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The map label for this gene is panF [H]

Identifier: 157961502

GI number: 157961502

Start: 2033989

End: 2035428

Strand: Direct

Name: panF [H]

Synonym: Spea_1677

Alternate gene names: 157961502

Gene position: 2033989-2035428 (Clockwise)

Preceding gene: 157961501

Following gene: 157961503

Centisome position: 39.31

GC content: 46.94

Gene sequence:

>1440_bases
ATGACGATGACTAGTCTGTTGCCTGTGTTAATTTATCTGGTTTTAAGCTTGGTTATCACTCGAGTCTGGAGTGCGCGTCA
ATCTCAGCAGCTCTGTGACGATAAAGCTCAGCGCTTCTTCATTGGTGGTGCTTTTCTTAGCGGCCCATTATTAGCATTAA
CTCTGGTAGCAACCTATACCAGTGCTGGTTCGTTTATTGGTGGTCCAGGAGCGGCTTATAAATTCGGTTTGGGGTGGGTT
TGGCTAGCCGTGATCCAGGTGCCAGTGGTTATTCTTACCTTGGGTGTGTTAGGGCCTAAGTTTCTCGCGCAAAAAAAACA
ATACAGCACCATTATTGAATGGCTAGACCACCGTTTTCAAAACAACTGGTTAAGTGCTATTGCCATGTTGAGCTTGGTCG
TTGGTTTTGTGGCGATGATCTCGGTGCAGTTTATTGGCGGCGCACGATTACTCTCTGGCGTCACTGGGATCAGCTATGAA
TTAGGTTTAGGGGTATTCGTGCTTACGGTCTTAGCCTATACCTTAACCGGTGGTTTCAGGGCGGTCGTACTCACTGACGC
TTTGCAAGGCATGGTGATGCTATTGGGATTAATCATCCTATTGCTCGTCATTCTTACTCAGCCCGACCTAAGCGCTCAAC
TTGCTCAGCAGACCGCTAAAACGCCGCAGTTATTAAGCCCTCATGGTGTTGATGACTTTTTAGGCTGGCCTATGATGTTG
TCATTTTGGGTGTTAATTTGCTTCGGCACTATGGGATTGCCGCATACGATTGTTAGGCTGCTGGCGGTTAAAGATCGCCA
GTCATTAAAAAAAGGCATGCTTTGGGGCACCATAATCTGCTTTTTGATGACACTGCTTCCGCATTTGTGTGGCTTCCTCG
GTCGGGCGCTGTTTCCTGACTTAACGGTACCCGATCAGATAATGCCGACCCTAATCGCTCAGCTCATGAGCCCATTTTGG
GCGGGTATTTTACTCGCCGCACCGATAGCCGCAGTTATGTCATCAGTTGACTCTATGTTGTTACAGTCGGCAGTGAGCAT
TGTGCGTGATGGCATGGTCAAAGCTAGACCACAGATGGGGGCAACTATACAGGTGCGTTTGACCCAAGTGGTGATGCTGC
TTATTACGGCATTAGCCTGCTTCTGGGCTGTAAAGCCTCCGGATATGATTGTATGGATTAACCTAGCTGCCTTTGGTGCC
CTGCAAGCGGTATTTTTATGGCCTATCATAGCGGGATTATTCTGGCCAAGTGTTAATGGGCATACGGCTCTAGTTGCTAT
GTGCAGCGGTATGGTTAGCTATTTAACTCTTCAGTTGCAGACACCACTGATTTTCAACATACATCCGATTGTTCCCGCAT
TGCTATTTTCGTTACTGATGTTGGTTACTAGTCACTTAATTAGCAAATCCTTTGTTAAGGGTTCTATTGAAACTCGTTAA

Upstream 100 bases:

>100_bases
AATTGGTTTGGCTTACCCCTGTGGTTTTGGTTTTCCTGTATCTGCGCGCCGCTTCTATTGATAGTGAGTCTTAGCTTTTT
GCTCAGCAAAGTTGTAGAGA

Downstream 100 bases:

>100_bases
AATTGATGGCAGCCTTGGCTAGCCAAGGGCCAGCCATTGGTTTATATTTGCCGCCATATAATAATAAAATGGTGGCGAAA
TGGACCCTGTTAACTCTTTT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTMTSLLPVLIYLVLSLVITRVWSARQSQQLCDDKAQRFFIGGAFLSGPLLALTLVATYTSAGSFIGGPGAAYKFGLGWV
WLAVIQVPVVILTLGVLGPKFLAQKKQYSTIIEWLDHRFQNNWLSAIAMLSLVVGFVAMISVQFIGGARLLSGVTGISYE
LGLGVFVLTVLAYTLTGGFRAVVLTDALQGMVMLLGLIILLLVILTQPDLSAQLAQQTAKTPQLLSPHGVDDFLGWPMML
SFWVLICFGTMGLPHTIVRLLAVKDRQSLKKGMLWGTIICFLMTLLPHLCGFLGRALFPDLTVPDQIMPTLIAQLMSPFW
AGILLAAPIAAVMSSVDSMLLQSAVSIVRDGMVKARPQMGATIQVRLTQVVMLLITALACFWAVKPPDMIVWINLAAFGA
LQAVFLWPIIAGLFWPSVNGHTALVAMCSGMVSYLTLQLQTPLIFNIHPIVPALLFSLLMLVTSHLISKSFVKGSIETR

Sequences:

>Translated_479_residues
MTMTSLLPVLIYLVLSLVITRVWSARQSQQLCDDKAQRFFIGGAFLSGPLLALTLVATYTSAGSFIGGPGAAYKFGLGWV
WLAVIQVPVVILTLGVLGPKFLAQKKQYSTIIEWLDHRFQNNWLSAIAMLSLVVGFVAMISVQFIGGARLLSGVTGISYE
LGLGVFVLTVLAYTLTGGFRAVVLTDALQGMVMLLGLIILLLVILTQPDLSAQLAQQTAKTPQLLSPHGVDDFLGWPMML
SFWVLICFGTMGLPHTIVRLLAVKDRQSLKKGMLWGTIICFLMTLLPHLCGFLGRALFPDLTVPDQIMPTLIAQLMSPFW
AGILLAAPIAAVMSSVDSMLLQSAVSIVRDGMVKARPQMGATIQVRLTQVVMLLITALACFWAVKPPDMIVWINLAAFGA
LQAVFLWPIIAGLFWPSVNGHTALVAMCSGMVSYLTLQLQTPLIFNIHPIVPALLFSLLMLVTSHLISKSFVKGSIETR
>Mature_478_residues
TMTSLLPVLIYLVLSLVITRVWSARQSQQLCDDKAQRFFIGGAFLSGPLLALTLVATYTSAGSFIGGPGAAYKFGLGWVW
LAVIQVPVVILTLGVLGPKFLAQKKQYSTIIEWLDHRFQNNWLSAIAMLSLVVGFVAMISVQFIGGARLLSGVTGISYEL
GLGVFVLTVLAYTLTGGFRAVVLTDALQGMVMLLGLIILLLVILTQPDLSAQLAQQTAKTPQLLSPHGVDDFLGWPMMLS
FWVLICFGTMGLPHTIVRLLAVKDRQSLKKGMLWGTIICFLMTLLPHLCGFLGRALFPDLTVPDQIMPTLIAQLMSPFWA
GILLAAPIAAVMSSVDSMLLQSAVSIVRDGMVKARPQMGATIQVRLTQVVMLLITALACFWAVKPPDMIVWINLAAFGAL
QAVFLWPIIAGLFWPSVNGHTALVAMCSGMVSYLTLQLQTPLIFNIHPIVPALLFSLLMLVTSHLISKSFVKGSIETR

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=453, Percent_Identity=27.8145695364238, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4507035, Length=420, Percent_Identity=24.5238095238095, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI157671931, Length=418, Percent_Identity=23.444976076555, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI14140236, Length=412, Percent_Identity=23.7864077669903, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082237, Length=457, Percent_Identity=46.6083150984683, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790113, Length=452, Percent_Identity=24.3362831858407, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787251, Length=478, Percent_Identity=24.6861924686192, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24651739, Length=425, Percent_Identity=21.1764705882353, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51998; Mature: 51866

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TMTSLLPVLIYLVLSLVITRVWSARQSQQLCDDKAQRFFIGGAFLSGPLLALTLVATYT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]