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The map label for this gene is parE [H]

Identifier: 157825436

GI number: 157825436

Start: 315190

End: 317178

Strand: Direct

Name: parE [H]

Synonym: A1C_01685

Alternate gene names: 157825436

Gene position: 315190-317178 (Clockwise)

Preceding gene: 157825435

Following gene: 157825437

Centisome position: 25.6

GC content: 33.38

Gene sequence:

>1989_bases
ATGAATGATTTATTAAGCTTTAACAAAGAAAAGAAAAATAAGCTAGTCGATAATAACTATAGTGCAAAAGATATTGAAGT
ATTAGAAGGGCTGGAGCCTGTTCGTAAAAGACCGGGGATGTATATCGGTGGTACTGATTCAAATGCTATGCATCATTTAG
TATCTGAGGTGCTAGATAATGCTATGGATGAAGCACTCGCCGGCTTTGCAAGTATCATCACGATAAAAATGCATCAAGAT
CATAGTATTACTATATTTGATAACGGTCGTGGTATTCCTATTGATAATCATCCTAAATTTCCTGATAAATCAGCTTTAGA
AGTAATTTTAACTACTCTTCATTCAGGCGGTAAATTCTCAAATAATGTTTATCATACTGCAGGCGGATTGCATGGCGTTG
GAATATCGGTCGTAAATGCTTTATCTAAACATTTAGAAATAAAGGTGTATAAACAAGGTAAATTATATAGCCAAAGTTAT
TCTCAAGGAAAAAAATTAACTGATTTAATATGTGAAGAATCATATAAAAGGCTAAGAGGTACATCAATAAATTTCACTCC
AGATCCAGAAATTTTTAGTGAAAAATTACATTTTAATCCTAAAAAGATTTATGAGCTTGCAAGGTCCAAAGCTTATTTAT
ATCGCGGTGTTACTATAGAATGGGAATGCGAAGTAGAAGTACTGTCAGATATACCTAAAAAGGCATTAATAAATTTCCCG
AACGGTTTAAAAGATTATTTAAGTTCAAAAATAACTTTAGATAATTTAATTATTCCGGAAATTTTTTCAGGTAATGTAGA
GTCTACGCCGGATGGAATAAAACTTGAATGGGCGATTTGTTGGCAAAATAATGATAACTCGGCATTTATTCAATCATATT
GTAATACTGTTACGACTCCTCAAGGAGGAACGCATGAGCAAGGACTTAAGTCGGCTATTTTACGTGGGCTTAAAGCGTAC
GGTGAAATGATAGGGAATAAAAAAGCTGCTAATCTAACTATTGAGGATATTTTAGAAACCGCATGTGTCGTACTTTCTAT
TTTTATAGCTGAACCGTCGTTTCAAGGACAAACTAAGGAAAAATTAGTGTCAAACGGTGTAAGTAAACCGGTTGAGAATA
TAATAAAAGATCATTTTGACCACTTCCTTAGTAGCGATAAAGCTTTAGCTACTAATTTACTTGAGCATGTAATTGCTATT
GCCGAGTTTAGAATAAGTAAGAAAAACGAAAAAAATATTTCCCGTAAAAATGCTACTCAAAAATTACGTTTACCCGGTAA
ACTTGCCGATTGTACACGAACTTCACCTGAAGGGACGGAATTATTTATTGTAGAAGGTGATTCGGCAGGAGGTTCTGCAA
AACAAGCACGTAATAGAGAAACGCAAGCAGTATTACCGCTATGGGGTAAAGTGCTAAATGTTGCGAGTTCTACGCTTGAG
AAAATCGTTAATAATCAAGCAATACAAGATTTAGAAATAGCACTTGCTTGTGGTAGTTTAAAGAATTATAAAAAAGAAAA
TTTGCGTTACGAAAAAATAATTATTATGACTGATGCAGATGTTGACGGTGCTCATATAGCTTCGTTGTTAATGACTTTCT
TTTTTTTACGAATGCCGAAATTGGTAGAAGAGGGGCATTTATATCTAGCTAAGCCTCCGCTTTATCGTTTAACGCAGTCT
AATAAAACTTATTATGCAGGCGATGAAGAGGAAAAAGCTAAATTAATGGGTAAATTATCGAAAGCTAGTAAAGCTAAAAT
TGAAGTAGGTAGGTTTAAAGGTCTCGGTGAAATGATGCCTGCACAATTAAAGGAAACTACTATGCATCCAGAAAAAAGAT
CGCTTTTAAATGTAACTTTAGAAGATTTCCAAAATGTCGATAAAATAGTAGATGATTTAATGGGTAAAAAGCCGGAAAAA
AGATTTCAATTTATTTATGAACAGGCGTTAGTTAAAATGGATAAAATTATTAACGAGTTGGATATTTAA

Upstream 100 bases:

>100_bases
TTTTTAGGTAATGCCACACCATTTCTTTAAAGCTTCATTGCTTTCTTGAGTTAAATAGTTTAATTTAGGAAAGAAAATAA
TTAATTCCTCCCCTATATAT

Downstream 100 bases:

>100_bases
GACAAGGCGTCATTGTGGGGCATTGTCAACGTTGACCGCATGGCTCGAAAAACTTACTAGATGTCATTCCCTCCTTCGAT
GGCATGACATATTAACTTTT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MNDLLSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEALAGFASIITIKMHQD
HSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFSNNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSY
SQGKKLTDLICEESYKRLRGTSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWECEVEVLSDIPKKALINFP
NGLKDYLSSKITLDNLIIPEIFSGNVESTPDGIKLEWAICWQNNDNSAFIQSYCNTVTTPQGGTHEQGLKSAILRGLKAY
GEMIGNKKAANLTIEDILETACVVLSIFIAEPSFQGQTKEKLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVIAI
AEFRISKKNEKNISRKNATQKLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLE
KIVNNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEEGHLYLAKPPLYRLTQS
NKTYYAGDEEEKAKLMGKLSKASKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLNVTLEDFQNVDKIVDDLMGKKPEK
RFQFIYEQALVKMDKIINELDI

Sequences:

>Translated_662_residues
MNDLLSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEALAGFASIITIKMHQD
HSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFSNNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSY
SQGKKLTDLICEESYKRLRGTSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWECEVEVLSDIPKKALINFP
NGLKDYLSSKITLDNLIIPEIFSGNVESTPDGIKLEWAICWQNNDNSAFIQSYCNTVTTPQGGTHEQGLKSAILRGLKAY
GEMIGNKKAANLTIEDILETACVVLSIFIAEPSFQGQTKEKLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVIAI
AEFRISKKNEKNISRKNATQKLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLE
KIVNNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEEGHLYLAKPPLYRLTQS
NKTYYAGDEEEKAKLMGKLSKASKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLNVTLEDFQNVDKIVDDLMGKKPEK
RFQFIYEQALVKMDKIINELDI
>Mature_662_residues
MNDLLSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEALAGFASIITIKMHQD
HSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFSNNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSY
SQGKKLTDLICEESYKRLRGTSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWECEVEVLSDIPKKALINFP
NGLKDYLSSKITLDNLIIPEIFSGNVESTPDGIKLEWAICWQNNDNSAFIQSYCNTVTTPQGGTHEQGLKSAILRGLKAY
GEMIGNKKAANLTIEDILETACVVLSIFIAEPSFQGQTKEKLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVIAI
AEFRISKKNEKNISRKNATQKLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLE
KIVNNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEEGHLYLAKPPLYRLTQS
NKTYYAGDEEEKAKLMGKLSKASKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLNVTLEDFQNVDKIVDDLMGKKPEK
RFQFIYEQALVKMDKIINELDI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=648, Percent_Identity=24.537037037037, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI19913408, Length=593, Percent_Identity=24.9578414839798, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1789408, Length=635, Percent_Identity=41.259842519685, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI48994957, Length=564, Percent_Identity=41.3120567375887, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212645845, Length=570, Percent_Identity=23.5087719298246, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17535065, Length=589, Percent_Identity=23.2597623089983, Blast_Score=103, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324241, Length=629, Percent_Identity=24.3243243243243, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136538, Length=591, Percent_Identity=24.0270727580372, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.3

Molecular weight: Translated: 74018; Mature: 74018

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLLSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDN
CCCCHHCCHHHHHHCCCCCCCCHHHHHHHCCHHHHHCCCEEECCCCCHHHHHHHHHHHHH
AMDEALAGFASIITIKMHQDHSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFS
HHHHHHHHHHHEEEEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
NNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSYSQGKKLTDLICEESYKRLRG
CCEEECCCCCCHHHHHHHHHHHHHCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHCC
TSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWECEVEVLSDIPKKALINFP
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHEEECCEEEEEECHHHHHCCCHHHHHCCC
NGLKDYLSSKITLDNLIIPEIFSGNVESTPDGIKLEWAICWQNNDNSAFIQSYCNTVTTP
CHHHHHHHCCCCHHHEECCHHHCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCC
QGGTHEQGLKSAILRGLKAYGEMIGNKKAANLTIEDILETACVVLSIFIAEPSFQGQTKE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
KLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVIAIAEFRISKKNEKNISRKNATQ
HHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHH
KLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLE
HCCCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KIVNNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPK
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
LVEEGHLYLAKPPLYRLTQSNKTYYAGDEEEKAKLMGKLSKASKAKIEVGRFKGLGEMMP
HHHCCCEEEECCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHEEHHHHCCCHHHHH
AQLKETTMHPEKRSLLNVTLEDFQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDKIINEL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DI
CC
>Mature Secondary Structure
MNDLLSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDN
CCCCHHCCHHHHHHCCCCCCCCHHHHHHHCCHHHHHCCCEEECCCCCHHHHHHHHHHHHH
AMDEALAGFASIITIKMHQDHSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFS
HHHHHHHHHHHEEEEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
NNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSYSQGKKLTDLICEESYKRLRG
CCEEECCCCCCHHHHHHHHHHHHHCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHCC
TSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWECEVEVLSDIPKKALINFP
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHEEECCEEEEEECHHHHHCCCHHHHHCCC
NGLKDYLSSKITLDNLIIPEIFSGNVESTPDGIKLEWAICWQNNDNSAFIQSYCNTVTTP
CHHHHHHHCCCCHHHEECCHHHCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCC
QGGTHEQGLKSAILRGLKAYGEMIGNKKAANLTIEDILETACVVLSIFIAEPSFQGQTKE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
KLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVIAIAEFRISKKNEKNISRKNATQ
HHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHH
KLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLE
HCCCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KIVNNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPK
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
LVEEGHLYLAKPPLYRLTQSNKTYYAGDEEEKAKLMGKLSKASKAKIEVGRFKGLGEMMP
HHHCCCEEEECCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHEEHHHHCCCHHHHH
AQLKETTMHPEKRSLLNVTLEDFQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDKIINEL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA