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The map label for this gene is rspB [H]

Identifier: 157371799

GI number: 157371799

Start: 3940937

End: 3941980

Strand: Direct

Name: rspB [H]

Synonym: Spro_3564

Alternate gene names: 157371799

Gene position: 3940937-3941980 (Clockwise)

Preceding gene: 157371798

Following gene: 157371800

Centisome position: 72.33

GC content: 58.33

Gene sequence:

>1044_bases
ATGGAACTGGTAACAGGAGAAAGCGCCATGCAAAGCGTGGTCATTGAACAGCCCGGCCTGCTGGCTATCCAGCAGCGCCC
CCTGCCGCAACCGGCGGCCAACGAAGTGCGGGTAAAGGTTAAATTTGCCGGTATCTGTGGTTCTGATGTGCATATTTACC
ATGGGCATAACCCGTTCGCCCGCTACCCACGAGTGATCGGCCACGAGTTTTTTGGCGTGATTGATCAGGTCGGCAGCGAT
GTCAGCCCACAGCGGCTCGGTGAACGCGTCTCGGTCGATCCGGTTGTCAGTTGCGGCCATTGCTATCCTTGCTCTATCGG
TCGTCCCAACGTCTGCACGGAGCTGCAGGTGATCGGTGTGCATCGCGACGGCGGCTTCAGTGACTACGCCTGTGCCCCGG
CGCGCAATGCCTACCCTATTCCGGACAGCATCAGCGATCGCCACGCCGCCATGGTCGAACCCTTCACCATTGCCGCCAAT
ATCACTGCCCATCTGCAGCCCAACGCCGATGATATCGCGTTGATCTACGGGGCCGGGCCGATGGGGCTGACGGTGATCCA
AACGCTGAAAGGCGTCTACGGCGTGAAACAGGTGATCGTCACCGATCGCATCCATGAACGACTGGTGATGGCACAGGAAA
ACGGCGCCGACTGGACATTCAATAATGCCGAAGCGTCATTGCCTGCCGAGCTGGAACGGCGCGGCATTCGCCCGACGTTG
ATCGTCGACGCCGCCTGCCATCCGGCCATTTTGCAAGAGGCGATCAATCTGGCGTCCCCGGCAGCGCGCATCGGCATCAT
GGGGTTCTCCGGCGATGCCTGCACCATTACCCAACAAAGCATCACCAGTAAAGAGCTGTCGATTTTCTCCTCACGTCTTA
ACAGTGCACGCTTCCCACAGGTTATCGATTGGATGGCCAGCGGGAAAATCGCCCCGCAGAAACTCATTACTCACTGCGTG
CCGGCCAACGAGGTTGAACAGGCGATGCTGATGTTCGAAAAAGATCAGCGCACCTGCTGCAAGGTGTTGCTGCAATTTGA
CTGA

Upstream 100 bases:

>100_bases
ACAAACCGGGGCTGGGCATTGAGTTCGACGAAAAACTGGCCGCCCGTTATCCGTACGAACCGGCTTATCTGCCGGTCGCG
CGCCTGGAGGATGGCACCCT

Downstream 100 bases:

>100_bases
TTGATTTACCAGGGCTGAGGGCGGCAGGAAAGCGCCCTCTACAACCATGAAACTTCGCGATTAAAACAACATTAAGTGGA
GTGCATTTATGTTTAAAAAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MELVTGESAMQSVVIEQPGLLAIQQRPLPQPAANEVRVKVKFAGICGSDVHIYHGHNPFARYPRVIGHEFFGVIDQVGSD
VSPQRLGERVSVDPVVSCGHCYPCSIGRPNVCTELQVIGVHRDGGFSDYACAPARNAYPIPDSISDRHAAMVEPFTIAAN
ITAHLQPNADDIALIYGAGPMGLTVIQTLKGVYGVKQVIVTDRIHERLVMAQENGADWTFNNAEASLPAELERRGIRPTL
IVDAACHPAILQEAINLASPAARIGIMGFSGDACTITQQSITSKELSIFSSRLNSARFPQVIDWMASGKIAPQKLITHCV
PANEVEQAMLMFEKDQRTCCKVLLQFD

Sequences:

>Translated_347_residues
MELVTGESAMQSVVIEQPGLLAIQQRPLPQPAANEVRVKVKFAGICGSDVHIYHGHNPFARYPRVIGHEFFGVIDQVGSD
VSPQRLGERVSVDPVVSCGHCYPCSIGRPNVCTELQVIGVHRDGGFSDYACAPARNAYPIPDSISDRHAAMVEPFTIAAN
ITAHLQPNADDIALIYGAGPMGLTVIQTLKGVYGVKQVIVTDRIHERLVMAQENGADWTFNNAEASLPAELERRGIRPTL
IVDAACHPAILQEAINLASPAARIGIMGFSGDACTITQQSITSKELSIFSSRLNSARFPQVIDWMASGKIAPQKLITHCV
PANEVEQAMLMFEKDQRTCCKVLLQFD
>Mature_347_residues
MELVTGESAMQSVVIEQPGLLAIQQRPLPQPAANEVRVKVKFAGICGSDVHIYHGHNPFARYPRVIGHEFFGVIDQVGSD
VSPQRLGERVSVDPVVSCGHCYPCSIGRPNVCTELQVIGVHRDGGFSDYACAPARNAYPIPDSISDRHAAMVEPFTIAAN
ITAHLQPNADDIALIYGAGPMGLTVIQTLKGVYGVKQVIVTDRIHERLVMAQENGADWTFNNAEASLPAELERRGIRPTL
IVDAACHPAILQEAINLASPAARIGIMGFSGDACTITQQSITSKELSIFSSRLNSARFPQVIDWMASGKIAPQKLITHCV
PANEVEQAMLMFEKDQRTCCKVLLQFD

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=345, Percent_Identity=27.536231884058, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI156523966, Length=381, Percent_Identity=25.1968503937008, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI71565154, Length=234, Percent_Identity=26.4957264957265, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501939, Length=373, Percent_Identity=24.9329758713137, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=20.3804347826087, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=20.3804347826087, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=64.3916913946587, Blast_Score=476, Evalue=1e-136,
Organism=Escherichia coli, GI226510992, Length=350, Percent_Identity=31.4285714285714, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788073, Length=344, Percent_Identity=28.4883720930233, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790045, Length=329, Percent_Identity=27.9635258358663, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788407, Length=315, Percent_Identity=30.4761904761905, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=25.5813953488372, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=28.1976744186047, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788075, Length=341, Percent_Identity=27.5659824046921, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786825, Length=395, Percent_Identity=23.7974683544304, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=24.0384615384615, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082401, Length=113, Percent_Identity=33.6283185840708, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786552, Length=354, Percent_Identity=24.8587570621469, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=29.2899408284024, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=205, Percent_Identity=33.6585365853659, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=257, Percent_Identity=31.5175097276265, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=168, Percent_Identity=29.7619047619048, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=157, Percent_Identity=30.5732484076433, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=365, Percent_Identity=21.6438356164384, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=26.4615384615385, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=26.3929618768328, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=26.1538461538462, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=224, Percent_Identity=30.8035714285714, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=135, Percent_Identity=34.8148148148148, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=215, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=192, Percent_Identity=30.2083333333333, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=383, Percent_Identity=23.4986945169713, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=315, Percent_Identity=24.7619047619048, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=137, Percent_Identity=32.8467153284672, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=26.9113149847095, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137530, Length=335, Percent_Identity=25.6716417910448, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221457811, Length=335, Percent_Identity=21.7910447761194, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550770, Length=335, Percent_Identity=21.7910447761194, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551930, Length=335, Percent_Identity=21.7910447761194, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=106, Percent_Identity=30.188679245283, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 37665; Mature: 37665

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVTGESAMQSVVIEQPGLLAIQQRPLPQPAANEVRVKVKFAGICGSDVHIYHGHNPFA
CCEECCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCHH
RYPRVIGHEFFGVIDQVGSDVSPQRLGERVSVDPVVSCGHCYPCSIGRPNVCTELQVIGV
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEECCCEEECCCCCCCCCCEEEEEEE
HRDGGFSDYACAPARNAYPIPDSISDRHAAMVEPFTIAANITAHLQPNADDIALIYGAGP
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEEEEEECCCCCCEEEEEECCC
MGLTVIQTLKGVYGVKQVIVTDRIHERLVMAQENGADWTFNNAEASLPAELERRGIRPTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCCCCHHHHHCCCCCEE
IVDAACHPAILQEAINLASPAARIGIMGFSGDACTITQQSITSKELSIFSSRLNSARFPQ
EEECCCCHHHHHHHHHHCCCCHHEEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCHH
VIDWMASGKIAPQKLITHCVPANEVEQAMLMFEKDQRTCCKVLLQFD
HHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MELVTGESAMQSVVIEQPGLLAIQQRPLPQPAANEVRVKVKFAGICGSDVHIYHGHNPFA
CCEECCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCHH
RYPRVIGHEFFGVIDQVGSDVSPQRLGERVSVDPVVSCGHCYPCSIGRPNVCTELQVIGV
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEECCCEEECCCCCCCCCCEEEEEEE
HRDGGFSDYACAPARNAYPIPDSISDRHAAMVEPFTIAANITAHLQPNADDIALIYGAGP
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEEEEEECCCCCCEEEEEECCC
MGLTVIQTLKGVYGVKQVIVTDRIHERLVMAQENGADWTFNNAEASLPAELERRGIRPTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCCCCHHHHHCCCCCEE
IVDAACHPAILQEAINLASPAARIGIMGFSGDACTITQQSITSKELSIFSSRLNSARFPQ
EEECCCCHHHHHHHHHHCCCCHHEEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCHH
VIDWMASGKIAPQKLITHCVPANEVEQAMLMFEKDQRTCCKVLLQFD
HHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]