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The map label for this gene is serS [H]

Identifier: 157826236

GI number: 157826236

Start: 1085018

End: 1086295

Strand: Direct

Name: serS [H]

Synonym: A1C_06075

Alternate gene names: 157826236

Gene position: 1085018-1086295 (Clockwise)

Preceding gene: 157826235

Following gene: 157826237

Centisome position: 88.14

GC content: 33.8

Gene sequence:

>1278_bases
ATGTTAAGTATCAAATGGATTAGAGAAAATCAAGAATTATTCGATGAAAAGCTTAGCAAAAGATTTATTGAACCTATGTC
TAGTAAAATTGCTATGCTCGACGGAGAGAAAAGAAAAATTACGAGTTTAATTCAAGAATTTCAGCATGCACGTAAGGTAA
AATCAAAGATTTTAGGTAATATGGCTTCTAAAAGCGGCGAAGAGTTTGAAGCGATACAAAGAGATGTCAAACATATAAAT
GAGAAGTTGGAAGAACTTGAACAGGATCTAAATAATAATAACGAATTAAATGAACTATTAAATATGCTTCCTAATATTCC
GGACGAAGAAGTACCTTACGGAATGGATGAAAGTATGAATAAATTAGTTCGTACTTACGGAGAGACAAATCCAAATGCTT
TAAATAAACAGCATTTTGAACTAGGTACAAAATTAAATTTAATGGATTTTGAACAAACTGCTAAAATTTCTGGAGCTAGA
TTTGTAACGTTAAAAGGTGATTTAGCAAAGTTAGAACGTGCTTTAATTAATTTTATGATTGATGTTCATACTAAAGAGTT
TAACTTCTTTGAGATGTCACCTCCAGTATTAGTTCGAGATAATGCTATGTATAATTCAGGACAACTACCTAAATTTGCTG
AAGAGTCTTTTGCAACAACAAATGGTTACAGACTAATTCCAACCGCAGAAGTATTTTTAGTAAATATAGTCGCCGATACT
ATAATACCAAGGGAAAAATTGCCGATGCGTTATGTTGCTTACACCCCGTGCTTTAGATCAGAAGCAGGTAGTAGCGGTAG
AGATACAAGAGGTATGATCAGATTACATCAGTTCGGTAAAGTTGAGCTAGTATCTATTACTACCCCGGAAGAATCAAAAC
ATGAGCATGAATATATAACTAATTCATCAGAGACTATTTTACAAAAACTGAATCTTCCTTATCGTGTTATGTTACTTTGC
ACCGGAGATATGGGATTTGCGGCAAAAAAAACCTATGATATAGAGGTGTGGCTTCCGGGACAAAAGCAATATCGTGAAAT
TGCTAGCTGTTCTAATTGTGGAGATTTTCAAGCACGTAGAATGAAAGCAAGATATAAGGAATTCGGCAGTAACGAAACTA
CCTTAGTCCATACTTTAAATGCTTCAGGATTACCTATCGGAAGAACTATGGTTGCAATACTTGAAAATTATCAGAATGAA
GATGGCTCAATAACTATACCTGATGTCTTGATAAATTACATGGGAGGGTTACAAAAAATCACTACACATGGTGAATAA

Upstream 100 bases:

>100_bases
CCTGACATTTTAAGCCAGTTTGCTCTTGCAATACCACTACTTTTATTATATGAAACTTCAATAATGATATGTAATTTTAT
AGAAAAACCGAGGACACTAA

Downstream 100 bases:

>100_bases
TTGTTTATTAAATGTAAATAATAAGGTAAAGTTTTGTTGTCTCCTTACTATTCATTTATTCGAGTATATCTTAAAAATTG
GCTCTGTATGGTAGAAGATG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLSIKWIRENQELFDEKLSKRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEAIQRDVKHIN
EKLEELEQDLNNNNELNELLNMLPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGTKLNLMDFEQTAKISGAR
FVTLKGDLAKLERALINFMIDVHTKEFNFFEMSPPVLVRDNAMYNSGQLPKFAEESFATTNGYRLIPTAEVFLVNIVADT
IIPREKLPMRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKHEHEYITNSSETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKITTHGE

Sequences:

>Translated_425_residues
MLSIKWIRENQELFDEKLSKRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEAIQRDVKHIN
EKLEELEQDLNNNNELNELLNMLPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGTKLNLMDFEQTAKISGAR
FVTLKGDLAKLERALINFMIDVHTKEFNFFEMSPPVLVRDNAMYNSGQLPKFAEESFATTNGYRLIPTAEVFLVNIVADT
IIPREKLPMRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKHEHEYITNSSETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKITTHGE
>Mature_425_residues
MLSIKWIRENQELFDEKLSKRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEAIQRDVKHIN
EKLEELEQDLNNNNELNELLNMLPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGTKLNLMDFEQTAKISGAR
FVTLKGDLAKLERALINFMIDVHTKEFNFFEMSPPVLVRDNAMYNSGQLPKFAEESFATTNGYRLIPTAEVFLVNIVADT
IIPREKLPMRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKHEHEYITNSSETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKITTHGE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=341, Percent_Identity=34.6041055718475, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI8923421, Length=352, Percent_Identity=30.9659090909091, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI225579074, Length=321, Percent_Identity=32.0872274143302, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=45.2655889145497, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539260, Length=342, Percent_Identity=33.0409356725146, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=316, Percent_Identity=28.7974683544304, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=358, Percent_Identity=34.0782122905028, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6321799, Length=405, Percent_Identity=28.3950617283951, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24581334, Length=351, Percent_Identity=33.9031339031339, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17737985, Length=340, Percent_Identity=31.4705882352941, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48531; Mature: 48531

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIKWIRENQELFDEKLSKRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGN
CCEEEEECCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
MASKSGEEFEAIQRDVKHINEKLEELEQDLNNNNELNELLNMLPNIPDEEVPYGMDESMN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHH
KLVRTYGETNPNALNKQHFELGTKLNLMDFEQTAKISGARFVTLKGDLAKLERALINFMI
HHHHHHCCCCCCCCCCHHHHHCCCCEEECHHHHHHCCCCEEEEECCHHHHHHHHHHHHHH
DVHTKEFNFFEMSPPVLVRDNAMYNSGQLPKFAEESFATTNGYRLIPTAEVFLVNIVADT
HEEECCCCEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEECCHHHHHHHHHHHHH
IIPREKLPMRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKHEHEYIT
HCCCCCCCCEEEEECCCHHCCCCCCCCCCHHHHEEECCCCEEEEEEECCCCCCCHHHHHC
NSSETILQKLNLPYRVMLLCTGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARR
CCHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCHHHHHH
MKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNEDGSITIPDVLINYMGGLQKI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCHHHH
TTHGE
HCCCC
>Mature Secondary Structure
MLSIKWIRENQELFDEKLSKRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGN
CCEEEEECCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
MASKSGEEFEAIQRDVKHINEKLEELEQDLNNNNELNELLNMLPNIPDEEVPYGMDESMN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHH
KLVRTYGETNPNALNKQHFELGTKLNLMDFEQTAKISGARFVTLKGDLAKLERALINFMI
HHHHHHCCCCCCCCCCHHHHHCCCCEEECHHHHHHCCCCEEEEECCHHHHHHHHHHHHHH
DVHTKEFNFFEMSPPVLVRDNAMYNSGQLPKFAEESFATTNGYRLIPTAEVFLVNIVADT
HEEECCCCEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEECCHHHHHHHHHHHHH
IIPREKLPMRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKHEHEYIT
HCCCCCCCCEEEEECCCHHCCCCCCCCCCHHHHEEECCCCEEEEEEECCCCCCCHHHHHC
NSSETILQKLNLPYRVMLLCTGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARR
CCHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCHHHHHH
MKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNEDGSITIPDVLINYMGGLQKI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCHHHH
TTHGE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA