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The map label for this gene is rnhA [H]

Identifier: 157826199

GI number: 157826199

Start: 1046642

End: 1047100

Strand: Direct

Name: rnhA [H]

Synonym: A1C_05880

Alternate gene names: 157826199

Gene position: 1046642-1047100 (Clockwise)

Preceding gene: 157826198

Following gene: 157826200

Centisome position: 85.02

GC content: 33.77

Gene sequence:

>459_bases
ATGAATTCAAAAGTAGTTATATATACTGATGGTGCATGTGCAGGTAACCCAGGTCCCGGAGGATGGGGGGCTTTATTAAA
GTTTAATGATGCTAGTAAAGAAATATTTGGGTATGAGTTAGATACAACTAATAATCGTATGGAAATCACGGCAGCATTTG
AAGCATTGAAAATTTTAAAAAAATCTTGTAATGTCGAGATTTATACTGATAGTAAATATTTGCAACAGGGAATTACCGCT
TGGATTCATAATTGGATAAAAAATAATTGGTGTAAAAGCAACAATGAACCCGTTAAAAATGCCGACTTATGGCAAAAATT
ATACGCAGAATTGAGTAAACATACTATTATTTGGAAATGGGTAAAAGGTCATGCAAATAATAGCGGTAATATTGCTGCCG
ATAAACTTGCAGTGCAAGGAAGAGAAACTGCTATAGAAGTTTTAAAATGTCGTGGATAG

Upstream 100 bases:

>100_bases
AAATACTAATAAAAGTTATAAAACTTCATTATCTCCAAATCAAAATGTTATAATGTTAGATAAGTTTCGTAACTCTTCTA
AACCTAGTTAATGCGCATAT

Downstream 100 bases:

>100_bases
ATAAGTTTTTTATTACTTTTTTTCACAAAAAAGTAGGAGAAGATGAATTTTTGAATCAATATTATGAAAGCCGTAATATT
GATTATTTAGGGCGTTCAAG

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MNSKVVIYTDGACAGNPGPGGWGALLKFNDASKEIFGYELDTTNNRMEITAAFEALKILKKSCNVEIYTDSKYLQQGITA
WIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEVLKCRG

Sequences:

>Translated_152_residues
MNSKVVIYTDGACAGNPGPGGWGALLKFNDASKEIFGYELDTTNNRMEITAAFEALKILKKSCNVEIYTDSKYLQQGITA
WIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEVLKCRG
>Mature_152_residues
MNSKVVIYTDGACAGNPGPGGWGALLKFNDASKEIFGYELDTTNNRMEITAAFEALKILKKSCNVEIYTDSKYLQQGITA
WIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEVLKCRG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=151, Percent_Identity=35.0993377483444, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=52.5547445255474, Blast_Score=154, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI115532542, Length=146, Percent_Identity=34.9315068493151, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=38.3561643835616, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=38.3561643835616, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 17019; Mature: 17019

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKVVIYTDGACAGNPGPGGWGALLKFNDASKEIFGYELDTTNNRMEITAAFEALKILK
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEEHHHHHHHHHHH
KSCNVEIYTDSKYLQQGITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKW
HHCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
VKGHANNSGNIAADKLAVQGRETAIEVLKCRG
EECCCCCCCCEEHHHEECCCHHHHHHHHHCCC
>Mature Secondary Structure
MNSKVVIYTDGACAGNPGPGGWGALLKFNDASKEIFGYELDTTNNRMEITAAFEALKILK
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEEHHHHHHHHHHH
KSCNVEIYTDSKYLQQGITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKW
HHCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
VKGHANNSGNIAADKLAVQGRETAIEVLKCRG
EECCCCCCCCEEHHHEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA