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The map label for this gene is glsA

Identifier: 157372274

GI number: 157372274

Start: 4477730

End: 4478653

Strand: Reverse

Name: glsA

Synonym: Spro_4040

Alternate gene names: 157372274

Gene position: 4478653-4477730 (Counterclockwise)

Preceding gene: 157372275

Following gene: 157372273

Centisome position: 82.19

GC content: 59.63

Gene sequence:

>924_bases
GTGGTAACTACATTGGATAACGCGTTGCTGGAAGAGATCCTGCAACAGGTGCGCCCGCTGATTGGCCAGGGCAAGGTGGC
GGACTATATTCCGGCGCTGGCGGAAGTGGCGTCCGATCGTCTGGCGATCGCCGTTTGCACCGTCGACGGTGAAATTTTCC
AGGCCGGTAACGCCACCGAGCGCTTCTCTATTCAGTCCATCTCCAAGGTGCTTAGCCTGACGCTGGCGCTGACACGCTAT
CAGGAGCACGAGATCTGGCAGCGGGTCGGCAAAGAGCCTTCCGGTCTGCCGTTCAACTCGCTGCTGCAGTTGGAGATGGA
GCAGGGCAAGCCGCGCAATCCGTTTATCAACCCCGGTGCGCTGGTGGTGTGCGACATGCTGCAAACCCGGCTCAGTGCCC
CCAAACAGCGCATGCTGGAAGTGGTGCGCCAACTGGCCGGTGAAGAAGACCTGGCCTATGATTCGCGGGTCGCCCGTTCC
GAGTTTGAACACTCCGATCGCAATGCGGCCATCGCCTATCTGATGAAGTCGTTCGGTAACTTTGAAAACGACGTGCTCAC
CGTGCTGCAAACCTATTTCCACTACTGTGCGTTGCGGATGAGCTGCCTGGAGCTGGCGCGCAGCTTTGTCTACCTGGCCA
ATCACGGTCGTGACCTTAGCGGGCGTGAAGTGATCAGCCCACTGCAGGCGCGCCAGATTAATGCGCTGATGATGACCAGC
GGCATGTACGACGGCGCGGGGGAATTTGCCTATCGCGTGGGCATGCCGGGCAAGTCCGGTGTCGGCGGCGGTATTGTCGC
CATCGTCCCCGATGAGCTGTCGATCGCCGTCTGGTCGCCAGAGCTGGATGCCTCCGGTAACTCACTGGCGGGAACTGCGG
CGCTGGAACTGTTGTCTCAACGGATTAGCCGTTCGATTTTTTAA

Upstream 100 bases:

>100_bases
ATATCTGGTGGGACTGATTTTCCCCGCCTGATTTTGCGCTGTATTCATTGATTGTAAGGTGCCTTAACGGCACCTTTATT
TTGTCCGGAGTGTGACCGCG

Downstream 100 bases:

>100_bases
TCCCACCACGGAAGGGAGTCAGGAGAAAATATGTTAAAGAAAACCGGGTTAGCCTTACTGCTGTTGACTGCTTCACAGGC
CCATGCCGAGTATCAGTGCA

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MVTTLDNALLEEILQQVRPLIGQGKVADYIPALAEVASDRLAIAVCTVDGEIFQAGNATERFSIQSISKVLSLTLALTRY
QEHEIWQRVGKEPSGLPFNSLLQLEMEQGKPRNPFINPGALVVCDMLQTRLSAPKQRMLEVVRQLAGEEDLAYDSRVARS
EFEHSDRNAAIAYLMKSFGNFENDVLTVLQTYFHYCALRMSCLELARSFVYLANHGRDLSGREVISPLQARQINALMMTS
GMYDGAGEFAYRVGMPGKSGVGGGIVAIVPDELSIAVWSPELDASGNSLAGTAALELLSQRISRSIF

Sequences:

>Translated_307_residues
MVTTLDNALLEEILQQVRPLIGQGKVADYIPALAEVASDRLAIAVCTVDGEIFQAGNATERFSIQSISKVLSLTLALTRY
QEHEIWQRVGKEPSGLPFNSLLQLEMEQGKPRNPFINPGALVVCDMLQTRLSAPKQRMLEVVRQLAGEEDLAYDSRVARS
EFEHSDRNAAIAYLMKSFGNFENDVLTVLQTYFHYCALRMSCLELARSFVYLANHGRDLSGREVISPLQARQINALMMTS
GMYDGAGEFAYRVGMPGKSGVGGGIVAIVPDELSIAVWSPELDASGNSLAGTAALELLSQRISRSIF
>Mature_307_residues
MVTTLDNALLEEILQQVRPLIGQGKVADYIPALAEVASDRLAIAVCTVDGEIFQAGNATERFSIQSISKVLSLTLALTRY
QEHEIWQRVGKEPSGLPFNSLLQLEMEQGKPRNPFINPGALVVCDMLQTRLSAPKQRMLEVVRQLAGEEDLAYDSRVARS
EFEHSDRNAAIAYLMKSFGNFENDVLTVLQTYFHYCALRMSCLELARSFVYLANHGRDLSGREVISPLQARQINALMMTS
GMYDGAGEFAYRVGMPGKSGVGGGIVAIVPDELSIAVWSPELDASGNSLAGTAALELLSQRISRSIF

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=287, Percent_Identity=36.9337979094077, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI20336214, Length=294, Percent_Identity=35.3741496598639, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1787804, Length=308, Percent_Identity=73.7012987012987, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1786693, Length=300, Percent_Identity=37.6666666666667, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17507019, Length=297, Percent_Identity=36.3636363636364, Blast_Score=190, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI193204073, Length=295, Percent_Identity=35.9322033898305, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193204075, Length=297, Percent_Identity=35.3535353535354, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17532727, Length=298, Percent_Identity=33.8926174496644, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI281363241, Length=286, Percent_Identity=34.965034965035, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653162, Length=286, Percent_Identity=34.965034965035, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363239, Length=286, Percent_Identity=34.965034965035, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653156, Length=286, Percent_Identity=34.965034965035, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653164, Length=286, Percent_Identity=34.965034965035, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653158, Length=286, Percent_Identity=34.965034965035, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI116008307, Length=286, Percent_Identity=34.965034965035, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24653166, Length=286, Percent_Identity=34.965034965035, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_SERP5 (A8GJ45)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480263.1
- ProteinModelPortal:   A8GJ45
- SMR:   A8GJ45
- STRING:   A8GJ45
- GeneID:   5605792
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4040
- eggNOG:   COG2066
- HOGENOM:   HBG512335
- OMA:   RNASIAY
- ProtClustDB:   PRK00971
- BioCyc:   SPRO399741:SPRO_4040-MONOMER
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33676; Mature: 33676

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTLDNALLEEILQQVRPLIGQGKVADYIPALAEVASDRLAIAVCTVDGEIFQAGNATE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCHHHCCCCCCH
RFSIQSISKVLSLTLALTRYQEHEIWQRVGKEPSGLPFNSLLQLEMEQGKPRNPFINPGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
LVVCDMLQTRLSAPKQRMLEVVRQLAGEEDLAYDSRVARSEFEHSDRNAAIAYLMKSFGN
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
FENDVLTVLQTYFHYCALRMSCLELARSFVYLANHGRDLSGREVISPLQARQINALMMTS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GMYDGAGEFAYRVGMPGKSGVGGGIVAIVPDELSIAVWSPELDASGNSLAGTAALELLSQ
CCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
RISRSIF
HHHHCCC
>Mature Secondary Structure
MVTTLDNALLEEILQQVRPLIGQGKVADYIPALAEVASDRLAIAVCTVDGEIFQAGNATE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCHHHCCCCCCH
RFSIQSISKVLSLTLALTRYQEHEIWQRVGKEPSGLPFNSLLQLEMEQGKPRNPFINPGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
LVVCDMLQTRLSAPKQRMLEVVRQLAGEEDLAYDSRVARSEFEHSDRNAAIAYLMKSFGN
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
FENDVLTVLQTYFHYCALRMSCLELARSFVYLANHGRDLSGREVISPLQARQINALMMTS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GMYDGAGEFAYRVGMPGKSGVGGGIVAIVPDELSIAVWSPELDASGNSLAGTAALELLSQ
CCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
RISRSIF
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA