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The map label for this gene is sdhA [H]

Identifier: 157825309

GI number: 157825309

Start: 175325

End: 177115

Strand: Direct

Name: sdhA [H]

Synonym: A1C_00955

Alternate gene names: 157825309

Gene position: 175325-177115 (Clockwise)

Preceding gene: 157825308

Following gene: 157825310

Centisome position: 14.24

GC content: 41.71

Gene sequence:

>1791_bases
ATGAACAAAGCATATAATATCATACATCATAAATTTGACGTAGTAGTTGTAGGTGCAGGCGGAGCTGGTCTTCGTTCTGC
ATTTGGTATGGCTCAAGAAGGGCTAGACACCGCCTGTATAACTAAGCTATTTCCGACTCGTAGTCATACTGTGGCTGCTC
AGGGCGGAATCAGTGCAGCTCTTGGGAATATGGGCGAAGATGATTGGCGTTGGCATATGTATGATACAGTAAAAGGTTCA
GACTGGTTAGGTGATCAGGATGCCATCGAGTATATGTGCAAGAATGCTCCCGATGCGATTTTAGAGCTTGAGCATTACGG
AGTACCTTTTTCAAGAACTAAAGAGGGAAAAATTTATCAGCGTCCTTTTGGCGGTATGACAACAGAGTACGGTAAAGGAA
AAGCGGCTCAGCGTACATGTGCTGCGGCAGATCGTACTGGGCATGCCATACTCCATACGTTATATCAGCAGTCACTAAAG
CATAAAGTGCAGTTTTTTGTTGAGTATTTTGCTATTGATCTATTGATGGAAGACGGCGAATGTAGAGGCGTAGTTGCTTG
GAATTTAGATGATGGGAGACTGCATTGTTTTAGAGCTCATAATGTAGTGCTTGCAACGGGAGGATATGGGCGTGCTTATT
TTTCAGCAACGTCTGCTCATACTTGTACGGGCGACGGGGGAGGTATGGCGATTAGAGCAGGTTTGCCGCTGCAAGATATG
GAGTTTGTACAGTTCCATCCGACAGGCATATATTCGGCTGGCTGTCTTATTACCGAGGGAGCTAGAGGTGAAGGGGGATA
TCTTGTTAATGTAAACGGAGAGCGTTTTATGGAGCGTTACGCTCCTGCTGCAAAGGATTTAGCTTCAAGAGACGTGGTTT
CAAGAGCGATGACTATCGAGATTCGTGAAGGGCGAGGAGTCGGCGAGCATAAAGATCATGTATTCCTGCATTTAAATCAT
TTATCGCCTGAGATTTTACATAGTCGTTTGCCAGGTATTGTGGAGACGGCTAAAATTTTTGCCGGTGTTGATGTCACTAA
AGAGCCGATACCAGTACTTCCTACAGTTCATTATAATATGGGAGGGATACCGACTAATTACCACGGTCAAGTCATAATCA
AAGACGGTAAAAATCACAATAGCGTAGTAAAAGGACTTATGGCAATCGGTGAAGCAGCTTGTGTATCGGTACACGGTGCT
AACAGGCTTGGGTCAAATTCTTTGCTTGATTTGGTGGTATTTGGTAGAAGCTCTGCATTAAAAGCAGCTGAACTTATCAA
ACCGGCAAGTCCACATAAGCCATTAAAAGAAGAAAGCCTTGAGAAAATTATAAATAGATTTGATAAAATTCGTTATAATA
ACGGTAATATTTTAACTGCAGATTTAAGGCTTAAAATGCAAAGAACTATGCAAAGTCACGCTTCGGTATTTAGAACTCAA
GAGGTACTAGACGAAGGAGCAGGAATGATTAGTGAGATAAGAAGCGGCTATAAAGATATAAAAATTAACGATAAATCTTT
AATTTGGAATAGTGATTTAGTAGAAGCCTTAGAGCTAGATAATCTACTTGATCAAGCTTTGGTTACAGTATATTCGGCAG
CTGCAAGGAAAGAAAGCAGAGGAGCTCATGCTAGGGAAGATTATCCTGGTCGTAATGATGAAGATTGGATGAAACATACT
CTTAGTTCTATCGATGCAGCAGGTAAAGTAGTTCTTGATTATAAACCTGTAACGCTAACCACTTTAACCGATGAGATAAG
TACAATTCCACCAGCAAAAAGAGTGTATTAA

Upstream 100 bases:

>100_bases
AATATAATACTGTATTTCGTGATTGAAAATGAAATTAGTATACTTAGGATGTGCATAAAAATATAGATATAACTGGAATA
TAGAGTAACAAATTAATTTA

Downstream 100 bases:

>100_bases
TGTATTATATACTCGGTGAATTTCAAAAATTGGCCTCTCGTTGTTTCGTAGATATCAAATCGTCATTGTGAGGAGGCATT
GTTGCGTAGACTCCCAGTCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MNKAYNIIHHKFDVVVVGAGGAGLRSAFGMAQEGLDTACITKLFPTRSHTVAAQGGISAALGNMGEDDWRWHMYDTVKGS
DWLGDQDAIEYMCKNAPDAILELEHYGVPFSRTKEGKIYQRPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLK
HKVQFFVEYFAIDLLMEDGECRGVVAWNLDDGRLHCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDM
EFVQFHPTGIYSAGCLITEGARGEGGYLVNVNGERFMERYAPAAKDLASRDVVSRAMTIEIREGRGVGEHKDHVFLHLNH
LSPEILHSRLPGIVETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGQVIIKDGKNHNSVVKGLMAIGEAACVSVHGA
NRLGSNSLLDLVVFGRSSALKAAELIKPASPHKPLKEESLEKIINRFDKIRYNNGNILTADLRLKMQRTMQSHASVFRTQ
EVLDEGAGMISEIRSGYKDIKINDKSLIWNSDLVEALELDNLLDQALVTVYSAAARKESRGAHAREDYPGRNDEDWMKHT
LSSIDAAGKVVLDYKPVTLTTLTDEISTIPPAKRVY

Sequences:

>Translated_596_residues
MNKAYNIIHHKFDVVVVGAGGAGLRSAFGMAQEGLDTACITKLFPTRSHTVAAQGGISAALGNMGEDDWRWHMYDTVKGS
DWLGDQDAIEYMCKNAPDAILELEHYGVPFSRTKEGKIYQRPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLK
HKVQFFVEYFAIDLLMEDGECRGVVAWNLDDGRLHCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDM
EFVQFHPTGIYSAGCLITEGARGEGGYLVNVNGERFMERYAPAAKDLASRDVVSRAMTIEIREGRGVGEHKDHVFLHLNH
LSPEILHSRLPGIVETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGQVIIKDGKNHNSVVKGLMAIGEAACVSVHGA
NRLGSNSLLDLVVFGRSSALKAAELIKPASPHKPLKEESLEKIINRFDKIRYNNGNILTADLRLKMQRTMQSHASVFRTQ
EVLDEGAGMISEIRSGYKDIKINDKSLIWNSDLVEALELDNLLDQALVTVYSAAARKESRGAHAREDYPGRNDEDWMKHT
LSSIDAAGKVVLDYKPVTLTTLTDEISTIPPAKRVY
>Mature_596_residues
MNKAYNIIHHKFDVVVVGAGGAGLRSAFGMAQEGLDTACITKLFPTRSHTVAAQGGISAALGNMGEDDWRWHMYDTVKGS
DWLGDQDAIEYMCKNAPDAILELEHYGVPFSRTKEGKIYQRPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLK
HKVQFFVEYFAIDLLMEDGECRGVVAWNLDDGRLHCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDM
EFVQFHPTGIYSAGCLITEGARGEGGYLVNVNGERFMERYAPAAKDLASRDVVSRAMTIEIREGRGVGEHKDHVFLHLNH
LSPEILHSRLPGIVETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGQVIIKDGKNHNSVVKGLMAIGEAACVSVHGA
NRLGSNSLLDLVVFGRSSALKAAELIKPASPHKPLKEESLEKIINRFDKIRYNNGNILTADLRLKMQRTMQSHASVFRTQ
EVLDEGAGMISEIRSGYKDIKINDKSLIWNSDLVEALELDNLLDQALVTVYSAAARKESRGAHAREDYPGRNDEDWMKHT
LSSIDAAGKVVLDYKPVTLTTLTDEISTIPPAKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=615, Percent_Identity=63.4146341463415, Blast_Score=776, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=553, Percent_Identity=56.2386980108499, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=42.9565217391304, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1788928, Length=580, Percent_Identity=31.7241379310345, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=612, Percent_Identity=60.4575163398693, Blast_Score=724, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=612, Percent_Identity=59.4771241830065, Blast_Score=699, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=595, Percent_Identity=66.3865546218487, Blast_Score=807, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=595, Percent_Identity=64.7058823529412, Blast_Score=781, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=483, Percent_Identity=28.1573498964803, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137288, Length=614, Percent_Identity=66.1237785016287, Blast_Score=811, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=614, Percent_Identity=66.1237785016287, Blast_Score=811, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=614, Percent_Identity=66.1237785016287, Blast_Score=811, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=56.8627450980392, Blast_Score=708, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65367; Mature: 65367

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAYNIIHHKFDVVVVGAGGAGLRSAFGMAQEGLDTACITKLFPTRSHTVAAQGGISAA
CCCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEECCCHHHH
LGNMGEDDWRWHMYDTVKGSDWLGDQDAIEYMCKNAPDAILELEHYGVPFSRTKEGKIYQ
HCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHEEHHHCCCCCCCCCCCCEEE
RPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLKHKVQFFVEYFAIDLLMEDGE
CCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
CRGVVAWNLDDGRLHCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDM
CCEEEEEECCCCCEEEEEECCEEEEECCCCEEEEECCCCCEECCCCCCEEEEECCCCCCC
EFVQFHPTGIYSAGCLITEGARGEGGYLVNVNGERFMERYAPAAKDLASRDVVSRAMTIE
CEEEECCCCEEECCEEEECCCCCCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHEEEEE
IREGRGVGEHKDHVFLHLNHLSPEILHSRLPGIVETAKIFAGVDVTKEPIPVLPTVHYNM
EECCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCEEEECC
GGIPTNYHGQVIIKDGKNHNSVVKGLMAIGEAACVSVHGANRLGSNSLLDLVVFGRSSAL
CCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHEEEEECCCCCCCCCEEEEEEECCCCHH
KAAELIKPASPHKPLKEESLEKIINRFDKIRYNNGNILTADLRLKMQRTMQSHASVFRTQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHH
EVLDEGAGMISEIRSGYKDIKINDKSLIWNSDLVEALELDNLLDQALVTVYSAAARKESR
HHHHHCCCHHHHHHCCCCEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAREDYPGRNDEDWMKHTLSSIDAAGKVVLDYKPVTLTTLTDEISTIPPAKRVY
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCEEEEEECHHHHCCCCHHCCC
>Mature Secondary Structure
MNKAYNIIHHKFDVVVVGAGGAGLRSAFGMAQEGLDTACITKLFPTRSHTVAAQGGISAA
CCCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEECCCHHHH
LGNMGEDDWRWHMYDTVKGSDWLGDQDAIEYMCKNAPDAILELEHYGVPFSRTKEGKIYQ
HCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHEEHHHCCCCCCCCCCCCEEE
RPFGGMTTEYGKGKAAQRTCAAADRTGHAILHTLYQQSLKHKVQFFVEYFAIDLLMEDGE
CCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
CRGVVAWNLDDGRLHCFRAHNVVLATGGYGRAYFSATSAHTCTGDGGGMAIRAGLPLQDM
CCEEEEEECCCCCEEEEEECCEEEEECCCCEEEEECCCCCEECCCCCCEEEEECCCCCCC
EFVQFHPTGIYSAGCLITEGARGEGGYLVNVNGERFMERYAPAAKDLASRDVVSRAMTIE
CEEEECCCCEEECCEEEECCCCCCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHEEEEE
IREGRGVGEHKDHVFLHLNHLSPEILHSRLPGIVETAKIFAGVDVTKEPIPVLPTVHYNM
EECCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCEEEECC
GGIPTNYHGQVIIKDGKNHNSVVKGLMAIGEAACVSVHGANRLGSNSLLDLVVFGRSSAL
CCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHEEEEECCCCCCCCCEEEEEEECCCCHH
KAAELIKPASPHKPLKEESLEKIINRFDKIRYNNGNILTADLRLKMQRTMQSHASVFRTQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHH
EVLDEGAGMISEIRSGYKDIKINDKSLIWNSDLVEALELDNLLDQALVTVYSAAARKESR
HHHHHCCCHHHHHHCCCCEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAREDYPGRNDEDWMKHTLSSIDAAGKVVLDYKPVTLTTLTDEISTIPPAKRVY
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCEEEEEECHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA