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The map label for this gene is mprA [H]

Identifier: 157371976

GI number: 157371976

Start: 4130083

End: 4130604

Strand: Direct

Name: mprA [H]

Synonym: Spro_3741

Alternate gene names: 157371976

Gene position: 4130083-4130604 (Clockwise)

Preceding gene: 157371975

Following gene: 157371977

Centisome position: 75.8

GC content: 50.19

Gene sequence:

>522_bases
ATGGAAAGCTCGTTTACTCCCATTGAACAAATGCTTAATTTCCGCGCAAAACGTCAGAAAGATTTTCCTTATCAGGAAAT
TCTGCTGACCCGGCTGTGCATGCACATGCAAAGCAAGCTGCTGGAAAACCGCAATAAAATGCTTAAGGCACAAGGGATTA
ACGAAACACTGTTTATGGCGCTGATTACTCTGGATGCGCAGGAGAATCACAGCATCCAGCCTTCTGAGCTAAGCTCTGCT
CTGGGCTCGTCACGCACCAATGCCACGCGGATTGCCGATGAACTGGAAAAACGCGGCTGGATTGAACGCCGGGAAAGCGA
CCATGACCGTCGTTGCCTGCATCTGCACATGACGCCGCAGGGAGAAGAGTTTCTCAACCAACTGCTGCCACCGCAGCACA
AATGTCTGCATTTCCTGTGGTCCACGCTGAACGATGATGAACAGCAACAGCTTGAACAGCTGACACGCAAGCTGTTAACG
CGTCTGGACCAGATGGAAGTTTCAGGACAGTTATCCCAATAA

Upstream 100 bases:

>100_bases
TACAAATGACACGAATTGCTAAATTATTCGCACGGCTGAAGATTTACATTATTAATCACTATCGTTACTATCTCGAACAA
AATTAATGAGGCCCCAAATT

Downstream 100 bases:

>100_bases
TTTCTGTTCAGGTAACCTACTATGCGATCCCCGTTTAACTGGAGATTCACCCCGCTGTTCGCCGTATTGCTGCTGGCCGG
GTGCGCTTCTACCGACAATA

Product: transcriptional repressor MprA

Products: NA

Alternate protein names: Protein emrR [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MESSFTPIEQMLNFRAKRQKDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLDAQENHSIQPSELSSA
LGSSRTNATRIADELEKRGWIERRESDHDRRCLHLHMTPQGEEFLNQLLPPQHKCLHFLWSTLNDDEQQQLEQLTRKLLT
RLDQMEVSGQLSQ

Sequences:

>Translated_173_residues
MESSFTPIEQMLNFRAKRQKDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLDAQENHSIQPSELSSA
LGSSRTNATRIADELEKRGWIERRESDHDRRCLHLHMTPQGEEFLNQLLPPQHKCLHFLWSTLNDDEQQQLEQLTRKLLT
RLDQMEVSGQLSQ
>Mature_173_residues
MESSFTPIEQMLNFRAKRQKDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLDAQENHSIQPSELSSA
LGSSRTNATRIADELEKRGWIERRESDHDRRCLHLHMTPQGEEFLNQLLPPQHKCLHFLWSTLNDDEQQQLEQLTRKLLT
RLDQMEVSGQLSQ

Specific function: Negative regulator of the multidrug operon emrAB [H]

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789040, Length=169, Percent_Identity=82.8402366863905, Blast_Score=290, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 20345; Mature: 20345

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS01117 HTH_MARR_1 ; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESSFTPIEQMLNFRAKRQKDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMA
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LITLDAQENHSIQPSELSSALGSSRTNATRIADELEKRGWIERRESDHDRRCLHLHMTPQ
HHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCCC
GEEFLNQLLPPQHKCLHFLWSTLNDDEQQQLEQLTRKLLTRLDQMEVSGQLSQ
HHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MESSFTPIEQMLNFRAKRQKDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMA
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LITLDAQENHSIQPSELSSALGSSRTNATRIADELEKRGWIERRESDHDRRCLHLHMTPQ
HHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCCC
GEEFLNQLLPPQHKCLHFLWSTLNDDEQQQLEQLTRKLLTRLDQMEVSGQLSQ
HHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]