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The map label for this gene is menA [H]

Identifier: 157373026

GI number: 157373026

Start: 5314071

End: 5314988

Strand: Direct

Name: menA [H]

Synonym: Spro_4794

Alternate gene names: 157373026

Gene position: 5314071-5314988 (Clockwise)

Preceding gene: 157373025

Following gene: 157373027

Centisome position: 97.53

GC content: 59.04

Gene sequence:

>918_bases
ATGAGCTCATCAACTACCATCTCCCCGGCCAGAGCCTGGCTTGAAAGTTTACGACCGCGCACCCTGCCGCTGGCCTTTGC
CTCGATCGTCGTCGGTTCCGCCATTGCCGCCTGGCAAGGTAGCCTGAAGCCCGGCGTGGCGCTGCTGGCGCTGCTGACGG
CCGGCCTTCTGCAAATTCTCTCCAACCTGGCGAACGACTATGGCGATGCGGTAAAAGGCAGCGACAAGGAAGATCGTATC
GGGCCGCTACGTGGTATGCAAAAAGGCATGATCACCCAGGCACAGATGAAACGGGCTTTGGTGGTAACGGTGGTACTGAT
CGCCATCGCCGGCAGTTCGCTAATTGCCGTAGCCTGTGAACAACCCAGCGATGTGGTGGGCTTCCTGGTGCTGGGCGGGC
TTTCTATCGTCGCAGCCATTACCTATACCGTCGGCAACAAACCTTACGGCTATCTGGGCTTGGGCGATATCTCGGTGCTG
GTGTTCTTCGGCTGGCTGAGCGTCGCAGGCACTTTCTACCTGCAAACCCACGCCTTTGACAGCATCGTGATGCTGCCGGC
CACCGCCTGTGGCCTGCTGGCAGCGGCGGTGCTCAATATCAATAATCTGCGCGATATCGAAAGCGATCGCGCCAACGGCA
AGAATACCCTGGCAGTCCGACTCGGGCCGCAGAAGGCGCGTTATTACCACCTGTTGCTGCTGATCGGCGCGGTGGCGTGC
TTTACGCTGTTCACGTTGCTCAACCTGCATAGCCTGTGGGGCTGGTTGTTTGTCTTGGCTATCCCGTTGCTGGTACGCCA
TGGCTTACGCGTGTTGCGTGACCCTACGCCAGCCGGTATGCGGCCGATGCTTGAACATATGGTCAAGGCGGCGCTGCTGG
CCAATATATTGTTCGCTATCGGCGTGGTGCTCAGTTAG

Upstream 100 bases:

>100_bases
CCTATAATCGCTCAATCATGTCCAGTCAGTCATCTGTGGGAGGCATTTTGCCTCCCACAATTATTTCTAACGGACACAGC
CACTAACTCTGAAGCGAAAA

Downstream 100 bases:

>100_bases
CCATCGAACTGATGATTTTGCCAACAGGGCGAATAAAGGGATATACTGGTTATTCCAGCGGCAAACAGACGTAAAATCCT
ATGAAATACGATACTTCCGA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSSSTTISPARAWLESLRPRTLPLAFASIVVGSAIAAWQGSLKPGVALLALLTAGLLQILSNLANDYGDAVKGSDKEDRI
GPLRGMQKGMITQAQMKRALVVTVVLIAIAGSSLIAVACEQPSDVVGFLVLGGLSIVAAITYTVGNKPYGYLGLGDISVL
VFFGWLSVAGTFYLQTHAFDSIVMLPATACGLLAAAVLNINNLRDIESDRANGKNTLAVRLGPQKARYYHLLLLIGAVAC
FTLFTLLNLHSLWGWLFVLAIPLLVRHGLRVLRDPTPAGMRPMLEHMVKAALLANILFAIGVVLS

Sequences:

>Translated_305_residues
MSSSTTISPARAWLESLRPRTLPLAFASIVVGSAIAAWQGSLKPGVALLALLTAGLLQILSNLANDYGDAVKGSDKEDRI
GPLRGMQKGMITQAQMKRALVVTVVLIAIAGSSLIAVACEQPSDVVGFLVLGGLSIVAAITYTVGNKPYGYLGLGDISVL
VFFGWLSVAGTFYLQTHAFDSIVMLPATACGLLAAAVLNINNLRDIESDRANGKNTLAVRLGPQKARYYHLLLLIGAVAC
FTLFTLLNLHSLWGWLFVLAIPLLVRHGLRVLRDPTPAGMRPMLEHMVKAALLANILFAIGVVLS
>Mature_304_residues
SSSTTISPARAWLESLRPRTLPLAFASIVVGSAIAAWQGSLKPGVALLALLTAGLLQILSNLANDYGDAVKGSDKEDRIG
PLRGMQKGMITQAQMKRALVVTVVLIAIAGSSLIAVACEQPSDVVGFLVLGGLSIVAAITYTVGNKPYGYLGLGDISVLV
FFGWLSVAGTFYLQTHAFDSIVMLPATACGLLAAAVLNINNLRDIESDRANGKNTLAVRLGPQKARYYHLLLLIGAVACF
TLFTLLNLHSLWGWLFVLAIPLLVRHGLRVLRDPTPAGMRPMLEHMVKAALLANILFAIGVVLS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=313, Percent_Identity=26.8370607028754, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790365, Length=303, Percent_Identity=69.96699669967, Blast_Score=435, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17737429, Length=267, Percent_Identity=28.4644194756554, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32384; Mature: 32253

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSTTISPARAWLESLRPRTLPLAFASIVVGSAIAAWQGSLKPGVALLALLTAGLLQIL
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SNLANDYGDAVKGSDKEDRIGPLRGMQKGMITQAQMKRALVVTVVLIAIAGSSLIAVACE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
QPSDVVGFLVLGGLSIVAAITYTVGNKPYGYLGLGDISVLVFFGWLSVAGTFYLQTHAFD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
SIVMLPATACGLLAAAVLNINNLRDIESDRANGKNTLAVRLGPQKARYYHLLLLIGAVAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
FTLFTLLNLHSLWGWLFVLAIPLLVRHGLRVLRDPTPAGMRPMLEHMVKAALLANILFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GVVLS
HHHCC
>Mature Secondary Structure 
SSSTTISPARAWLESLRPRTLPLAFASIVVGSAIAAWQGSLKPGVALLALLTAGLLQIL
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SNLANDYGDAVKGSDKEDRIGPLRGMQKGMITQAQMKRALVVTVVLIAIAGSSLIAVACE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
QPSDVVGFLVLGGLSIVAAITYTVGNKPYGYLGLGDISVLVFFGWLSVAGTFYLQTHAFD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
SIVMLPATACGLLAAAVLNINNLRDIESDRANGKNTLAVRLGPQKARYYHLLLLIGAVAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
FTLFTLLNLHSLWGWLFVLAIPLLVRHGLRVLRDPTPAGMRPMLEHMVKAALLANILFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GVVLS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]