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The map label for this gene is nhaA

Identifier: 157826365

GI number: 157826365

Start: 1215462

End: 1215668

Strand: Direct

Name: nhaA

Synonym: A1C_06770

Alternate gene names: 157826365

Gene position: 1215462-1215668 (Clockwise)

Preceding gene: 157826360

Following gene: 157826366

Centisome position: 98.73

GC content: 31.88

Gene sequence:

>207_bases
GTGGTAGTTCATGCCTTAATATACATATTTTTTAATTATGATAAACCTGGATTAATAAAAGGATGGGCTGTTCCTATAGC
AACCGATACTGCTTTTGTCCTTGGTATTGTATCTTTTTTCAGTCGACATATATCTTTAGAATTACGAACTTTTATTATAG
GTTTCTCATTAATTGACGATGCTTTTGCGCCAATTATACTATCCTGA

Upstream 100 bases:

>100_bases
TTCTTTTTATTAATAGGTTTAGAAATGAAATTTCACCTAGTAGAATGTGAATATAAAAATAAAAAAACTATTATTACGTT
AGGCAACAGCCATTGGATGT

Downstream 100 bases:

>100_bases
TTTTATACTAAAACAATCAATACTCCAGCATTATTAATTTCCTCTGTAATTATATTCATCTTGTTTATATTGAATTATAG
ACAAGTTAAACAATTATTGT

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 68; Mature: 68

Protein sequence:

>68_residues
MVVHALIYIFFNYDKPGLIKGWAVPIATDTAFVLGIVSFFSRHISLELRTFIIGFSLIDDAFAPIILS

Sequences:

>Translated_68_residues
MVVHALIYIFFNYDKPGLIKGWAVPIATDTAFVLGIVSFFSRHISLELRTFIIGFSLIDDAFAPIILS
>Mature_68_residues
MVVHALIYIFFNYDKPGLIKGWAVPIATDTAFVLGIVSFFSRHISLELRTFIIGFSLIDDAFAPIILS

Specific function: This Is A Na(+)/H(+) Antiporter. It Can Mediate Sodium Uptake When A Transmembrane Ph Gradient Is Applied. It Probably Acts In The Regulation Of Internal Ph At The Alkaline Ph Range. It Catalyzes The Exchange Of 2h(+) Per Na(+). Its Activity Is Highly Dep

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=68, Percent_Identity=42.6470588235294, Blast_Score=62, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_RICAH (A8GQA2)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001494085.1
- ProteinModelPortal:   A8GQA2
- SMR:   A8GQA2
- GeneID:   5644596
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_06770
- eggNOG:   COG3004
- BioCyc:   RAKA293614:A1C_06770-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 7603; Mature: 7603

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13119314)-; HASH(0x10b56d20)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVHALIYIFFNYDKPGLIKGWAVPIATDTAFVLGIVSFFSRHISLELRTFIIGFSLIDD
CHHHEEEEEEECCCCCCCEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AFAPIILS
CCCCEECH
>Mature Secondary Structure
MVVHALIYIFFNYDKPGLIKGWAVPIATDTAFVLGIVSFFSRHISLELRTFIIGFSLIDD
CHHHEEEEEEECCCCCCCEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AFAPIILS
CCCCEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA