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The map label for this gene is dnaX [H]

Identifier: 157826351

GI number: 157826351

Start: 1204294

End: 1205823

Strand: Direct

Name: dnaX [H]

Synonym: A1C_06700

Alternate gene names: 157826351

Gene position: 1204294-1205823 (Clockwise)

Preceding gene: 157826350

Following gene: 157826352

Centisome position: 97.83

GC content: 30.65

Gene sequence:

>1530_bases
GTGCTATATATAAATTCATCAAATCAATATATTCCTTTTGCAAGGAAATATCGTCCTAGTAACTTTGCCGAGCTTCAGGG
GCAAGAGGTATTAGTCAAAGTTTTAAGCTATACTATTTTAAACGATAGGCTAGCCGGAGGCTATCTTTTAACGGGTATTA
GAGGAGTCGGTAAAACTACTTCCGCCCGAATTATTGCTAAAGCCGTAAACTGTTCTGCTTTAATTACAGAAAATACGACT
ATTAAAACATGCGAAGAATGTACAAATTGTATCAGCTTTAATAATCATAATCACCCTGATATAATCGAAATTGACGCAGC
AAGTAAAACTAGCGTAGATGATATACGTAGAATTATAGAATCTGCTGAATATAAACCTCTACAAGGTAAACATAAAATCT
TCATCATTGATGAGGTGCATATGCTCTCTAAGGGAGCGTTTAATGCACTTCTTAAGACTTTAGAAGAACCGCCGCCTCAT
ATAATATTTATCTTTGCAACAACGGAAGTACAAAAGATACCTGCAACTATCATCTCAAGATGTCAACGTTATGATTTAAG
GCGGTTGAATTTTGAAGAAATTTTTAAGCTACTTGAATATATAGCTAAGCAAGAAAACTTAAAAACCGATATAGAATCTT
TAAGAATTATAGCTTATAAGTCTGAAGGATCGGCACGTGATGCAGTATCTATTTTAGATCAAGCAGCTAGTATGTCGGCG
AAATCTGATAATATCATTAGCCCTCAAGTAATTAATCAAATACTTGGGCTTGTTGATACTTCGGTTATAATAGAATTTGT
GGAGTATATAATTCATAGAGAGACGGAAAAAGCTATAAATTTAATAAATAAACTTTACGGTTTTTCTGTTAATCTTGAGA
TTTTTATAGAATCGGTAGCAGATTTTATTGCTTATCTTAACAAAGCAAAAATGTTACATAATTATAGTTTACCGATATAT
GAATCATTTAACGATAGGACTAACAGCATATTAGATACAATCAGCTTGCCACATCTATCAATCTTATGGCAAATATATAA
TAAGGGAGTAGTGGAAATAAAAAGTTCCTATAATCAACTAACAGAAACGGAAATGTTAGTTATAAAATCTATATATTCGA
CGTCGCTGCCGCTGCTTGACGATTCTGATGGTAATAATCAAAATTTAAATCAATCAATTAATCCGGAAATAAAAAAAAAT
TTTGAAATTGTAGATTTTCTTAAATATCTATATAAAAATAATGAGATAGATATATATTATTTCCTACTCAATCATGCGGA
GCTTAAAAATCTCAGTGATAATAGATTAGAGTTCTGCAGTCTTGAAATTAAAAGTAAATTAAAGAAACAAATAGAAGATT
TGTTAGCTGATTTTACTAAAGAAAAGTGTAAATTTATAGTAATAAAAGAGCAGAACAAGCAAACCTTAAAGAGCCAGTTA
ATAGATAAGATTGCAGCAAGTAATGATTTTGGTTTAATTAAAAAACATTTCCCGAATGCGGAAATTTCAGATATATTACT
TAAAAATTAA

Upstream 100 bases:

>100_bases
ATTGATCCACGCAACAACGCACGAAAGCGGGAATGACATAGAGAATTACACAATAACACCGGTTTTTAGCTAGAATGCCA
TAAAAAGTCTTATAACAATC

Downstream 100 bases:

>100_bases
AGGATAGAATTATGGTAAATTTTAATCAGTTTTTAAAGCAAGCCCAATCAATGCAAAAAAAAATGCAAGAAGCACAAGAG
CAAATGGCAAATGCAAGGTA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MLYINSSNQYIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTTSARIIAKAVNCSALITENTT
IKTCEECTNCISFNNHNHPDIIEIDAASKTSVDDIRRIIESAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPH
IIFIFATTEVQKIPATIISRCQRYDLRRLNFEEIFKLLEYIAKQENLKTDIESLRIIAYKSEGSARDAVSILDQAASMSA
KSDNIISPQVINQILGLVDTSVIIEFVEYIIHRETEKAINLINKLYGFSVNLEIFIESVADFIAYLNKAKMLHNYSLPIY
ESFNDRTNSILDTISLPHLSILWQIYNKGVVEIKSSYNQLTETEMLVIKSIYSTSLPLLDDSDGNNQNLNQSINPEIKKN
FEIVDFLKYLYKNNEIDIYYFLLNHAELKNLSDNRLEFCSLEIKSKLKKQIEDLLADFTKEKCKFIVIKEQNKQTLKSQL
IDKIAASNDFGLIKKHFPNAEISDILLKN

Sequences:

>Translated_509_residues
MLYINSSNQYIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTTSARIIAKAVNCSALITENTT
IKTCEECTNCISFNNHNHPDIIEIDAASKTSVDDIRRIIESAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPH
IIFIFATTEVQKIPATIISRCQRYDLRRLNFEEIFKLLEYIAKQENLKTDIESLRIIAYKSEGSARDAVSILDQAASMSA
KSDNIISPQVINQILGLVDTSVIIEFVEYIIHRETEKAINLINKLYGFSVNLEIFIESVADFIAYLNKAKMLHNYSLPIY
ESFNDRTNSILDTISLPHLSILWQIYNKGVVEIKSSYNQLTETEMLVIKSIYSTSLPLLDDSDGNNQNLNQSINPEIKKN
FEIVDFLKYLYKNNEIDIYYFLLNHAELKNLSDNRLEFCSLEIKSKLKKQIEDLLADFTKEKCKFIVIKEQNKQTLKSQL
IDKIAASNDFGLIKKHFPNAEISDILLKN
>Mature_509_residues
MLYINSSNQYIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTTSARIIAKAVNCSALITENTT
IKTCEECTNCISFNNHNHPDIIEIDAASKTSVDDIRRIIESAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPH
IIFIFATTEVQKIPATIISRCQRYDLRRLNFEEIFKLLEYIAKQENLKTDIESLRIIAYKSEGSARDAVSILDQAASMSA
KSDNIISPQVINQILGLVDTSVIIEFVEYIIHRETEKAINLINKLYGFSVNLEIFIESVADFIAYLNKAKMLHNYSLPIY
ESFNDRTNSILDTISLPHLSILWQIYNKGVVEIKSSYNQLTETEMLVIKSIYSTSLPLLDDSDGNNQNLNQSINPEIKKN
FEIVDFLKYLYKNNEIDIYYFLLNHAELKNLSDNRLEFCSLEIKSKLKKQIEDLLADFTKEKCKFIVIKEQNKQTLKSQL
IDKIAASNDFGLIKKHFPNAEISDILLKN

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=373, Percent_Identity=34.5844504021448, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71986063, Length=319, Percent_Identity=26.0188087774295, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541988, Length=287, Percent_Identity=24.7386759581882, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=300, Percent_Identity=24.3333333333333, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=277, Percent_Identity=26.7148014440433, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647857, Length=298, Percent_Identity=22.8187919463087, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI18859927, Length=304, Percent_Identity=22.3684210526316, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58134; Mature: 58134

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYINSSNQYIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTT
CEEECCCCCCCCHHHHCCCCCHHHHCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCH
SARIIAKAVNCSALITENTTIKTCEECTNCISFNNHNHPDIIEIDAASKTSVDDIRRIIE
HHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHH
SAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATIISR
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHH
CQRYDLRRLNFEEIFKLLEYIAKQENLKTDIESLRIIAYKSEGSARDAVSILDQAASMSA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCC
KSDNIISPQVINQILGLVDTSVIIEFVEYIIHRETEKAINLINKLYGFSVNLEIFIESVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHH
DFIAYLNKAKMLHNYSLPIYESFNDRTNSILDTISLPHLSILWQIYNKGVVEIKSSYNQL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEHHHHHHH
TETEMLVIKSIYSTSLPLLDDSDGNNQNLNQSINPEIKKNFEIVDFLKYLYKNNEIDIYY
HHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCEEEEE
FLLNHAELKNLSDNRLEFCSLEIKSKLKKQIEDLLADFTKEKCKFIVIKEQNKQTLKSQL
EEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHH
IDKIAASNDFGLIKKHFPNAEISDILLKN
HHHHHCCCCCCHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure
MLYINSSNQYIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTT
CEEECCCCCCCCHHHHCCCCCHHHHCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCH
SARIIAKAVNCSALITENTTIKTCEECTNCISFNNHNHPDIIEIDAASKTSVDDIRRIIE
HHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHH
SAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATIISR
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHH
CQRYDLRRLNFEEIFKLLEYIAKQENLKTDIESLRIIAYKSEGSARDAVSILDQAASMSA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCC
KSDNIISPQVINQILGLVDTSVIIEFVEYIIHRETEKAINLINKLYGFSVNLEIFIESVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHH
DFIAYLNKAKMLHNYSLPIYESFNDRTNSILDTISLPHLSILWQIYNKGVVEIKSSYNQL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEHHHHHHH
TETEMLVIKSIYSTSLPLLDDSDGNNQNLNQSINPEIKKNFEIVDFLKYLYKNNEIDIYY
HHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCEEEEE
FLLNHAELKNLSDNRLEFCSLEIKSKLKKQIEDLLADFTKEKCKFIVIKEQNKQTLKSQL
EEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHH
IDKIAASNDFGLIKKHFPNAEISDILLKN
HHHHHCCCCCCHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]