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The map label for this gene is rnc [H]

Identifier: 157371904

GI number: 157371904

Start: 4061399

End: 4062079

Strand: Reverse

Name: rnc [H]

Synonym: Spro_3669

Alternate gene names: 157371904

Gene position: 4062079-4061399 (Counterclockwise)

Preceding gene: 157371905

Following gene: 157371903

Centisome position: 74.55

GC content: 53.16

Gene sequence:

>681_bases
ATGAACCCCATCGTAATAAATAGGCTACAGCGGAAGCTGGGCTACACTTTTCAACAGCAGGAGCTCTTGCTGCAAGCGTT
AACTCACCGTAGCGCCAGCAGTAAACACAATGAACGTCTTGAGTTTCTGGGTGACTCCATTCTCAGTTTTGTCATCGCCA
ATGCGCTGTTCCAGCGTTTTCCTCGCGTAGACGAGGGCGATATGAGCCGTATGCGCGCCACGCTGGTGCGCGGTAATACG
CTGGCAGAGATGGGGCGTGAGTTTGATCTGGGCGAATGTCTGCGTCTTGGTCCGGGTGAGTTGAAAAGTGGTGGATTCCG
CCGCGAATCAATCCTGGCGGATACGGTGGAAGCCTTGATTGGCGGCGTTTTCCTGGATAGCGACATCCAAACTGTTGAAC
GACTGATTTTGGACTGGTATCGCAGCCGGTTGGACGAAATCAGCCCCGGTGATAAGCAGAAAGACCCAAAAACCCGTTTG
CAGGAGTTTTTACAAGGTCGTCATCTGCCGTTACCTTCTTATCTGGTGGTGCAGGTTCGCGGTGAGGCGCACGATCAGGA
ATTTACTATCCACTGTCAGGTGAGTGGTTTGAGCGAACCCGTCGTGGGAACCGGCTCAAGCCGCCGTAAAGCCGAACAAG
CGGCAGCGGAACAAGCGTTAATAAAGCTGGAGCTTGAATGA

Upstream 100 bases:

>100_bases
GGGCCACTGCAAACGAAACAGCTTTGGATTGGCTTTCGGCAAAGCAGGCCTGTTCCGTATGCTGCAAGTTTTTGACGCAT
TCTTGATCTATTGGTAACTC

Downstream 100 bases:

>100_bases
GCGAAGAGAAACAATACTGTGGTTTTATTGCGATAGTCGGTCGCCCCAACGTGGGCAAGTCCACGTTGCTGAACCAACTG
CTGGGGCAAAAAGTCTCCAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANALFQRFPRVDEGDMSRMRATLVRGNT
LAEMGREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVERLILDWYRSRLDEISPGDKQKDPKTRL
QEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALIKLELE

Sequences:

>Translated_226_residues
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANALFQRFPRVDEGDMSRMRATLVRGNT
LAEMGREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVERLILDWYRSRLDEISPGDKQKDPKTRL
QEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALIKLELE
>Mature_226_residues
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANALFQRFPRVDEGDMSRMRATLVRGNT
LAEMGREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVERLILDWYRSRLDEISPGDKQKDPKTRL
QEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALIKLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=29.1304347826087, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=29.1304347826087, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=92.9203539823009, Blast_Score=415, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=30.3964757709251, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=30.3964757709251, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=27.1929824561404, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25487; Mature: 25487

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANALFQRF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMGREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSDIQTVERLILDWYRSRLDEISPGDKQKDPKTRLQEFLQGRHLPLPSYLVVQVR
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALIKLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANALFQRF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMGREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSDIQTVERLILDWYRSRLDEISPGDKQKDPKTRLQEFLQGRHLPLPSYLVVQVR
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALIKLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA