| Definition | Rickettsia akari str. Hartford, complete genome. |
|---|---|
| Accession | NC_009881 |
| Length | 1,231,060 |
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The map label for this gene is phbB [H]
Identifier: 157825142
GI number: 157825142
Start: 14696
End: 15421
Strand: Direct
Name: phbB [H]
Synonym: A1C_00095
Alternate gene names: 157825142
Gene position: 14696-15421 (Clockwise)
Preceding gene: 157825141
Following gene: 157825143
Centisome position: 1.19
GC content: 37.05
Gene sequence:
>726_bases ATGTCAGAAATTGCAATTGTAACAGGCGGTACTAGAGGAATAGGTAAAGCTACCGCTTTAAAATTAAAAAATAATGGTAT TACGGTAGTTGCTAATTTTTTCAGTAATTACGATGCTGCTAAAGAGATGGAAGAAAAATACGGTATCAAAACTAAACGCT GGAATGTTGCGGATTTTGAAGAATGCAGGCAAGCAGTAAAGGAAATTGAAGAGGAATTTAAAAAACCGGTAAGTATTCTT GTTAACAATGCCGGTATTACCAAAGATACAATGCTACATAGAATGATTCATCAAGATTGGCATGAGGTCATTAACGTTAA TCTCAATTCTTGCTTTAATATGTCTAGCAGCGTAATTGAGCAGATGCGAAACCAAGATTACGGTCGTATAGTAAATATCA GTTCAATTAATGCTCAAACAGGACAAATCGGACAGACTAATTATTCTGCCGCTAAAGCCGGAATCATCGGTTTTACTAAG GCTCTTGCACGTGAAACTGCTTCTAAAAATATCACTGTTAACTGTATAGCTCCAGGATATATTGCAACCGAAATGGTAGG AGCAGTACCTGAAGACGTGCTTGCTAAAATCGTTAATAGTATCCCCAAAAAAAGACTAGGACAGCCTGAAGAAATAGCTA GAGCCGTAGCATTTTTAGTTGATGAAAATGCCGGCTTTATAACAGGCGAGACTATTTCCATCAATGGCGGCCATAATATG ATTTAA
Upstream 100 bases:
>100_bases AAGTTGTTAAACCGTTAACTAAATCTGTGTCACAGCTTAAACCAAGTATAACCCCACCGGTTAAATCTAATAAAAGTCAC AATATAGGTATGGAGAAATA
Downstream 100 bases:
>100_bases ACAATTAACTAACTACTATAGAAGAGAGGAAATCATGGGATGATATAAAGAAAACTACTCCAGGTAATGTAGAATATGAT TTATGGCAAATAGAAAAGCA
Product: acetoacetyl-CoA reductase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 241; Mature: 240
Protein sequence:
>241_residues MSEIAIVTGGTRGIGKATALKLKNNGITVVANFFSNYDAAKEMEEKYGIKTKRWNVADFEECRQAVKEIEEEFKKPVSIL VNNAGITKDTMLHRMIHQDWHEVINVNLNSCFNMSSSVIEQMRNQDYGRIVNISSINAQTGQIGQTNYSAAKAGIIGFTK ALARETASKNITVNCIAPGYIATEMVGAVPEDVLAKIVNSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGGHNM I
Sequences:
>Translated_241_residues MSEIAIVTGGTRGIGKATALKLKNNGITVVANFFSNYDAAKEMEEKYGIKTKRWNVADFEECRQAVKEIEEEFKKPVSIL VNNAGITKDTMLHRMIHQDWHEVINVNLNSCFNMSSSVIEQMRNQDYGRIVNISSINAQTGQIGQTNYSAAKAGIIGFTK ALARETASKNITVNCIAPGYIATEMVGAVPEDVLAKIVNSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGGHNM I >Mature_240_residues SEIAIVTGGTRGIGKATALKLKNNGITVVANFFSNYDAAKEMEEKYGIKTKRWNVADFEECRQAVKEIEEEFKKPVSILV NNAGITKDTMLHRMIHQDWHEVINVNLNSCFNMSSSVIEQMRNQDYGRIVNISSINAQTGQIGQTNYSAAKAGIIGFTKA LARETASKNITVNCIAPGYIATEMVGAVPEDVLAKIVNSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGGHNMI
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=39.4422310756972, Blast_Score=174, Evalue=8e-44, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=34.6938775510204, Blast_Score=131, Evalue=5e-31, Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=32.2709163346614, Blast_Score=117, Evalue=7e-27, Organism=Homo sapiens, GI4504505, Length=234, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=30.9917355371901, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=31.1023622047244, Blast_Score=105, Evalue=2e-23, Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=28.1632653061224, Blast_Score=90, Evalue=1e-18, Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=28.3950617283951, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI7705925, Length=235, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=9e-18, Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=27.8884462151394, Blast_Score=84, Evalue=9e-17, Organism=Homo sapiens, GI226371731, Length=210, Percent_Identity=31.9047619047619, Blast_Score=82, Evalue=3e-16, Organism=Homo sapiens, GI10190704, Length=243, Percent_Identity=29.2181069958848, Blast_Score=81, Evalue=9e-16, Organism=Homo sapiens, GI59889578, Length=193, Percent_Identity=29.0155440414508, Blast_Score=78, Evalue=6e-15, Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=27.363184079602, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI4557649, Length=216, Percent_Identity=28.2407407407407, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=30.2197802197802, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=29.4736842105263, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI7705855, Length=197, Percent_Identity=30.9644670050761, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI109715829, Length=239, Percent_Identity=26.7782426778243, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI4503301, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI150247226, Length=182, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI225579078, Length=200, Percent_Identity=30, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=44.8132780082988, Blast_Score=203, Evalue=8e-54, Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=32.0987654320988, Blast_Score=128, Evalue=3e-31, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=34.6938775510204, Blast_Score=126, Evalue=1e-30, Organism=Escherichia coli, GI87082160, Length=240, Percent_Identity=34.5833333333333, Blast_Score=125, Evalue=3e-30, Organism=Escherichia coli, GI1790717, Length=238, Percent_Identity=32.7731092436975, Blast_Score=125, Evalue=3e-30, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=30.4347826086957, Blast_Score=116, Evalue=2e-27, Organism=Escherichia coli, GI1789208, Length=242, Percent_Identity=30.9917355371901, Blast_Score=114, Evalue=6e-27, Organism=Escherichia coli, GI1786812, Length=244, Percent_Identity=29.5081967213115, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI2367365, Length=234, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1787905, Length=240, Percent_Identity=32.5, Blast_Score=91, Evalue=5e-20, Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=25.8823529411765, Blast_Score=83, Evalue=1e-17, Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=27.6923076923077, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1787526, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=42.9752066115703, Blast_Score=174, Evalue=3e-44, Organism=Caenorhabditis elegans, GI25147288, Length=242, Percent_Identity=40.495867768595, Blast_Score=167, Evalue=6e-42, Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=32.8, Blast_Score=111, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=33.201581027668, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=33.1983805668016, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17568967, Length=233, Percent_Identity=30.0429184549356, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=31.0606060606061, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=30.0751879699248, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17563726, Length=256, Percent_Identity=30.859375, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=32.7800829875519, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=30.6513409961686, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=29.1187739463602, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=28.2352941176471, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17560150, Length=255, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=28.1746031746032, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562990, Length=256, Percent_Identity=28.90625, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=29.7709923664122, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=29.6153846153846, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=28.735632183908, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=27.0992366412214, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17536025, Length=247, Percent_Identity=26.7206477732794, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI193203115, Length=257, Percent_Identity=26.0700389105058, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI193203117, Length=257, Percent_Identity=26.0700389105058, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=26.7175572519084, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=23.8805970149254, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=27.5193798449612, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17561272, Length=193, Percent_Identity=27.4611398963731, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=28.1368821292776, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=30.2083333333333, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=25.1908396946565, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=25.3787878787879, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17560176, Length=197, Percent_Identity=29.4416243654822, Blast_Score=64, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=232, Percent_Identity=31.8965517241379, Blast_Score=107, Evalue=2e-24, Organism=Saccharomyces cerevisiae, GI6322795, Length=276, Percent_Identity=26.4492753623188, Blast_Score=73, Evalue=4e-14, Organism=Saccharomyces cerevisiae, GI6324126, Length=190, Percent_Identity=30, Blast_Score=72, Evalue=6e-14, Organism=Saccharomyces cerevisiae, GI6323882, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6320089, Length=229, Percent_Identity=25.3275109170306, Blast_Score=62, Evalue=9e-11, Organism=Drosophila melanogaster, GI24639444, Length=240, Percent_Identity=38.75, Blast_Score=165, Evalue=3e-41, Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=34.4262295081967, Blast_Score=116, Evalue=2e-26, Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=33.203125, Blast_Score=115, Evalue=2e-26, Organism=Drosophila melanogaster, GI18859837, Length=230, Percent_Identity=33.9130434782609, Blast_Score=105, Evalue=4e-23, Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=30.9236947791165, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=27.2, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=27.710843373494, Blast_Score=94, Evalue=6e-20, Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=29.3172690763052, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=33.8624338624339, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=33.8624338624339, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI28574402, Length=191, Percent_Identity=33.5078534031414, Blast_Score=87, Evalue=8e-18, Organism=Drosophila melanogaster, GI24584744, Length=191, Percent_Identity=33.5078534031414, Blast_Score=87, Evalue=9e-18, Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=29.7619047619048, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI24644337, Length=203, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=31.6062176165803, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24640442, Length=197, Percent_Identity=30.4568527918782, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21356301, Length=183, Percent_Identity=27.3224043715847, Blast_Score=68, Evalue=7e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011283 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.36 [H]
Molecular weight: Translated: 26338; Mature: 26207
Theoretical pI: Translated: 7.50; Mature: 7.50
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSEIAIVTGGTRGIGKATALKLKNNGITVVANFFSNYDAAKEMEEKYGIKTKRWNVADFE CCCEEEEECCCCCCCCCEEEEEECCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCCCCCHH ECRQAVKEIEEEFKKPVSILVNNAGITKDTMLHRMIHQDWHEVINVNLNSCFNMSSSVIE HHHHHHHHHHHHHHCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHH QMRNQDYGRIVNISSINAQTGQIGQTNYSAAKAGIIGFTKALARETASKNITVNCIAPGY HHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCH IATEMVGAVPEDVLAKIVNSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGGHNM HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCEEEECCCCCC I C >Mature Secondary Structure SEIAIVTGGTRGIGKATALKLKNNGITVVANFFSNYDAAKEMEEKYGIKTKRWNVADFE CCEEEEECCCCCCCCCEEEEEECCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCCCCCHH ECRQAVKEIEEEFKKPVSILVNNAGITKDTMLHRMIHQDWHEVINVNLNSCFNMSSSVIE HHHHHHHHHHHHHHCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHH QMRNQDYGRIVNISSINAQTGQIGQTNYSAAKAGIIGFTKALARETASKNITVNCIAPGY HHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCH IATEMVGAVPEDVLAKIVNSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGGHNM HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCEEEECCCCCC I C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2546004; 3286259 [H]