Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 157825483

GI number: 157825483

Start: 359376

End: 360827

Strand: Direct

Name: icd [H]

Synonym: A1C_01920

Alternate gene names: 157825483

Gene position: 359376-360827 (Clockwise)

Preceding gene: 157825482

Following gene: 157825484

Centisome position: 29.19

GC content: 35.61

Gene sequence:

>1452_bases
ATGGCAGAATTTACACCGATTACAATTGCATACGGGGACGGTATAGGTCCTGAAATAATGGAGGCAGTGCTTTATATATT
ACGTAAAGCTGAGGCTCGTATTCGCTTAGAAACCATTGAAGTAGGTGAAAAGCTTTACAAGAAGCATTATACTGCAGGCA
TAAGCGAAGAAAGTTGGGAATCAATACAACGTACCGGTATTATACTTAAAGCCCCGATTACTACCCCGCAAGGTGGAGGA
TATAAAAGTTTAAACGTCACGATTCGTAAAACATTACAGCTTTTTGCTAATATTCGTCCTTCTGTTTCGTTTCATCCTTT
TACTAGAACTCTGCATCCAAATTTAAATCTAACTATTATACGTGAGAATGAGGAAGATTTATACGCAGGTATAGAATACC
GCCAAACGCATAATATTTATGAATCAATAAAGTTGATAAGTCATACTGGTTGTGAAAAAATTATTAGATATGCTTTTGAA
TATGCAGTAAAAAATAACCGTAAAAAAGTCACGTGCTTAAGCAAAGATAATATTATGAAATTTTCCGATGGTGTCTTTCA
TAAAGTATTTAATGAGATTGCAAAAGAATATCCACAAATTAGTAACGAGCATTATATTATCGATATCGGAACTGCAAGGC
TTTCTACCAAACCGGAAATATTTGACGTTATCGTGACTTCTAATCTATACGGTGATATCATATCCGATGTAGCTGCTGAA
ATTTCAGGCTCGGTAGGTTTAGCCGGTTCTGCAAATATTGGGCAGCATTATGCGATGTTTGAAGCAGTACATGGAAGTGC
TCCCAATATTGCCGGTAAAGATATTGCAAATCCGTCAGGGCTGTTAAATGCTGCTATAATGATGCTAGTACATATAGGAC
AGGGTGATATCGCTACATTAATCGAAAATGCTTGGAAAAAAACTATAGAGGATGGAGTTCATACAGCCGATATATATAAT
CAGCAGAATTCTAGTAAAAAAGTTGGTACAAAAGAATTTGCTGAAGAAGTAACGAAAAGATTAGGAAAGATACCGACAAA
GCTACCTAGAGCAGATTATCCGTTAATTGCCGAGAAACAAGAAAGTAATATAGACTATAAAATTGATACTAAAGAGGTTA
AGAAATTGGTTGGTACAGATATATTTGTGAATATTAATGTATCTTCCGCTCACGATATAGCAGATACAGTTAATAAGCTT
GAGCTTGGTAATGTTGAGTTAAAAACAATCTCGTCAAAAGGATTAAAATTGTGGCCCCGTGATACAAGGTTTGAAACTGT
TTCCGATCATTGGTGTTGTCGTTTTATGAATAAAGACGGCACAGAAATAAAGCATTTAGATATAACAAGATTGCTTGAAG
CTTTAAGCAAAGCAAATATCGATTTTATCAAAGTAGAGAATTTATTTGAGTTTGACGGGGTGGCAGGGTATAGTTTGGCT
CAAGGTGAGTGA

Upstream 100 bases:

>100_bases
AAGTAATGATAAACTATTGATTGTATTGTATATGTCATTCTTGTCTACGCTGGGATAACATAGGACATAACAACACTATT
ATTTAACAAGAGTATTTAAT

Downstream 100 bases:

>100_bases
TATACTCGATCAACTTCAAAAATTGGCTACGTAATCCTACAAGTACTGAGGTGCTCACGTGTTAAGTATATGCTCAGCTC
CTCGTCTTGTGGATTCCTTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MAEFTPITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTAGISEESWESIQRTGIILKAPITTPQGGG
YKSLNVTIRKTLQLFANIRPSVSFHPFTRTLHPNLNLTIIRENEEDLYAGIEYRQTHNIYESIKLISHTGCEKIIRYAFE
YAVKNNRKKVTCLSKDNIMKFSDGVFHKVFNEIAKEYPQISNEHYIIDIGTARLSTKPEIFDVIVTSNLYGDIISDVAAE
ISGSVGLAGSANIGQHYAMFEAVHGSAPNIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHTADIYN
QQNSSKKVGTKEFAEEVTKRLGKIPTKLPRADYPLIAEKQESNIDYKIDTKEVKKLVGTDIFVNINVSSAHDIADTVNKL
ELGNVELKTISSKGLKLWPRDTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSKANIDFIKVENLFEFDGVAGYSLA
QGE

Sequences:

>Translated_483_residues
MAEFTPITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTAGISEESWESIQRTGIILKAPITTPQGGG
YKSLNVTIRKTLQLFANIRPSVSFHPFTRTLHPNLNLTIIRENEEDLYAGIEYRQTHNIYESIKLISHTGCEKIIRYAFE
YAVKNNRKKVTCLSKDNIMKFSDGVFHKVFNEIAKEYPQISNEHYIIDIGTARLSTKPEIFDVIVTSNLYGDIISDVAAE
ISGSVGLAGSANIGQHYAMFEAVHGSAPNIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHTADIYN
QQNSSKKVGTKEFAEEVTKRLGKIPTKLPRADYPLIAEKQESNIDYKIDTKEVKKLVGTDIFVNINVSSAHDIADTVNKL
ELGNVELKTISSKGLKLWPRDTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSKANIDFIKVENLFEFDGVAGYSLA
QGE
>Mature_482_residues
AEFTPITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTAGISEESWESIQRTGIILKAPITTPQGGGY
KSLNVTIRKTLQLFANIRPSVSFHPFTRTLHPNLNLTIIRENEEDLYAGIEYRQTHNIYESIKLISHTGCEKIIRYAFEY
AVKNNRKKVTCLSKDNIMKFSDGVFHKVFNEIAKEYPQISNEHYIIDIGTARLSTKPEIFDVIVTSNLYGDIISDVAAEI
SGSVGLAGSANIGQHYAMFEAVHGSAPNIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHTADIYNQ
QNSSKKVGTKEFAEEVTKRLGKIPTKLPRADYPLIAEKQESNIDYKIDTKEVKKLVGTDIFVNINVSSAHDIADTVNKLE
LGNVELKTISSKGLKLWPRDTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSKANIDFIKVENLFEFDGVAGYSLAQ
GE

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=337, Percent_Identity=40.6528189910979, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI4758582, Length=326, Percent_Identity=36.5030674846626, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI28178838, Length=308, Percent_Identity=36.6883116883117, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI28178816, Length=311, Percent_Identity=34.4051446945338, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI28178821, Length=311, Percent_Identity=34.4051446945338, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI28178819, Length=173, Percent_Identity=36.9942196531792, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1787381, Length=384, Percent_Identity=32.03125, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1788101, Length=304, Percent_Identity=31.9078947368421, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081683, Length=363, Percent_Identity=30.0275482093664, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71986051, Length=336, Percent_Identity=38.6904761904762, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17505779, Length=320, Percent_Identity=38.4375, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI25144293, Length=330, Percent_Identity=36.969696969697, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17550882, Length=320, Percent_Identity=34.375, Blast_Score=171, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324709, Length=335, Percent_Identity=42.6865671641791, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324291, Length=345, Percent_Identity=36.231884057971, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322097, Length=360, Percent_Identity=31.6666666666667, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319830, Length=366, Percent_Identity=27.0491803278689, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24643270, Length=336, Percent_Identity=40.1785714285714, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24643268, Length=336, Percent_Identity=40.1785714285714, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24661184, Length=327, Percent_Identity=40.0611620795107, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI161078633, Length=352, Percent_Identity=36.3636363636364, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24650122, Length=352, Percent_Identity=36.3636363636364, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI161078635, Length=327, Percent_Identity=37.9204892966361, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161078637, Length=327, Percent_Identity=37.9204892966361, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161078639, Length=347, Percent_Identity=37.463976945245, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281362242, Length=332, Percent_Identity=33.7349397590361, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24648872, Length=332, Percent_Identity=33.7349397590361, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI20130355, Length=327, Percent_Identity=27.5229357798165, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45550436, Length=273, Percent_Identity=23.8095238095238, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 53972; Mature: 53841

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFTPITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTAGISEESWE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHCHHEEEHHHHHHHHHHHHHHCCCCCHHHHH
SIQRTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTRTLHPNLNLTII
HHHHCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEECCCEEEECCCCEEEEE
RENEEDLYAGIEYRQTHNIYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMK
ECCCCCHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEE
FSDGVFHKVFNEIAKEYPQISNEHYIIDIGTARLSTKPEIFDVIVTSNLYGDIISDVAAE
CCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
ISGSVGLAGSANIGQHYAMFEAVHGSAPNIAGKDIANPSGLLNAAIMMLVHIGQGDIATL
HCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
IENAWKKTIEDGVHTADIYNQQNSSKKVGTKEFAEEVTKRLGKIPTKLPRADYPLIAEKQ
HHHHHHHHHHCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCC
ESNIDYKIDTKEVKKLVGTDIFVNINVSSAHDIADTVNKLELGNVELKTISSKGLKLWPR
CCCCCEEECHHHHHHHHCCEEEEEEECCCCHHHHHHHHHEECCCEEEEEECCCCCEECCC
DTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSKANIDFIKVENLFEFDGVAGYSLA
CCCCCCCCCCHHHEECCCCCCEEEEECHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
QGE
CCC
>Mature Secondary Structure 
AEFTPITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTAGISEESWE
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCHHEEEHHHHHHHHHHHHHHCCCCCHHHHH
SIQRTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTRTLHPNLNLTII
HHHHCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEECCCEEEECCCCEEEEE
RENEEDLYAGIEYRQTHNIYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMK
ECCCCCHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEE
FSDGVFHKVFNEIAKEYPQISNEHYIIDIGTARLSTKPEIFDVIVTSNLYGDIISDVAAE
CCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
ISGSVGLAGSANIGQHYAMFEAVHGSAPNIAGKDIANPSGLLNAAIMMLVHIGQGDIATL
HCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
IENAWKKTIEDGVHTADIYNQQNSSKKVGTKEFAEEVTKRLGKIPTKLPRADYPLIAEKQ
HHHHHHHHHHCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCC
ESNIDYKIDTKEVKKLVGTDIFVNINVSSAHDIADTVNKLELGNVELKTISSKGLKLWPR
CCCCCEEECHHHHHHHHCCEEEEEEECCCCHHHHHHHHHEECCCEEEEEECCCCCEECCC
DTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSKANIDFIKVENLFEFDGVAGYSLA
CCCCCCCCCCHHHEECCCCCCEEEEECHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
QGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA