| Definition | Rickettsia akari str. Hartford, complete genome. |
|---|---|
| Accession | NC_009881 |
| Length | 1,231,060 |
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The map label for this gene is mrcA [H]
Identifier: 157826265
GI number: 157826265
Start: 1120674
End: 1123049
Strand: Reverse
Name: mrcA [H]
Synonym: A1C_06240
Alternate gene names: 157826265
Gene position: 1123049-1120674 (Counterclockwise)
Preceding gene: 157826266
Following gene: 157826263
Centisome position: 91.23
GC content: 36.28
Gene sequence:
>2376_bases ATGTATAAATCTCTGTTTTTTTGTTTAAAAATTTTTGCCGTACTTATTCTAATAGGTTGTGCGGTTGTGTGGTATATAAT ATATCACTATTCACGTGATTTACCTGATTACTCACAACTTGCACGTTATTATCCAGCGTCTGTAACGCGTATTTATTCTC GTGACGGTAAATTAATGGAGGAGTACGCTTTTGAACGTCGTGTATTTGTACCGATTAATAGCGTACCGATTTCATTAATA GAAAGTTTTATCGCAGCTGAGGATAAGAATTTCTATAACCATCCGGGCGTCGATTTGCTTGGAATAGTTAGAGCGACATT TTTAAACATATCTAATTATCTACATCATAGGCGTATGGAAGGCGCCTCTACTATTACTCAGCAAGTGGTTAAAAATTTTC TACTAACTAATGAGGTTTCTCTTGAACGTAAGATTAAAGAAGCGATTCTTTCTTATATGATTTCAAGAGTATTTACTAAG GATCAAATCTTAGAATTATATCTTAATCAAACATTCTTTGGTCGTGGTGCATATGGCGTTGCGGCGGCTGCACAAAATTA TTTTAATAAATCCATAGAGGAACTTACCATTGCAGAATCAGCTTTTATTGCAGCACTTCCTAAAGCCCCTTCCGAACTTA ATCCAGCGAGAAATTACGCTAGAGTAAAAGCTCGTCGTGATTACGTAATAGGACGTATGTTTGAAGATGGTTATATAACA AAAGATGCTGCGAAAGAAGCTATGGATAGCCCGATAGTTTTACGTAAACGAGCTCAAGAAGAAACTGTTACGGCAGATTA TTATGTAGCACAGGTCAGAGAAGAAGTAATTAGGATGTTAAATAGTAAGGAAGAATTTTATACCGGAGGTCTTACTATTA TTACTTCTTTGGATGCAAAGATGCAGCAATTAGCTGAAAACTCTTTAAGAAAAGGTCTCAGGGAGTTTGATAGAAGACGT GGTTTTAGAAAGCCTATAGCTAATATTCCTGTTGATAATTGGCAAGAGGAGATAAAAAAACTACCGACTCCTCCATCGCT TTTAGAGTATAAATTAGCTGTAGTTCTGGATGTGGCCGATAATCATGCAGAGATTGGACTTATAGACGGTAATAAATCTA GGATTCCTATTGCTGAAATGAAATGGACAAGAAGTAATCTTAAATCAGTTAAGGCTCTACTTAAAAAAGGTGATGTGATA GTAGTTGAACCTGTAAAAGATGCTCTTTATGCTTTGCGTCAGATCCCTGAAGTAAACGGTGCTATTATGGTTATGAATCC AAATACCGGGCAGGTACTTGCAAGCGTCGGGGGTTATGATTTTTCCACAAGTAAATTTGATAGAGTAACTCAAGCACTTC GTCAACCCGGTTCTTTGAGTAAAACCTTTGTTTATCTAGCAGCTCTTGAAAATGGTATTAAGCCGAATCAGATTTTTAAC GATGGGCCTATTGAGATTGCGCAAGGTCCTGGGATGCCTAGTTGGCGTCCTAAAAATTATGAAGGTAAGTTTTTGGGTGA AATCACTATGCGTACTGGTTTTGAAAAATCCCGTAATCTTATAACGGTCAGAGTAGCAGCTGCCGTAGGACTTACAAAAA TCGTTGATATAATTAAGCGATTCGGTATTAATAGTGAACCAAAAAAGGTTTACTCTATGGTCCTTGGTTCAATTGAAACT ACACTTAGCAGAATGACCAATGCTTATGCAATTATTGCTAACGGTGGTAAAAAAGTTGAACCTCATTTTGTAGAATTAAT TAAAGACCGTAACGGTAAAATTATTTATAGGCGAGATGATAGAGAATGTCTTTCTTGTAATGTTTCGGACGCCAATTTAG ATATCGCAATATTAGAAATACCGCAAGAAGGTATTTATAGAGTTACGGATGAAGCTAGCAATTATCAAATTACTTCGTTT TTAACAGGAGCAATAGATAGAGGAACCGGTTATGCTGCGAAGAAGTTAGGAAAAATTATCGGTGGAAAAACCGGTACTAG TAATTATAGTAAAGATACATGGTTTATAGGTTTTACGCCTAAGATAGTAGTTGGCAGTTATGTTGGTTATGATACACCGA AAGAACTGGGAAAAAGAGCAACAGGTTCAAACGTAGTATTGCCGATTTTTATTGATTTTATGAGTAATGCTTATAAGGAT GAGTCATCGCTGCCTTTCAAAGTGCCCGATTCAATTAAGCTAATCGCCGTAGATAGAGCAACCGGTACAATTACACCAAA CGGCACTGTTATAGAAGCATTTAAAGTAAATAATGTTCAGATGCTTGAGAATGAAGATATGATTGATACGCAAGATAATA ATGATATTTTTGATTATGTACCGAGTAAGGGAGATCAGTCTCAAGAGATTTATTAA
Upstream 100 bases:
>100_bases ATATATCCAAAACCCTAATAAATCTTTACTTGGTAAAATCATTGATGTAAAAATTACTAAAGCTTCACTTAATAGTTTAA CCGGCGAAATATTATAATTC
Downstream 100 bases:
>100_bases ACTGTATACTTGTTTAAGCCGATGTAATTCCCGCTTCCGCGGGCATGACATCGTATACAACAAAGCTACCTGCTTATTTA TTCAGAATTTTAATTATGTG
Product: 1A family penicillin-binding protein
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 791; Mature: 791
Protein sequence:
>791_residues MYKSLFFCLKIFAVLILIGCAVVWYIIYHYSRDLPDYSQLARYYPASVTRIYSRDGKLMEEYAFERRVFVPINSVPISLI ESFIAAEDKNFYNHPGVDLLGIVRATFLNISNYLHHRRMEGASTITQQVVKNFLLTNEVSLERKIKEAILSYMISRVFTK DQILELYLNQTFFGRGAYGVAAAAQNYFNKSIEELTIAESAFIAALPKAPSELNPARNYARVKARRDYVIGRMFEDGYIT KDAAKEAMDSPIVLRKRAQEETVTADYYVAQVREEVIRMLNSKEEFYTGGLTIITSLDAKMQQLAENSLRKGLREFDRRR GFRKPIANIPVDNWQEEIKKLPTPPSLLEYKLAVVLDVADNHAEIGLIDGNKSRIPIAEMKWTRSNLKSVKALLKKGDVI VVEPVKDALYALRQIPEVNGAIMVMNPNTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGIKPNQIFN DGPIEIAQGPGMPSWRPKNYEGKFLGEITMRTGFEKSRNLITVRVAAAVGLTKIVDIIKRFGINSEPKKVYSMVLGSIET TLSRMTNAYAIIANGGKKVEPHFVELIKDRNGKIIYRRDDRECLSCNVSDANLDIAILEIPQEGIYRVTDEASNYQITSF LTGAIDRGTGYAAKKLGKIIGGKTGTSNYSKDTWFIGFTPKIVVGSYVGYDTPKELGKRATGSNVVLPIFIDFMSNAYKD ESSLPFKVPDSIKLIAVDRATGTITPNGTVIEAFKVNNVQMLENEDMIDTQDNNDIFDYVPSKGDQSQEIY
Sequences:
>Translated_791_residues MYKSLFFCLKIFAVLILIGCAVVWYIIYHYSRDLPDYSQLARYYPASVTRIYSRDGKLMEEYAFERRVFVPINSVPISLI ESFIAAEDKNFYNHPGVDLLGIVRATFLNISNYLHHRRMEGASTITQQVVKNFLLTNEVSLERKIKEAILSYMISRVFTK DQILELYLNQTFFGRGAYGVAAAAQNYFNKSIEELTIAESAFIAALPKAPSELNPARNYARVKARRDYVIGRMFEDGYIT KDAAKEAMDSPIVLRKRAQEETVTADYYVAQVREEVIRMLNSKEEFYTGGLTIITSLDAKMQQLAENSLRKGLREFDRRR GFRKPIANIPVDNWQEEIKKLPTPPSLLEYKLAVVLDVADNHAEIGLIDGNKSRIPIAEMKWTRSNLKSVKALLKKGDVI VVEPVKDALYALRQIPEVNGAIMVMNPNTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGIKPNQIFN DGPIEIAQGPGMPSWRPKNYEGKFLGEITMRTGFEKSRNLITVRVAAAVGLTKIVDIIKRFGINSEPKKVYSMVLGSIET TLSRMTNAYAIIANGGKKVEPHFVELIKDRNGKIIYRRDDRECLSCNVSDANLDIAILEIPQEGIYRVTDEASNYQITSF LTGAIDRGTGYAAKKLGKIIGGKTGTSNYSKDTWFIGFTPKIVVGSYVGYDTPKELGKRATGSNVVLPIFIDFMSNAYKD ESSLPFKVPDSIKLIAVDRATGTITPNGTVIEAFKVNNVQMLENEDMIDTQDNNDIFDYVPSKGDQSQEIY >Mature_791_residues MYKSLFFCLKIFAVLILIGCAVVWYIIYHYSRDLPDYSQLARYYPASVTRIYSRDGKLMEEYAFERRVFVPINSVPISLI ESFIAAEDKNFYNHPGVDLLGIVRATFLNISNYLHHRRMEGASTITQQVVKNFLLTNEVSLERKIKEAILSYMISRVFTK DQILELYLNQTFFGRGAYGVAAAAQNYFNKSIEELTIAESAFIAALPKAPSELNPARNYARVKARRDYVIGRMFEDGYIT KDAAKEAMDSPIVLRKRAQEETVTADYYVAQVREEVIRMLNSKEEFYTGGLTIITSLDAKMQQLAENSLRKGLREFDRRR GFRKPIANIPVDNWQEEIKKLPTPPSLLEYKLAVVLDVADNHAEIGLIDGNKSRIPIAEMKWTRSNLKSVKALLKKGDVI VVEPVKDALYALRQIPEVNGAIMVMNPNTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGIKPNQIFN DGPIEIAQGPGMPSWRPKNYEGKFLGEITMRTGFEKSRNLITVRVAAAVGLTKIVDIIKRFGINSEPKKVYSMVLGSIET TLSRMTNAYAIIANGGKKVEPHFVELIKDRNGKIIYRRDDRECLSCNVSDANLDIAILEIPQEGIYRVTDEASNYQITSF LTGAIDRGTGYAAKKLGKIIGGKTGTSNYSKDTWFIGFTPKIVVGSYVGYDTPKELGKRATGSNVVLPIFIDFMSNAYKD ESSLPFKVPDSIKLIAVDRATGTITPNGTVIEAFKVNNVQMLENEDMIDTQDNNDIFDYVPSKGDQSQEIY
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=831, Percent_Identity=32.3706377858002, Blast_Score=413, Evalue=1e-116, Organism=Escherichia coli, GI1786343, Length=305, Percent_Identity=29.5081967213115, Blast_Score=125, Evalue=1e-29, Organism=Escherichia coli, GI1788867, Length=266, Percent_Identity=29.6992481203008, Blast_Score=115, Evalue=9e-27, Organism=Escherichia coli, GI1789601, Length=156, Percent_Identity=39.1025641025641, Blast_Score=102, Evalue=7e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 88848; Mature: 88848
Theoretical pI: Translated: 9.14; Mature: 9.14
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MYKSLFFCLKIFAVLILIGCAVVWYIIYHYSRDLPDYSQLARYYPASVTRIYSRDGKLME CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHCCCHHHH EYAFERRVFVPINSVPISLIESFIAAEDKNFYNHPGVDLLGIVRATFLNISNYLHHRRME HHHHCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC GASTITQQVVKNFLLTNEVSLERKIKEAILSYMISRVFTKDQILELYLNQTFFGRGAYGV HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHH AAAAQNYFNKSIEELTIAESAFIAALPKAPSELNPARNYARVKARRDYVIGRMFEDGYIT HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCC KDAAKEAMDSPIVLRKRAQEETVTADYYVAQVREEVIRMLNSKEEFYTGGLTIITSLDAK HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCHH MQQLAENSLRKGLREFDRRRGFRKPIANIPVDNWQEEIKKLPTPPSLLEYKLAVVLDVAD HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHEEEEEEEEECC NHAEIGLIDGNKSRIPIAEMKWTRSNLKSVKALLKKGDVIVVEPVKDALYALRQIPEVNG CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCC AIMVMNPNTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGIKPNQIFN EEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC DGPIEIAQGPGMPSWRPKNYEGKFLGEITMRTGFEKSRNLITVRVAAAVGLTKIVDIIKR CCCEEEECCCCCCCCCCCCCCCCEEEEEHHHCCCHHHCCEEEEEHHHHHHHHHHHHHHHH FGINSEPKKVYSMVLGSIETTLSRMTNAYAIIANGGKKVEPHFVELIKDRNGKIIYRRDD CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEECC RECLSCNVSDANLDIAILEIPQEGIYRVTDEASNYQITSFLTGAIDRGTGYAAKKLGKII CHHHCCCCCCCCEEEEEEECCCCCCEEECCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHH GGKTGTSNYSKDTWFIGFTPKIVVGSYVGYDTPKELGKRATGSNVVLPIFIDFMSNAYKD CCCCCCCCCCCCEEEEECCHHHEEECCCCCCCHHHHCCCCCCCCEEHHHHHHHHHHHCCC ESSLPFKVPDSIKLIAVDRATGTITPNGTVIEAFKVNNVQMLENEDMIDTQDNNDIFDYV CCCCCEECCCCEEEEEEECCCCEECCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHCC PSKGDQSQEIY CCCCCCCCCCC >Mature Secondary Structure MYKSLFFCLKIFAVLILIGCAVVWYIIYHYSRDLPDYSQLARYYPASVTRIYSRDGKLME CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHCCCHHHH EYAFERRVFVPINSVPISLIESFIAAEDKNFYNHPGVDLLGIVRATFLNISNYLHHRRME HHHHCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC GASTITQQVVKNFLLTNEVSLERKIKEAILSYMISRVFTKDQILELYLNQTFFGRGAYGV HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHH AAAAQNYFNKSIEELTIAESAFIAALPKAPSELNPARNYARVKARRDYVIGRMFEDGYIT HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCC KDAAKEAMDSPIVLRKRAQEETVTADYYVAQVREEVIRMLNSKEEFYTGGLTIITSLDAK HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCHH MQQLAENSLRKGLREFDRRRGFRKPIANIPVDNWQEEIKKLPTPPSLLEYKLAVVLDVAD HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHEEEEEEEEECC NHAEIGLIDGNKSRIPIAEMKWTRSNLKSVKALLKKGDVIVVEPVKDALYALRQIPEVNG CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCC AIMVMNPNTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGIKPNQIFN EEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC DGPIEIAQGPGMPSWRPKNYEGKFLGEITMRTGFEKSRNLITVRVAAAVGLTKIVDIIKR CCCEEEECCCCCCCCCCCCCCCCEEEEEHHHCCCHHHCCEEEEEHHHHHHHHHHHHHHHH FGINSEPKKVYSMVLGSIETTLSRMTNAYAIIANGGKKVEPHFVELIKDRNGKIIYRRDD CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEECC RECLSCNVSDANLDIAILEIPQEGIYRVTDEASNYQITSFLTGAIDRGTGYAAKKLGKII CHHHCCCCCCCCEEEEEEECCCCCCEEECCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHH GGKTGTSNYSKDTWFIGFTPKIVVGSYVGYDTPKELGKRATGSNVVLPIFIDFMSNAYKD CCCCCCCCCCCCEEEEECCHHHEEECCCCCCCHHHHCCCCCCCCEEHHHHHHHHHHHCCC ESSLPFKVPDSIKLIAVDRATGTITPNGTVIEAFKVNNVQMLENEDMIDTQDNNDIFDYV CCCCCEECCCCEEEEEEECCCCEECCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHCC PSKGDQSQEIY CCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11557893 [H]