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The map label for this gene is adk [H]

Identifier: 157826042

GI number: 157826042

Start: 902578

End: 903216

Strand: Reverse

Name: adk [H]

Synonym: A1C_05000

Alternate gene names: 157826042

Gene position: 903216-902578 (Counterclockwise)

Preceding gene: 157826043

Following gene: 157826041

Centisome position: 73.37

GC content: 26.29

Gene sequence:

>639_bases
GTGATAGTAATTTTTTTAGGTCCTCCAGGAGCTGGAAAGGGAACACAAGGAAAAAAGATCGCTAAAAAAATTGATTTACC
ACATATAGCACTCGGTGATATATTTAGGACAATTATTAAAACATCAACTAGTGAAGCAGAATTAATTAATAATTATGTTA
AGCAAGGGGAGCTTGTCCCTAATGCAATAGTTAATCAAGTAATCAAAAATTTTTTATTATCCTCTGCATATAAAAACGGC
TATATATTAGATGGATATCCACGTAATTTAGAGCAAGCAAAATTCTTTGAATCATTTATTAAAGAAAAAATTAAAATCAT
ATATTTTGATGTTTCAGATGAATTATTAATTAAAAGAGTTTTAGGAAGATATAGTTGTAAAAATTGCCGTAAAATATACA
ATAGTTACTTCTTGCAGCCTAAAACTGATAATGTATGTGATGTTTGCGGTTCAAGTACATTTGATTATAGAAAAGACGAT
AATGAAGAAGTAGTAAAAAAAAGAATTGAAGTATATAAAACAGAAACATATCCGTTAATAGATTATTATAAGAATAGTGG
TAATTTTTATCTAGTTAATGGAAGTAAAAATGAACAAGAAATAGAAATTGATATACAGAAAATACTAAAAATAAATTGA

Upstream 100 bases:

>100_bases
ACTTGATACTATGACTCAGGTTCAAACTTACTTATTTAGTAGTAAGTATGAAGGTTTAATGAAGAAAGTAAAATTAAAAA
ATTAAAAATGAGCTTAAGTA

Downstream 100 bases:

>100_bases
CTTTATCAACGATTTTTATATTATCCTTTAGTTACTAGTAAAATTTTGGAGATTGTTTGTGGCAAGAATTGCAAGTGTTA
ATATTCCCGATAATAAACGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MIVIFLGPPGAGKGTQGKKIAKKIDLPHIALGDIFRTIIKTSTSEAELINNYVKQGELVPNAIVNQVIKNFLLSSAYKNG
YILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRVLGRYSCKNCRKIYNSYFLQPKTDNVCDVCGSSTFDYRKDD
NEEVVKKRIEVYKTETYPLIDYYKNSGNFYLVNGSKNEQEIEIDIQKILKIN

Sequences:

>Translated_212_residues
MIVIFLGPPGAGKGTQGKKIAKKIDLPHIALGDIFRTIIKTSTSEAELINNYVKQGELVPNAIVNQVIKNFLLSSAYKNG
YILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRVLGRYSCKNCRKIYNSYFLQPKTDNVCDVCGSSTFDYRKDD
NEEVVKKRIEVYKTETYPLIDYYKNSGNFYLVNGSKNEQEIEIDIQKILKIN
>Mature_212_residues
MIVIFLGPPGAGKGTQGKKIAKKIDLPHIALGDIFRTIIKTSTSEAELINNYVKQGELVPNAIVNQVIKNFLLSSAYKNG
YILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRVLGRYSCKNCRKIYNSYFLQPKTDNVCDVCGSSTFDYRKDD
NEEVVKKRIEVYKTETYPLIDYYKNSGNFYLVNGSKNEQEIEIDIQKILKIN

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=199, Percent_Identity=34.1708542713568, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI4502013, Length=199, Percent_Identity=34.1708542713568, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=29.7435897435897, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=29.7435897435897, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=29.7435897435897, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=29.7435897435897, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI4502011, Length=193, Percent_Identity=28.4974093264249, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI19923437, Length=195, Percent_Identity=28.2051282051282, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI7706497, Length=209, Percent_Identity=30.622009569378, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI28144899, Length=201, Percent_Identity=25.3731343283582, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI28144897, Length=201, Percent_Identity=25.3731343283582, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=35.5140186915888, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=31.7535545023697, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=202, Percent_Identity=31.1881188118812, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=27.4418604651163, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=212, Percent_Identity=26.8867924528302, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=203, Percent_Identity=28.0788177339901, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=212, Percent_Identity=20.7547169811321, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=208, Percent_Identity=36.0576923076923, Blast_Score=138, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=33.4975369458128, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=28.3018867924528, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=32.5471698113208, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=35.1485148514851, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=35.1485148514851, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=27.3584905660377, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=27.3584905660377, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17647141, Length=184, Percent_Identity=25, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24663208, Length=184, Percent_Identity=25, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24365; Mature: 24365

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIFLGPPGAGKGTQGKKIAKKIDLPHIALGDIFRTIIKTSTSEAELINNYVKQGELVP
CEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
NAIVNQVIKNFLLSSAYKNGYILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRV
HHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCEEEEEEECCHHHHHHHH
LGRYSCKNCRKIYNSYFLQPKTDNVCDVCGSSTFDYRKDDNEEVVKKRIEVYKTETYPLI
HHHHCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
DYYKNSGNFYLVNGSKNEQEIEIDIQKILKIN
EEEECCCCEEEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIVIFLGPPGAGKGTQGKKIAKKIDLPHIALGDIFRTIIKTSTSEAELINNYVKQGELVP
CEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
NAIVNQVIKNFLLSSAYKNGYILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRV
HHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCEEEEEEECCHHHHHHHH
LGRYSCKNCRKIYNSYFLQPKTDNVCDVCGSSTFDYRKDDNEEVVKKRIEVYKTETYPLI
HHHHCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
DYYKNSGNFYLVNGSKNEQEIEIDIQKILKIN
EEEECCCCEEEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA