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The map label for this gene is mutL [H]

Identifier: 157826372

GI number: 157826372

Start: 1219680

End: 1221509

Strand: Reverse

Name: mutL [H]

Synonym: A1C_06805

Alternate gene names: 157826372

Gene position: 1221509-1219680 (Counterclockwise)

Preceding gene: 157826373

Following gene: 157826371

Centisome position: 99.22

GC content: 35.03

Gene sequence:

>1830_bases
ATGACTATCAAATTTCTTTCAGAAAATACTATAAACCGAATTGCTGCCGGTGAGGTTATAGAAAGACCCGCATCGGTAGT
AAAGGAATTAGTTGAAAATGCTGTTGATGCTGGTAGTACAAAAATAGATATTATTTTAGAACGTGCCGGTAAAAATCTAA
TCATTATTTCCGATGACGGTATCGGTATGACTGATAAGGAATTAGAAATTGCCGTTGAACGTCACACAACTTCTAAGCTT
GATGAAAGCGATTTCCTAAATATTCATACTTTCGGTTTTCGAGGTGAAGCATTGCCGTCTATTGCTGCCATTAGCAAAAT
GCTAATTACTTCTAAGAAACAAGGGTATGACAAAGCATTTCAGATTAAGTTAATCGGTGGTAATGAAAAACAAGTTACTA
TTTCTGTTCATAATGAAGGTACTAAAATAGAGATACGTGATTTATTTTTCGCAACACCTGCACGTTTAAAATTTCTTAGA
TCCGACAAAACTGAGCTTGTAGCAACAGTAGACGTGGTTAAGAAAATCGCTCTAGCACATCCTAAAATTTCTTTTAGCTT
AACGCATGATGACAGAAATCTGTTAAAGTTTAAAGGACACAATAAAGATGTAGAAACTAACCTAAAACAGCGTATAATTG
ATGTAATAGGTGATGATTTTATAAAAAATGCTGCTTATATAGATTTCAAAACTCCTGATTTCTCTATTTGCGGCTATACT
AGTATCCCGACATATAATAGAGCTTCAAGTGAAGATCAGTTTTTATTTATCAATAATAGACCGGTAAAAGATAAGTTGCT
ACAAGTAGCTTTAAGGGTAGCATATCAGGATTATTTAGCTCGTGATCGTTATCCGCTGTGTGCTATATTCTTACAAATCG
ATCCGCAGCTTGTTGACGTTAACGTACATCCGGCAAAAGCAGAGGTTAGATTTCATGACCCGAATTATGTACGAAACTTA
TTAATAGAAGCGATTAAAAATGCTTTAACAAATACAAGCCATGTTACTTCTACTACTATCGCCTCTGATGCTCTTCAGTT
ATTTAAAAATCATTTAGTTAACAAACAACCATCAGTAAGTAAAGCTGTAAGCGTGAATAGCAAACCTACAGATTATAGAC
CTGCTATGTCGCCTAGTTTTAAATCTACGCCAAATACTGATTGTCAAAAACTAATCGATACATTACCGCACGCTAAAATA
GAACAAGAAGTAGAAAGGCGTATAGAACGTGAGCAGCAAGCCCATAAACAATATAAACTTGGTGCAGCTAAAGCACAACT
TCATACTACTTACATTATTTCACAAACCGAAGATAGTATAGTAATTACCGACCAGCATGCAGCACATGAACGTTTAGGAT
ATGAAAAAATAAAAGATTACCTTAAAACGGAAGAGTTAATAAGACAGCGTTTGCTTATTCCTGAGATAGTAGAACTGCCA
AATGAAAGAAACGCAGATTCTTTATATGAAAATAGAGAAAAACTATATAAACTTGGTTTAACTCTAGAAAAATTCGGTGA
GAAATCTATTATAGTGACTGAAATTCCAAATATCCTTGGAGATGTCAACGTACAAAAATTAATTCATGATCTCGCTGATC
ATTTATCGGATTTCGGTGAGAATATAGCTTTGACGGAGTTAATAGAGCATGTGACAGAAACTTATGCCTGTCATTACTCT
ATTAGAGCAGGACGAAAATTGTCGGCAGATGAAATGAATGCTTTACTGCGTCAAATGGAAAATACGCCGTTTTCAGGTCA
ATGTAATCACGGCAGACCTACTTATATTGAGTTGAAGCTTAAGGATATCGAACGCTTATTTGGACGGTAG

Upstream 100 bases:

>100_bases
AACCTCCATATGACCATCCAAAAATTTATTTAGAGATAGATAAGGAAAAAAAGGAAGTTATCTGCCCATATTGTAGTAAG
AAATTTAAATTAGTAACAAA

Downstream 100 bases:

>100_bases
TGAATAGGTATTGCCTAGGGGAGCATAACGTTTTGATATCATTCCCGCTTTTGCGGAAATGATATCATTTTAGGCAATGC
AGGTTAAATTATTTCATTTT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MTIKFLSENTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKL
DESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGYDKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLR
SDKTELVATVDVVKKIALAHPKISFSLTHDDRNLLKFKGHNKDVETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
SIPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNL
LIEAIKNALTNTSHVTSTTIASDALQLFKNHLVNKQPSVSKAVSVNSKPTDYRPAMSPSFKSTPNTDCQKLIDTLPHAKI
EQEVERRIEREQQAHKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIRQRLLIPEIVELP
NERNADSLYENREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIHDLADHLSDFGENIALTELIEHVTETYACHYS
IRAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKLKDIERLFGR

Sequences:

>Translated_609_residues
MTIKFLSENTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKL
DESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGYDKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLR
SDKTELVATVDVVKKIALAHPKISFSLTHDDRNLLKFKGHNKDVETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
SIPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNL
LIEAIKNALTNTSHVTSTTIASDALQLFKNHLVNKQPSVSKAVSVNSKPTDYRPAMSPSFKSTPNTDCQKLIDTLPHAKI
EQEVERRIEREQQAHKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIRQRLLIPEIVELP
NERNADSLYENREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIHDLADHLSDFGENIALTELIEHVTETYACHYS
IRAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKLKDIERLFGR
>Mature_608_residues
TIKFLSENTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKLD
ESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGYDKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRS
DKTELVATVDVVKKIALAHPKISFSLTHDDRNLLKFKGHNKDVETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYTS
IPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNLL
IEAIKNALTNTSHVTSTTIASDALQLFKNHLVNKQPSVSKAVSVNSKPTDYRPAMSPSFKSTPNTDCQKLIDTLPHAKIE
QEVERRIEREQQAHKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIRQRLLIPEIVELPN
ERNADSLYENREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIHDLADHLSDFGENIALTELIEHVTETYACHYSI
RAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKLKDIERLFGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=36.2179487179487, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI4505913, Length=357, Percent_Identity=29.6918767507003, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI310128478, Length=357, Percent_Identity=29.6918767507003, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4505911, Length=350, Percent_Identity=28, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI189458898, Length=350, Percent_Identity=28, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI189458896, Length=339, Percent_Identity=29.7935103244838, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI310128480, Length=315, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=294, Percent_Identity=29.2517006802721, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI91992160, Length=294, Percent_Identity=29.2517006802721, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=29.8165137614679, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1790612, Length=614, Percent_Identity=29.6416938110749, Blast_Score=258, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=31.8885448916409, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=348, Percent_Identity=28.1609195402299, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=343, Percent_Identity=34.6938775510204, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=339, Percent_Identity=28.023598820059, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=726, Percent_Identity=21.900826446281, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136968, Length=317, Percent_Identity=35.3312302839117, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=27.3743016759777, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68983; Mature: 68851

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKFLSENTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDG
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCC
IGMTDKELEIAVERHTTSKLDESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGYDKAF
CCCCCCHHEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEE
QIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRSDKTELVATVDVVKKIALAH
EEEEECCCCEEEEEEEECCCCEEEEEHEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
PKISFSLTHDDRNLLKFKGHNKDVETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
CCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
SIPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDV
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEE
NVHPAKAEVRFHDPNYVRNLLIEAIKNALTNTSHVTSTTIASDALQLFKNHLVNKQPSVS
EECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
KAVSVNSKPTDYRPAMSPSFKSTPNTDCQKLIDTLPHAKIEQEVERRIEREQQAHKQYKL
HHEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIRQRLLIPEIVELP
CHHHHHEEEEEEEEECCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCC
NERNADSLYENREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIHDLADHLSDFGE
CCCCHHHHHHHHHHHHHHCCCHHHHCCCCEEEECCHHHHCCCCHHHHHHHHHHHHHHHCC
NIALTELIEHVTETYACHYSIRAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKL
CCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEH
KDIERLFGR
HHHHHHHCC
>Mature Secondary Structure 
TIKFLSENTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCC
IGMTDKELEIAVERHTTSKLDESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGYDKAF
CCCCCCHHEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEE
QIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRSDKTELVATVDVVKKIALAH
EEEEECCCCEEEEEEEECCCCEEEEEHEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
PKISFSLTHDDRNLLKFKGHNKDVETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
CCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
SIPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDV
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEE
NVHPAKAEVRFHDPNYVRNLLIEAIKNALTNTSHVTSTTIASDALQLFKNHLVNKQPSVS
EECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
KAVSVNSKPTDYRPAMSPSFKSTPNTDCQKLIDTLPHAKIEQEVERRIEREQQAHKQYKL
HHEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIRQRLLIPEIVELP
CHHHHHEEEEEEEEECCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCC
NERNADSLYENREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIHDLADHLSDFGE
CCCCHHHHHHHHHHHHHHCCCHHHHCCCCEEEECCHHHHCCCCHHHHHHHHHHHHHHHCC
NIALTELIEHVTETYACHYSIRAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKL
CCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEH
KDIERLFGR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA