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The map label for this gene is gltP [H]

Identifier: 157961158

GI number: 157961158

Start: 1624590

End: 1625843

Strand: Direct

Name: gltP [H]

Synonym: Spea_1330

Alternate gene names: 157961158

Gene position: 1624590-1625843 (Clockwise)

Preceding gene: 157961157

Following gene: 157961161

Centisome position: 31.4

GC content: 49.36

Gene sequence:

>1254_bases
ATGTGGAATAAAATTCGCAGTTCTTTGCCACTGCAGCTCATCATAGCTGCGGGCGCAGCTTGGCTATTTGCAACCTCGCT
AACCTCTCTTGCTCAGCCTAACGTGATAGCCGACGTTGATCAGCAAGCTTGGTATCAATTTCTAATGCTAGGCAAAACCG
TCTATATCGGTTTACTCAAGATGGTCGTCGGCATAATGGTGATGCTGTCGCTTATCGAGGGGATCAGCAACATAGGCGCG
ATAACCAAATTAAAAACATTGGGTATGCGTACGCTTGGCTTTTACACCTTCACTACCACGATAGCGGTATCTCTTGGTTT
GGGAGCATCTTTACTCTTGCCAGTTTGGCAACCATTAACTCAAGCCGTTCCTTTAGCCGAAGGGGCTACGCTTATTGGTG
AGCAGGCAGCATCGGGCGGCGCTATCGCCACTAAGCTATTGAATATGGCGCTAGTAAACCCGGTTGCCGCTATTGTTAAT
GGCAACCTGCTCGCTGTGGTGGTGTTTTCAATTATGTTTGGAATCGCACTGTTAACCGCGTTACCTGAAAAGCACCTGCT
GTTTGAGGTGATCGCTGGTCTTAACAAGGGCATTAACGCCATGATTGGCGGCATTATTCGCCTCTCCCCCTTGGCTATCT
TTGCCATCGTATTCGAGTTTTCCCTCACGGGAGCTGAGGCGCTATTTAGTCAATTAGCCCTATTTGCACTATTGGTCTTT
GTGTTAACAGTGATCCATGGGCTGGTGGTACTGCCAGGTCTGGCTAAGTTGTTTACTGGGATTAAAATAACCACCTTATT
TAAAGGTATTAGCGCGCCGTTAGCGATGGCCTTTGCTACCTCATCGAGCGCCGCGACTCTACCCTTATCGATGCGAAGCG
CCGAGGAGCTTGGGGTTTCCCCCGCGACCAGCAGCATGGTTTTACCGCTAGGTTCGGTGATGAATATGGATGGTACTGCA
CTATTTGAAGGGGTCGCCGCTATATTTTTGGCTCAACTGTTTGGCGTGGATCTGACTACAACAGGCATGGTGATGATTTT
TATCATGGCCATGGTGTCTTCAATCGGCGCACCGGGCATGCCATCAGGATCTATGTCGGGCATGCAATTAGTGCTGTTAG
CTGCAGGGATCCCCCTAGAAGCTATCGCAATCTTGCTGATAATCGAGAGGCCACTTGATACCTTCCGCACCGCAGTGAAT
GTTGAGGGCGATATCATCGCCGCGCTAGTGGTAGATAAATGGCAGAAAGGCTAA

Upstream 100 bases:

>100_bases
TTAGGTGCGCAATCGCTTGAACCGCGATTGACTACCTATTCGTCGCTATAGAGCATTAGTTCATAGCTCGCTAACCCATT
AAGTCAATTTGGAATGCCCT

Downstream 100 bases:

>100_bases
GAGGTTGCTGATGTGGGCGCTAGAATGGCAGCGCGTATGAATGCCTGTGTAAGTAACGGACTGTGTAAGTAACGGACTGT
GTAAAAAATAGAAAGCTACA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MWNKIRSSLPLQLIIAAGAAWLFATSLTSLAQPNVIADVDQQAWYQFLMLGKTVYIGLLKMVVGIMVMLSLIEGISNIGA
ITKLKTLGMRTLGFYTFTTTIAVSLGLGASLLLPVWQPLTQAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIVN
GNLLAVVVFSIMFGIALLTALPEKHLLFEVIAGLNKGINAMIGGIIRLSPLAIFAIVFEFSLTGAEALFSQLALFALLVF
VLTVIHGLVVLPGLAKLFTGIKITTLFKGISAPLAMAFATSSSAATLPLSMRSAEELGVSPATSSMVLPLGSVMNMDGTA
LFEGVAAIFLAQLFGVDLTTTGMVMIFIMAMVSSIGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVN
VEGDIIAALVVDKWQKG

Sequences:

>Translated_417_residues
MWNKIRSSLPLQLIIAAGAAWLFATSLTSLAQPNVIADVDQQAWYQFLMLGKTVYIGLLKMVVGIMVMLSLIEGISNIGA
ITKLKTLGMRTLGFYTFTTTIAVSLGLGASLLLPVWQPLTQAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIVN
GNLLAVVVFSIMFGIALLTALPEKHLLFEVIAGLNKGINAMIGGIIRLSPLAIFAIVFEFSLTGAEALFSQLALFALLVF
VLTVIHGLVVLPGLAKLFTGIKITTLFKGISAPLAMAFATSSSAATLPLSMRSAEELGVSPATSSMVLPLGSVMNMDGTA
LFEGVAAIFLAQLFGVDLTTTGMVMIFIMAMVSSIGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVN
VEGDIIAALVVDKWQKG
>Mature_417_residues
MWNKIRSSLPLQLIIAAGAAWLFATSLTSLAQPNVIADVDQQAWYQFLMLGKTVYIGLLKMVVGIMVMLSLIEGISNIGA
ITKLKTLGMRTLGFYTFTTTIAVSLGLGASLLLPVWQPLTQAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIVN
GNLLAVVVFSIMFGIALLTALPEKHLLFEVIAGLNKGINAMIGGIIRLSPLAIFAIVFEFSLTGAEALFSQLALFALLVF
VLTVIHGLVVLPGLAKLFTGIKITTLFKGISAPLAMAFATSSSAATLPLSMRSAEELGVSPATSSMVLPLGSVMNMDGTA
LFEGVAAIFLAQLFGVDLTTTGMVMIFIMAMVSSIGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVN
VEGDIIAALVVDKWQKG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468566, Length=261, Percent_Identity=38.6973180076628, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI5032093, Length=267, Percent_Identity=37.8277153558052, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI223468564, Length=252, Percent_Identity=38.4920634920635, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4827012, Length=276, Percent_Identity=34.7826086956522, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI169790839, Length=310, Percent_Identity=32.5806451612903, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI21314632, Length=287, Percent_Identity=32.404181184669, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI66773030, Length=257, Percent_Identity=34.2412451361868, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI40254478, Length=258, Percent_Identity=35.6589147286822, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI194239697, Length=253, Percent_Identity=34.3873517786561, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI262359914, Length=233, Percent_Identity=33.4763948497854, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI301601644, Length=127, Percent_Identity=40.1574803149606, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=31.6425120772947, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789947, Length=369, Percent_Identity=27.3712737127371, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=23.5148514851485, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789473, Length=267, Percent_Identity=26.9662921348315, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=381, Percent_Identity=30.1837270341207, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=404, Percent_Identity=29.9504950495049, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=404, Percent_Identity=29.9504950495049, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71996953, Length=313, Percent_Identity=33.5463258785943, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=255, Percent_Identity=33.7254901960784, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=257, Percent_Identity=32.295719844358, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=262, Percent_Identity=33.206106870229, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24583025, Length=258, Percent_Identity=29.4573643410853, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17137668, Length=258, Percent_Identity=29.4573643410853, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24583023, Length=258, Percent_Identity=29.4573643410853, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281360481, Length=272, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281360483, Length=272, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137666, Length=272, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43505; Mature: 43505

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure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CCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]