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The map label for this gene is helD [C]

Identifier: 157372284

GI number: 157372284

Start: 4489655

End: 4491100

Strand: Reverse

Name: helD [C]

Synonym: Spro_4050

Alternate gene names: 157372284

Gene position: 4491100-4489655 (Counterclockwise)

Preceding gene: 157372289

Following gene: 157372283

Centisome position: 82.42

GC content: 53.67

Gene sequence:

>1446_bases
ATGTCTTATTGTGATACACCTGAACAAGCCGCCATCATCGGTTGGTCTGGAACAAAACTGGTGGTTAGGGCTTTTGCCGG
CACCGGAAAAACGTCCACACTGGTGCGGTTCGCGTTAGCAAATCCGGACAGCAGGATGCTCTATCTTGCCTATAACCGGG
CTGTCAGGAACGAAGCAGAGCAAAAATTCCCATTCAATGTGGAATGTAAAACCTCCCATCAACTGGCCTGGCCTAACTTC
GGGCGCCACTATCAACAACGGTTGACAGGCAATCTGCGGATCACTGACGTTGCTCGTCAACTCAATACGCGTCACTGGCC
TCTGGCTCGCGTGGCCACCATCACCCTCAATGCTTTTCTCTGCAGTGCCGATTGCCAATTTGGCCCGCAACACCTGCCTG
ATGAGAACGCGCGCAGCGGGTTATCAGCTGAAAAAATTCTGGCGGCCGCACAGTTACTCTGGCGCGAATCAGCTCGTCAG
GACGGCGTATTCCCTGTCACCCATGATGTTTACCTCAAACTGTATCAGCTCTCAGAGCCAGATCTCGCCAAACGCTGGCA
GACCGTGTTGTTTGATGAGGGTCAAGACGCCAATCCAGTCACGCAAGCCCTGGTCTTGTCACAGTGCTGTAATGTGGTCA
TGGTTGGTGATCGCCATCAACAAATTTACCGGTTCCGTGGGGCGGAGAATGCGCTCGACGCTGAGCAACTGGCAGATGCC
GAACAGCTGTGTCTGACACACAGCTTCCGGTTTGGCCCAGGAGTGGCCAGGGTGGCGAATATGCTGCTTAAACGGCAGGG
GGAAACGCTGCCCCTGGTCGGGAACGGCGGTGAAGACAACGTCGTGGCGAGCTTGCCGGAACAGGACAAATCAACACACA
TTGCTGTCCTCAGTCGGACTGTCGCTGGCGTGATTGGTATGGCACTTGAAGCCAGTCTTGCGGGCAAAAAAGTGTATTGG
GTTGGCGGTATTGCCGGCTACAAAACAGATGAGCTTGAGGATTTGTATTGGTTTTCGGCTGATATGCCTGAACGAATGCA
ATCCCCGCTGCTGGCGCGAGAATACCGAAATTTTGAGGAATTTGAGTCGGTGGCCAGAGCAACCAAAGACGCTGAAATGA
ACCAGGGTCTTAGGTTACTCGACCAGTACTTCCCGCTGCCACAAAAGCTGCAGGTAATGCGTGAGCATGCGGTCACAGAT
GAAAGCCAGGCGCAGGTGACCGTTTCGACAGCACATCGCAGCAAAGGCCTGGAGTGGCCCGTGGTGATGTTGAACGATGA
TTTTGCGGATATCACCGATCCCCTGATGGTTGACAGCGAACGTACTGATGAAACGAATCTGCTGTATGTCGCTGTTACCC
GGGCTCAGCAAACACTGGTACTGAATGATTTACTGCAGGTGTTGATGGACAGCGAAGGAGATATCGCTGGAGGCCCTGCA
TGCTGA

Upstream 100 bases:

>100_bases
CCACAGGAAACCTTTTCAACTGGAAAAAGGATTTCCTGTGGTGATTGCCGTATTGACCTGCGCAGCATAAGCGCCGGTCA
AGTTTTACGGAGTTCTGCTG

Downstream 100 bases:

>100_bases
AGGCCATCAAAGAGCTGCTGGTTGGGACCCGGGATATGCCGGTAAAGCCAACGGCAAGCATTTCAGCCTCTCGAGGCCCT
GCAGGCTACTATATGCCCGC

Product: hypothetical protein

Products: Separated DNA [C]

Alternate protein names: Superfamily I DNA/RNA Helicase-Like Protein; Helicase; Superfamily I DNA/RNA Helicase; Superfamily I DNA And RNA Helicase; Helicase Superfamily Protein I; F-Box Only Protein; I DNA And RNA Helicase Protein; I DNA And RNA Helicase; I DNA/RNA Helicase; UvrD/REP Helicase; UvrD/Rep Family Helicase; Helicase Superfamily I

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSYCDTPEQAAIIGWSGTKLVVRAFAGTGKTSTLVRFALANPDSRMLYLAYNRAVRNEAEQKFPFNVECKTSHQLAWPNF
GRHYQQRLTGNLRITDVARQLNTRHWPLARVATITLNAFLCSADCQFGPQHLPDENARSGLSAEKILAAAQLLWRESARQ
DGVFPVTHDVYLKLYQLSEPDLAKRWQTVLFDEGQDANPVTQALVLSQCCNVVMVGDRHQQIYRFRGAENALDAEQLADA
EQLCLTHSFRFGPGVARVANMLLKRQGETLPLVGNGGEDNVVASLPEQDKSTHIAVLSRTVAGVIGMALEASLAGKKVYW
VGGIAGYKTDELEDLYWFSADMPERMQSPLLAREYRNFEEFESVARATKDAEMNQGLRLLDQYFPLPQKLQVMREHAVTD
ESQAQVTVSTAHRSKGLEWPVVMLNDDFADITDPLMVDSERTDETNLLYVAVTRAQQTLVLNDLLQVLMDSEGDIAGGPA
C

Sequences:

>Translated_481_residues
MSYCDTPEQAAIIGWSGTKLVVRAFAGTGKTSTLVRFALANPDSRMLYLAYNRAVRNEAEQKFPFNVECKTSHQLAWPNF
GRHYQQRLTGNLRITDVARQLNTRHWPLARVATITLNAFLCSADCQFGPQHLPDENARSGLSAEKILAAAQLLWRESARQ
DGVFPVTHDVYLKLYQLSEPDLAKRWQTVLFDEGQDANPVTQALVLSQCCNVVMVGDRHQQIYRFRGAENALDAEQLADA
EQLCLTHSFRFGPGVARVANMLLKRQGETLPLVGNGGEDNVVASLPEQDKSTHIAVLSRTVAGVIGMALEASLAGKKVYW
VGGIAGYKTDELEDLYWFSADMPERMQSPLLAREYRNFEEFESVARATKDAEMNQGLRLLDQYFPLPQKLQVMREHAVTD
ESQAQVTVSTAHRSKGLEWPVVMLNDDFADITDPLMVDSERTDETNLLYVAVTRAQQTLVLNDLLQVLMDSEGDIAGGPA
C
>Mature_480_residues
SYCDTPEQAAIIGWSGTKLVVRAFAGTGKTSTLVRFALANPDSRMLYLAYNRAVRNEAEQKFPFNVECKTSHQLAWPNFG
RHYQQRLTGNLRITDVARQLNTRHWPLARVATITLNAFLCSADCQFGPQHLPDENARSGLSAEKILAAAQLLWRESARQD
GVFPVTHDVYLKLYQLSEPDLAKRWQTVLFDEGQDANPVTQALVLSQCCNVVMVGDRHQQIYRFRGAENALDAEQLADAE
QLCLTHSFRFGPGVARVANMLLKRQGETLPLVGNGGEDNVVASLPEQDKSTHIAVLSRTVAGVIGMALEASLAGKKVYWV
GGIAGYKTDELEDLYWFSADMPERMQSPLLAREYRNFEEFESVARATKDAEMNQGLRLLDQYFPLPQKLQVMREHAVTDE
SQAQVTVSTAHRSKGLEWPVVMLNDDFADITDPLMVDSERTDETNLLYVAVTRAQQTLVLNDLLQVLMDSEGDIAGGPAC

Specific function: Helicase IV Catalyzes The Unwinding Of Duplex DNA In The 3' To 5' Direction With Respect To The Bound Single Strand In A Reaction That Is Dependent Upon The Hydrolysis Of ATP. [C]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI30795119, Length=493, Percent_Identity=31.8458417849899, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI30795117, Length=493, Percent_Identity=31.8458417849899, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 53625; Mature: 53494

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYCDTPEQAAIIGWSGTKLVVRAFAGTGKTSTLVRFALANPDSRMLYLAYNRAVRNEAE
CCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHEEEEEECCCCCCEEEEEECHHHHHHHH
QKFPFNVECKTSHQLAWPNFGRHYQQRLTGNLRITDVARQLNTRHWPLARVATITLNAFL
HCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHCCCCCCHHHHHHEEEEEEE
CSADCQFGPQHLPDENARSGLSAEKILAAAQLLWRESARQDGVFPVTHDVYLKLYQLSEP
EECCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCC
DLAKRWQTVLFDEGQDANPVTQALVLSQCCNVVMVGDRHQQIYRFRGAENALDAEQLADA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHCCCCCCCCHHHHCCH
EQLCLTHSFRFGPGVARVANMLLKRQGETLPLVGNGGEDNVVASLPEQDKSTHIAVLSRT
HHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHH
VAGVIGMALEASLAGKKVYWVGGIAGYKTDELEDLYWFSADMPERMQSPLLAREYRNFEE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHEEECCCCHHHHHCCHHHHHHCCHHH
FESVARATKDAEMNQGLRLLDQYFPLPQKLQVMREHAVTDESQAQVTVSTAHRSKGLEWP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCCC
VVMLNDDFADITDPLMVDSERTDETNLLYVAVTRAQQTLVLNDLLQVLMDSEGDIAGGPA
EEEECCCHHHCCCCCEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
C
C
>Mature Secondary Structure 
SYCDTPEQAAIIGWSGTKLVVRAFAGTGKTSTLVRFALANPDSRMLYLAYNRAVRNEAE
CCCCCCCCEEEEECCCCEEEEEECCCCCCHHHEEEEEECCCCCCEEEEEECHHHHHHHH
QKFPFNVECKTSHQLAWPNFGRHYQQRLTGNLRITDVARQLNTRHWPLARVATITLNAFL
HCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHCCCCCCHHHHHHEEEEEEE
CSADCQFGPQHLPDENARSGLSAEKILAAAQLLWRESARQDGVFPVTHDVYLKLYQLSEP
EECCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCC
DLAKRWQTVLFDEGQDANPVTQALVLSQCCNVVMVGDRHQQIYRFRGAENALDAEQLADA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHCCCCCCCCHHHHCCH
EQLCLTHSFRFGPGVARVANMLLKRQGETLPLVGNGGEDNVVASLPEQDKSTHIAVLSRT
HHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHH
VAGVIGMALEASLAGKKVYWVGGIAGYKTDELEDLYWFSADMPERMQSPLLAREYRNFEE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHEEECCCCHHHHHCCHHHHHHCCHHH
FESVARATKDAEMNQGLRLLDQYFPLPQKLQVMREHAVTDESQAQVTVSTAHRSKGLEWP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCCC
VVMLNDDFADITDPLMVDSERTDETNLLYVAVTRAQQTLVLNDLLQVLMDSEGDIAGGPA
EEEECCCHHHCCCCCEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
C
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Duplex DNA; DNA [C]

Specific reaction: Catalyzes the unwinding and separation of duplex DNA in vivo Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA