Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 157373030

GI number: 157373030

Start: 5317279

End: 5318787

Strand: Direct

Name: glpK [H]

Synonym: Spro_4798

Alternate gene names: 157373030

Gene position: 5317279-5318787 (Clockwise)

Preceding gene: 157373029

Following gene: 157373031

Centisome position: 97.59

GC content: 58.05

Gene sequence:

>1509_bases
ATGACTGTAGAAAAAAAATACATTGTCGCTCTCGACCAGGGAACTACCAGTTCACGTGCCGTAGTGCTAGACCACGATGC
CAATATTGTTGCGGTGTCGCAGCGTGAATTCACGCAGATTTACCCGAAAGCCGGCTGGGTTGAGCATGATCCAATGGAGA
TTTGGTCATCACAGAGCTCCACGCTGGTGGAAGTGCTGGCGAAAGCCGACATCAATTCCGATCAGATCGCCGGCATCGGC
ATCACCAACCAGCGCGAAACCACCATCGTCTGGGAAAAAGACACCGGCAAACCGATCTATAACGCCATCGTCTGGCAATG
CCGCCGCACCGCCGATATCTGTGAAAAACTCAAACGCGACGGCATGGAAGAGTACATCCGTCACAACACCGGCCTGGTAG
TTGACCCGTACTTCTCCGGCACCAAGGTAAAATGGATCCTCGATCACGTTGAAGGCGCCCGTGAACGCGCCAAGCGCGGC
GAGCTGCTGTTCGGTACCGTCGACACCTGGCTGGTGTGGAAAATGACCCAGGGGCGGGTGCATGTGACCGATTACACCAA
CGCCTCGCGCACCATGATGTTCAATATCCATGAGCTGGACTGGGATGAGCGCATGCTGGAAGCGCTGGATATCCCGCGCG
CGATGCTGCCGAAAGTCCGTCCATCCTCTGAAGTGTACGGCCAGACCAACATCGGTGGTAAAGGCGGTACGCGTATTCCT
ATCGCCGGTATTGCCGGTGACCAGCAGGCGGCACTGTACGGCCAACTGTGCGTTCAACCGGGCATGGCGAAAAACACCTA
CGGCACCGGCTGCTTCCTGTTGATGAACACCGGCAAAGAAGCGGTACGTTCCAGCCACGGCCTGCTGACCACTATCGCCT
GCGGCCCACGCGGCGAAGTGAACTATGCGCTGGAAGGCGCAGTCTTCATCGGCGGCGCTTCTATTCAGTGGCTGCGCGAT
GAGCTGAAACTGATCAGCGATGCGGCCGACTCCGAATACTTCGCCACCAAGGTGAAAGACAGCAACGGGGTATATGTGGT
GCCTGCCTTTACCGGTCTGGGCGCGCCTTACTGGGACCCGTATGCCCGTGGCGCGATCTTCGGCCTGACCCGTGGCGCAA
ACAGCAACCACATTATCCGTGCCACGCTGGAATCCATTGCCTACCAGACGCGCGACGTGCTGGATGCCATGCAGGCCGAC
TCCAACACCCGCCTGCAATCGCTGCGTGTGGACGGTGGTGCGGTCGCCAACAACTTCCTGATGCAGTTCCAGTCTGACAT
CCTCGGGACCCGTGTAGAGCGTCCTGAGGTGCGTGAGTCGACGGCACTGGGTGCCGCATTCCTGGCAGGCCTGGCTATCG
GCTACTGGAATGACCTGGATGAAGTGAAGAGCAAGACGGTCATCGAGCGTGAGTTCCGTCCAAGCATTGAAACCACCGAG
CGTAACTTCCGTTACAGCGGCTGGAAAAAAGCAGTTGCCCGCGCGCAAGCATGGGAAGAGCACGACTAA

Upstream 100 bases:

>100_bases
GACGTTTGCGTAGAAGAAGAAAAACCCGCCGCCAAGGCTCAGCAGCGTAAAGCATGATTGGCACAGTTTTAAAACGGTTA
ACAACAGCAGGACTAAAATC

Downstream 100 bases:

>100_bases
CGCTGTTTTGCTTTGTTGACCTCATCACGCGCTGCCTCCGGGGGGCGCGTTTTTTTTGCCCCGCCCCACCATCGCCCGCT
GTGATAAACTTTGTCGATAT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTVEKKYIVALDQGTTSSRAVVLDHDANIVAVSQREFTQIYPKAGWVEHDPMEIWSSQSSTLVEVLAKADINSDQIAGIG
ITNQRETTIVWEKDTGKPIYNAIVWQCRRTADICEKLKRDGMEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAKRG
ELLFGTVDTWLVWKMTQGRVHVTDYTNASRTMMFNIHELDWDERMLEALDIPRAMLPKVRPSSEVYGQTNIGGKGGTRIP
IAGIAGDQQAALYGQLCVQPGMAKNTYGTGCFLLMNTGKEAVRSSHGLLTTIACGPRGEVNYALEGAVFIGGASIQWLRD
ELKLISDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGANSNHIIRATLESIAYQTRDVLDAMQAD
SNTRLQSLRVDGGAVANNFLMQFQSDILGTRVERPEVRESTALGAAFLAGLAIGYWNDLDEVKSKTVIEREFRPSIETTE
RNFRYSGWKKAVARAQAWEEHD

Sequences:

>Translated_502_residues
MTVEKKYIVALDQGTTSSRAVVLDHDANIVAVSQREFTQIYPKAGWVEHDPMEIWSSQSSTLVEVLAKADINSDQIAGIG
ITNQRETTIVWEKDTGKPIYNAIVWQCRRTADICEKLKRDGMEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAKRG
ELLFGTVDTWLVWKMTQGRVHVTDYTNASRTMMFNIHELDWDERMLEALDIPRAMLPKVRPSSEVYGQTNIGGKGGTRIP
IAGIAGDQQAALYGQLCVQPGMAKNTYGTGCFLLMNTGKEAVRSSHGLLTTIACGPRGEVNYALEGAVFIGGASIQWLRD
ELKLISDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGANSNHIIRATLESIAYQTRDVLDAMQAD
SNTRLQSLRVDGGAVANNFLMQFQSDILGTRVERPEVRESTALGAAFLAGLAIGYWNDLDEVKSKTVIEREFRPSIETTE
RNFRYSGWKKAVARAQAWEEHD
>Mature_501_residues
TVEKKYIVALDQGTTSSRAVVLDHDANIVAVSQREFTQIYPKAGWVEHDPMEIWSSQSSTLVEVLAKADINSDQIAGIGI
TNQRETTIVWEKDTGKPIYNAIVWQCRRTADICEKLKRDGMEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAKRGE
LLFGTVDTWLVWKMTQGRVHVTDYTNASRTMMFNIHELDWDERMLEALDIPRAMLPKVRPSSEVYGQTNIGGKGGTRIPI
AGIAGDQQAALYGQLCVQPGMAKNTYGTGCFLLMNTGKEAVRSSHGLLTTIACGPRGEVNYALEGAVFIGGASIQWLRDE
LKLISDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGANSNHIIRATLESIAYQTRDVLDAMQADS
NTRLQSLRVDGGAVANNFLMQFQSDILGTRVERPEVRESTALGAAFLAGLAIGYWNDLDEVKSKTVIEREFRPSIETTER
NFRYSGWKKAVARAQAWEEHD

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=516, Percent_Identity=46.3178294573643, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI4504007, Length=516, Percent_Identity=46.3178294573643, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI42794763, Length=520, Percent_Identity=46.1538461538462, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI41393575, Length=502, Percent_Identity=45.6175298804781, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI88196792, Length=510, Percent_Identity=33.5294117647059, Blast_Score=315, Evalue=5e-86,
Organism=Escherichia coli, GI1790361, Length=499, Percent_Identity=86.372745490982, Blast_Score=924, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=494, Percent_Identity=23.8866396761134, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789987, Length=503, Percent_Identity=24.0556660039761, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=25.3465346534653, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1789138, Length=511, Percent_Identity=22.1135029354207, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789168, Length=513, Percent_Identity=23.0019493177388, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535599, Length=504, Percent_Identity=40.8730158730159, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71986140, Length=522, Percent_Identity=25.4789272030651, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI71986147, Length=266, Percent_Identity=31.5789473684211, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321755, Length=554, Percent_Identity=36.6425992779783, Blast_Score=314, Evalue=2e-86,
Organism=Drosophila melanogaster, GI17864214, Length=507, Percent_Identity=43.5897435897436, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24654573, Length=436, Percent_Identity=45.8715596330275, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655555, Length=498, Percent_Identity=40.9638554216867, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655560, Length=498, Percent_Identity=40.9638554216867, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655570, Length=498, Percent_Identity=40.9638554216867, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655574, Length=498, Percent_Identity=40.9638554216867, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655565, Length=498, Percent_Identity=40.9638554216867, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19922058, Length=518, Percent_Identity=33.2046332046332, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24652871, Length=497, Percent_Identity=33.1991951710262, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24656367, Length=513, Percent_Identity=27.8752436647173, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI21357867, Length=530, Percent_Identity=27.1698113207547, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24656372, Length=362, Percent_Identity=31.2154696132597, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45552909, Length=307, Percent_Identity=28.6644951140065, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55820; Mature: 55689

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEKKYIVALDQGTTSSRAVVLDHDANIVAVSQREFTQIYPKAGWVEHDPMEIWSSQSS
CCCCCEEEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHCCCCCCCCCCHHHHHCCCCH
TLVEVLAKADINSDQIAGIGITNQRETTIVWEKDTGKPIYNAIVWQCRRTADICEKLKRD
HHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
GMEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAKRGELLFGTVDTWLVWKMTQGRV
CHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCEEEEECCEEEEEEEECCEE
HVTDYTNASRTMMFNIHELDWDERMLEALDIPRAMLPKVRPSSEVYGQTNIGGKGGTRIP
EEEECCCCCEEEEEEEECCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEE
IAGIAGDQQAALYGQLCVQPGMAKNTYGTGCFLLMNTGKEAVRSSHGLLTTIACGPRGEV
EEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHCCCCCEEEEECCCCCCE
NYALEGAVFIGGASIQWLRDELKLISDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDP
EEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCH
YARGAIFGLTRGANSNHIIRATLESIAYQTRDVLDAMQADSNTRLQSLRVDGGAVANNFL
HHCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
MQFQSDILGTRVERPEVRESTALGAAFLAGLAIGYWNDLDEVKSKTVIEREFRPSIETTE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
RNFRYSGWKKAVARAQAWEEHD
CCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TVEKKYIVALDQGTTSSRAVVLDHDANIVAVSQREFTQIYPKAGWVEHDPMEIWSSQSS
CCCCEEEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHCCCCCCCCCCHHHHHCCCCH
TLVEVLAKADINSDQIAGIGITNQRETTIVWEKDTGKPIYNAIVWQCRRTADICEKLKRD
HHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
GMEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAKRGELLFGTVDTWLVWKMTQGRV
CHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCEEEEECCEEEEEEEECCEE
HVTDYTNASRTMMFNIHELDWDERMLEALDIPRAMLPKVRPSSEVYGQTNIGGKGGTRIP
EEEECCCCCEEEEEEEECCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEE
IAGIAGDQQAALYGQLCVQPGMAKNTYGTGCFLLMNTGKEAVRSSHGLLTTIACGPRGEV
EEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHCCCCCEEEEECCCCCCE
NYALEGAVFIGGASIQWLRDELKLISDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDP
EEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCH
YARGAIFGLTRGANSNHIIRATLESIAYQTRDVLDAMQADSNTRLQSLRVDGGAVANNFL
HHCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
MQFQSDILGTRVERPEVRESTALGAAFLAGLAIGYWNDLDEVKSKTVIEREFRPSIETTE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
RNFRYSGWKKAVARAQAWEEHD
CCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA