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The map label for this gene is penA [H]

Identifier: 157825939

GI number: 157825939

Start: 791777

End: 793462

Strand: Reverse

Name: penA [H]

Synonym: A1C_04395

Alternate gene names: 157825939

Gene position: 793462-791777 (Counterclockwise)

Preceding gene: 157825940

Following gene: 157825938

Centisome position: 64.45

GC content: 34.1

Gene sequence:

>1686_bases
ATGAAACAAATTTTAGGAAAATGGAAACCTGCAATTAAAAGTCTGATAATTTGGAACGTTTGTAGTAAAAATACAAAAAT
CCGATTATTAATGGTTATTTGTGGCTTTTCTTTTCTTTTTTGTACTTTATCTTACAGATTGATAATCGTTGCTACGAGTG
TTTACGATAAAAATATTAATTCCTTTAAAAAAAATCATCAATTTAGAAAAGAAATAGTTGATCGAAATGGTAATTTATTA
GCAGTTAACCTACCTTCTGCCTCATTATTTGCTAATCCACAAATAGTTCTCGATCCTGAAACTTCCGTAAAAAAACTAGC
AGAAATTCTACCTGATATTAATAAAGCTAAATTACTTTCTGAACTAAAATCAAATAAAAGCTTTATATGGGTAAAAAGGG
ATTTATTACCTAGTCAGCAGGAAAAAATAACTAGCCTTGGGTTACCTGGTTTTGAATTTGAAGAAGAGCAGAAACGCATT
TATACTTTTTCTAATTTATTGTCGCATGTTGTCGGTTATGTAGGTAGAGATTTGGTAGGGCTTAGTGGCTTAGAACTCGC
TTATGATAAATATTTAACTAATTCCGATTATGAATTAAACGAACCAAAGAATAGGAAAGAACCGCTGCAATTATCTATTG
ATATTAGATTACAAAGTATTTTAAGTGAAGAGATTGATAAAACTTTAAAGCAATTTAAGGCCATAGGAGCAGTAGGAATT
ATTGCAGATCCAAATAATGGCGAGATTTTAGCATTAGTAAATAAGCCTGATTTCGATCCGCATCATCCGAGTTTAGCAAA
ACCGGAAGAGTTGTTTAATATAGCAAGTCTTGGCATTTACGAAATGGGTTCGGTGTTTAAGGCATTAACTATGGCAGTCG
GTTTTGATACTGGTGCAATAAATATGAATGATGCTTATGATATAAGTTATATGAAAGTGGGAGGATTCCAGCTTAAGGAT
TATACGCCAAGGCAAGGGTGGCATAGTGTGCCTGAGATTTTTCTATATTCTTCAAATATTGGCACAAGTCAAATTATGCT
TGAAATCGGTAAAAGCAATTTTAAAAAATACCTTAAGAAATTAGGTCTATTAGATCAGTTACAAATAGAATTACCTGAAC
GAGGTACTCCGTTATTTCCTTCCGAGAAAAGATGGAATGAGTTAACTAGTGTTACTATGTCGTACGGCTACGGCATTTCA
ATTAGTCCTTTGCATTTTGTTAGAGCAATGTTACCGGTCGTTAACGGCGGTACTTTATATGATATTACTTTATTAAAAAG
AAAGGATGCAAAAGTAATAGGTACAAAAGTTTTTAGTGAAAATACCTCTACCCAAATGAAGAAATTATTTAGGTCGGTAG
TAAAAGAAGGTAATGGTAAAAGAGCAGAGGTCAAAGGGTATCTTATCGGCGGTAAGACCGGTACAGCAGAAAAACTTTCA
CAAGGTTCAGGGGGGAAAAAGAAATATCTAAAAAATAGTAGAGCTTCATCATTTTTAGGTGTGCTGCCCGCATCTAACCC
GCAATATATTATTTTTATTAGATTTGATGAGCCGAAACCGACTAAAGAAAGTTTTGGCTTTGCAACGGCAAGCTGGACGG
CTGCCCCTACTGCCGGTAGAGTGTTTGAGCGTATGATATCTTTATATGGTTTAGAGCCGATAGAACAAAGTGAGGAAGAG
AGTTGA

Upstream 100 bases:

>100_bases
AAGTATACACTCCGCTCATTGTCTTATGGGCTCATTGCTCTTTTGCAGTTGATCTTCGTGTCGTAGTAGGATTGTTTATA
AACGTCATTATAAATAATAT

Downstream 100 bases:

>100_bases
AAATATTACCTAATCACTATCAGGCGTCTTAAGTATTTTAATGTCCTATTAAAAAGAAATAACGTTACAACCGTTTTTCT
TCTTAAATTCCGATGAACAA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MKQILGKWKPAIKSLIIWNVCSKNTKIRLLMVICGFSFLFCTLSYRLIIVATSVYDKNINSFKKNHQFRKEIVDRNGNLL
AVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLSELKSNKSFIWVKRDLLPSQQEKITSLGLPGFEFEEEQKRI
YTFSNLLSHVVGYVGRDLVGLSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
IADPNNGEILALVNKPDFDPHHPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGAINMNDAYDISYMKVGGFQLKD
YTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKKLGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGIS
ISPLHFVRAMLPVVNGGTLYDITLLKRKDAKVIGTKVFSENTSTQMKKLFRSVVKEGNGKRAEVKGYLIGGKTGTAEKLS
QGSGGKKKYLKNSRASSFLGVLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGRVFERMISLYGLEPIEQSEEE
S

Sequences:

>Translated_561_residues
MKQILGKWKPAIKSLIIWNVCSKNTKIRLLMVICGFSFLFCTLSYRLIIVATSVYDKNINSFKKNHQFRKEIVDRNGNLL
AVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLSELKSNKSFIWVKRDLLPSQQEKITSLGLPGFEFEEEQKRI
YTFSNLLSHVVGYVGRDLVGLSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
IADPNNGEILALVNKPDFDPHHPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGAINMNDAYDISYMKVGGFQLKD
YTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKKLGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGIS
ISPLHFVRAMLPVVNGGTLYDITLLKRKDAKVIGTKVFSENTSTQMKKLFRSVVKEGNGKRAEVKGYLIGGKTGTAEKLS
QGSGGKKKYLKNSRASSFLGVLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGRVFERMISLYGLEPIEQSEEE
S
>Mature_561_residues
MKQILGKWKPAIKSLIIWNVCSKNTKIRLLMVICGFSFLFCTLSYRLIIVATSVYDKNINSFKKNHQFRKEIVDRNGNLL
AVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLSELKSNKSFIWVKRDLLPSQQEKITSLGLPGFEFEEEQKRI
YTFSNLLSHVVGYVGRDLVGLSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
IADPNNGEILALVNKPDFDPHHPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGAINMNDAYDISYMKVGGFQLKD
YTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKKLGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGIS
ISPLHFVRAMLPVVNGGTLYDITLLKRKDAKVIGTKVFSENTSTQMKKLFRSVVKEGNGKRAEVKGYLIGGKTGTAEKLS
QGSGGKKKYLKNSRASSFLGVLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGRVFERMISLYGLEPIEQSEEE
S

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=508, Percent_Identity=28.3464566929134, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1786854, Length=418, Percent_Identity=23.9234449760766, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62823; Mature: 62823

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQILGKWKPAIKSLIIWNVCSKNTKIRLLMVICGFSFLFCTLSYRLIIVATSVYDKNIN
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCEEEEEEEHHHHCCHH
SFKKNHQFRKEIVDRNGNLLAVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLS
HHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHHHH
ELKSNKSFIWVKRDLLPSQQEKITSLGLPGFEFEEEQKRIYTFSNLLSHVVGYVGRDLVG
HHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHC
LSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEE
IADPNNGEILALVNKPDFDPHHPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGAI
EECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NMNDAYDISYMKVGGFQLKDYTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKK
ECCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
LGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGISISPLHFVRAMLPVVNGGTLY
CCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
DITLLKRKDAKVIGTKVFSENTSTQMKKLFRSVVKEGNGKRAEVKGYLIGGKTGTAEKLS
EEEEEECCCCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHH
QGSGGKKKYLKNSRASSFLGVLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGR
CCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHCCCEEECCCCCCCHHH
VFERMISLYGLEPIEQSEEES
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKQILGKWKPAIKSLIIWNVCSKNTKIRLLMVICGFSFLFCTLSYRLIIVATSVYDKNIN
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCEEEEEEEHHHHCCHH
SFKKNHQFRKEIVDRNGNLLAVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLS
HHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHHHH
ELKSNKSFIWVKRDLLPSQQEKITSLGLPGFEFEEEQKRIYTFSNLLSHVVGYVGRDLVG
HHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHC
LSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEE
IADPNNGEILALVNKPDFDPHHPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGAI
EECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NMNDAYDISYMKVGGFQLKDYTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKK
ECCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
LGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGISISPLHFVRAMLPVVNGGTLY
CCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
DITLLKRKDAKVIGTKVFSENTSTQMKKLFRSVVKEGNGKRAEVKGYLIGGKTGTAEKLS
EEEEEECCCCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHH
QGSGGKKKYLKNSRASSFLGVLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGR
CCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHCCCEEECCCCCCCHHH
VFERMISLYGLEPIEQSEEES
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]