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The map label for this gene is nhaC [H]

Identifier: 157960304

GI number: 157960304

Start: 584666

End: 586195

Strand: Direct

Name: nhaC [H]

Synonym: Spea_0475

Alternate gene names: 157960304

Gene position: 584666-586195 (Clockwise)

Preceding gene: 157960301

Following gene: 157960308

Centisome position: 11.3

GC content: 48.04

Gene sequence:

>1530_bases
ATGAGCTCAAACAATGATCTTCAACAGTCTGAACCAGTGACTATGGAGCCTCTGCAAGATAGCAAACATACCACCCCAAC
ATTACTTGATGCACTTCTACCTATTATCGCTTTAGTGATAATGCTCACAGCTGCCGTCTACCTATTCTCATCCGACAGCT
CTTATGGGGCAAACCAGATAGCCTTGATTATGGCTGGCTGTATCGGGTTATTGATAGGTTGGAAGAATGGTTATAGCTGG
GCGGAAATGGAGCAAGGCATCGTCCGCAGTATCGGTGTCGCCACCGGGGCAATACTCATTCTATTTACCGTTGGTTCCCT
CATTGGCAGCTGGATCCTTGCTGGCACGGTCCCGACCATGATCTATTACGGCATGTTGGTGCTAAATCCTGAATATTTTT
ATGCGGCTTGTTGTTTGTTATGTGCGGTTGTCGCCATCAGTATCGGTAGCTCATGGACGGTCGCAGGTACGTTAGGTATC
GCCTTGGTCGGCGTGGCGTCAGCCATGGGACTCAGTGTCGAAATCACCGCTGGTGCCATCATTAGTGGTGCGTACTTTGG
CGATAAGATGTCTCCTATGTCAGACACCACAAATTTAGCGCCAGCCGTTGCAGGAACCGATATTTTTAGCCATATCCGAC
ATATGGTTTGGACCACAGTGCCAAGTATCATCATTGCCATGATCTGTTTTCTATTGTTAGGTTTTAATAATCAGGCAGTT
ATAGACAACAATAACTTTGAGCAGACCTTATCCCTAATTCAGACGCAGTTTAATCCTGGAGTTCACCTGCTGTTACCACT
GTTAGTCGTGTTTATCTTAGCCTGGAAAAAAATCCCCGCCTTTCCAACAGTCATCATAGGCACTATAGCTGGAGCTATCT
GCGCGGTGCTGTTTCAGTTTGATAACGTCGTGAATTTTGCAGGTGATGACAGCCTAAGCCCAGTGGTTGCTTTGGTAAAA
GGGGTCTGGGTGGCAATGTTTAATGGCTATACGGCGAGCACGGGTGACGAGGTGCTGGATAACCTACTGAGCCGCGGCGG
CATGAGTAGCATGATCAATACCGTGTGGTTGATCCTATGCGCGATGACCTTCGGTGGCATCATGGAAGTGACAGGCCTGC
TTAAGCGCATTTTGCAAAGTGTTTTAGGCTTAGTGAAATCTAGCGGCAGCTTGATTATAACCACGCTAGCAAGTTGTATT
GGCGCCAACCTTATCACCGCCGATCAGTTTATCGCTATCGTGCTTCCGGGGAGAATGCTTAAGGTGGAGTACACCAAACG
CGGCTTAGCACCGGTTAATTTGAGTCGTGCTCTTGAGGATTCAGCCACCATTACCAGTCCGCTTATTCCGTGGAATACCT
GTGGCGCCTACATGGCGAGTACTCTAGGCGTTGCGACGGTGGCATATCTTCCATACGCATTTTTCAATTTAGTTTGTCCG
CTGATCAGCGCCGCCTATGCTAAATATGACTTTAAAGTTGAGCGTTTACCTCAAGCAGAAGTACCACAAACCGAGCAGGC
GGTAGCTTAA

Upstream 100 bases:

>100_bases
TTTTTCAGCGTGAAAATCGATTTAATTTTAAAGATTTAATTCTAGAAGTTCTATTTTAGAAAGAGTGCTTAGGTCATAAG
AATAATAAAAAGGATGCTAC

Downstream 100 bases:

>100_bases
GCTGGCACATTACTTTGGTAGAAGGTAAGGCAAAAAAAAGCCTTGTCGGCTAGGAATCGACAAGGCACTTGGCGTAGCTA
TTAATCGAATTATTAATAAG

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSSNNDLQQSEPVTMEPLQDSKHTTPTLLDALLPIIALVIMLTAAVYLFSSDSSYGANQIALIMAGCIGLLIGWKNGYSW
AEMEQGIVRSIGVATGAILILFTVGSLIGSWILAGTVPTMIYYGMLVLNPEYFYAACCLLCAVVAISIGSSWTVAGTLGI
ALVGVASAMGLSVEITAGAIISGAYFGDKMSPMSDTTNLAPAVAGTDIFSHIRHMVWTTVPSIIIAMICFLLLGFNNQAV
IDNNNFEQTLSLIQTQFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAICAVLFQFDNVVNFAGDDSLSPVVALVK
GVWVAMFNGYTASTGDEVLDNLLSRGGMSSMINTVWLILCAMTFGGIMEVTGLLKRILQSVLGLVKSSGSLIITTLASCI
GANLITADQFIAIVLPGRMLKVEYTKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
LISAAYAKYDFKVERLPQAEVPQTEQAVA

Sequences:

>Translated_509_residues
MSSNNDLQQSEPVTMEPLQDSKHTTPTLLDALLPIIALVIMLTAAVYLFSSDSSYGANQIALIMAGCIGLLIGWKNGYSW
AEMEQGIVRSIGVATGAILILFTVGSLIGSWILAGTVPTMIYYGMLVLNPEYFYAACCLLCAVVAISIGSSWTVAGTLGI
ALVGVASAMGLSVEITAGAIISGAYFGDKMSPMSDTTNLAPAVAGTDIFSHIRHMVWTTVPSIIIAMICFLLLGFNNQAV
IDNNNFEQTLSLIQTQFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAICAVLFQFDNVVNFAGDDSLSPVVALVK
GVWVAMFNGYTASTGDEVLDNLLSRGGMSSMINTVWLILCAMTFGGIMEVTGLLKRILQSVLGLVKSSGSLIITTLASCI
GANLITADQFIAIVLPGRMLKVEYTKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
LISAAYAKYDFKVERLPQAEVPQTEQAVA
>Mature_508_residues
SSNNDLQQSEPVTMEPLQDSKHTTPTLLDALLPIIALVIMLTAAVYLFSSDSSYGANQIALIMAGCIGLLIGWKNGYSWA
EMEQGIVRSIGVATGAILILFTVGSLIGSWILAGTVPTMIYYGMLVLNPEYFYAACCLLCAVVAISIGSSWTVAGTLGIA
LVGVASAMGLSVEITAGAIISGAYFGDKMSPMSDTTNLAPAVAGTDIFSHIRHMVWTTVPSIIIAMICFLLLGFNNQAVI
DNNNFEQTLSLIQTQFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAICAVLFQFDNVVNFAGDDSLSPVVALVKG
VWVAMFNGYTASTGDEVLDNLLSRGGMSSMINTVWLILCAMTFGGIMEVTGLLKRILQSVLGLVKSSGSLIITTLASCIG
ANLITADQFIAIVLPGRMLKVEYTKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCPL
ISAAYAKYDFKVERLPQAEVPQTEQAVA

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 54030; Mature: 53899

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNDLQQSEPVTMEPLQDSKHTTPTLLDALLPIIALVIMLTAAVYLFSSDSSYGANQI
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALIMAGCIGLLIGWKNGYSWAEMEQGIVRSIGVATGAILILFTVGSLIGSWILAGTVPTM
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYYGMLVLNPEYFYAACCLLCAVVAISIGSSWTVAGTLGIALVGVASAMGLSVEITAGAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHH
ISGAYFGDKMSPMSDTTNLAPAVAGTDIFSHIRHMVWTTVPSIIIAMICFLLLGFNNQAV
HCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IDNNNFEQTLSLIQTQFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAICAVLFQF
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DNVVNFAGDDSLSPVVALVKGVWVAMFNGYTASTGDEVLDNLLSRGGMSSMINTVWLILC
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AMTFGGIMEVTGLLKRILQSVLGLVKSSGSLIITTLASCIGANLITADQFIAIVLPGRML
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCEE
KVEYTKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
EEEHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISAAYAKYDFKVERLPQAEVPQTEQAVA
HHHHHHHHCCCCHHCCCCCCCCCCHHCCC
>Mature Secondary Structure 
SSNNDLQQSEPVTMEPLQDSKHTTPTLLDALLPIIALVIMLTAAVYLFSSDSSYGANQI
CCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALIMAGCIGLLIGWKNGYSWAEMEQGIVRSIGVATGAILILFTVGSLIGSWILAGTVPTM
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYYGMLVLNPEYFYAACCLLCAVVAISIGSSWTVAGTLGIALVGVASAMGLSVEITAGAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHH
ISGAYFGDKMSPMSDTTNLAPAVAGTDIFSHIRHMVWTTVPSIIIAMICFLLLGFNNQAV
HCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IDNNNFEQTLSLIQTQFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAICAVLFQF
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DNVVNFAGDDSLSPVVALVKGVWVAMFNGYTASTGDEVLDNLLSRGGMSSMINTVWLILC
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AMTFGGIMEVTGLLKRILQSVLGLVKSSGSLIITTLASCIGANLITADQFIAIVLPGRML
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCEE
KVEYTKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
EEEHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISAAYAKYDFKVERLPQAEVPQTEQAVA
HHHHHHHHCCCCHHCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]