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The map label for this gene is lysC [H]

Identifier: 157826160

GI number: 157826160

Start: 1012866

End: 1014071

Strand: Reverse

Name: lysC [H]

Synonym: A1C_05685

Alternate gene names: 157826160

Gene position: 1014071-1012866 (Counterclockwise)

Preceding gene: 157826161

Following gene: 157826159

Centisome position: 82.37

GC content: 29.52

Gene sequence:

>1206_bases
ATGGCCTTAATAATTCAAAAGTTTGGTGGTACTTCCGTTGCAAATATTGATAGAATAAAACAAATCGTCTCTATCATTAA
AGCCGCAATAGCTAAAAATAACCAAGTAATTGTAGTAGTTTCGGCTATGGCGGGTGTTACTAATCAACTTGTCACATTAT
GTAATGAAGTATCAAGCCTTAACAGTATTTCTCAATTTGCAGAATATGATGTGGCACTTTCTAGCGGTGAAATAGTCACA
GCATCATTACTAGCACTAGCTCTTCAAGAAAAAGATATAAAGGCACGATCATTCCTAGCTTGGCAATTACCGATTCTCAC
CAATAATAATCATAGTAAATCTGTAGTAGAATCAGTTACTACAGATTTACTAAAAAAATGTTTACAGTTAAATATCGTCC
CTATAATAGCCGGTTTTCAAGGAATTAACAAATCCAATAGGTTAACCACTTTGGGCAGAGGAGGATCCGATACTACTGCC
GCTTTAATCGCTGCAGCTATGAAAGCCGATAGATGTGATATTTATACCGATGTAGAGGGAATATTTACTGCTGATCCAAG
AATTATTCCAAATGCAAAGAGAATAAAAGAAATAGATTTTTTAGAAATGTTAGAACTAGCATCAAGTGGAGCAAAAGTAT
TACACCCTAGAGCTGTAGAGCTGGTCATGCGGTATAAAATAGATATGTGTGTTCTTTCAACATTTTCACCGAATAAAGAA
GGTACGTTAATTACTTCAAAGGATAAAAATATGGAGAATGGCATTATTAACAGCATTACTTCTAATAAAAATTTATTAAA
AATATCTGTAAAGAGTATTTCTTTAAGTTTTTTGCAAGTTGCAAATATTATTACACAAAATAATAATCATATTGAATTTA
TGCAAGAGGTAAATAATAATGAAGAATATAGTTTTATTGCAAGTTTAACCGATAAAAATAATTTACAAGCTTTACTTACT
AATTTAAAAAATGATAAGCAGATACAAGATTTTACTTTTGATGCAGAAATTGCTACAATCTCTCTTATTGGTTATGGGAT
TAAAAATGATTGTAAAGTACTTGAAACTATATTATCAAAGTTAACGAAAGATAATATAAATGTTAACATGATACAATTAT
CAGAAGTTAAAATTACCTTATTAATAAATGATCAAGATGTAGAAAAAACAATTTTTAATTTATATAATCTTTTTAAAATA
TCTTAG

Upstream 100 bases:

>100_bases
ACTTAATGCTCTATGTCATTTATGTCTACGCAGGAATGACATAGAGTAAGAGTGTTTTGTTAATCCACTAATAATACTCA
TAAATAGTCTCCCTTTAGTT

Downstream 100 bases:

>100_bases
ATTCTGCATCTAAAATTTAATTTATATCTTAAGTTATTTGATGTTAAAATTATAAGATTTTGAAAATGCATGGTTTCTAT
TTCATAAAATTTTATAATTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALIIQKFGGTSVANIDRIKQIVSIIKAAIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSLNSISQFAEYDVALSSGEIVT
ASLLALALQEKDIKARSFLAWQLPILTNNNHSKSVVESVTTDLLKKCLQLNIVPIIAGFQGINKSNRLTTLGRGGSDTTA
ALIAAAMKADRCDIYTDVEGIFTADPRIIPNAKRIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMCVLSTFSPNKE
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANIITQNNNHIEFMQEVNNNEEYSFIASLTDKNNLQALLT
NLKNDKQIQDFTFDAEIATISLIGYGIKNDCKVLETILSKLTKDNINVNMIQLSEVKITLLINDQDVEKTIFNLYNLFKI
S

Sequences:

>Translated_401_residues
MALIIQKFGGTSVANIDRIKQIVSIIKAAIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSLNSISQFAEYDVALSSGEIVT
ASLLALALQEKDIKARSFLAWQLPILTNNNHSKSVVESVTTDLLKKCLQLNIVPIIAGFQGINKSNRLTTLGRGGSDTTA
ALIAAAMKADRCDIYTDVEGIFTADPRIIPNAKRIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMCVLSTFSPNKE
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANIITQNNNHIEFMQEVNNNEEYSFIASLTDKNNLQALLT
NLKNDKQIQDFTFDAEIATISLIGYGIKNDCKVLETILSKLTKDNINVNMIQLSEVKITLLINDQDVEKTIFNLYNLFKI
S
>Mature_400_residues
ALIIQKFGGTSVANIDRIKQIVSIIKAAIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSLNSISQFAEYDVALSSGEIVTA
SLLALALQEKDIKARSFLAWQLPILTNNNHSKSVVESVTTDLLKKCLQLNIVPIIAGFQGINKSNRLTTLGRGGSDTTAA
LIAAAMKADRCDIYTDVEGIFTADPRIIPNAKRIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMCVLSTFSPNKEG
TLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANIITQNNNHIEFMQEVNNNEEYSFIASLTDKNNLQALLTN
LKNDKQIQDFTFDAEIATISLIGYGIKNDCKVLETILSKLTKDNINVNMIQLSEVKITLLINDQDVEKTIFNLYNLFKIS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartokinase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=446, Percent_Identity=26.6816143497758, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1790455, Length=459, Percent_Identity=28.9760348583878, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790376, Length=397, Percent_Identity=23.1738035264484, Blast_Score=85, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320893, Length=282, Percent_Identity=27.3049645390071, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR001057 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44134; Mature: 44003

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIIQKFGGTSVANIDRIKQIVSIIKAAIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSL
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
NSISQFAEYDVALSSGEIVTASLLALALQEKDIKARSFLAWQLPILTNNNHSKSVVESVT
HHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHEEEEEEEEEEECCCCHHHHHHHHH
TDLLKKCLQLNIVPIIAGFQGINKSNRLTTLGRGGSDTTAALIAAAMKADRCDIYTDVEG
HHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCE
IFTADPRIIPNAKRIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMCVLSTFSPNKE
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHCEEEEECCCCCCC
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANIITQNNNHIEFMQEVNNN
CCEEEECCCCCCCCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
EEYSFIASLTDKNNLQALLTNLKNDKQIQDFTFDAEIATISLIGYGIKNDCKVLETILSK
CCEEEEEECCCCCHHHHHHHHCCCCCEEHHEEECCCEEEEEEEECCCCCHHHHHHHHHHH
LTKDNINVNMIQLSEVKITLLINDQDVEKTIFNLYNLFKIS
HCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALIIQKFGGTSVANIDRIKQIVSIIKAAIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSL
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
NSISQFAEYDVALSSGEIVTASLLALALQEKDIKARSFLAWQLPILTNNNHSKSVVESVT
HHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHEEEEEEEEEEECCCCHHHHHHHHH
TDLLKKCLQLNIVPIIAGFQGINKSNRLTTLGRGGSDTTAALIAAAMKADRCDIYTDVEG
HHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCE
IFTADPRIIPNAKRIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMCVLSTFSPNKE
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHCEEEEECCCCCCC
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANIITQNNNHIEFMQEVNNN
CCEEEECCCCCCCCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
EEYSFIASLTDKNNLQALLTNLKNDKQIQDFTFDAEIATISLIGYGIKNDCKVLETILSK
CCEEEEEECCCCCHHHHHHHHCCCCCEEHHEEECCCEEEEEEEECCCCCHHHHHHHHHHH
LTKDNINVNMIQLSEVKITLLINDQDVEKTIFNLYNLFKIS
HCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]