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The map label for this gene is pntAA [H]

Identifier: 157826349

GI number: 157826349

Start: 1202095

End: 1203216

Strand: Reverse

Name: pntAA [H]

Synonym: A1C_06690

Alternate gene names: 157826349

Gene position: 1203216-1202095 (Counterclockwise)

Preceding gene: 157826353

Following gene: 157826348

Centisome position: 97.74

GC content: 36.99

Gene sequence:

>1122_bases
ATGAAAATCGTTGCTTTAAAAGAAAAAGCCAAGCATGAATCGCGTGCCGCCATAACGCCTGAAGTAGCGGAGTTACTAGT
CAAAAAAGGTTATGCAGTTACGGTAGAAAAAGATATAGGTCTTCATGCCGGTTTTCTTGATGAAGAGTATATTGCTCGAG
GTGCTAAAATATCTTCGGTACCACTCGAGATTATTTCTGATGCCGATATTATATTAAAGGTACAACCTTCATCCGTTACG
GATAAATATAGTGAGCTTGAATTCGCAAAAAAAGGAGCAATTATTGTAGGATTATTATCGCCTTATTTAAATCATGAATA
TATAAAAGCGGCAGCTAAAAAAAATCTTACGACTTTTGCTATGGAATTTGTGCCGAGAATTACTAAAGCTCAAAATATGG
ATGCTTTGTCTTCTCAAAGTAACTTAGTTGGTTATAGAGCCGTAATTGAAGCAAGCTATCATTATACAAGGGCTTTTCCT
ATGATGATGACGGCAGCAGGTACGATTTCACCGTGCAAAACTTTGGTGCTTGGTATCGGTGTTGCAGGACTCCAAGCTAT
TGCAACGGCAAAAAGACTCGGTAGTATTGTTGCAGGATATGATGTAAGGGCTGCTACCAAAGAGCAGGTAGAAAGCTTAG
GAGCTAAGTTTGTTTCACTGGAACTACAAGAAGATTTACAAGATAAATCAGGTTATGCTAATGAGAGTTCGGGAGATTAT
AAGGCGAAACAAGCAGAGTTTCTAGCAAAAATTATTAAAGGATATGATATAGTTATTACTACTGCACAAATTCCAGGCAA
AAAAGCCCCTCTGCTTGTTACAGAAAAAATGTTAGAATCTATGAAGTATGGCTCAGTGATTGTTGATATATCGACTAGTA
CAGGCGGAAACGTAGAAGGTTCAGAACCGGATAAGATCGTTAATAAGCACGGAGTTACAATAATAGGTTTATCAAACCTT
GCTACTAAAATTGCTACAGACAGCTCAAAATTATATGCTAAGAATTTGTATAATTTTCTAACCTATGCGTTGCAAGACGG
TAAATTTAATATGGATGATGGGTTAGTACGTGATATGTTGATTACTAAAGACGGCAAAATTGTGAGTGAGAAGGTTAAGT
AA

Upstream 100 bases:

>100_bases
ACACAAATAATAACTAAGAATATTTTTTTCATTTTTATTGTTTTATATTTTAAATTATGTTTAAAATACCTTAGTTATTT
TGTTAAAACAAATGATATTT

Downstream 100 bases:

>100_bases
TTATTTAACTGGATTGCCGCGTCGATGCTGGTGCATCTCCTCGCAATGAAAATGAAAAAATAACCAAGAGAAAAGTATGA
ATCAATTACCGATAATGGCT

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Pyridine nucleotide transhydrogenase subunit alpha 1 [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKIVALKEKAKHESRAAITPEVAELLVKKGYAVTVEKDIGLHAGFLDEEYIARGAKISSVPLEIISDADIILKVQPSSVT
DKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFAMEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFP
MMMTAAGTISPCKTLVLGIGVAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSLELQEDLQDKSGYANESSGDY
KAKQAEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKYGSVIVDISTSTGGNVEGSEPDKIVNKHGVTIIGLSNL
ATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDGLVRDMLITKDGKIVSEKVK

Sequences:

>Translated_373_residues
MKIVALKEKAKHESRAAITPEVAELLVKKGYAVTVEKDIGLHAGFLDEEYIARGAKISSVPLEIISDADIILKVQPSSVT
DKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFAMEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFP
MMMTAAGTISPCKTLVLGIGVAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSLELQEDLQDKSGYANESSGDY
KAKQAEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKYGSVIVDISTSTGGNVEGSEPDKIVNKHGVTIIGLSNL
ATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDGLVRDMLITKDGKIVSEKVK
>Mature_373_residues
MKIVALKEKAKHESRAAITPEVAELLVKKGYAVTVEKDIGLHAGFLDEEYIARGAKISSVPLEIISDADIILKVQPSSVT
DKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFAMEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFP
MMMTAAGTISPCKTLVLGIGVAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSLELQEDLQDKSGYANESSGDY
KAKQAEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKYGSVIVDISTSTGGNVEGSEPDKIVNKHGVTIIGLSNL
ATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDGLVRDMLITKDGKIVSEKVK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=375, Percent_Identity=37.3333333333333, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI122939153, Length=375, Percent_Identity=37.3333333333333, Blast_Score=244, Evalue=6e-65,
Organism=Escherichia coli, GI1787887, Length=372, Percent_Identity=40.0537634408602, Blast_Score=267, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=369, Percent_Identity=41.7344173441734, Blast_Score=298, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40344; Mature: 40344

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVALKEKAKHESRAAITPEVAELLVKKGYAVTVEKDIGLHAGFLDEEYIARGAKISSV
CEEEEECHHHCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCEECCC
PLEIISDADIILKVQPSSVTDKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFA
CHHEECCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHCHHHHHHHHHCCHHHHH
MEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFPMMMTAAGTISPCKTLVLGIG
HHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSLELQEDLQDKSGYANESSGDY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCCCCCCCC
KAKQAEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKYGSVIVDISTSTGGNVEG
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
SEPDKIVNKHGVTIIGLSNLATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDGLVRDML
CCCHHHHHHCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
ITKDGKIVSEKVK
CCCCCCCHHCCCC
>Mature Secondary Structure
MKIVALKEKAKHESRAAITPEVAELLVKKGYAVTVEKDIGLHAGFLDEEYIARGAKISSV
CEEEEECHHHCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCEECCC
PLEIISDADIILKVQPSSVTDKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFA
CHHEECCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHCHHHHHHHHHCCHHHHH
MEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFPMMMTAAGTISPCKTLVLGIG
HHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSLELQEDLQDKSGYANESSGDY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCCCCCCCC
KAKQAEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKYGSVIVDISTSTGGNVEG
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
SEPDKIVNKHGVTIIGLSNLATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDGLVRDML
CCCHHHHHHCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
ITKDGKIVSEKVK
CCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893; 9335295; 8662004 [H]