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The map label for this gene is nadC [H]

Identifier: 157960244

GI number: 157960244

Start: 508211

End: 509095

Strand: Reverse

Name: nadC [H]

Synonym: Spea_0415

Alternate gene names: 157960244

Gene position: 509095-508211 (Counterclockwise)

Preceding gene: 157960253

Following gene: 157960243

Centisome position: 9.84

GC content: 46.33

Gene sequence:

>885_bases
ATGCTTGAAAATGATATTCGTCTCTCAGTCAAAGCCGCATTAGATGAAGATTTAGGTCACCAAGATCCCAATTCTAAACT
CACTTCTGCCCAAAGAGCCGACACAGACATCACAGCACTACTTATTCCAGCGGATAAAACTGCACAAGCCAGCTTAATCA
CTCGAGAAGAAGGTGTATTTTGTGGAAAAGCCTGGGCTGAACAAGTGTTTAACCAGCTAGGTGGTGAAGTCGCACTGCAT
TGGCATGTTGATGATGGCGACTTAGTGCTGCCCAACCAACTCCTTTGTGAGCTAGAAGGGCCAGCAAGAGCCATCCTAAC
GGGTGAGCGCACGGCTATGAACTTCATCCAGACTCTATCTGGTGTTGCAACGCTGACCAAACATTACGTGGATAAACTTG
CCGGCACACATACCCGCCTGCTCGATACCCGTAAAACGATTCCAGGCCTGCGCACCGCACAGAAGTATGCGGTCACTTGT
GGTGGTGGACAAAACCATCGCATAGGTTTATTCGATGCATTTCTGATCAAAGAAAATCACATCATGGCCTGCGGCAGCAT
AGCTAAAGCGATTCAAGCAGCCAGAGAACTCAATGCAGACAAACCAGTAGAAGTAGAAGTTGAGAGTATTGATGAGCTAA
AGCAGGCCCTCGACGCGCAGTCTGATATTGTTATGTTAGATAATTTCGATGTCACCATGATGATAGAAGCCGTTGAGCTC
AACAACAGCTATAAGGCGAGAGGACAAGGTGTGAAACTTGAAGTCTCTGGCGACGTAACCTTAGATACTATCGCCAACTT
CGCAAAAACAGGTGTCGATTATATTTCAGTAGGTGCATTAACTAAGCATGTGCGCGCACTGGATCTATCGTTAAGACTTA
AGTAA

Upstream 100 bases:

>100_bases
GACTTATGTTAAGATTAAAACCTCTATTAAAGCGTGCCCCATGTATACAACAGTTATAACCCAGTTATAGATAAGTTATA
AGTCAGTAAGGATAGCCACC

Downstream 100 bases:

>100_bases
CACATAAGCCATATTAGCATCATTTGTCTAGCCCAAATAAGAGTCCAAAGTGTCAACTTATCTCAGGACGGGACTTATCT
CAGGACGAGACAAAGGCTAA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MLENDIRLSVKAALDEDLGHQDPNSKLTSAQRADTDITALLIPADKTAQASLITREEGVFCGKAWAEQVFNQLGGEVALH
WHVDDGDLVLPNQLLCELEGPARAILTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTC
GGGQNHRIGLFDAFLIKENHIMACGSIAKAIQAARELNADKPVEVEVESIDELKQALDAQSDIVMLDNFDVTMMIEAVEL
NNSYKARGQGVKLEVSGDVTLDTIANFAKTGVDYISVGALTKHVRALDLSLRLK

Sequences:

>Translated_294_residues
MLENDIRLSVKAALDEDLGHQDPNSKLTSAQRADTDITALLIPADKTAQASLITREEGVFCGKAWAEQVFNQLGGEVALH
WHVDDGDLVLPNQLLCELEGPARAILTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTC
GGGQNHRIGLFDAFLIKENHIMACGSIAKAIQAARELNADKPVEVEVESIDELKQALDAQSDIVMLDNFDVTMMIEAVEL
NNSYKARGQGVKLEVSGDVTLDTIANFAKTGVDYISVGALTKHVRALDLSLRLK
>Mature_294_residues
MLENDIRLSVKAALDEDLGHQDPNSKLTSAQRADTDITALLIPADKTAQASLITREEGVFCGKAWAEQVFNQLGGEVALH
WHVDDGDLVLPNQLLCELEGPARAILTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTC
GGGQNHRIGLFDAFLIKENHIMACGSIAKAIQAARELNADKPVEVEVESIDELKQALDAQSDIVMLDNFDVTMMIEAVEL
NNSYKARGQGVKLEVSGDVTLDTIANFAKTGVDYISVGALTKHVRALDLSLRLK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=259, Percent_Identity=36.2934362934363, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1786299, Length=291, Percent_Identity=58.7628865979381, Blast_Score=311, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6321162, Length=256, Percent_Identity=33.984375, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31960; Mature: 31960

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDIRLSVKAALDEDLGHQDPNSKLTSAQRADTDITALLIPADKTAQASLITREEGVF
CCCCCEEEEEEEHHHHHCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCEEEECCCCCE
CGKAWAEQVFNQLGGEVALHWHVDDGDLVLPNQLLCELEGPARAILTGERTAMNFIQTLS
EHHHHHHHHHHHCCCEEEEEEEECCCCEECCCHHEEEECCCCEEEEECCHHHHHHHHHHH
GVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGQNHRIGLFDAFLIKENH
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCC
IMACGSIAKAIQAARELNADKPVEVEVESIDELKQALDAQSDIVMLDNFDVTMMIEAVEL
EEEHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEEC
NNSYKARGQGVKLEVSGDVTLDTIANFAKTGVDYISVGALTKHVRALDLSLRLK
CCCCCCCCCCEEEEECCCEEHHHHHHHHHCCCCCEEHHHHHHHHHHEEEEEECC
>Mature Secondary Structure
MLENDIRLSVKAALDEDLGHQDPNSKLTSAQRADTDITALLIPADKTAQASLITREEGVF
CCCCCEEEEEEEHHHHHCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCEEEECCCCCE
CGKAWAEQVFNQLGGEVALHWHVDDGDLVLPNQLLCELEGPARAILTGERTAMNFIQTLS
EHHHHHHHHHHHCCCEEEEEEEECCCCEECCCHHEEEECCCCEEEEECCHHHHHHHHHHH
GVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGQNHRIGLFDAFLIKENH
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCC
IMACGSIAKAIQAARELNADKPVEVEVESIDELKQALDAQSDIVMLDNFDVTMMIEAVEL
EEEHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEEC
NNSYKARGQGVKLEVSGDVTLDTIANFAKTGVDYISVGALTKHVRALDLSLRLK
CCCCCCCCCCEEEEECCCEEHHHHHHHHHCCCCCEEHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]