Click here to switch to the map view.

The map label for this gene is malI [H]

Identifier: 157372516

GI number: 157372516

Start: 4747776

End: 4748801

Strand: Direct

Name: malI [H]

Synonym: Spro_4283

Alternate gene names: 157372516

Gene position: 4747776-4748801 (Clockwise)

Preceding gene: 157372510

Following gene: 157372518

Centisome position: 87.13

GC content: 57.02

Gene sequence:

>1026_bases
ATGAGCACAATAACCTTGGCGGACGTCGCCGCACTTGCAAAAGTCTCCACCGCGACGGTATCGATGGTGTTGCGCAATCG
AGGCCGCATATCGGATGCCACCCGCAAGCGCGTGCTGAGCGCCATTGATGAGCTGGGTTATGTCTACAATCAGACCGCCG
CTAACCTGCGCAATCGCAGCAGCAATCAGGTCGGCCTGCTGCTGCATGACATCACCAATCCGTTTTATGCGGAGATGACC
GCCGGGCTGAGCCAGGAAATGGAGCGCCATCAGTTGATGCTGTTTCTGGCCAACAGCGAAGAGTCCGCCGACAGGCAGCA
AAAATTTGTCGACTCCCTGTTGCAGAACAATACCAGCGGCATGGTGCTGTGCGCCGCAAGACAAACGCCACCGCTGTTTT
TTGAAACGCTGAAACGCCGCAAGATACCGGCCATTATGGTAGTCCGCCCGGTGGCCGATGCGCACTTTGACTTCGTCGGC
ACCGATAACTTCCTGGGCACTCAATTGGCGACTCAGCATCTGCTGAATCTGGGGCATCGTCATATCGCCTTTATCGGGGG
ATCCATCAGCTCGACTACCCGCGCACAACGGCTGGGCGGCTACACCAGCAAGCTGGTAGAGCACGGTATCGCGGTCAACG
GAGAATGGATTGTGGATAGCGAGGCCAGCCAAAGCTCCGGAGCCATGGCGGCGGAACAGTTACTGAAAGCCCATCCGGAA
ATCACTGCGGCCTTATGCTATCAGGACATTGTCGCGCTGGGGGTGATGCAGACATTGCGCAAACTCAACCGCCAGATTGG
CCGTGATTTTGCGCTAATTGGTTTTGATGATATTACCGAAGCCTCGCTGGTGCAGCCGGGTTTGACCACCGTGTCGGTGG
CCTCGCGCGAGATTGGCCGTAAGGCCGGGGAACTGTTGTACAGCCGTATTCAGGGTAATGATGAGCCGCCAAAACGTATC
ATCCTGCCGCCTTCTCTGGTGATCCGCGAGTCCTGCGGTTTTGCCGATAAATCCACGCCAGCCTGA

Upstream 100 bases:

>100_bases
CAAACTTTCGTGACGCGAATCACGATTTATCGGCAGGGTTTTACAAAATAAGGTTAATCGTTATACCTTGCTATGACAGT
CGGCACCGACAGGAGATGAA

Downstream 100 bases:

>100_bases
GCTGGCGTGAATGATCTAGCCGATCTGCACTGACAGCATGCTCAATGAGCTCATCTCAATGCCATCTACCGGCACGGTGA
TCGCTTCCTTGCCGTCCCAA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSTITLADVAALAKVSTATVSMVLRNRGRISDATRKRVLSAIDELGYVYNQTAANLRNRSSNQVGLLLHDITNPFYAEMT
AGLSQEMERHQLMLFLANSEESADRQQKFVDSLLQNNTSGMVLCAARQTPPLFFETLKRRKIPAIMVVRPVADAHFDFVG
TDNFLGTQLATQHLLNLGHRHIAFIGGSISSTTRAQRLGGYTSKLVEHGIAVNGEWIVDSEASQSSGAMAAEQLLKAHPE
ITAALCYQDIVALGVMQTLRKLNRQIGRDFALIGFDDITEASLVQPGLTTVSVASREIGRKAGELLYSRIQGNDEPPKRI
ILPPSLVIRESCGFADKSTPA

Sequences:

>Translated_341_residues
MSTITLADVAALAKVSTATVSMVLRNRGRISDATRKRVLSAIDELGYVYNQTAANLRNRSSNQVGLLLHDITNPFYAEMT
AGLSQEMERHQLMLFLANSEESADRQQKFVDSLLQNNTSGMVLCAARQTPPLFFETLKRRKIPAIMVVRPVADAHFDFVG
TDNFLGTQLATQHLLNLGHRHIAFIGGSISSTTRAQRLGGYTSKLVEHGIAVNGEWIVDSEASQSSGAMAAEQLLKAHPE
ITAALCYQDIVALGVMQTLRKLNRQIGRDFALIGFDDITEASLVQPGLTTVSVASREIGRKAGELLYSRIQGNDEPPKRI
ILPPSLVIRESCGFADKSTPA
>Mature_340_residues
STITLADVAALAKVSTATVSMVLRNRGRISDATRKRVLSAIDELGYVYNQTAANLRNRSSNQVGLLLHDITNPFYAEMTA
GLSQEMERHQLMLFLANSEESADRQQKFVDSLLQNNTSGMVLCAARQTPPLFFETLKRRKIPAIMVVRPVADAHFDFVGT
DNFLGTQLATQHLLNLGHRHIAFIGGSISSTTRAQRLGGYTSKLVEHGIAVNGEWIVDSEASQSSGAMAAEQLLKAHPEI
TAALCYQDIVALGVMQTLRKLNRQIGRDFALIGFDDITEASLVQPGLTTVSVASREIGRKAGELLYSRIQGNDEPPKRII
LPPSLVIRESCGFADKSTPA

Specific function: Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787906, Length=333, Percent_Identity=34.8348348348348, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=29.8780487804878, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=33.030303030303, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1787948, Length=330, Percent_Identity=30.6060606060606, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789202, Length=337, Percent_Identity=29.9703264094956, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788474, Length=329, Percent_Identity=29.1793313069909, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI48994940, Length=324, Percent_Identity=29.9382716049383, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789068, Length=326, Percent_Identity=30.9815950920245, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787580, Length=318, Percent_Identity=28.3018867924528, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786540, Length=349, Percent_Identity=27.7936962750716, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790715, Length=318, Percent_Identity=26.7295597484277, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786268, Length=319, Percent_Identity=22.257053291536, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789456, Length=342, Percent_Identity=26.0233918128655, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790689, Length=330, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37206; Mature: 37075

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTITLADVAALAKVSTATVSMVLRNRGRISDATRKRVLSAIDELGYVYNQTAANLRNRS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNQVGLLLHDITNPFYAEMTAGLSQEMERHQLMLFLANSEESADRQQKFVDSLLQNNTSG
CCCEEEEEHHHCCHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
MVLCAARQTPPLFFETLKRRKIPAIMVVRPVADAHFDFVGTDNFLGTQLATQHLLNLGHR
EEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHCCCC
HIAFIGGSISSTTRAQRLGGYTSKLVEHGIAVNGEWIVDSEASQSSGAMAAEQLLKAHPE
EEEEECCCCCHHHHHHHHCCHHHHHHHCCCEECCCEEECCCCCCCCCHHHHHHHHHHCCH
ITAALCYQDIVALGVMQTLRKLNRQIGRDFALIGFDDITEASLVQPGLTTVSVASREIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHH
KAGELLYSRIQGNDEPPKRIILPPSLVIRESCGFADKSTPA
HHHHHHHHHHCCCCCCCCEEECCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
STITLADVAALAKVSTATVSMVLRNRGRISDATRKRVLSAIDELGYVYNQTAANLRNRS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNQVGLLLHDITNPFYAEMTAGLSQEMERHQLMLFLANSEESADRQQKFVDSLLQNNTSG
CCCEEEEEHHHCCHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
MVLCAARQTPPLFFETLKRRKIPAIMVVRPVADAHFDFVGTDNFLGTQLATQHLLNLGHR
EEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHCCCC
HIAFIGGSISSTTRAQRLGGYTSKLVEHGIAVNGEWIVDSEASQSSGAMAAEQLLKAHPE
EEEEECCCCCHHHHHHHHCCHHHHHHHCCCEECCCEEECCCCCCCCCHHHHHHHHHHCCH
ITAALCYQDIVALGVMQTLRKLNRQIGRDFALIGFDDITEASLVQPGLTTVSVASREIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHH
KAGELLYSRIQGNDEPPKRIILPPSLVIRESCGFADKSTPA
HHHHHHHHHHCCCCCCCCEEECCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2670898; 1856179; 9097039; 9278503 [H]