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The map label for this gene is tyrB [H]

Identifier: 157372678

GI number: 157372678

Start: 4918284

End: 4919477

Strand: Reverse

Name: tyrB [H]

Synonym: Spro_4445

Alternate gene names: 157372678

Gene position: 4919477-4918284 (Counterclockwise)

Preceding gene: 157372679

Following gene: 157372677

Centisome position: 90.28

GC content: 57.12

Gene sequence:

>1194_bases
GTGTTTCAGAACGTTGATGCCTATGCAGGTGACCCGATCCTGTCGCTGATGGAAAAATTCAAAAAAGATCCCCGTTCGCA
CAAGGTTAACCTGAGTATCGGCCTTTACTATGACGAGCAGGGCATTATCCCGCAGATGAAGGCGGTTGCCGCCGCAGAAG
CGCAACTGAGCAGCGTGGATCACGGCGCGTCAGTATACCTGCCGATGGAAGGCCTGCAGCCTTACCGTATTGCCATTCAG
CATCTGCTGTTTGGCGCCGAGCACCCGATGTTGCAACAGGAGCGTATCGCCACCATTCAAACCGTGGGCGGTTCCGGCGC
GCTGAAGGTCGGTGCCGACTTCCTGAAAAGCTATTTCCCGGATTCGCAGGTGTGGGTCAGCGATCCGACCTGGGAAAACC
ACATCGCCATCTTTGGCGGTGCCGGCTTCAAGGTCAATACCTATCCCTACTTCGACAGCGAAAGCCTGGGCGTGAAGTTT
GACGCCATGCTGAGCGCATTGAAACAGTTGCCGAAGCACAGCATCGCGCTGCTGCACCCATGCTGCCATAACCCGACCGG
CTCTGACCTGACTCATGCCCAGTGGGATGAAGTGGTCAAAGTGATTGCCGAACGTGAACTGATCCCGTTCCTTGATATCG
CCTATCAGGGTTTTGGCGGTGGAATTGCCGATGATGCCTATGCCATCCGCACTATGGCTGCGGCCGGTCTGCCATGCCTG
GTAAGTAATTCGTTCTCGAAAATCTTCTCGCTGTACGGCGAACGCGTCGGCGGCCTGTCGGTGGTGTGTGAAAGCGAAGA
GGCGGCGGGGCGCGTATTGGGTCAACTGAAAGCCACGGTTCGCCGCAACTATTCCAGCCCGCCGAACTTCGGTGCGCAGG
TGGTGGCGAAGGTGCTGAACGATACGCAACTGAAAGCCCAGTGGCTGGCAGAAGTGGAAATCATGCGTACCCGCATCCTT
GAGATGCGCAAAACGCTGGTGGAAGCTCTGAAGGTTGCTCTGCCGCAGCGTAACTTCGATTACCTGCTGGAACAGCGCGG
TATGTTCAGCTACACCGGTTTCAGCGCGGCACAGGTCGATCGCCTGCGTGAAGAGTTCGGTGTGTACCTGATCCACAGCG
GCCGTGTCTGCATGGCCGGCCTGAACCATAACAACGTGCATCAGGTGGCCGAGGCGTTTGCCGCAGTGCAATAA

Upstream 100 bases:

>100_bases
GTTGCCGGTTGCGAGATAAAGCTCAAACTGAACGGCCTTTTCCGTCTATATTAGAGCCTGATGCTGTGCCCCGAACCCTA
ATAATCCAGGAGAACAACCC

Downstream 100 bases:

>100_bases
TGTTGTTAGGGTTTGAAGTTCGCAAGGGAGCGATAGCGATATCGCTCCCTTTTTGTTGTCGGTTTGCCGCCGGAGTTGCT
GCAAACTGGATAGAGAATAT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQNVDAYAGDPILSLMEKFKKDPRSHKVNLSIGLYYDEQGIIPQMKAVAAAEAQLSSVDHGASVYLPMEGLQPYRIAIQ
HLLFGAEHPMLQQERIATIQTVGGSGALKVGADFLKSYFPDSQVWVSDPTWENHIAIFGGAGFKVNTYPYFDSESLGVKF
DAMLSALKQLPKHSIALLHPCCHNPTGSDLTHAQWDEVVKVIAERELIPFLDIAYQGFGGGIADDAYAIRTMAAAGLPCL
VSNSFSKIFSLYGERVGGLSVVCESEEAAGRVLGQLKATVRRNYSSPPNFGAQVVAKVLNDTQLKAQWLAEVEIMRTRIL
EMRKTLVEALKVALPQRNFDYLLEQRGMFSYTGFSAAQVDRLREEFGVYLIHSGRVCMAGLNHNNVHQVAEAFAAVQ

Sequences:

>Translated_397_residues
MFQNVDAYAGDPILSLMEKFKKDPRSHKVNLSIGLYYDEQGIIPQMKAVAAAEAQLSSVDHGASVYLPMEGLQPYRIAIQ
HLLFGAEHPMLQQERIATIQTVGGSGALKVGADFLKSYFPDSQVWVSDPTWENHIAIFGGAGFKVNTYPYFDSESLGVKF
DAMLSALKQLPKHSIALLHPCCHNPTGSDLTHAQWDEVVKVIAERELIPFLDIAYQGFGGGIADDAYAIRTMAAAGLPCL
VSNSFSKIFSLYGERVGGLSVVCESEEAAGRVLGQLKATVRRNYSSPPNFGAQVVAKVLNDTQLKAQWLAEVEIMRTRIL
EMRKTLVEALKVALPQRNFDYLLEQRGMFSYTGFSAAQVDRLREEFGVYLIHSGRVCMAGLNHNNVHQVAEAFAAVQ
>Mature_397_residues
MFQNVDAYAGDPILSLMEKFKKDPRSHKVNLSIGLYYDEQGIIPQMKAVAAAEAQLSSVDHGASVYLPMEGLQPYRIAIQ
HLLFGAEHPMLQQERIATIQTVGGSGALKVGADFLKSYFPDSQVWVSDPTWENHIAIFGGAGFKVNTYPYFDSESLGVKF
DAMLSALKQLPKHSIALLHPCCHNPTGSDLTHAQWDEVVKVIAERELIPFLDIAYQGFGGGIADDAYAIRTMAAAGLPCL
VSNSFSKIFSLYGERVGGLSVVCESEEAAGRVLGQLKATVRRNYSSPPNFGAQVVAKVLNDTQLKAQWLAEVEIMRTRIL
EMRKTLVEALKVALPQRNFDYLLEQRGMFSYTGFSAAQVDRLREEFGVYLIHSGRVCMAGLNHNNVHQVAEAFAAVQ

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=40.2061855670103, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI4504067, Length=399, Percent_Identity=39.0977443609023, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=26.246719160105, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=75.7575757575758, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=41.9191919191919, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=38.1313131313131, Blast_Score=310, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI25147133, Length=387, Percent_Identity=38.2428940568475, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17569539, Length=396, Percent_Identity=39.3939393939394, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.7414448669202, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=30.1790281329923, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147136, Length=212, Percent_Identity=33.4905660377358, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323055, Length=408, Percent_Identity=37.7450980392157, Blast_Score=285, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=34.6698113207547, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI19922362, Length=385, Percent_Identity=38.961038961039, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24654046, Length=385, Percent_Identity=38.961038961039, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=38.5390428211587, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=38.5390428211587, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.9175257731959, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43720; Mature: 43720

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNVDAYAGDPILSLMEKFKKDPRSHKVNLSIGLYYDEQGIIPQMKAVAAAEAQLSSVD
CCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCC
HGASVYLPMEGLQPYRIAIQHLLFGAEHPMLQQERIATIQTVGGSGALKVGADFLKSYFP
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHIAIFGGAGFKVNTYPYFDSESLGVKFDAMLSALKQLPKHSIALLHP
CCCEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCCEEHHHHHHHHHHCCCHHEEEEEH
CCHNPTGSDLTHAQWDEVVKVIAERELIPFLDIAYQGFGGGIADDAYAIRTMAAAGLPCL
HCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHH
VSNSFSKIFSLYGERVGGLSVVCESEEAAGRVLGQLKATVRRNYSSPPNFGAQVVAKVLN
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
DTQLKAQWLAEVEIMRTRILEMRKTLVEALKVALPQRNFDYLLEQRGMFSYTGFSAAQVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEECCCCHHHHH
RLREEFGVYLIHSGRVCMAGLNHNNVHQVAEAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFQNVDAYAGDPILSLMEKFKKDPRSHKVNLSIGLYYDEQGIIPQMKAVAAAEAQLSSVD
CCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCC
HGASVYLPMEGLQPYRIAIQHLLFGAEHPMLQQERIATIQTVGGSGALKVGADFLKSYFP
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHIAIFGGAGFKVNTYPYFDSESLGVKFDAMLSALKQLPKHSIALLHP
CCCEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCCEEHHHHHHHHHHCCCHHEEEEEH
CCHNPTGSDLTHAQWDEVVKVIAERELIPFLDIAYQGFGGGIADDAYAIRTMAAAGLPCL
HCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHH
VSNSFSKIFSLYGERVGGLSVVCESEEAAGRVLGQLKATVRRNYSSPPNFGAQVVAKVLN
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
DTQLKAQWLAEVEIMRTRILEMRKTLVEALKVALPQRNFDYLLEQRGMFSYTGFSAAQVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEECCCCHHHHH
RLREEFGVYLIHSGRVCMAGLNHNNVHQVAEAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]