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The map label for this gene is tyrP [H]

Identifier: 157960469

GI number: 157960469

Start: 792238

End: 793437

Strand: Direct

Name: tyrP [H]

Synonym: Spea_0641

Alternate gene names: 157960469

Gene position: 792238-793437 (Clockwise)

Preceding gene: 157960467

Following gene: 157960470

Centisome position: 15.31

GC content: 48.92

Gene sequence:

>1200_bases
GTGAACACAAAAATACTTGGCTCAGTAGCCATTGTCGCCGGAACGGCAATTGGTGGTGGCATGTTGGCATTGCCGCTTGC
TACAGCTTCATTAGGTACAATCCCTGCACTGCTTTTACTGCTCTCTATCTGGGGAGTCTCTATCTATACCTCCCTATTAA
TGCTTGAGATTAATCTAGGTGTCGGTGTGGGCCTAAACCTGCATAGCATCACGGGCAAAACTTTAGGTAGGGTTGGACAA
ATTCTTCAGGGCGGCTCGTTTTTAAGCCTGCTATTCGCGCTCACCATGGTCTATCTGATGGGCGGTTCTTCACTGCTTGA
ATCTAAGATGAAACTGCTAGGCATGGATATGGACAGCCAGTTAGCGGTACTGCTATTTGCGCTAGTTTTTGGTGGGTTCA
TTGCTGTGGGCGTCGGCTGGATCGATAAAGTCTCACGGGTGCTGTTTACTACTATGATTGGCCTACTGGTTGTCGTGGTT
GCATATTTGATGCCTGAGGTCGACATGGGCATGATGATGAGCAACACCACCGAGGGGTTAGTTGAGGGGCGCGATCTGAC
TAATCTGTGGCTTGCGGCTATCCCAATTGTGTTTACTTCGTTCGGTTTCCACGTGTGTATCGCCACTATCGTGCGTTACC
TAGATGGCGATGCCATGTCACTGCGTAAGGTATTGATTATCGGCTCTACCATTCCGCTAGTCTGTTATATCCTCTGGCTT
GTCGTGACCTTAGGCACTCTAGGTGGCAAAACGGTTCATGAGTTTGATGGTTCACTGCCACTGCTAGTGACAGCGCTGCA
AGGCGTTGCAGAGTCTTCAATTTTGAAGCACTTTATTGAGTTATTCGCCAATCTTGCGCTAGTAACCTCGTTCCTTGGCG
TGACCATGAGCCTGTTCGATTATATCGCTGAGTTGACTCGCGCCAAAGAGAGCTGGGCTGGCCGTGCACAAACTTGGTTA
CTGACCTTTGTGCCACCACTATTGTGCGCACTTTACTACCCAGATGGTTTTATTAAGGTGCTTGGTTTTGCTGCGATTCC
GTTGGTGGTGATTATTATCTTTCTGCCGATTGCGATGGCGCTGGGACTACGTAAGCAAAACTTAGGTGGCTATCAGGTCA
GTGGTGGTAATGCTGCACTAGGCTTAGCTGGTCTAGCTGGTGTTGCCATTATCTTGGCTCAGCTATGGGTGGCACTATAA

Upstream 100 bases:

>100_bases
GGGCTGTTAATGATATTGTTAGCTTGCACAATTCTCTCCCTCAAAGTCGTTCTAAATCTGACCTATCTAAATAAAAAATA
AAATTTAACAGGACCATTTT

Downstream 100 bases:

>100_bases
TAGGCACTCTAATCGAATAGATAGCGAGAAAGTAACGCCAATGGCTGCGGGTCACTGCTTTGTAAGAGAGTAATTCATAG
GCTGTTGTTACCCGCGTCTC

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNTKILGSVAIVAGTAIGGGMLALPLATASLGTIPALLLLLSIWGVSIYTSLLMLEINLGVGVGLNLHSITGKTLGRVGQ
ILQGGSFLSLLFALTMVYLMGGSSLLESKMKLLGMDMDSQLAVLLFALVFGGFIAVGVGWIDKVSRVLFTTMIGLLVVVV
AYLMPEVDMGMMMSNTTEGLVEGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIELFANLALVTSFLGVTMSLFDYIAELTRAKESWAGRAQTWL
LTFVPPLLCALYYPDGFIKVLGFAAIPLVVIIIFLPIAMALGLRKQNLGGYQVSGGNAALGLAGLAGVAIILAQLWVAL

Sequences:

>Translated_399_residues
MNTKILGSVAIVAGTAIGGGMLALPLATASLGTIPALLLLLSIWGVSIYTSLLMLEINLGVGVGLNLHSITGKTLGRVGQ
ILQGGSFLSLLFALTMVYLMGGSSLLESKMKLLGMDMDSQLAVLLFALVFGGFIAVGVGWIDKVSRVLFTTMIGLLVVVV
AYLMPEVDMGMMMSNTTEGLVEGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIELFANLALVTSFLGVTMSLFDYIAELTRAKESWAGRAQTWL
LTFVPPLLCALYYPDGFIKVLGFAAIPLVVIIIFLPIAMALGLRKQNLGGYQVSGGNAALGLAGLAGVAIILAQLWVAL
>Mature_399_residues
MNTKILGSVAIVAGTAIGGGMLALPLATASLGTIPALLLLLSIWGVSIYTSLLMLEINLGVGVGLNLHSITGKTLGRVGQ
ILQGGSFLSLLFALTMVYLMGGSSLLESKMKLLGMDMDSQLAVLLFALVFGGFIAVGVGWIDKVSRVLFTTMIGLLVVVV
AYLMPEVDMGMMMSNTTEGLVEGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIELFANLALVTSFLGVTMSLFDYIAELTRAKESWAGRAQTWL
LTFVPPLLCALYYPDGFIKVLGFAAIPLVVIIIFLPIAMALGLRKQNLGGYQVSGGNAALGLAGLAGVAIILAQLWVAL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=42.1836228287841, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI1790145, Length=395, Percent_Identity=29.873417721519, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789552, Length=379, Percent_Identity=26.3852242744063, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42199; Mature: 42199

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure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HCCHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]