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The map label for this gene is hemE [H]

Identifier: 157960256

GI number: 157960256

Start: 530134

End: 531198

Strand: Direct

Name: hemE [H]

Synonym: Spea_0427

Alternate gene names: 157960256

Gene position: 530134-531198 (Clockwise)

Preceding gene: 157960254

Following gene: 157960257

Centisome position: 10.24

GC content: 45.54

Gene sequence:

>1065_bases
ATGGCAGAATTAAAGAATGATCGTTATTTACGTGCGTTATTAAAACAGCCTGTCGATAGAACTCCTGTCTGGATGATGCG
TCAAGCTGGCCGTTATCTTCCAGAATATAAAGCAACCCGCGCAGAAGCTGGCGACTTCATGTCTCTTTGTAAGAACCAAG
ACTTAGCTTGTGAAGTGACTCTTCAACCTCTACGTCGCTACGATTTAGATGCAGCAATCCTGTTCTCTGATATTTTAACT
GTTCCTGATGCGATGGGCTTAGGTCTGTACTTTGAAGCTGGTGAAGGTCCACGTTTCGAACGTCCAACCGATACCATCGA
TTCAATTAAAAAGCTTTGCATTCCAGATCCAGAAGATGAACTTGGTTATGTAATGCGTGCAGTAAGCACTATTCGTCGTG
AACTTAAAGGTGAAGTGCCACTAATCGGTTTCTCAGGTTCACCTTGGACACTCGCGACTTACATGGTTGAAGGTGGTTCA
AGCAAGGCATTCGAAAAGATTAAGAAGATGGCTTACGAAGAGCCAGCTACTCTGCACATGCTGCTAGATAAGCTAGCTGA
CTCTGTCACTTTGTACCTAAATGCTCAAGTTGCAAACGGTGCTCAGTCACTAATGATTTTCGATTCATGGGGTGGTGCAC
TTTCTCACCACGCATACCGTGAATTCTCACTACGTTACATGCAAAAAATCGTTGATGGCCTAACTCGCCATGCAGACGGT
CGCCAAGTACCAGTGACTCTGTTCACTAAAGGTGGCGGACTATGGCTTGAGTCTATGGCTGAAACAGGTTGTGATGCACT
AGGTCTAGACTGGACTGTTGATATCGGTGACGCACGTCGCCGTGTAGGTCATAAAGTTGCTCTACAAGGTAACATGGACC
CATCGGTACTTTACGGTACACCAGAGCGTATTCACCAAGAAGTGGATCAAATCCTTGCTTCTTATGGAGAAGGCACTGGC
CATGTATTTAACTTGGGTCATGGTATTCACCAGCACGTTGATCCAGAGCGCGCTGGCTCGTTTATCAACTCAGTTCATGA
GTTATCGCCTCAGTATCACAAGTAA

Upstream 100 bases:

>100_bases
TACTTGTCACATTATTTTACCTATGGAGGTTACTTTATTAACGTAAATGCTAAACTACTGCCCCAAGCGGATATCACTAT
AAGTTTAGGAATCAAGCCAA

Downstream 100 bases:

>100_bases
TCGAATCGCTTATATAGCGAAATGATTTACCATCGATTGGTATAAATAAGGGCTCAGTTTACTGGGCCTTTATTGTTTCC
GCCTTTAATTTTATTTCCAG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVTLQPLRRYDLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFERPTDTIDSIKKLCIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFEKIKKMAYEEPATLHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGTPERIHQEVDQILASYGEGTG
HVFNLGHGIHQHVDPERAGSFINSVHELSPQYHK

Sequences:

>Translated_354_residues
MAELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVTLQPLRRYDLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFERPTDTIDSIKKLCIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFEKIKKMAYEEPATLHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGTPERIHQEVDQILASYGEGTG
HVFNLGHGIHQHVDPERAGSFINSVHELSPQYHK
>Mature_353_residues
AELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVTLQPLRRYDLDAAILFSDILTV
PDAMGLGLYFEAGEGPRFERPTDTIDSIKKLCIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFEKIKKMAYEEPATLHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADGR
QVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGTPERIHQEVDQILASYGEGTGH
VFNLGHGIHQHVDPERAGSFINSVHELSPQYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=47.0254957507082, Blast_Score=315, Evalue=5e-86,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=78.8135593220339, Blast_Score=579, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=39.6600566572238, Blast_Score=271, Evalue=9e-74,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.3631123919308, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.3631123919308, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39505; Mature: 39373

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLRRYDLDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDSIKKLCIPDPEDE
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHH
LGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFEKIKKMAYEEPATLHM
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
HHHHHHCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGT
CCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCEEEEECCCCCCEEECC
PERIHQEVDQILASYGEGTGHVFNLGHGIHQHVDPERAGSFINSVHELSPQYHK
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLRRYDLDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDSIKKLCIPDPEDE
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHH
LGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFEKIKKMAYEEPATLHM
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
HHHHHHCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGT
CCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCEEEEECCCCCCEEECC
PERIHQEVDQILASYGEGTGHVFNLGHGIHQHVDPERAGSFINSVHELSPQYHK
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA