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The map label for this gene is lysC [H]

Identifier: 157960563

GI number: 157960563

Start: 912895

End: 914265

Strand: Direct

Name: lysC [H]

Synonym: Spea_0735

Alternate gene names: 157960563

Gene position: 912895-914265 (Clockwise)

Preceding gene: 157960562

Following gene: 157960564

Centisome position: 17.64

GC content: 50.69

Gene sequence:

>1371_bases
ATGTCTTTAGAATCTGTTGTTAGCTTAAATGTTGCCAAGTTTGGTGGTACCTCTGTTGCCGACTATGACGCAATGCAGCG
CTGCGCCGATATCATTATTGCTAATCCACAAACTCGAGTCGTGGTGGTGAGTGCATCGAGCGGGGTGACTAATCAGCTAG
TCGCCTTGACCCAAGCCGAAACCAGTGTTGAAGAATCTAAAGCCTTGATCAAGAAGATCGCTTCGATTCAATATCAAATC
CTCGATAAGCTGGGGAACCCGAGCGATGTGGCGGCAAGAATTGATCACATTCTCAGCCATATCTCGACCCTAAGTGAGCG
CTTAAAGCTGACTCGTAGCAAGGCGGTGATGGATGAACTCTTATCTCAAGGTGAGATGTGCTCTTCAGTATTTTTTGCCG
CGGTACTGCGGGAGAAAGGCGCTAGTGCATCGGCTTTCGATGTGCGCCAAGTGCTGAGAACCGACAGTCATCATGGACGC
GCCGAGCCGCAAATCGAAATGATCGCCGAGTTGGCTAAGCAGCATCTAGAGCCTTTATTATGCGATCAAGTTATCGTCAC
TCAAGGGTTTGTGGGCGCCGATAGCGAAGGCAACACCACAACCCTAGGCCGTGGTGGTAGTGATTACTCTGCCGCGTTGT
TAGCCGAGGCGCTGCAAGCCGATGCGGTAGAGATCTGGACCGATGTTGCGGGGATCTATACTACCGACCCTCGTCTGGCC
CCTAATGCTCGCCCAATCCCTGAGATTAGCTTTAACGAAGCGGCTGAGATGGCAACGTTTGGTGCTAAGGTGCTTCACCC
TGCAACCATTTTACCGGCAGTGAGACAGAAGATTCAGGTCTTCGTTGGCTCTAGTTGGGCACCGGAGCAAGGTGGCACTT
GGATCCGTCATCAGGTTAAAAGTGAGCCTGTGTATCGCGCCGTAGCGGTGCGCCGAGACCAAACCTTGCTAAATCTCCAT
AGCCTACAGATGCTACATGCTCAAGGTTTCCTTGCCGAGACGTTTGCGACACTGGCAAAGCATAAGATCAGTGTCGACTT
GATCACCACATCTGAGGTGAACGTAGCACTGACACTCGATAAAACAGGCTCGGACTCGAGCGGTCAAGGTTTATTGAGTG
AGGCGTTGCTGCAAGAGTTATCGCAACATTGCCGCGTTAGAGTCGAAGAGGGCTTAGCTCTGGTTGCCGTTATTGGCAAC
AATATCGCTTCAACAGCAGGGGTATGTCGCCGCGTATTTGAAGTATTAGAGACTTACAATGTTCGTATGATCTGCCAAGG
GGCGAGCCCACATAATCTGTGTATCTTGGTGGATGAAGCTGAGGCTGCTAATGTTATTGGCGCTTTGCATGAAAACTTGT
TTGAAGCCTAG

Upstream 100 bases:

>100_bases
CTCTTCGAACGAAGTTAGTTCGGAGCTTATTCATGTTAGTTTTTCAAAATACCCATTCTCGTCAATGCCTGCCGTGCCTA
TTATGCGTGGAGGCAGCGTT

Downstream 100 bases:

>100_bases
TTAACAGTCGACGCGAACAGGAAGTAGAGCCTTTTATGAAATTTACCCAATCTAGCCTAAGAGTGGGAGAGTTGGCGACT
GGGCAGGAGCTGAGCGTTCC

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSLESVVSLNVAKFGGTSVADYDAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAETSVEESKALIKKIASIQYQI
LDKLGNPSDVAARIDHILSHISTLSERLKLTRSKAVMDELLSQGEMCSSVFFAAVLREKGASASAFDVRQVLRTDSHHGR
AEPQIEMIAELAKQHLEPLLCDQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQADAVEIWTDVAGIYTTDPRLA
PNARPIPEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHQVKSEPVYRAVAVRRDQTLLNLH
SLQMLHAQGFLAETFATLAKHKISVDLITTSEVNVALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEEGLALVAVIGN
NIASTAGVCRRVFEVLETYNVRMICQGASPHNLCILVDEAEAANVIGALHENLFEA

Sequences:

>Translated_456_residues
MSLESVVSLNVAKFGGTSVADYDAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAETSVEESKALIKKIASIQYQI
LDKLGNPSDVAARIDHILSHISTLSERLKLTRSKAVMDELLSQGEMCSSVFFAAVLREKGASASAFDVRQVLRTDSHHGR
AEPQIEMIAELAKQHLEPLLCDQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQADAVEIWTDVAGIYTTDPRLA
PNARPIPEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHQVKSEPVYRAVAVRRDQTLLNLH
SLQMLHAQGFLAETFATLAKHKISVDLITTSEVNVALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEEGLALVAVIGN
NIASTAGVCRRVFEVLETYNVRMICQGASPHNLCILVDEAEAANVIGALHENLFEA
>Mature_455_residues
SLESVVSLNVAKFGGTSVADYDAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAETSVEESKALIKKIASIQYQIL
DKLGNPSDVAARIDHILSHISTLSERLKLTRSKAVMDELLSQGEMCSSVFFAAVLREKGASASAFDVRQVLRTDSHHGRA
EPQIEMIAELAKQHLEPLLCDQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQADAVEIWTDVAGIYTTDPRLAP
NARPIPEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHQVKSEPVYRAVAVRRDQTLLNLHS
LQMLHAQGFLAETFATLAKHKISVDLITTSEVNVALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEEGLALVAVIGNN
IASTAGVCRRVFEVLETYNVRMICQGASPHNLCILVDEAEAANVIGALHENLFEA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=445, Percent_Identity=57.5280898876405, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1786183, Length=473, Percent_Identity=29.8097251585624, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1790376, Length=453, Percent_Identity=28.0353200883002, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320893, Length=490, Percent_Identity=27.3469387755102, Blast_Score=172, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49027; Mature: 48896

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLESVVSLNVAKFGGTSVADYDAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAE
CCCHHHHEEEHHHCCCCCCHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHHHHHHH
TSVEESKALIKKIASIQYQILDKLGNPSDVAARIDHILSHISTLSERLKLTRSKAVMDEL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSQGEMCSSVFFAAVLREKGASASAFDVRQVLRTDSHHGRAEPQIEMIAELAKQHLEPLL
HHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHH
CDQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQADAVEIWTDVAGIYTTDPRLA
HHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
PNARPIPEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHQVK
CCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
SEPVYRAVAVRRDQTLLNLHSLQMLHAQGFLAETFATLAKHKISVDLITTSEVNVALTLD
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEEEEECCEEEEEEEE
KTGSDSSGQGLLSEALLQELSQHCRVRVEEGLALVAVIGNNIASTAGVCRRVFEVLETYN
CCCCCCCCCHHHHHHHHHHHHHHHCEEHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHCC
VRMICQGASPHNLCILVDEAEAANVIGALHENLFEA
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLESVVSLNVAKFGGTSVADYDAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAE
CCHHHHEEEHHHCCCCCCHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHHHHHHH
TSVEESKALIKKIASIQYQILDKLGNPSDVAARIDHILSHISTLSERLKLTRSKAVMDEL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSQGEMCSSVFFAAVLREKGASASAFDVRQVLRTDSHHGRAEPQIEMIAELAKQHLEPLL
HHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHH
CDQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQADAVEIWTDVAGIYTTDPRLA
HHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
PNARPIPEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHQVK
CCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
SEPVYRAVAVRRDQTLLNLHSLQMLHAQGFLAETFATLAKHKISVDLITTSEVNVALTLD
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEEEEECCEEEEEEEE
KTGSDSSGQGLLSEALLQELSQHCRVRVEEGLALVAVIGNNIASTAGVCRRVFEVLETYN
CCCCCCCCCHHHHHHHHHHHHHHHCEEHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHCC
VRMICQGASPHNLCILVDEAEAANVIGALHENLFEA
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]