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The map label for this gene is eco [C]

Identifier: 157826073

GI number: 157826073

Start: 921913

End: 922047

Strand: Direct

Name: eco [C]

Synonym: A1C_05165

Alternate gene names: 157826073

Gene position: 921913-922047 (Clockwise)

Preceding gene: 157826072

Following gene: 157826076

Centisome position: 74.89

GC content: 36.3

Gene sequence:

>135_bases
ATGACAAATTGTAATCGTGTTTGGTTTTGCGGTAAGCTAGAAACAAAAACTTTAGAAGAATGGGGATATAATTATTATAT
AATCGAGCAAGTTAGCGATCACACTGCTAGTACAATGATGGCATGCCCAAGGTGA

Upstream 100 bases:

>100_bases
ATCTACAACACTTAAAAATCAAAAGCGTTATGTAATTTATTTATCTACATAGTCTAATGAAGCAACGCTAAAAGTAGAAT
TGTAAGCAACAAAAAATGCA

Downstream 100 bases:

>100_bases
TGAAACATTTTTAAGATATAATAGCAAACTACCTATCTAGTATATGCTCCGAAAGATGTTAAACTATATTACGTTATTTG
GTATCAAAATGATATAATCA

Product: ecotin precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 44; Mature: 43

Protein sequence:

>44_residues
MTNCNRVWFCGKLETKTLEEWGYNYYIIEQVSDHTASTMMACPR

Sequences:

>Translated_44_residues
MTNCNRVWFCGKLETKTLEEWGYNYYIIEQVSDHTASTMMACPR
>Mature_43_residues
TNCNRVWFCGKLETKTLEEWGYNYYIIEQVSDHTASTMMACPR

Specific function: General Inhibitor Of Pancreatic Serine Proteases: Inhibits Chymotrypsin, Trypsin, Elastases, Factor X, Kallikrein As Well As A Variety Of Other Proteases. The Strength Of Inhibition Does Not Appear To Be Correlated With A Particular Protease Specificity.

COG id: COG4574

COG function: function code R; Serine protease inhibitor ecotin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protease inhibitor I11 (ecotin) family [H]

Homologues:

None

Paralogues:

None

Copy number: 260 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023189 [H]

Pfam domain/function: PF03974 Ecotin [H]

EC number: NA

Molecular weight: Translated: 5222; Mature: 5091

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.8 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
13.6 %Cys+Met (Translated Protein)
7.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
11.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNCNRVWFCGKLETKTLEEWGYNYYIIEQVSDHTASTMMACPR
CCCCCEEEEECCCCCCCHHHCCCCEEEEEECCCCCCCCEEECCC
>Mature Secondary Structure 
TNCNRVWFCGKLETKTLEEWGYNYYIIEQVSDHTASTMMACPR
CCCCEEEEECCCCCCCHHHCCCCEEEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]