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The map label for this gene is yfhK [H]

Identifier: 157371888

GI number: 157371888

Start: 4041396

End: 4042832

Strand: Reverse

Name: yfhK [H]

Synonym: Spro_3653

Alternate gene names: 157371888

Gene position: 4042832-4041396 (Counterclockwise)

Preceding gene: 157371889

Following gene: 157371887

Centisome position: 74.2

GC content: 57.41

Gene sequence:

>1437_bases
ATGATTTCATTGAAAAGATGGCGTTTATTTCCCCGATCGCTGCGCCAACTGGTGCTGATGGCGTTCCTGCTGGTGCTGCT
GCCACTGCTGGTGCTGGCCTATCAGGCTTACCAGAGCCTGGATCACCTCAGCGCGCAGGCGGCAGACATCAACCGCACCA
CGCTGGTGGATGCGCGACGCAGTGAGGCAATGACCAGCGTGGCGCTGGAAATGGAACGCAGTTACCGCCAGTATTGCGTA
CTGGTCGATCCCACTCTGGCGCGGTTGTACCAAAACCAGCGCAAACAGTATTCACAGATGCTCGATGCCCACGCGCCGAT
CCTGCCGGATGAACGCTATTATCAAACCTTGCGCGATCTGCTGACCCAGCTTGCGGCGATTAAATGCCAAAGCAGCGGCC
CGGACGCACAGGCTTCGACGTTGCTGGAGTCATTCTCGCGTTCCAATGCCGAAATGGTGCAGGCCACGCGCGCCGTGGTG
TTCTCTCGCGGCCAGCAGTTACAGCAGGCGATTGCCGAGCGCGGTCAGTTCTTCGGCTGGCAGGCATTGATGCTGTTCCT
GGTCAGCGTAATGCTGGTGGTGTTATTCACCCGGATGATTATCGGCCCGGTAAAAGCGGTAGAGCGAATGATCAACCGCC
TGGGGGAAGGTCGGGCGTTGGGCAGTACCGACTCTTTCAAAGGGCCGCGTGAACTGCGTTCTCTGGCTCAGCGCATTATT
TGGCTGAGTGAACGTCTGGCGTGGCTGGAGTCGCAGCGCCATGAGTTCCTGCGCCATATATCGCATGAGCTGAAGACGCC
GTTGGCCAGCATGCGTGAGGGCACCGAATTGCTGGCGGACGAAGTGGCCGGTCCGCTGACCTCCGATCAGAAAGAGGTGG
TAACCATTCTCGACGGCAGCAGCCGTCACCTGCAGCAACTGATTGAACAACTGCTGGATTACAACCGCAAACTGGCCGAT
GGCCCGGCAGAGCATGAGAATGTCGAGCTGAAAGAGATGGTCGAAATGGTGGTGGCGGCACACAGTTTGCCGGCCCGGGC
AAAATTGATCCGCACCGAGATCCAATTGGATGCGGAAATATGCTGGGCAGAGCCTACGCTATTAATGCGCGTGCTGGATA
ATCTCTACTCCAATGCGGTGCACTACGGCAAGGAATCCGGTAACATTTGGATCCGCAGCCGTCAGGTTGGGCAACGGGTG
CAGATTGATGTCGCCAACAGCGGCACGCCGATCCCCGAAGCCGAGAGAACCATGATTTTTGAGCCTTTTTTCCAGGGTAG
TCACCAGCGAAAAGGGGCGGTAAAAGGAAGCGGTCTGGGGCTGAGCATTGCGCAGGATTGTATCCGCCGCATGCGTGGCG
AACTGCAGTTGGTTGAAGTCGCCGGCACCGACGTCTGCTTCCGTATTGAATTGCCATTAACCGCCGAGAATGAATAA

Upstream 100 bases:

>100_bases
TTATGGCTCGCTGACCTGTATTTTCCTGACGCTCCGCTGAACGCCGGGCTTTCCTCTCATCGGCGACTCGGTTAGCATCG
GAGCAACTAGAGACAGTGAG

Downstream 100 bases:

>100_bases
TAATGTACACATGGTCTAAACGCCTTCGTCTCTCGCAGACCGAACGTTCACCGCGTGCCACACAGGGCACGCCGCTCGGC
AAGCGTCGATTTTCCTTTTT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSAQAADINRTTLVDARRSEAMTSVALEMERSYRQYCV
LVDPTLARLYQNQRKQYSQMLDAHAPILPDERYYQTLRDLLTQLAAIKCQSSGPDAQASTLLESFSRSNAEMVQATRAVV
FSRGQQLQQAIAERGQFFGWQALMLFLVSVMLVVLFTRMIIGPVKAVERMINRLGEGRALGSTDSFKGPRELRSLAQRII
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTSDQKEVVTILDGSSRHLQQLIEQLLDYNRKLAD
GPAEHENVELKEMVEMVVAAHSLPARAKLIRTEIQLDAEICWAEPTLLMRVLDNLYSNAVHYGKESGNIWIRSRQVGQRV
QIDVANSGTPIPEAERTMIFEPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMRGELQLVEVAGTDVCFRIELPLTAENE

Sequences:

>Translated_478_residues
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSAQAADINRTTLVDARRSEAMTSVALEMERSYRQYCV
LVDPTLARLYQNQRKQYSQMLDAHAPILPDERYYQTLRDLLTQLAAIKCQSSGPDAQASTLLESFSRSNAEMVQATRAVV
FSRGQQLQQAIAERGQFFGWQALMLFLVSVMLVVLFTRMIIGPVKAVERMINRLGEGRALGSTDSFKGPRELRSLAQRII
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTSDQKEVVTILDGSSRHLQQLIEQLLDYNRKLAD
GPAEHENVELKEMVEMVVAAHSLPARAKLIRTEIQLDAEICWAEPTLLMRVLDNLYSNAVHYGKESGNIWIRSRQVGQRV
QIDVANSGTPIPEAERTMIFEPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMRGELQLVEVAGTDVCFRIELPLTAENE
>Mature_478_residues
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSAQAADINRTTLVDARRSEAMTSVALEMERSYRQYCV
LVDPTLARLYQNQRKQYSQMLDAHAPILPDERYYQTLRDLLTQLAAIKCQSSGPDAQASTLLESFSRSNAEMVQATRAVV
FSRGQQLQQAIAERGQFFGWQALMLFLVSVMLVVLFTRMIIGPVKAVERMINRLGEGRALGSTDSFKGPRELRSLAQRII
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTSDQKEVVTILDGSSRHLQQLIEQLLDYNRKLAD
GPAEHENVELKEMVEMVVAAHSLPARAKLIRTEIQLDAEICWAEPTLLMRVLDNLYSNAVHYGKESGNIWIRSRQVGQRV
QIDVANSGTPIPEAERTMIFEPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMRGELQLVEVAGTDVCFRIELPLTAENE

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=469, Percent_Identity=74.4136460554371, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI87081816, Length=227, Percent_Identity=30.3964757709251, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=28.8793103448276, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=30.8333333333333, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=25.4295532646048, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=25.7042253521127, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786783, Length=301, Percent_Identity=26.2458471760797, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=26.8, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789149, Length=351, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=29.1845493562232, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=232, Percent_Identity=28.8793103448276, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=22.7272727272727, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=27.4261603375527, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790346, Length=293, Percent_Identity=22.5255972696246, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=26.6094420600858, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54137; Mature: 54137

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSAQAADINRTTLVDARR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SEAMTSVALEMERSYRQYCVLVDPTLARLYQNQRKQYSQMLDAHAPILPDERYYQTLRDL
HHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LTQLAAIKCQSSGPDAQASTLLESFSRSNAEMVQATRAVVFSRGQQLQQAIAERGQFFGW
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
QALMLFLVSVMLVVLFTRMIIGPVKAVERMINRLGEGRALGSTDSFKGPRELRSLAQRII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTSDQKEVVTILDGS
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
SRHLQQLIEQLLDYNRKLADGPAEHENVELKEMVEMVVAAHSLPARAKLIRTEIQLDAEI
HHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHH
CWAEPTLLMRVLDNLYSNAVHYGKESGNIWIRSRQVGQRVQIDVANSGTPIPEAERTMIF
HHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCHHEEE
EPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMRGELQLVEVAGTDVCFRIELPLTAENE
CHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCCCC
>Mature Secondary Structure
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSAQAADINRTTLVDARR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SEAMTSVALEMERSYRQYCVLVDPTLARLYQNQRKQYSQMLDAHAPILPDERYYQTLRDL
HHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LTQLAAIKCQSSGPDAQASTLLESFSRSNAEMVQATRAVVFSRGQQLQQAIAERGQFFGW
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
QALMLFLVSVMLVVLFTRMIIGPVKAVERMINRLGEGRALGSTDSFKGPRELRSLAQRII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTSDQKEVVTILDGS
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
SRHLQQLIEQLLDYNRKLADGPAEHENVELKEMVEMVVAAHSLPARAKLIRTEIQLDAEI
HHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHH
CWAEPTLLMRVLDNLYSNAVHYGKESGNIWIRSRQVGQRVQIDVANSGTPIPEAERTMIF
HHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCHHEEE
EPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMRGELQLVEVAGTDVCFRIELPLTAENE
CHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]