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The map label for this gene is czcC [H]

Identifier: 157960214

GI number: 157960214

Start: 463306

End: 464730

Strand: Direct

Name: czcC [H]

Synonym: Spea_0385

Alternate gene names: 157960214

Gene position: 463306-464730 (Clockwise)

Preceding gene: 157960213

Following gene: 157960215

Centisome position: 8.95

GC content: 48.63

Gene sequence:

>1425_bases
ATGTTTTATAATACTTATTGCACGAAATCTGCCACAAAAATCGGCATACTTTGTGTTTGGCGAGGGCTCTATTGCACCTT
GGCGCTCATCGCTCTGTTATGGGCGGGCTCACTTGCCGCGGCTACTGCTAACACTGCACCGGCTAATACCTTGTCGTTAA
CCACGGTTATTGAACGGGTACAACTGCAACACCCTTCACTGAAGGTTTTTCAGTTTAGACAACAAGCGCTCGATGGTGCG
GCGCACACCCAAGCGCTAACTCCTGGTTATGAGATTGGATTTGATCTCGATAACGTTGCGGGCTCTGGTGAATTCCAAGG
TATCGACAGTGCTGAGTTTAGTGTGTCTTTATCGTCGGTGATTGAACTGGGTGACAAACTTGATGCTCGCACTGGTGTTG
TCAATGAGCAGCGTGCCGTACTGGATGCTGAGCAGAAAATTACCGCGTTAAATTTACTTGCAGAAGCAACGCGTCGCTAT
ATCGATGTGTTAGCGGCGCAATCGCAACTGCAATTAGCGGTCGATGCATTACAGCTTGCCGAGGAAACCCAAGTAGTAGT
GGCTAAGCGAGCAAAGGCTGGCGTGACGCCAGACGCCGAAGTTAAGCGCGCCCAAGCTGCGGTATTTAATGCCCGTCTCG
TGGCAGAAACCCAATTACACCAGCTCGATTACGCCAAGCTTGCGCTAAGCATGATGTGGGGCGAGTCTCAGATTAGCTTT
GATTCACTCGAAGGGGGCTTATTTGCCTTTACCGACGATGTGGCACTCGAGCCGTTATTTGAGAAAGTAAAATACAGCCC
TGCTATCACAGCCTATTTGACTCAGGCACAACTTAAAGAGGCCGAGCTGCGTTTTGCCAAAACTCAGTCAAGTAGCGATA
TCAGTTGGTCTGTAGGCGTTAAACAACTACAGCAAACCAACGATATGGCATTGTCTGCGGGCTTTAGTATGCCGCTGTTT
AATGGCGAACGTAATACTGGCACCGTGCTTTCGGCTCAGGCCGCAAAAGAGCAAGTACTTGTCAACCGAGAAGTGGCTCT
TTTAGAGCTATATGGTCAACTGTACCGGGCTTATGCTAGCCGTAAACAAGCCATAGTGACGGTAAATCGACTACAGGCTA
GTGTGATCCCGACCTTAACCTCAGCCCTTGAAGATACCAAGCAAGCTTACGAGCAGGGGCTTTACAGCTATCTTGATTAC
TTAACCGCCCGAGAGGAGCTGTTATTTGCACGCCGTGCGCTAATTGATGCTGCGGCCTCTGCACTGCGTTATGGCGTGGA
TATTGAGCAGCTTATTGCTGAGCCATTACCTGCTTCTCAACATACCTTCTTCAATGATTTTTCAAATGCAGCCAACTCTT
CTGCGACTGCTGATTTCTCAAAGTCAGCTAATTTTTCTGACGCTGCAAAAGGACATACAAAATGA

Upstream 100 bases:

>100_bases
GTTTTGCCTATGGCACTTGCTTAGGATCTGTCGTACTTATTTTGCAACTTTGCATCGAACAGATCTGAGATTTTTGTATT
AAATCGAGGCTTATTCTCTG

Downstream 100 bases:

>100_bases
ATCCTAGCTTATTAAATAAATTCTCCTTAGTTCACCTTGCTGTAGTAGCGGCGGTTGCATTGATGATTAGCGCCTCGGTT
AACGCATCACCAGAGCACAG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MFYNTYCTKSATKIGILCVWRGLYCTLALIALLWAGSLAAATANTAPANTLSLTTVIERVQLQHPSLKVFQFRQQALDGA
AHTQALTPGYEIGFDLDNVAGSGEFQGIDSAEFSVSLSSVIELGDKLDARTGVVNEQRAVLDAEQKITALNLLAEATRRY
IDVLAAQSQLQLAVDALQLAEETQVVVAKRAKAGVTPDAEVKRAQAAVFNARLVAETQLHQLDYAKLALSMMWGESQISF
DSLEGGLFAFTDDVALEPLFEKVKYSPAITAYLTQAQLKEAELRFAKTQSSSDISWSVGVKQLQQTNDMALSAGFSMPLF
NGERNTGTVLSAQAAKEQVLVNREVALLELYGQLYRAYASRKQAIVTVNRLQASVIPTLTSALEDTKQAYEQGLYSYLDY
LTAREELLFARRALIDAAASALRYGVDIEQLIAEPLPASQHTFFNDFSNAANSSATADFSKSANFSDAAKGHTK

Sequences:

>Translated_474_residues
MFYNTYCTKSATKIGILCVWRGLYCTLALIALLWAGSLAAATANTAPANTLSLTTVIERVQLQHPSLKVFQFRQQALDGA
AHTQALTPGYEIGFDLDNVAGSGEFQGIDSAEFSVSLSSVIELGDKLDARTGVVNEQRAVLDAEQKITALNLLAEATRRY
IDVLAAQSQLQLAVDALQLAEETQVVVAKRAKAGVTPDAEVKRAQAAVFNARLVAETQLHQLDYAKLALSMMWGESQISF
DSLEGGLFAFTDDVALEPLFEKVKYSPAITAYLTQAQLKEAELRFAKTQSSSDISWSVGVKQLQQTNDMALSAGFSMPLF
NGERNTGTVLSAQAAKEQVLVNREVALLELYGQLYRAYASRKQAIVTVNRLQASVIPTLTSALEDTKQAYEQGLYSYLDY
LTAREELLFARRALIDAAASALRYGVDIEQLIAEPLPASQHTFFNDFSNAANSSATADFSKSANFSDAAKGHTK
>Mature_474_residues
MFYNTYCTKSATKIGILCVWRGLYCTLALIALLWAGSLAAATANTAPANTLSLTTVIERVQLQHPSLKVFQFRQQALDGA
AHTQALTPGYEIGFDLDNVAGSGEFQGIDSAEFSVSLSSVIELGDKLDARTGVVNEQRAVLDAEQKITALNLLAEATRRY
IDVLAAQSQLQLAVDALQLAEETQVVVAKRAKAGVTPDAEVKRAQAAVFNARLVAETQLHQLDYAKLALSMMWGESQISF
DSLEGGLFAFTDDVALEPLFEKVKYSPAITAYLTQAQLKEAELRFAKTQSSSDISWSVGVKQLQQTNDMALSAGFSMPLF
NGERNTGTVLSAQAAKEQVLVNREVALLELYGQLYRAYASRKQAIVTVNRLQASVIPTLTSALEDTKQAYEQGLYSYLDY
LTAREELLFARRALIDAAASALRYGVDIEQLIAEPLPASQHTFFNDFSNAANSSATADFSKSANFSDAAKGHTK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51488; Mature: 51488

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]