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The map label for this gene is rickA [H]

Identifier: 157825980

GI number: 157825980

Start: 836378

End: 837949

Strand: Reverse

Name: rickA [H]

Synonym: A1C_04650

Alternate gene names: 157825980

Gene position: 837949-836378 (Counterclockwise)

Preceding gene: 157825982

Following gene: 157825976

Centisome position: 68.07

GC content: 31.11

Gene sequence:

>1572_bases
GTGGCTCAGGAAATAGATATAAATAAATTATTAGCACAAGAAAATAATGCTTTAAATGCTATATTAAGCCAAGTAAATGA
ATTATGCACACAAAATAAGAAGTTGCAAGGTTTAATCGAAATACAAAATAAAACTAAAGAACTAGCAAAAGAACATAATA
GATCGTTGCCTTGGTTTAAAAGACTTGTAAAAACAGTTTCTAACGTAAAGTATATTTTTGTAAAGAGTGAAGAACAGTTA
ACAAATGAAGCGATAAAATATAATAACAAAGTATTAAAAAGTATTGATAATAAGATATATAATATAGCGGCAAAATCTGC
ACCGTTAAAGCAAGAATTACAAGAAGAAATCGCAAAAAATTTTAAGGATTTAACAAAGAAAGATTTATCTAAAGAGCAAA
GAGAAAGATTATCAGAAGTATATTTTAGCTATAAGAGCAAACCTGAAAGATTCTCAGCTCTACATATTACAAATCCTTTA
CAATTCATTAATGCTGAAGAACTAGAGAAACAATATAATTCTTTAAATGCTACAAGACAAAACATCCAAAATTTAATATC
CGAGAATTCTAATATCAAAGAGCTTAAAGAAATACAAAAACAGGTTGCTGAAATTAGAGAAGAAATACCTTATACATTTT
TTGAAAAATTAAATAATATTTGGCAAAATGTTAAAAATGTTTTTGTAAATAATAAGGAGAAGATTTTAGCAAAAAACAAA
GAAAGTAATACTAGAACAATTAGAAAGATTGATGAACAATTATATAAAACGAAGCATAAATTTGAGGAATTAATTGAAAA
TAAGGAAAGAAATATTAATGATATAATTTCAAAGTTACCTGACAATGAGGAGTTAAAAAATATAGTAAGTAATTTTGCAA
ATCATATGACTTCAAAAAAGGAGCCAATCTTAACCACCTCGTCCATCGCTAAACCTTTGGAAAATAATATAACAAGGCCT
CCTCTTTTATCACAAAATAATATTCCATCACCCCCGCCTTTATCGAAAAATAACATTCCGCCACCGCCACCGCCACCGCC
GCCCCCTATGCCTACGGCTCAAACTGATGCATTATCTAAGCCTGTAGGCGTTACTACGGTTAAAAAACTGGAAAATCAAC
AACGTCCTTCTCTAGATACTTCTGATTTAATGAGAGAAATAGCAGGACCAAACAATCTAAGAAAAGTTGAAAAAACGGAT
GTTAAGATACAAGATTCTAGAGATTTATTGCTGCAGTCTATAAGAGGTGAACACAAACTAAGAAAAGTTGCATTTGATCC
TAATACAGGAAAACCGGTTGCACATTCTCATAGTAAGCCTGCTAAGAATGTTAATCAACCTAATGGAGTTGCATCAATTT
TAGCACGCAGAGTTGCTATGGAGATGAGTGATAGCAGCAGTAGTGGAAGTGAAAGCGATAGTGATAGTGGTAACTGGAGT
GATATTAGTGTTAATAGCGATAAACCAAAGGCTCTAAAAAATCGAAGAGAACGAGATGGTAAAAGGACTACGCATGCTCA
AAAGATTCTAAGTAATAGGAGTTCACAAAAACCATCATTTGTTAGAAGTTAA

Upstream 100 bases:

>100_bases
CATTAAAATTACGTTAAATATAACATAAATTAACGTTCTCTTTGATTTTGTACAAGAAATTTACTATAATGCTGACATTA
ATTTATAGTAGGTGTATGGC

Downstream 100 bases:

>100_bases
TCTTTAAGTATGCTTTGTTGTGTGGATACCTAAGCCGTCATTGCGAGGAGCCGTATGTGACGTGGCAATCCAGAAAATAA
TTAAAAAAATTTTGTAAATA

Product: Actin polymerization protein RickA

Products: NA

Alternate protein names: Actin polymerization protein rickA [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MAQEIDINKLLAQENNALNAILSQVNELCTQNKKLQGLIEIQNKTKELAKEHNRSLPWFKRLVKTVSNVKYIFVKSEEQL
TNEAIKYNNKVLKSIDNKIYNIAAKSAPLKQELQEEIAKNFKDLTKKDLSKEQRERLSEVYFSYKSKPERFSALHITNPL
QFINAEELEKQYNSLNATRQNIQNLISENSNIKELKEIQKQVAEIREEIPYTFFEKLNNIWQNVKNVFVNNKEKILAKNK
ESNTRTIRKIDEQLYKTKHKFEELIENKERNINDIISKLPDNEELKNIVSNFANHMTSKKEPILTTSSIAKPLENNITRP
PLLSQNNIPSPPPLSKNNIPPPPPPPPPPMPTAQTDALSKPVGVTTVKKLENQQRPSLDTSDLMREIAGPNNLRKVEKTD
VKIQDSRDLLLQSIRGEHKLRKVAFDPNTGKPVAHSHSKPAKNVNQPNGVASILARRVAMEMSDSSSSGSESDSDSGNWS
DISVNSDKPKALKNRRERDGKRTTHAQKILSNRSSQKPSFVRS

Sequences:

>Translated_523_residues
MAQEIDINKLLAQENNALNAILSQVNELCTQNKKLQGLIEIQNKTKELAKEHNRSLPWFKRLVKTVSNVKYIFVKSEEQL
TNEAIKYNNKVLKSIDNKIYNIAAKSAPLKQELQEEIAKNFKDLTKKDLSKEQRERLSEVYFSYKSKPERFSALHITNPL
QFINAEELEKQYNSLNATRQNIQNLISENSNIKELKEIQKQVAEIREEIPYTFFEKLNNIWQNVKNVFVNNKEKILAKNK
ESNTRTIRKIDEQLYKTKHKFEELIENKERNINDIISKLPDNEELKNIVSNFANHMTSKKEPILTTSSIAKPLENNITRP
PLLSQNNIPSPPPLSKNNIPPPPPPPPPPMPTAQTDALSKPVGVTTVKKLENQQRPSLDTSDLMREIAGPNNLRKVEKTD
VKIQDSRDLLLQSIRGEHKLRKVAFDPNTGKPVAHSHSKPAKNVNQPNGVASILARRVAMEMSDSSSSGSESDSDSGNWS
DISVNSDKPKALKNRRERDGKRTTHAQKILSNRSSQKPSFVRS
>Mature_522_residues
AQEIDINKLLAQENNALNAILSQVNELCTQNKKLQGLIEIQNKTKELAKEHNRSLPWFKRLVKTVSNVKYIFVKSEEQLT
NEAIKYNNKVLKSIDNKIYNIAAKSAPLKQELQEEIAKNFKDLTKKDLSKEQRERLSEVYFSYKSKPERFSALHITNPLQ
FINAEELEKQYNSLNATRQNIQNLISENSNIKELKEIQKQVAEIREEIPYTFFEKLNNIWQNVKNVFVNNKEKILAKNKE
SNTRTIRKIDEQLYKTKHKFEELIENKERNINDIISKLPDNEELKNIVSNFANHMTSKKEPILTTSSIAKPLENNITRPP
LLSQNNIPSPPPLSKNNIPPPPPPPPPPMPTAQTDALSKPVGVTTVKKLENQQRPSLDTSDLMREIAGPNNLRKVEKTDV
KIQDSRDLLLQSIRGEHKLRKVAFDPNTGKPVAHSHSKPAKNVNQPNGVASILARRVAMEMSDSSSSGSESDSDSGNWSD
ISVNSDKPKALKNRRERDGKRTTHAQKILSNRSSQKPSFVRS

Specific function: Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell surface [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 WH2 domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003124 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 59634; Mature: 59503

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS51082 WH2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQEIDINKLLAQENNALNAILSQVNELCTQNKKLQGLIEIQNKTKELAKEHNRSLPWFK
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RLVKTVSNVKYIFVKSEEQLTNEAIKYNNKVLKSIDNKIYNIAAKSAPLKQELQEEIAKN
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FKDLTKKDLSKEQRERLSEVYFSYKSKPERFSALHITNPLQFINAEELEKQYNSLNATRQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCEEEECCCHHHCCHHHHHHHHHHHHHHHH
NIQNLISENSNIKELKEIQKQVAEIREEIPYTFFEKLNNIWQNVKNVFVNNKEKILAKNK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
ESNTRTIRKIDEQLYKTKHKFEELIENKERNINDIISKLPDNEELKNIVSNFANHMTSKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
EPILTTSSIAKPLENNITRPPLLSQNNIPSPPPLSKNNIPPPPPPPPPPMPTAQTDALSK
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
PVGVTTVKKLENQQRPSLDTSDLMREIAGPNNLRKVEKTDVKIQDSRDLLLQSIRGEHKL
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHCCCEECCHHHHHHHHHHHHHHH
RKVAFDPNTGKPVAHSHSKPAKNVNQPNGVASILARRVAMEMSDSSSSGSESDSDSGNWS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DISVNSDKPKALKNRRERDGKRTTHAQKILSNRSSQKPSFVRS
EEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQEIDINKLLAQENNALNAILSQVNELCTQNKKLQGLIEIQNKTKELAKEHNRSLPWFK
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RLVKTVSNVKYIFVKSEEQLTNEAIKYNNKVLKSIDNKIYNIAAKSAPLKQELQEEIAKN
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FKDLTKKDLSKEQRERLSEVYFSYKSKPERFSALHITNPLQFINAEELEKQYNSLNATRQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCEEEECCCHHHCCHHHHHHHHHHHHHHHH
NIQNLISENSNIKELKEIQKQVAEIREEIPYTFFEKLNNIWQNVKNVFVNNKEKILAKNK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
ESNTRTIRKIDEQLYKTKHKFEELIENKERNINDIISKLPDNEELKNIVSNFANHMTSKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
EPILTTSSIAKPLENNITRPPLLSQNNIPSPPPLSKNNIPPPPPPPPPPMPTAQTDALSK
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
PVGVTTVKKLENQQRPSLDTSDLMREIAGPNNLRKVEKTDVKIQDSRDLLLQSIRGEHKL
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHCCCEECCHHHHHHHHHHHHHHH
RKVAFDPNTGKPVAHSHSKPAKNVNQPNGVASILARRVAMEMSDSSSSGSESDSDSGNWS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DISVNSDKPKALKNRRERDGKRTTHAQKILSNRSSQKPSFVRS
EEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA