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The map label for this gene is gltP [H]

Identifier: 157960547

GI number: 157960547

Start: 888179

End: 889435

Strand: Direct

Name: gltP [H]

Synonym: Spea_0719

Alternate gene names: 157960547

Gene position: 888179-889435 (Clockwise)

Preceding gene: 157960546

Following gene: 157960550

Centisome position: 17.16

GC content: 49.32

Gene sequence:

>1257_bases
ATGACTAAATCACTTTCTACACGGATCTTTATCGGTCTGTTTTCTGGGCTTATTTTTGGCTCAATCATTCAATACTTCCT
CGCAGACATCAGCTTATTTTCTGGCACTATCGTTGAATTAGCCTCGGGCGCAGGCACCATGTTCGTTAATATGATCATGA
TGCTAGTGGTGCCACTGGTATTCGTCAGTATCGTATGCGGCGTGTGCGAGCTTAAAGATCTCAATAGCTTCGGTCGCTTA
GGCGGCAAAACATTTGGCTTCTATATCATCAACACCTTAGTGGCTATTTTTGCTGCACTAGGCGTGGCGCTACTGCTTTC
TCCAGGCAAGGGCGTGGATATGTCTAACGGTGGCGGCGTGGATATCGTGGCCACAGAGCTACCTAATCTGGTCGACTTAG
TAGTCAGCATTGTACCGAGTAACCCGATAGCGGCGTTTAGCTCGGGTAACATGCTACAGGTTATCTTTATGGCACTGCTG
CTTGGCGGCGTGATTAAGTCTCTTGGTGAAGCGGCGCAGAGCGCGGTAAACGGCTTCCAAGTGGCGAATAAGATCATGAT
GAAGCTGATTAGCGTGGTGATGCAGCTAGCGCCTATCGGTGTATTTGCATTAATGCTGAAGCTAGGTGCAACCCTAGAAG
CGGCAATATTTGGCAGCGTGGTGGAATACCTAGCACTGATCTTAGGCTTGTTGCTGTTATGGATTTTTGTGGTATACCCA
TTCGCGGTTGGCTTATTTACCCAGATTTCGGCGAAAGAGTTCCGCGCTAAGACTCGCGAGCAGATCCTATTTTCACTGTC
GACGGCCAGCTCAAATGCAACCATTCCAGTGACTATGCGCACTCTTACCGATAAACTCGGCGTTAATCGCTCGGTTGCAG
GCTTTGGTGTGCCACTCGGCGCGACCATGAACATGGGCGGCGTATCGATTTATATCACTATTGCTATCTTCTTTGTGGCC
AACGCATTTGGCGCGCCAATCCCTATGGAGCAGCTACCCGCATTACTATTTAGTATCTTCTTACTGTCAGTAGGGGCTGG
TGGCGTACCAGGCGGTGGCATGGTGATGATTGGTGTGCTTATCCATCAGATGGGATTACCTGTAGAAGCGTTCGCAATTG
TGGCAGCGCTAGACCGCCTCATCGACATGGTGCTGACATCTTGTAACGTTGTAGGTGATACAGCTGTACTAACCATAGTT
AATGAAACTGAGAAGAGCAGCGATGCTAAGTTAGCAGCGGCGCCGGCGCAGGCTTAA

Upstream 100 bases:

>100_bases
TGTTTCACTATCCCTGCCACAACGAGATGGAAATCAAGTTTTCATCAAAATTGAAGGCAATAGAAGGCATGCGTTAAGAC
ATGTCCAATAAGGCAAGCAA

Downstream 100 bases:

>100_bases
ACCGCGCTAGAGTCTTTTTAGCTCGCTGTTTTAAAAAGGAAAATGCCAGCAATTTGCTGGCATTTTTGTTTTTAGATTAA
ACCGCCGAAGCTGTTATTTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTKSLSTRIFIGLFSGLIFGSIIQYFLADISLFSGTIVELASGAGTMFVNMIMMLVVPLVFVSIVCGVCELKDLNSFGRL
GGKTFGFYIINTLVAIFAALGVALLLSPGKGVDMSNGGGVDIVATELPNLVDLVVSIVPSNPIAAFSSGNMLQVIFMALL
LGGVIKSLGEAAQSAVNGFQVANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILGLLLLWIFVVYP
FAVGLFTQISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTDKLGVNRSVAGFGVPLGATMNMGGVSIYITIAIFFVA
NAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPVEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIV
NETEKSSDAKLAAAPAQA

Sequences:

>Translated_418_residues
MTKSLSTRIFIGLFSGLIFGSIIQYFLADISLFSGTIVELASGAGTMFVNMIMMLVVPLVFVSIVCGVCELKDLNSFGRL
GGKTFGFYIINTLVAIFAALGVALLLSPGKGVDMSNGGGVDIVATELPNLVDLVVSIVPSNPIAAFSSGNMLQVIFMALL
LGGVIKSLGEAAQSAVNGFQVANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILGLLLLWIFVVYP
FAVGLFTQISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTDKLGVNRSVAGFGVPLGATMNMGGVSIYITIAIFFVA
NAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPVEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIV
NETEKSSDAKLAAAPAQA
>Mature_417_residues
TKSLSTRIFIGLFSGLIFGSIIQYFLADISLFSGTIVELASGAGTMFVNMIMMLVVPLVFVSIVCGVCELKDLNSFGRLG
GKTFGFYIINTLVAIFAALGVALLLSPGKGVDMSNGGGVDIVATELPNLVDLVVSIVPSNPIAAFSSGNMLQVIFMALLL
GGVIKSLGEAAQSAVNGFQVANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILGLLLLWIFVVYPF
AVGLFTQISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTDKLGVNRSVAGFGVPLGATMNMGGVSIYITIAIFFVAN
AFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPVEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIVN
ETEKSSDAKLAAAPAQA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=431, Percent_Identity=27.3781902552204, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI40254478, Length=452, Percent_Identity=26.9911504424779, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI169790839, Length=436, Percent_Identity=25, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI66773030, Length=400, Percent_Identity=26, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5032093, Length=395, Percent_Identity=27.5949367088608, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4827012, Length=272, Percent_Identity=29.7794117647059, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223468564, Length=270, Percent_Identity=27.4074074074074, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194239697, Length=289, Percent_Identity=27.681660899654, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI223468566, Length=270, Percent_Identity=27.4074074074074, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI262359914, Length=365, Percent_Identity=26.027397260274, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI301601644, Length=151, Percent_Identity=31.1258278145695, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1790514, Length=427, Percent_Identity=30.6791569086651, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1789947, Length=419, Percent_Identity=27.6849642004773, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1788024, Length=422, Percent_Identity=31.042654028436, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789473, Length=291, Percent_Identity=32.6460481099656, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=450, Percent_Identity=27.5555555555556, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=450, Percent_Identity=27.5555555555556, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17537407, Length=421, Percent_Identity=28.2660332541568, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=424, Percent_Identity=25.4716981132075, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71996953, Length=419, Percent_Identity=27.9236276849642, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=418, Percent_Identity=24.8803827751196, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=403, Percent_Identity=26.5508684863524, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24583025, Length=446, Percent_Identity=26.0089686098655, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137668, Length=446, Percent_Identity=26.0089686098655, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583023, Length=446, Percent_Identity=26.0089686098655, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360483, Length=464, Percent_Identity=24.5689655172414, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17137666, Length=464, Percent_Identity=24.5689655172414, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281360481, Length=463, Percent_Identity=24.622030237581, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43567; Mature: 43436

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEECCCCCCC
>Mature Secondary Structure 
TKSLSTRIFIGLFSGLIFGSIIQYFLADISLFSGTIVELASGAGTMFVNMIMMLVVPLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FVSIVCGVCELKDLNSFGRLGGKTFGFYIINTLVAIFAALGVALLLSPGKGVDMSNGGGV
HHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DIVATELPNLVDLVVSIVPSNPIAAFSSGNMLQVIFMALLLGGVIKSLGEAAQSAVNGFQ
EEEHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILGLLLLWIFVVYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAVGLFTQISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTDKLGVNRSVAGFGVPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCC
ATMNMGGVSIYITIAIFFVANAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IHQMGLPVEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIVNETEKSSDAKLAAAPAQA
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]