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The map label for this gene is virB11 [H]

Identifier: 157825513

GI number: 157825513

Start: 387230

End: 388234

Strand: Direct

Name: virB11 [H]

Synonym: A1C_02070

Alternate gene names: 157825513

Gene position: 387230-388234 (Clockwise)

Preceding gene: 157825512

Following gene: 157825514

Centisome position: 31.46

GC content: 36.52

Gene sequence:

>1005_bases
ATGAATGAAGAATTTGCAGCTTTAGAGACGTTTTTACTTCCTTTTAAAAATTTATTTGCTGAAGACGGTATTAACGAGAT
TATGGTTAATAAGCCTGGAGAAGTATGGGTTGAAAAAAAAGGCGATATATATTCTAAGCAAATACCGGAATTGGATAGTG
AGCATCTACTTTCATTAGGGCGTTTAGTTGCTCAATCTACCGAACAGATGATTTCGGAAGAAAAGCCTTTACTTTCTGCA
ACTTTGCCTAACGGTTACCGTATTCAAATAGTATTTCCTCCTGCTTGTGAGATAGGACAAATCATTTATTCTATAAGAAA
GCCTAGCGGTATGACTCTAACTTTAGATGAGTACGCTAAAATGGGGGTATTTGATGATACTGCAACAGAGAGTTTAGTAG
ATGAAGATGTAGTAATGTTAAATAATTTCTTAGCTGAAAAAAAGATTAAAGAATTTATTAGATATGCAGTTGTTTCAAAG
AAAAATATCATAATTAGTGGTGGTACTTCAACCGGTAAAACTACTTTTACTAATACAGCACTTACTGAAATACCTGCAAG
AGAAAGATTAATTACTGTAGAAGATGCTCGTGAGGTTGTGCTATCAAGCCATCCTAACAGAGTGCATTTACTTGCTTCCA
AAGGAGGACAGGGGCGTGCAAATGTTACTACTCAAGATTTAATAGAGGCATGTTTGCGTTTAAGACCGGATAGAATTATA
GTAGGTGAGCTTCGAGGTAAGGAAGCTTTTAGTTTTTTGCGTGCTATTAATACAGGTCATCCCGGTTCAATATCAACACT
GCATGCCGATAGCCCTGCTATGGCTATTGAGCAGTTAAAGCTTATGGTTATGCAAGCAGATCTTGGTATGCCGCCTGAAG
AAGTAAAGAAGTATATTTTAACCGTTGTAGATATAGTTGTGCAGTTAAAACGCGGTAGCGATGGGAAAAGATATGTTTCG
GAAGTGTATTATAAGAATAATAAGAACGCTGAAGGTATGGTGTAG

Upstream 100 bases:

>100_bases
AGCCGACGACAACGGTTAATCAAGGTACGCCGGTTAGAATATACGTTAATAAGGATTATAAATTTCCAAAAGCCGTTTTA
TTAAAATCGAAGGTAATGCA

Downstream 100 bases:

>100_bases
CGTACTTACTGTCATCCCCTGATCAAGGCCACGGGATCCATAAAAAAATAAAAAAAGTTGGATTCCGCGATCAAGTTTTG
GGATGACACTGGGAAAGTCA

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNEEFAALETFLLPFKNLFAEDGINEIMVNKPGEVWVEKKGDIYSKQIPELDSEHLLSLGRLVAQSTEQMISEEKPLLSA
TLPNGYRIQIVFPPACEIGQIIYSIRKPSGMTLTLDEYAKMGVFDDTATESLVDEDVVMLNNFLAEKKIKEFIRYAVVSK
KNIIISGGTSTGKTTFTNTALTEIPARERLITVEDAREVVLSSHPNRVHLLASKGGQGRANVTTQDLIEACLRLRPDRII
VGELRGKEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQADLGMPPEEVKKYILTVVDIVVQLKRGSDGKRYVS
EVYYKNNKNAEGMV

Sequences:

>Translated_334_residues
MNEEFAALETFLLPFKNLFAEDGINEIMVNKPGEVWVEKKGDIYSKQIPELDSEHLLSLGRLVAQSTEQMISEEKPLLSA
TLPNGYRIQIVFPPACEIGQIIYSIRKPSGMTLTLDEYAKMGVFDDTATESLVDEDVVMLNNFLAEKKIKEFIRYAVVSK
KNIIISGGTSTGKTTFTNTALTEIPARERLITVEDAREVVLSSHPNRVHLLASKGGQGRANVTTQDLIEACLRLRPDRII
VGELRGKEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQADLGMPPEEVKKYILTVVDIVVQLKRGSDGKRYVS
EVYYKNNKNAEGMV
>Mature_334_residues
MNEEFAALETFLLPFKNLFAEDGINEIMVNKPGEVWVEKKGDIYSKQIPELDSEHLLSLGRLVAQSTEQMISEEKPLLSA
TLPNGYRIQIVFPPACEIGQIIYSIRKPSGMTLTLDEYAKMGVFDDTATESLVDEDVVMLNNFLAEKKIKEFIRYAVVSK
KNIIISGGTSTGKTTFTNTALTEIPARERLITVEDAREVVLSSHPNRVHLLASKGGQGRANVTTQDLIEACLRLRPDRII
VGELRGKEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQADLGMPPEEVKKYILTVVDIVVQLKRGSDGKRYVS
EVYYKNNKNAEGMV

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 37118; Mature: 37118

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEEFAALETFLLPFKNLFAEDGINEIMVNKPGEVWVEKKGDIYSKQIPELDSEHLLSLG
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHCCCCCHHHHHHHH
RLVAQSTEQMISEEKPLLSATLPNGYRIQIVFPPACEIGQIIYSIRKPSGMTLTLDEYAK
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEHHHHHH
MGVFDDTATESLVDEDVVMLNNFLAEKKIKEFIRYAVVSKKNIIISGGTSTGKTTFTNTA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCCH
LTEIPARERLITVEDAREVVLSSHPNRVHLLASKGGQGRANVTTQDLIEACLRLRPDRII
HHHCCCCCCEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
VGELRGKEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQADLGMPPEEVKKYIL
EECCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TVVDIVVQLKRGSDGKRYVSEVYYKNNKNAEGMV
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNEEFAALETFLLPFKNLFAEDGINEIMVNKPGEVWVEKKGDIYSKQIPELDSEHLLSLG
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHCCCCCHHHHHHHH
RLVAQSTEQMISEEKPLLSATLPNGYRIQIVFPPACEIGQIIYSIRKPSGMTLTLDEYAK
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEHHHHHH
MGVFDDTATESLVDEDVVMLNNFLAEKKIKEFIRYAVVSKKNIIISGGTSTGKTTFTNTA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCCH
LTEIPARERLITVEDAREVVLSSHPNRVHLLASKGGQGRANVTTQDLIEACLRLRPDRII
HHHCCCCCCEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
VGELRGKEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQADLGMPPEEVKKYIL
EECCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TVVDIVVQLKRGSDGKRYVSEVYYKNNKNAEGMV
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]