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The map label for this gene is lysA [H]

Identifier: 157960206

GI number: 157960206

Start: 456668

End: 457912

Strand: Direct

Name: lysA [H]

Synonym: Spea_0377

Alternate gene names: 157960206

Gene position: 456668-457912 (Clockwise)

Preceding gene: 157960205

Following gene: 157960207

Centisome position: 8.83

GC content: 49.64

Gene sequence:

>1245_bases
TTGGATCATTTTTTATATCAGGCAGATGAACTCTACGCGGAGCAGTGTCAAGTTGCTGAGCTTGCAAAGCAGCACGGAAC
ACCGCTTTATATCTATTCTCGTGCGACACTAGAGCGCCATTGGCGTGCATTTGATAATGCGGTGAGCGAGCATCCACATC
TTATCTGCTATGCGGTGAAGGCTAACTCAAACATTGCAGTGCTAAACGTACTGGCACGTTTAGGCAGTGGCTTCGATATT
GTCTCGGGCGGTGAGCTGTCTCGTGTGATTGAAGCCGGCGGCGATCCTACTAAAGTGGTTTTCTCTGGCGTGGGCAAAAC
TGTCAGTGAGATGGAGATGGCACTTAACCTAGGCATCTATTGCTTTAATGTTGAGTCGGCAGCTGAGCTTGAGCAGCTTA
ACCTTGTGGCCTTGCGCCTAGGTAAAGTGGCGCCGGTATCGCTACGCATAAACCCTGATGTAGACGCGGGTACTCATCCC
TATATTTCGACTGGCCTGAAAGAGAATAAATTTGGTATCGCGATGGAAGAGGCGGAAGCTATCTTTGCTCGTGCTAACGA
ATTGCCGGGTCTTGCGGTAAAAGGCGTCGATTGTCATATTGGTTCTCAATTAACTGAGATTAAGCCTTTCTTAGATGCCA
TGGATCGCATGTTGGCGCTAATCGATCGTTTAGCAGAGCAAGGCATCGAGATTAAGCATTTCGATGTGGGCGGTGGACTC
GGAGTGACTTACGATGACGAGCAACCACCTCAACCAGATGTATACGCAGCAGCGCTACTTGAGCGTCTTGGCGATCGCGA
TCTCAAGTTGATCTTTGAACCTGGCAGAGCGATTGCGGCGAATGCCGGGATTTTCGTCACCCAAGTGCTATATCTGAAAG
AAAACAGCGATAAGCGTTTTGCTTTAGTCGACGGCGCAATGAATGACTTGATCCGTCCATCACTTTACAGCGCTTGGCAG
AAGATCGTTCCGGTTATTGAACGTGCGGGTGAAAGCCACAGTTATGACGTTGTCGGCCCAGTTTGCGAAACGGGAGACTT
CTTAGGTAAAGACCGTCAGCTTAACGTTCAGGAGGGCGACTACCTTGCGGTGCGTTCATCGGGCGCCTATGGCTTTACCA
TGGCGTCTAATTATAATTCACGTCCACGTGCTGCAGAGCTGATGGTGGATGGTGATAAAGCCTATGTCATTCGAGAGCGA
GAAAAAGTCGCTCAATTATGGCAAGGCGAGCAGATCCTGCCGTAA

Upstream 100 bases:

>100_bases
TTAGAGCGCCGCCGCAAGACGTTAATCAGCAGGCAGCTGACAAGCAGGTGTCTGACGCTAAGCATGAGCAAAGCGAACAG
AACAAAAAGGACTAAAGACG

Downstream 100 bases:

>100_bases
ACTAGAATAATACTAAGCCGCGGACGCAAGGCGTGCGCGGCAGATACTTTTTTAAGGATGTCCATCTTGATCCAATTCAC
TAAGATGCATGGGCTAGGCA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWRAFDNAVSEHPHLICYAVKANSNIAVLNVLARLGSGFDI
VSGGELSRVIEAGGDPTKVVFSGVGKTVSEMEMALNLGIYCFNVESAAELEQLNLVALRLGKVAPVSLRINPDVDAGTHP
YISTGLKENKFGIAMEEAEAIFARANELPGLAVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
GVTYDDEQPPQPDVYAAALLERLGDRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFALVDGAMNDLIRPSLYSAWQ
KIVPVIERAGESHSYDVVGPVCETGDFLGKDRQLNVQEGDYLAVRSSGAYGFTMASNYNSRPRAAELMVDGDKAYVIRER
EKVAQLWQGEQILP

Sequences:

>Translated_414_residues
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWRAFDNAVSEHPHLICYAVKANSNIAVLNVLARLGSGFDI
VSGGELSRVIEAGGDPTKVVFSGVGKTVSEMEMALNLGIYCFNVESAAELEQLNLVALRLGKVAPVSLRINPDVDAGTHP
YISTGLKENKFGIAMEEAEAIFARANELPGLAVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
GVTYDDEQPPQPDVYAAALLERLGDRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFALVDGAMNDLIRPSLYSAWQ
KIVPVIERAGESHSYDVVGPVCETGDFLGKDRQLNVQEGDYLAVRSSGAYGFTMASNYNSRPRAAELMVDGDKAYVIRER
EKVAQLWQGEQILP
>Mature_414_residues
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWRAFDNAVSEHPHLICYAVKANSNIAVLNVLARLGSGFDI
VSGGELSRVIEAGGDPTKVVFSGVGKTVSEMEMALNLGIYCFNVESAAELEQLNLVALRLGKVAPVSLRINPDVDAGTHP
YISTGLKENKFGIAMEEAEAIFARANELPGLAVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
GVTYDDEQPPQPDVYAAALLERLGDRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFALVDGAMNDLIRPSLYSAWQ
KIVPVIERAGESHSYDVVGPVCETGDFLGKDRQLNVQEGDYLAVRSSGAYGFTMASNYNSRPRAAELMVDGDKAYVIRER
EKVAQLWQGEQILP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=354, Percent_Identity=26.271186440678, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI22538418, Length=357, Percent_Identity=26.3305322128852, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI21361583, Length=357, Percent_Identity=26.3305322128852, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789203, Length=446, Percent_Identity=30.2690582959641, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789307, Length=301, Percent_Identity=24.5847176079734, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=370, Percent_Identity=23.7837837837838, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322664, Length=377, Percent_Identity=25.7294429708223, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24586472, Length=381, Percent_Identity=24.4094488188976, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586474, Length=377, Percent_Identity=26.2599469496021, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45420; Mature: 45420

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWRAFDNAVSEHPHLICYAVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEE
ANSNIAVLNVLARLGSGFDIVSGGELSRVIEAGGDPTKVVFSGVGKTVSEMEMALNLGIY
CCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCEE
CFNVESAAELEQLNLVALRLGKVAPVSLRINPDVDAGTHPYISTGLKENKFGIAMEEAEA
EEECCCHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCEEHHHHHH
IFARANELPGLAVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
HHHHHCCCCCEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYDDEQPPQPDVYAAALLERLGDRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEEEEEEECCCCCEE
ALVDGAMNDLIRPSLYSAWQKIVPVIERAGESHSYDVVGPVCETGDFLGKDRQLNVQEGD
EEECCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
YLAVRSSGAYGFTMASNYNSRPRAAELMVDGDKAYVIREREKVAQLWQGEQILP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWRAFDNAVSEHPHLICYAVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEE
ANSNIAVLNVLARLGSGFDIVSGGELSRVIEAGGDPTKVVFSGVGKTVSEMEMALNLGIY
CCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCEE
CFNVESAAELEQLNLVALRLGKVAPVSLRINPDVDAGTHPYISTGLKENKFGIAMEEAEA
EEECCCHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCEEHHHHHH
IFARANELPGLAVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
HHHHHCCCCCEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYDDEQPPQPDVYAAALLERLGDRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEEEEEEECCCCCEE
ALVDGAMNDLIRPSLYSAWQKIVPVIERAGESHSYDVVGPVCETGDFLGKDRQLNVQEGD
EEECCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
YLAVRSSGAYGFTMASNYNSRPRAAELMVDGDKAYVIREREKVAQLWQGEQILP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]