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The map label for this gene is uvrC

Identifier: 157825946

GI number: 157825946

Start: 798356

End: 800311

Strand: Reverse

Name: uvrC

Synonym: A1C_04430

Alternate gene names: 157825946

Gene position: 800311-798356 (Counterclockwise)

Preceding gene: 157825947

Following gene: 157825942

Centisome position: 65.01

GC content: 35.58

Gene sequence:

>1956_bases
ATGACTCTAGAAATTACCAGAAGTGAGTTAATTAAATCTAAACTTATAGATGCTCCTGAACGTTGCGGGGTTTATCGAAT
GTTTGACGTTAACAAACAGGTTATCTATGTCGGTAAAGCTAAAAATTTAAAGAAACGTCTTACTCATTACATTAAAAGCG
ATTTAGATAATAAGACGCTTCGGATGATTGCAAATACTTGTTTTTTAGAGTACAGCATTACTAATTCCGAAGTTGAGGCA
CTACTTTTAGAAGCCCAGCTAATCAAAAAATTTCAGCCGAAATTTAATATTCTTCTTAAGGATGACAAATCTTTTCCTTT
CATTAAGTTACGTTTAGATCATGATTTCCCACAATTGCTAAAGTATCGCGGTAAAACTCTAAATGATGGAAAATGTTTTG
GTCCTTTTGCTTCCGCCACGGAAGTTAACACTACTTTAACGGAATTGCAAAAAATCTTTAAATTACGTTCCTGCACAGAT
AATTACTTTAATTCACGTACTCGTCCTTGTATGCAATATGAAATAAAACGTTGTTATGCTCCTTGCGTCGGTAAAATAAA
TAAGGAGGACTATAGGGACTTAGTAGCTCAGGTGAAAGATTTCTTACAAGGTCGTACCAAAGCACTCCAAGAGAACCTAT
CTAAAAAGATGGAAGAGCTAAGTAGTCAGATGCGTTTTGAAGAGGCGGCAGAAATTAGAGACCGTATTAAGGCACTTAGT
TATGTGCAGCTTAAGTCATGTGTTTCAGATATTGTTAAAGATGCAGATATAATCGTTGTTGTAGAAAAGAATGGACATTA
TTGCGTAGAAGTTTTTTTATATAGGGCATGGCAAGCATGCGGTAATATTCCTTATTTTCCTACTTCTACTGAAAATAGTA
CCAAAGAAGAAGTATTAGAATATTTTTTATTACAATTTTATCAAAAACAACAAGTGCCTGCGGAAATTATCATTAATCAT
GAAATTAATGATAAAGAGAATATGATAGAGGCGATTAAGAAAATCAATAATATTACTAAACTCAATATTATAATACCTAT
TAGTGGAGGTAAAGCCAAGCTAGTTCAGAATGCAGCAATAAAGGCTTTATTCTCTCTAGAGCAATATTTGAAGAAATTTG
TAAAAAATCAAGAGATTATGCTTGAAATCAAAGCGCTATTTGGTCTTCATGAAATTCCTGAAAGAATTGAGATTTATGAT
AATAGCCATATTCAAGGTAAGTTTGCCGTCGGCGTTGTGGTAGTTGTTGGTAAAGCCGGTTTTGATAAAAAGGAATATCG
GGTTTTCTCATTATCGTCCTGCGACGCTTCATTATCATCTCACGCCTATCCATTTTCACCCCGCAACTTGATCGCGGGAT
CCAGTACATTAACAAACCCTATGGATCCCGTTGTCAGGTCACGGGAGGATGACACCAGCAGTACGCATAATTATGCTGTA
GGTGACGATTATGAAATGCTCAGGCAAGTTTTAATACGCAGATTAACTAGACTTAAGAATGAGCCGCATAAATTGCCGAG
CTTGATGATTATAGACGGTGGCAAAGGGCATTTAGGTATTGTTAAAGAGGTAATGGATAAATTTGCAATGCATATTCCTT
TTGTTTGTATGTCAAAAGGAGTAGATAGAAATGCCGGCATTGAGCAATTTCATATGACAGGTAAAGAAGTATTTACGCTG
GATACAAACTTGCCGATTATGAAATATTTACAAATCTTGCGGGATGAGGCACATAATTTCGCTATAAAGAATCATAGACT
CGGTAGATCACGTGCTATAAAAATATCAAGCCTTGATAACATAGAGGGCGTAGGTGAAACTCGTAAAAAAGCATTGCTGC
ACTATTTCGGTTCTTATAAAGCAGTATGTGATGCCACAATAGATGAGCTTACTAAAGTAAACGGTATTAACAAGTCACTT
GCCGCGATGATTTTTAGAACGTTGCATAAGAGATGA

Upstream 100 bases:

>100_bases
ATTAAAGGTCATACCACGGGGCTTGTAGCGGTATCTCAGAATAAAGCCTGTGATATAAGATCCTGTGGTCAAACCACGGT
ATGACAAATGCACAATATAC

Downstream 100 bases:

>100_bases
GGCATCATTACTCATAATGTCCCCACATGCTAAGTATTTTTATAATTTTTTATCCTCTAATATTTCATAAACCAGTCTAT
GTTGTAAACTAATTCTTATA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MTLEITRSELIKSKLIDAPERCGVYRMFDVNKQVIYVGKAKNLKKRLTHYIKSDLDNKTLRMIANTCFLEYSITNSEVEA
LLLEAQLIKKFQPKFNILLKDDKSFPFIKLRLDHDFPQLLKYRGKTLNDGKCFGPFASATEVNTTLTELQKIFKLRSCTD
NYFNSRTRPCMQYEIKRCYAPCVGKINKEDYRDLVAQVKDFLQGRTKALQENLSKKMEELSSQMRFEEAAEIRDRIKALS
YVQLKSCVSDIVKDADIIVVVEKNGHYCVEVFLYRAWQACGNIPYFPTSTENSTKEEVLEYFLLQFYQKQQVPAEIIINH
EINDKENMIEAIKKINNITKLNIIIPISGGKAKLVQNAAIKALFSLEQYLKKFVKNQEIMLEIKALFGLHEIPERIEIYD
NSHIQGKFAVGVVVVVGKAGFDKKEYRVFSLSSCDASLSSHAYPFSPRNLIAGSSTLTNPMDPVVRSREDDTSSTHNYAV
GDDYEMLRQVLIRRLTRLKNEPHKLPSLMIIDGGKGHLGIVKEVMDKFAMHIPFVCMSKGVDRNAGIEQFHMTGKEVFTL
DTNLPIMKYLQILRDEAHNFAIKNHRLGRSRAIKISSLDNIEGVGETRKKALLHYFGSYKAVCDATIDELTKVNGINKSL
AAMIFRTLHKR

Sequences:

>Translated_651_residues
MTLEITRSELIKSKLIDAPERCGVYRMFDVNKQVIYVGKAKNLKKRLTHYIKSDLDNKTLRMIANTCFLEYSITNSEVEA
LLLEAQLIKKFQPKFNILLKDDKSFPFIKLRLDHDFPQLLKYRGKTLNDGKCFGPFASATEVNTTLTELQKIFKLRSCTD
NYFNSRTRPCMQYEIKRCYAPCVGKINKEDYRDLVAQVKDFLQGRTKALQENLSKKMEELSSQMRFEEAAEIRDRIKALS
YVQLKSCVSDIVKDADIIVVVEKNGHYCVEVFLYRAWQACGNIPYFPTSTENSTKEEVLEYFLLQFYQKQQVPAEIIINH
EINDKENMIEAIKKINNITKLNIIIPISGGKAKLVQNAAIKALFSLEQYLKKFVKNQEIMLEIKALFGLHEIPERIEIYD
NSHIQGKFAVGVVVVVGKAGFDKKEYRVFSLSSCDASLSSHAYPFSPRNLIAGSSTLTNPMDPVVRSREDDTSSTHNYAV
GDDYEMLRQVLIRRLTRLKNEPHKLPSLMIIDGGKGHLGIVKEVMDKFAMHIPFVCMSKGVDRNAGIEQFHMTGKEVFTL
DTNLPIMKYLQILRDEAHNFAIKNHRLGRSRAIKISSLDNIEGVGETRKKALLHYFGSYKAVCDATIDELTKVNGINKSL
AAMIFRTLHKR
>Mature_650_residues
TLEITRSELIKSKLIDAPERCGVYRMFDVNKQVIYVGKAKNLKKRLTHYIKSDLDNKTLRMIANTCFLEYSITNSEVEAL
LLEAQLIKKFQPKFNILLKDDKSFPFIKLRLDHDFPQLLKYRGKTLNDGKCFGPFASATEVNTTLTELQKIFKLRSCTDN
YFNSRTRPCMQYEIKRCYAPCVGKINKEDYRDLVAQVKDFLQGRTKALQENLSKKMEELSSQMRFEEAAEIRDRIKALSY
VQLKSCVSDIVKDADIIVVVEKNGHYCVEVFLYRAWQACGNIPYFPTSTENSTKEEVLEYFLLQFYQKQQVPAEIIINHE
INDKENMIEAIKKINNITKLNIIIPISGGKAKLVQNAAIKALFSLEQYLKKFVKNQEIMLEIKALFGLHEIPERIEIYDN
SHIQGKFAVGVVVVVGKAGFDKKEYRVFSLSSCDASLSSHAYPFSPRNLIAGSSTLTNPMDPVVRSREDDTSSTHNYAVG
DDYEMLRQVLIRRLTRLKNEPHKLPSLMIIDGGKGHLGIVKEVMDKFAMHIPFVCMSKGVDRNAGIEQFHMTGKEVFTLD
TNLPIMKYLQILRDEAHNFAIKNHRLGRSRAIKISSLDNIEGVGETRKKALLHYFGSYKAVCDATIDELTKVNGINKSLA
AMIFRTLHKR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=640, Percent_Identity=35.15625, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=30.0518134715026, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_RICAH (A8GP33)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493666.1
- ProteinModelPortal:   A8GP33
- STRING:   A8GP33
- GeneID:   5645752
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_04430
- NMPDR:   fig|293614.3.peg.823
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   RAKA293614:A1C_04430-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR022439
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR03777
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 74558; Mature: 74426

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEITRSELIKSKLIDAPERCGVYRMFDVNKQVIYVGKAKNLKKRLTHYIKSDLDNKTL
CCEEECHHHHHHHHHCCCHHHCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCHHHH
RMIANTCFLEYSITNSEVEALLLEAQLIKKFQPKFNILLKDDKSFPFIKLRLDHDFPQLL
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHH
KYRGKTLNDGKCFGPFASATEVNTTLTELQKIFKLRSCTDNYFNSRTRPCMQYEIKRCYA
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
PCVGKINKEDYRDLVAQVKDFLQGRTKALQENLSKKMEELSSQMRFEEAAEIRDRIKALS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVQLKSCVSDIVKDADIIVVVEKNGHYCVEVFLYRAWQACGNIPYFPTSTENSTKEEVLE
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
YFLLQFYQKQQVPAEIIINHEINDKENMIEAIKKINNITKLNIIIPISGGKAKLVQNAAI
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHH
KALFSLEQYLKKFVKNQEIMLEIKALFGLHEIPERIEIYDNSHIQGKFAVGVVVVVGKAG
HHHHHHHHHHHHHHCCCHHEEHHHHHHCHHHCCHHHEECCCCCCCCEEEEEEEEEEECCC
FDKKEYRVFSLSSCDASLSSHAYPFSPRNLIAGSSTLTNPMDPVVRSREDDTSSTHNYAV
CCCCCEEEEEECCCCCHHHCCCCCCCCCCEECCCCCCCCCCCHHHCCCCCCCCCCCCCCC
GDDYEMLRQVLIRRLTRLKNEPHKLPSLMIIDGGKGHLGIVKEVMDKFAMHIPFVCMSKG
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHCC
VDRNAGIEQFHMTGKEVFTLDTNLPIMKYLQILRDEAHNFAIKNHRLGRSRAIKISSLDN
CCCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCEEECCCCCCCCCEEEEECCCC
IEGVGETRKKALLHYFGSYKAVCDATIDELTKVNGINKSLAAMIFRTLHKR
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLEITRSELIKSKLIDAPERCGVYRMFDVNKQVIYVGKAKNLKKRLTHYIKSDLDNKTL
CEEECHHHHHHHHHCCCHHHCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCHHHH
RMIANTCFLEYSITNSEVEALLLEAQLIKKFQPKFNILLKDDKSFPFIKLRLDHDFPQLL
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHH
KYRGKTLNDGKCFGPFASATEVNTTLTELQKIFKLRSCTDNYFNSRTRPCMQYEIKRCYA
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
PCVGKINKEDYRDLVAQVKDFLQGRTKALQENLSKKMEELSSQMRFEEAAEIRDRIKALS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVQLKSCVSDIVKDADIIVVVEKNGHYCVEVFLYRAWQACGNIPYFPTSTENSTKEEVLE
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
YFLLQFYQKQQVPAEIIINHEINDKENMIEAIKKINNITKLNIIIPISGGKAKLVQNAAI
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHH
KALFSLEQYLKKFVKNQEIMLEIKALFGLHEIPERIEIYDNSHIQGKFAVGVVVVVGKAG
HHHHHHHHHHHHHHCCCHHEEHHHHHHCHHHCCHHHEECCCCCCCCEEEEEEEEEEECCC
FDKKEYRVFSLSSCDASLSSHAYPFSPRNLIAGSSTLTNPMDPVVRSREDDTSSTHNYAV
CCCCCEEEEEECCCCCHHHCCCCCCCCCCEECCCCCCCCCCCHHHCCCCCCCCCCCCCCC
GDDYEMLRQVLIRRLTRLKNEPHKLPSLMIIDGGKGHLGIVKEVMDKFAMHIPFVCMSKG
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHCC
VDRNAGIEQFHMTGKEVFTLDTNLPIMKYLQILRDEAHNFAIKNHRLGRSRAIKISSLDN
CCCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCEEECCCCCCCCCEEEEECCCC
IEGVGETRKKALLHYFGSYKAVCDATIDELTKVNGINKSLAAMIFRTLHKR
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA