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The map label for this gene is hemC [H]

Identifier: 157960202

GI number: 157960202

Start: 452118

End: 453050

Strand: Reverse

Name: hemC [H]

Synonym: Spea_0373

Alternate gene names: 157960202

Gene position: 453050-452118 (Counterclockwise)

Preceding gene: 157960204

Following gene: 157960201

Centisome position: 8.76

GC content: 48.34

Gene sequence:

>933_bases
ATGTCTCAAAATCTGATCCGTATCGCAACACGTAAGAGCCCTCTTGCCATGTGGCAAGCCGAATTTGTGAAAGCTGAACT
GGAAAAAATCCATGAAGGTCTCACTGTAGAATTGCTACCAATGAGCACTAAAGGTGACATCATCTTAGACACGCCACTTG
CTAAAGTGGGCGGTAAAGGCTTATTCGTTAAAGAACTCGAAGTGGCCATGTTAGAAGGCCTGGCAGATATCGCTGTTCAC
TCGATGAAAGACGTACCAGTAGACTTCCCAGAAGGTCTAGGTCTTGAAGTGATTTGTGAGCGTGAAGATCCGCGCGATGC
TTTCGTATCAAATACCTATAAGACAATTGAAGATTTGCCACAAGGCGCAGTAGTCGGTACATCTAGCCTACGTCGTCAGT
GCCAAATTCGCGCTGCGCGTCCAGATCTAGTTATCAAAGATCTGCGTGGTAACGTCGGGACTCGTCTAGCAAAACTAGAT
GCTGGCAACTATGACGCAATTATCCTTGCTGCCGCAGGTCTTAAACGCCTTAAGCTAGAAGAAAGAATCGCAAGCTTCAT
CTCAGCAGAGCAATCACTACCAGCAAACGGCCAAGGCGCTGTAGGTATTGAGTGTCGTACTGATGACGCTCGTGTTAAAG
CCCTGCTTGCACCGCTTGAGCACGCTGAAACTCGTATGCGTGTTACCGCTGAGCGTGCAATGAATACTCGCCTTGAAGGT
GGTTGTCAGGTACCTATTGGTGCTTACGCTGAAATCGACGGTGACACATTAAGCCTACGCGGTTTAGTAGGTAACCCAGA
TGGTAGCCAAATCATCACGGCTTCATCGTCAGGCAGCACTGCCGATGCAGAGAAGCTAGGCGTTGCACTAGCAGAAGAAC
TGCTAAGCAAAGGTGCTAAAACGATTCTTGACGCTGTTTACGCGAACGCGTAA

Upstream 100 bases:

>100_bases
AGAACAGGGTGAACTTCAAAGAATCAAAAGCAGAGCGTTACATCTGTAATCGGGCAGTGTTAGCATTGAAGCAAATAAGT
TCTAAGATGGAATATCGAGC

Downstream 100 bases:

>100_bases
CACTCAATGAAAATCTTACTGACGCGCCCTGAAGGGCGCAATCAGTTGATGAAAGAGGCGTTGACTCAGCGCAACGTCTC
TTACTTCATCACGCCCCTAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSQNLIRIATRKSPLAMWQAEFVKAELEKIHEGLTVELLPMSTKGDIILDTPLAKVGGKGLFVKELEVAMLEGLADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKTIEDLPQGAVVGTSSLRRQCQIRAARPDLVIKDLRGNVGTRLAKLD
AGNYDAIILAAAGLKRLKLEERIASFISAEQSLPANGQGAVGIECRTDDARVKALLAPLEHAETRMRVTAERAMNTRLEG
GCQVPIGAYAEIDGDTLSLRGLVGNPDGSQIITASSSGSTADAEKLGVALAEELLSKGAKTILDAVYANA

Sequences:

>Translated_310_residues
MSQNLIRIATRKSPLAMWQAEFVKAELEKIHEGLTVELLPMSTKGDIILDTPLAKVGGKGLFVKELEVAMLEGLADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKTIEDLPQGAVVGTSSLRRQCQIRAARPDLVIKDLRGNVGTRLAKLD
AGNYDAIILAAAGLKRLKLEERIASFISAEQSLPANGQGAVGIECRTDDARVKALLAPLEHAETRMRVTAERAMNTRLEG
GCQVPIGAYAEIDGDTLSLRGLVGNPDGSQIITASSSGSTADAEKLGVALAEELLSKGAKTILDAVYANA
>Mature_309_residues
SQNLIRIATRKSPLAMWQAEFVKAELEKIHEGLTVELLPMSTKGDIILDTPLAKVGGKGLFVKELEVAMLEGLADIAVHS
MKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKTIEDLPQGAVVGTSSLRRQCQIRAARPDLVIKDLRGNVGTRLAKLDA
GNYDAIILAAAGLKRLKLEERIASFISAEQSLPANGQGAVGIECRTDDARVKALLAPLEHAETRMRVTAERAMNTRLEGG
CQVPIGAYAEIDGDTLSLRGLVGNPDGSQIITASSSGSTADAEKLGVALAEELLSKGAKTILDAVYANA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=41.4414414414414, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=41.4414414414414, Blast_Score=229, Evalue=2e-60,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=69.3811074918567, Blast_Score=434, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=37.0716510903427, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI20130425, Length=281, Percent_Identity=41.9928825622776, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33070; Mature: 32939

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNLIRIATRKSPLAMWQAEFVKAELEKIHEGLTVELLPMSTKGDIILDTPLAKVGGKG
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCHHHHCCCC
LFVKELEVAMLEGLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKTIEDLP
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
QGAVVGTSSLRRQCQIRAARPDLVIKDLRGNVGTRLAKLDAGNYDAIILAAAGLKRLKLE
CCCEECCHHHHHHHHHCCCCCCEEEEHHCCCHHCEEEEECCCCCCEEEEEECCHHHHHHH
ERIASFISAEQSLPANGQGAVGIECRTDDARVKALLAPLEHAETRMRVTAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GCQVPIGAYAEIDGDTLSLRGLVGNPDGSQIITASSSGSTADAEKLGVALAEELLSKGAK
CCCCCCCCEEEECCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHH
TILDAVYANA
HHHHHHHCCC
>Mature Secondary Structure 
SQNLIRIATRKSPLAMWQAEFVKAELEKIHEGLTVELLPMSTKGDIILDTPLAKVGGKG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCHHHHCCCC
LFVKELEVAMLEGLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNTYKTIEDLP
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
QGAVVGTSSLRRQCQIRAARPDLVIKDLRGNVGTRLAKLDAGNYDAIILAAAGLKRLKLE
CCCEECCHHHHHHHHHCCCCCCEEEEHHCCCHHCEEEEECCCCCCEEEEEECCHHHHHHH
ERIASFISAEQSLPANGQGAVGIECRTDDARVKALLAPLEHAETRMRVTAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GCQVPIGAYAEIDGDTLSLRGLVGNPDGSQIITASSSGSTADAEKLGVALAEELLSKGAK
CCCCCCCCEEEECCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHH
TILDAVYANA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA