA

Upstream 100 bases:

>100_bases
TGGCTCGGCAATTTTAGGAGTGAAATTGGTTATTTAAAGCATTGAATATTGCTTTATCGCGCAGTTATTACGCCAAAGTA
GTGCTATTTACTGTAATGAA

Downstream 100 bases:

>100_bases
TGAAGAGACTAATAAAAAAGCCCACTTTCATGTAGTGGGCTTAAGTTCATATTGAGATCGATTACTTGTCTTCAATTCGC
TTTTTAAAGGCTTTTCGCGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MDTKFVNNDHSVIPLDLKSLYWAERISMKMLRYFYVASHSKTLTQAAQRLHISKSPLSAQMRELEAILGVKLFNREQRSI
QLTSTGLMLRHECQSIFSVMETSVNKVTQYARETQGHLRLGIVSSVFWAGFGYACQQLKTQYPSIQFEFLELSPQEQKVA
LFNNEIDIGFVRYADTLDITPLESCNLYCESMVIALSDKHELSKRAQLCLSELATEKFVIMSQKNSASAQLVVNHCIKEG
FLPQITQEVVEPMTLMNVIESHAGISVVPHSFSRQSWKHVRFVSLEQEIIANICAVYNPQKMTAEKQALIQSLHQFMNLE
ASKQV

Sequences:

>Translated_325_residues
MDTKFVNNDHSVIPLDLKSLYWAERISMKMLRYFYVASHSKTLTQAAQRLHISKSPLSAQMRELEAILGVKLFNREQRSI
QLTSTGLMLRHECQSIFSVMETSVNKVTQYARETQGHLRLGIVSSVFWAGFGYACQQLKTQYPSIQFEFLELSPQEQKVA
LFNNEIDIGFVRYADTLDITPLESCNLYCESMVIALSDKHELSKRAQLCLSELATEKFVIMSQKNSASAQLVVNHCIKEG
FLPQITQEVVEPMTLMNVIESHAGISVVPHSFSRQSWKHVRFVSLEQEIIANICAVYNPQKMTAEKQALIQSLHQFMNLE
ASKQV
>Mature_325_residues
MDTKFVNNDHSVIPLDLKSLYWAERISMKMLRYFYVASHSKTLTQAAQRLHISKSPLSAQMRELEAILGVKLFNREQRSI
QLTSTGLMLRHECQSIFSVMETSVNKVTQYARETQGHLRLGIVSSVFWAGFGYACQQLKTQYPSIQFEFLELSPQEQKVA
LFNNEIDIGFVRYADTLDITPLESCNLYCESMVIALSDKHELSKRAQLCLSELATEKFVIMSQKNSASAQLVVNHCIKEG
FLPQITQEVVEPMTLMNVIESHAGISVVPHSFSRQSWKHVRFVSLEQEIIANICAVYNPQKMTAEKQALIQSLHQFMNLE
ASKQV

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=291, Percent_Identity=29.8969072164948, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787879, Length=265, Percent_Identity=27.9245283018868, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI157672245, Length=232, Percent_Identity=29.3103448275862, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788887, Length=283, Percent_Identity=25.0883392226148, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788748, Length=255, Percent_Identity=24.3137254901961, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790399, Length=280, Percent_Identity=21.0714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=23.1404958677686, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790262, Length=257, Percent_Identity=22.9571984435798, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789173, Length=142, Percent_Identity=28.169014084507, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 37059; Mature: 37059

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKFVNNDHSVIPLDLKSLYWAERISMKMLRYFYVASHSKTLTQAAQRLHISKSPLSAQ
CCCCEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
MRELEAILGVKLFNREQRSIQLTSTGLMLRHECQSIFSVMETSVNKVTQYARETQGHLRL
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEH
GIVSSVFWAGFGYACQQLKTQYPSIQFEFLELSPQEQKVALFNNEIDIGFVRYADTLDIT
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCC
PLESCNLYCESMVIALSDKHELSKRAQLCLSELATEKFVIMSQKNSASAQLVVNHCIKEG
CCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
FLPQITQEVVEPMTLMNVIESHAGISVVPHSFSRQSWKHVRFVSLEQEIIANICAVYNPQ
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHCHHHHHEEHHHHHHHHHHHHHCCCH
KMTAEKQALIQSLHQFMNLEASKQV
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDTKFVNNDHSVIPLDLKSLYWAERISMKMLRYFYVASHSKTLTQAAQRLHISKSPLSAQ
CCCCEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
MRELEAILGVKLFNREQRSIQLTSTGLMLRHECQSIFSVMETSVNKVTQYARETQGHLRL
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEH
GIVSSVFWAGFGYACQQLKTQYPSIQFEFLELSPQEQKVALFNNEIDIGFVRYADTLDIT
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCC
PLESCNLYCESMVIALSDKHELSKRAQLCLSELATEKFVIMSQKNSASAQLVVNHCIKEG
CCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
FLPQITQEVVEPMTLMNVIESHAGISVVPHSFSRQSWKHVRFVSLEQEIIANICAVYNPQ
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHCHHHHHEEHHHHHHHHHHHHHCCCH
KMTAEKQALIQSLHQFMNLEASKQV
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]