Click here to switch to the map view.

The map label for this gene is rnd [H]

Identifier: 157825886

GI number: 157825886

Start: 744676

End: 745521

Strand: Direct

Name: rnd [H]

Synonym: A1C_04125

Alternate gene names: 157825886

Gene position: 744676-745521 (Clockwise)

Preceding gene: 157825885

Following gene: 157825895

Centisome position: 60.49

GC content: 27.19

Gene sequence:

>846_bases
ATGCAAATTATTGATAGTCAAAAAACATTAGAAGAATTTTGTAACAGGTTAGCAAATAAGACATGCTTAAGCATAGATAC
GGAATTTGAGCGTCGCTATACCTATTATGCTCAGCTTAGTATAATTCAAGTTAAAGCAGAAGAATATTGCGGAATAATTG
ATGCATTAAGCAATTTAGATCTGAATGTTTTTAATAAGTTACTTGAAGATAATAATATTACTAAAATATTTCATGCTCCT
CGGGAAGATTTAGAGATTTTCTATAATTTATTTAAAACACTACCTGCTAATGTTTTTGATATACAAATTGCAGCAAATAT
TTGCGGATTCGGTAAACAACTAAGCTATGATGACATTTGTTATAAGCTAATCGGTATTACTATTGATAAAACCCACCAAA
AATCTAACTGGCTAAAACGCCCTATCACTAGTGATATGTTAAATTATGCAATGTTAGACGTGAAGTATTTGTATAAGATA
TATCAAGAGCTAAATAATATAATTATTAGAAATAATTTAACTAATAAATACAAAACTACTCTTAGTTCTTTATTAGACGT
TATAAATTATAAGGTTGAGCCGAAAGATGCGTGGAAAAAAATAAAATATAGAAGTGATGATGAGAGTTTTAACCGTAAAA
TTCAAGTACTTGCAGCTTATCGTGAAGAGAATGTACAAACTATAAATATTCCTCGTAAGCATTTTATTTTAGATGAAGAT
ATAATAAAGCTTAGTAAATACCCGCCATTGAATCACAGGGATTTTAAAAATCTCAATTTAAAAAGTAAATATTTACACAA
ACAAAAATATAAAGATGAAATAATAAGTTTGTGTAATAACTTATAA

Upstream 100 bases:

>100_bases
TGAGTGGATTATTATTATTTTAATCGGTCTTGAAGTTGTCCTGTCGTTGTCTCATACTAATCTTTTCTTAAAAATTATCG
GAGCTTTATAAATATCTTCT

Downstream 100 bases:

>100_bases
GAAAAAAGATACAAATCAAATAATGTGCAGCCTATATATTATACCGAAATCACAAAATCAAGTTTACGATCATGAGGTTC
AACAGGAAAATTATCTATTA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQIIDSQKTLEEFCNRLANKTCLSIDTEFERRYTYYAQLSIIQVKAEEYCGIIDALSNLDLNVFNKLLEDNNITKIFHAP
REDLEIFYNLFKTLPANVFDIQIAANICGFGKQLSYDDICYKLIGITIDKTHQKSNWLKRPITSDMLNYAMLDVKYLYKI
YQELNNIIIRNNLTNKYKTTLSSLLDVINYKVEPKDAWKKIKYRSDDESFNRKIQVLAAYREENVQTINIPRKHFILDED
IIKLSKYPPLNHRDFKNLNLKSKYLHKQKYKDEIISLCNNL

Sequences:

>Translated_281_residues
MQIIDSQKTLEEFCNRLANKTCLSIDTEFERRYTYYAQLSIIQVKAEEYCGIIDALSNLDLNVFNKLLEDNNITKIFHAP
REDLEIFYNLFKTLPANVFDIQIAANICGFGKQLSYDDICYKLIGITIDKTHQKSNWLKRPITSDMLNYAMLDVKYLYKI
YQELNNIIIRNNLTNKYKTTLSSLLDVINYKVEPKDAWKKIKYRSDDESFNRKIQVLAAYREENVQTINIPRKHFILDED
IIKLSKYPPLNHRDFKNLNLKSKYLHKQKYKDEIISLCNNL
>Mature_281_residues
MQIIDSQKTLEEFCNRLANKTCLSIDTEFERRYTYYAQLSIIQVKAEEYCGIIDALSNLDLNVFNKLLEDNNITKIFHAP
REDLEIFYNLFKTLPANVFDIQIAANICGFGKQLSYDDICYKLIGITIDKTHQKSNWLKRPITSDMLNYAMLDVKYLYKI
YQELNNIIIRNNLTNKYKTTLSSLLDVINYKVEPKDAWKKIKYRSDDESFNRKIQVLAAYREENVQTINIPRKHFILDED
IIKLSKYPPLNHRDFKNLNLKSKYLHKQKYKDEIISLCNNL

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=164, Percent_Identity=28.0487804878049, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4505917, Length=164, Percent_Identity=28.0487804878049, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788105, Length=269, Percent_Identity=28.996282527881, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17531757, Length=210, Percent_Identity=24.7619047619048, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=171, Percent_Identity=24.5614035087719, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 33282; Mature: 33282

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIDSQKTLEEFCNRLANKTCLSIDTEFERRYTYYAQLSIIQVKAEEYCGIIDALSNLD
CCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHEEEEEEEEEEEEEHHHHHHHHHHHHCCC
LNVFNKLLEDNNITKIFHAPREDLEIFYNLFKTLPANVFDIQIAANICGFGKQLSYDDIC
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCHHHHH
YKLIGITIDKTHQKSNWLKRPITSDMLNYAMLDVKYLYKIYQELNNIIIRNNLTNKYKTT
HHHHHCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHH
LSSLLDVINYKVEPKDAWKKIKYRSDDESFNRKIQVLAAYREENVQTINIPRKHFILDED
HHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCHH
IIKLSKYPPLNHRDFKNLNLKSKYLHKQKYKDEIISLCNNL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIIDSQKTLEEFCNRLANKTCLSIDTEFERRYTYYAQLSIIQVKAEEYCGIIDALSNLD
CCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHEEEEEEEEEEEEEHHHHHHHHHHHHCCC
LNVFNKLLEDNNITKIFHAPREDLEIFYNLFKTLPANVFDIQIAANICGFGKQLSYDDIC
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCHHHHH
YKLIGITIDKTHQKSNWLKRPITSDMLNYAMLDVKYLYKIYQELNNIIIRNNLTNKYKTT
HHHHHCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHH
LSSLLDVINYKVEPKDAWKKIKYRSDDESFNRKIQVLAAYREENVQTINIPRKHFILDED
HHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCHH
IIKLSKYPPLNHRDFKNLNLKSKYLHKQKYKDEIISLCNNL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]