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The map label for this gene is speA [H]

Identifier: 157372207

GI number: 157372207

Start: 4401850

End: 4403826

Strand: Reverse

Name: speA [H]

Synonym: Spro_3973

Alternate gene names: 157372207

Gene position: 4403826-4401850 (Counterclockwise)

Preceding gene: 157372209

Following gene: 157372206

Centisome position: 80.82

GC content: 57.01

Gene sequence:

>1977_bases
ATGTCTGATGATCTATTGATTCACCGTCCGTCAGCAACGGGCGAATCTATATCTTTGCGCTCCATGCAGGAGGTTGCTAT
GAATGACCGTGATGCCAGCAAGATGCTGCGCACTTATAACGTCGCCTACTGGGGCAACAACTATTATGACGTCAATGAAC
TGGGCCACATCAGCGTGTGCCCGGATCCAGACGTCCCGCAGGCACGTGTCGACCTGGCCGATTTGGTAAAACAACGCCAA
AAAGATGGCCTGCGTTTACCGGCGCTGTTCTGTTTCCCGCAGATCCTGCAGCACCGCCTGCGTTCGATCAATGCCGCGTT
CAAACGCGCGCGTGAATCGTTCGGCTATGAAGGCGGTTATTTCCTGGTTTACCCGATCAAAGTGAATCAGCACCGTCGCG
TGATTGAGTCCCTGGTCAACTCCGGCGAACCGCTGGGGCTGGAAGCCGGCTCCAAAGCCGAGCTGATGGCGGTGCTGGCG
CATGCCGGCATGACCCGTTCGGTGATCGTCTGTAATGGTTATAAAGACCGTGAATACATCCGTCTGGCGCTGATCGGCGA
AAAACTGGGGCACAAGGTGTACCTGGTGATCGAGAAGATGTCCGAGATCAACATGGTGCTGGAAGAAGCTGAACGTCTGA
ACGTGGTACCGCGTCTGGGTGTGCGTGCGCGTCTGGCGTCACAAGGTTCCGGTAAATGGCAGTCGAGCGGTGGCGAAAAA
TCCAAGTTCGGTCTGGCAGCCATTCAGGTGCTGAAGCTGGTGGAAACCCTGCGCGAAGCGGGTCGTCTCGACAGCCTGCA
ACTGCTGCACTTCCACCTGGGATCGCAACTGGCCAATATCCGCGATATCGCTACCGGCGTGCGCGAGTCTGCACGTTTCT
ACGTTGAACTGCACAAGCTGGGCGTTAACATCCAGTGCTTCGACGTGGGCGGCGGTCTGGGCGTGGATTATGAAGGCACC
CGTTCGCAGTCCGACTGCTCGGTGAACTATGGCCTGAACGAATACGCCAACAACGTAATCTGGGGTATCGGCGACGCCTG
TAATGAACATGGTTTACCGCACCCGACGGTGATCACCGAATCCGGCCGTGCGGTCACCGCGCACCATACGGTGCTGGTAT
CTAACGTGATCGGCGTTGAACGCAACGAATTCAGCGAGCCATTGCCGCCGGCAGAAGACGCGCCGCGCGCGTTGGAAAGC
ATGTGGGAAACCTGGCAGGAATTGAACGAGCCGGAAAACCGTCGCTCGCTGCGCGAATGGCTGCACGACAGCCAGATGGA
CCTGCATGATGTTCACACTCAGTACGCTCACGGCATGCTGGATCTGACCAAGCGTGCCTGGGCCGAGCAGCTGTATCTGA
ACATCTGCAACAAAATCCAGCAGCAGTTGGATCCAAGCAACCGCGCCCACCGTCCTATCATCGACGAACTGCAAGAGCGT
ATGGCGGACAAGTTCTACGTCAACTTCTCGCTGTTCCAGTCAATGCCGGACGCCTGGGGTATCGATCAACTGTTCCCGGT
GCTGCCGCTGGAAGGGTTGGACAAGCCGCCGGAAGGCCGCGCGGTGCTGCTGGACATCACCTGTGACTCTGACGGCACCA
TCGATCACTACATCGACGGTGACGGCGTGGCGACCACCATGCCAATGCCACCGTACGATCCGGAAAACCCGCCGGCGCTG
GGCTTCTTTATGGTCGGTGCCTATCAGGAAATTCTGGGCAACATGCACAACCTGTTCGGTGATACCGCCTCGGTTGACGT
GTTTGTCTTCCCCGACGGCACGGTAGAAAGCGAAGTATCCGATGAAGGCGATACCGTTGCCGACATGCTGGAGTACGTGC
AGCTCGATCCTACCGCGCTGCTGGCCAAATTCCGCGATCAGGTGAAAGAAACCGATCTGGACAGCGAGCTGCAGGCGCAG
TTCCTGGAAGAGTTTGAGGCCGGTTTATACGGTTATACTTATTTAGAAGATGAATAA

Upstream 100 bases:

>100_bases
TTTTATTCGCTGCCGCAAGGGCGGTTTGTTGGGTTGTTCTCGCGGGTTGTAGCTGCGATAGTGGCTGACTGTATCGTCAG
TACGGGATGTGAGGCGAGTA

Downstream 100 bases:

>100_bases
GTAGAGCCGAACTGAAAGGCCGGGCATCTCAAGGATGCTTGGCCTTTTTTAATTTTTTTCTTCTATTATTTTCAGTTTTA
TGAGTTTTTATAATCACCAT

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSDDLLIHRPSATGESISLRSMQEVAMNDRDASKMLRTYNVAYWGNNYYDVNELGHISVCPDPDVPQARVDLADLVKQRQ
KDGLRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGYFLVYPIKVNQHRRVIESLVNSGEPLGLEAGSKAELMAVLA
HAGMTRSVIVCNGYKDREYIRLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAAIQVLKLVETLREAGRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGT
RSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITESGRAVTAHHTVLVSNVIGVERNEFSEPLPPAEDAPRALES
MWETWQELNEPENRRSLREWLHDSQMDLHDVHTQYAHGMLDLTKRAWAEQLYLNICNKIQQQLDPSNRAHRPIIDELQER
MADKFYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPEGRAVLLDITCDSDGTIDHYIDGDGVATTMPMPPYDPENPPAL
GFFMVGAYQEILGNMHNLFGDTASVDVFVFPDGTVESEVSDEGDTVADMLEYVQLDPTALLAKFRDQVKETDLDSELQAQ
FLEEFEAGLYGYTYLEDE

Sequences:

>Translated_658_residues
MSDDLLIHRPSATGESISLRSMQEVAMNDRDASKMLRTYNVAYWGNNYYDVNELGHISVCPDPDVPQARVDLADLVKQRQ
KDGLRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGYFLVYPIKVNQHRRVIESLVNSGEPLGLEAGSKAELMAVLA
HAGMTRSVIVCNGYKDREYIRLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAAIQVLKLVETLREAGRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGT
RSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITESGRAVTAHHTVLVSNVIGVERNEFSEPLPPAEDAPRALES
MWETWQELNEPENRRSLREWLHDSQMDLHDVHTQYAHGMLDLTKRAWAEQLYLNICNKIQQQLDPSNRAHRPIIDELQER
MADKFYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPEGRAVLLDITCDSDGTIDHYIDGDGVATTMPMPPYDPENPPAL
GFFMVGAYQEILGNMHNLFGDTASVDVFVFPDGTVESEVSDEGDTVADMLEYVQLDPTALLAKFRDQVKETDLDSELQAQ
FLEEFEAGLYGYTYLEDE
>Mature_657_residues
SDDLLIHRPSATGESISLRSMQEVAMNDRDASKMLRTYNVAYWGNNYYDVNELGHISVCPDPDVPQARVDLADLVKQRQK
DGLRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGYFLVYPIKVNQHRRVIESLVNSGEPLGLEAGSKAELMAVLAH
AGMTRSVIVCNGYKDREYIRLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEKS
KFGLAAIQVLKLVETLREAGRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGTR
SQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITESGRAVTAHHTVLVSNVIGVERNEFSEPLPPAEDAPRALESM
WETWQELNEPENRRSLREWLHDSQMDLHDVHTQYAHGMLDLTKRAWAEQLYLNICNKIQQQLDPSNRAHRPIIDELQERM
ADKFYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPEGRAVLLDITCDSDGTIDHYIDGDGVATTMPMPPYDPENPPALG
FFMVGAYQEILGNMHNLFGDTASVDVFVFPDGTVESEVSDEGDTVADMLEYVQLDPTALLAKFRDQVKETDLDSELQAQF
LEEFEAGLYGYTYLEDE

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=658, Percent_Identity=86.6261398176292, Blast_Score=1206, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 73777; Mature: 73646

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDLLIHRPSATGESISLRSMQEVAMNDRDASKMLRTYNVAYWGNNYYDVNELGHISVC
CCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHEEEEECCCEEECCCCCEEEEC
PDPDVPQARVDLADLVKQRQKDGLRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGY
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FLVYPIKVNQHRRVIESLVNSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
EEEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHE
RLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
EEEEEHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
SKFGLAAIQVLKLVETLREAGRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHH
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITE
CCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHCCEEECCCCHHHCCCCCCCEEEEC
SGRAVTAHHTVLVSNVIGVERNEFSEPLPPAEDAPRALESMWETWQELNEPENRRSLREW
CCCEEEEHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
LHDSQMDLHDVHTQYAHGMLDLTKRAWAEQLYLNICNKIQQQLDPSNRAHRPIIDELQER
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MADKFYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPEGRAVLLDITCDSDGTIDHYIDG
HHHHEEEEHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECC
DGVATTMPMPPYDPENPPALGFFMVGAYQEILGNMHNLFGDTASVDVFVFPDGTVESEVS
CCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
DEGDTVADMLEYVQLDPTALLAKFRDQVKETDLDSELQAQFLEEFEAGLYGYTYLEDE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
SDDLLIHRPSATGESISLRSMQEVAMNDRDASKMLRTYNVAYWGNNYYDVNELGHISVC
CCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHEEEEECCCEEECCCCCEEEEC
PDPDVPQARVDLADLVKQRQKDGLRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGY
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FLVYPIKVNQHRRVIESLVNSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
EEEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHE
RLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
EEEEEHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
SKFGLAAIQVLKLVETLREAGRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHH
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITE
CCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHCCEEECCCCHHHCCCCCCCEEEEC
SGRAVTAHHTVLVSNVIGVERNEFSEPLPPAEDAPRALESMWETWQELNEPENRRSLREW
CCCEEEEHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
LHDSQMDLHDVHTQYAHGMLDLTKRAWAEQLYLNICNKIQQQLDPSNRAHRPIIDELQER
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MADKFYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPEGRAVLLDITCDSDGTIDHYIDG
HHHHEEEEHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECC
DGVATTMPMPPYDPENPPALGFFMVGAYQEILGNMHNLFGDTASVDVFVFPDGTVESEVS
CCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
DEGDTVADMLEYVQLDPTALLAKFRDQVKETDLDSELQAQFLEEFEAGLYGYTYLEDE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]