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The map label for this gene is codB [H]

Identifier: 157372427

GI number: 157372427

Start: 4647876

End: 4649171

Strand: Direct

Name: codB [H]

Synonym: Spro_4194

Alternate gene names: 157372427

Gene position: 4647876-4649171 (Clockwise)

Preceding gene: 157372426

Following gene: 157372428

Centisome position: 85.3

GC content: 58.02

Gene sequence:

>1296_bases
GTGATCAAAATTGAAGACTATCCGTTAACCCGGGTACCTCAGGATAAAAGAGTCTCGTTTCTAAGCGTGGCCATTGTGCA
TATGGGCATGCTGACCGCGCTGGATCAGTTTATGCTCGGCGCCGTATTGGGCCACTCAATGACGCTGTTCGATGCCTTTA
CCGCCATTTTCGTCGGCAGCCTGATCTTTGGCGTAGTCACCTACGGCCTCGGGCTGGCGGGGATGCGCGAAGGGATCTCC
GGCAGCCTGCTGGCCCGCTGGTGCGGCTTTGGCCGACTGGGTTCGGTGCTGATCGGCGTGGTGGTAGCCGTCAGCCTGCT
GGGCTGGTTTGGCATACAGAACGCCATTTTCGCCAAGTCGCTGGATTTCGCGCTGGGCAATAAGCTGGGCTTTGGGCTGG
CGGCTGGCCTGTCCGGTACCCTGCTGACCATACTGGTGGCCTTTGGCTTCAAGGCATTACGTATCGCCGCCCGAATTGCG
GTACCGATGTTTATTATGCTGGTAGCCTATATCTCTTACATCACCCTCACCGGCCATAATCTGCCGGAAATTATTCAATT
AATGCCGCCAGGTGAGCCACTGTCGATCAGTGCCGGCATCACCATCGTGGTCGGTGGCGCCATCGTTGCCAGCCTGATGA
CCCCCGATCTGACGCGTTATTCCAAAAACGGCAAGCACGTGTTTGGCGTGACCCTGCTCACCATTGTCGCCGGGGAGTTC
GTGGTTAACGGTCTGGCGCTGCTGATCGCCAAAACGCTCGGCACGGCGGATGTCGTGACCATCATGTCGCAGGTCGCCGG
AGGGGCTGGCCTGCTGGTGGTAGTGTTCTCCACCTTAAGGGTCAATGACCTCAACCTGTACTCATCTTCACTGGGCATCG
TCAACGCGGTTGAAGGCATGACCGGTAAAAGGCTGAAATACACCGCCACCACGCTGGTGATTGGCGTGTTGGGCACAACG
CTTTCGGTGCTGGGGATCCTGGATCGGTTCGTCGACTTCCTGACGGTACTGGGCGTGGTGTTCCCGCCGATTATCGGCGT
GATGCTGGTGGATTATTACTTGCTGCGGACTCACCGTAAAATTCTGGATGACAGCCGCCGGGAAGGCAAACTGCCCGACC
AGACGCCGACCATTGGCTGGGCAGCGATCGTCGCCAGCATTGCCGGCAGCATCGTCGGGTTAGTGACCGAATGGGGTGTG
CCGACCATCAACTCATTGCTGGCCGCCAGCCTGTTGTATTGGGTATTCAAGTTGGCGCTGAATCGTTCGCAGAAACCGGC
CCCGGCGCAAAGCTGA

Upstream 100 bases:

>100_bases
TTTGAAGAATTTTGCAAATATGCGCATCTGGACAATTACATTCCCGATCGCCTGATAGCTAAAGGCATTCAGTTTATTTA
ATAGCAAGGAATACCTCACC

Downstream 100 bases:

>100_bases
TTCGGTTGCCAGCGACGAAATGCTATTACCACTCTCCTGCAACGGGTGAGTGGTAATACTATAGAATGAGCATTTAGTGG
ACTAAAAACTGAGGTTTTAA

Product: cytosine/purines uracil thiamine allantoin permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MIKIEDYPLTRVPQDKRVSFLSVAIVHMGMLTALDQFMLGAVLGHSMTLFDAFTAIFVGSLIFGVVTYGLGLAGMREGIS
GSLLARWCGFGRLGSVLIGVVVAVSLLGWFGIQNAIFAKSLDFALGNKLGFGLAAGLSGTLLTILVAFGFKALRIAARIA
VPMFIMLVAYISYITLTGHNLPEIIQLMPPGEPLSISAGITIVVGGAIVASLMTPDLTRYSKNGKHVFGVTLLTIVAGEF
VVNGLALLIAKTLGTADVVTIMSQVAGGAGLLVVVFSTLRVNDLNLYSSSLGIVNAVEGMTGKRLKYTATTLVIGVLGTT
LSVLGILDRFVDFLTVLGVVFPPIIGVMLVDYYLLRTHRKILDDSRREGKLPDQTPTIGWAAIVASIAGSIVGLVTEWGV
PTINSLLAASLLYWVFKLALNRSQKPAPAQS

Sequences:

>Translated_431_residues
MIKIEDYPLTRVPQDKRVSFLSVAIVHMGMLTALDQFMLGAVLGHSMTLFDAFTAIFVGSLIFGVVTYGLGLAGMREGIS
GSLLARWCGFGRLGSVLIGVVVAVSLLGWFGIQNAIFAKSLDFALGNKLGFGLAAGLSGTLLTILVAFGFKALRIAARIA
VPMFIMLVAYISYITLTGHNLPEIIQLMPPGEPLSISAGITIVVGGAIVASLMTPDLTRYSKNGKHVFGVTLLTIVAGEF
VVNGLALLIAKTLGTADVVTIMSQVAGGAGLLVVVFSTLRVNDLNLYSSSLGIVNAVEGMTGKRLKYTATTLVIGVLGTT
LSVLGILDRFVDFLTVLGVVFPPIIGVMLVDYYLLRTHRKILDDSRREGKLPDQTPTIGWAAIVASIAGSIVGLVTEWGV
PTINSLLAASLLYWVFKLALNRSQKPAPAQS
>Mature_431_residues
MIKIEDYPLTRVPQDKRVSFLSVAIVHMGMLTALDQFMLGAVLGHSMTLFDAFTAIFVGSLIFGVVTYGLGLAGMREGIS
GSLLARWCGFGRLGSVLIGVVVAVSLLGWFGIQNAIFAKSLDFALGNKLGFGLAAGLSGTLLTILVAFGFKALRIAARIA
VPMFIMLVAYISYITLTGHNLPEIIQLMPPGEPLSISAGITIVVGGAIVASLMTPDLTRYSKNGKHVFGVTLLTIVAGEF
VVNGLALLIAKTLGTADVVTIMSQVAGGAGLLVVVFSTLRVNDLNLYSSSLGIVNAVEGMTGKRLKYTATTLVIGVLGTT
LSVLGILDRFVDFLTVLGVVFPPIIGVMLVDYYLLRTHRKILDDSRREGKLPDQTPTIGWAAIVASIAGSIVGLVTEWGV
PTINSLLAASLLYWVFKLALNRSQKPAPAQS

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=434, Percent_Identity=29.2626728110599, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 45571; Mature: 45571

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]