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The map label for this gene is purM [H]

Identifier: 157371761

GI number: 157371761

Start: 3897830

End: 3898909

Strand: Direct

Name: purM [H]

Synonym: Spro_3524

Alternate gene names: 157371761

Gene position: 3897830-3898909 (Clockwise)

Preceding gene: 157371758

Following gene: 157371762

Centisome position: 71.53

GC content: 57.78

Gene sequence:

>1080_bases
ATGCACAGTTTTCAAACCGCAAACCGTCGTGGGGATCGCGCAGTGACCGACAAAACCTCTCTCAGCTATAAAGACGCAGG
TGTCGATATCGATGCTGGCAATGCATTGGTAGACCGCATCAAAGGTGTAGTTAAACAGACCCGCCGCCCTGAAGTGATGG
GTGGTCTGGGCGGTTTTGGCGCCCTGTGTGCGTTGCCGCAGAAATACCGCGAGCCGATACTGGTTTCCGGTACCGACGGC
GTAGGCACCAAGCTGCGTCTGGCGATGGACCTGAAACGACACGACACCATCGGCATCGATCTGGTTGCAATGTGTGTGAA
CGATTTGGTGGTACAGGGCGCTGAGCCGCTGTTCTTCCTGGATTACTTCGCGACCGGCAAGCTGGACGTGGACACCGCGG
CCAGCGTGATCACCGGTATCGCCGAGGGCTGCAAGCAGTCCGGTTGTGCGCTGGTGGGCGGTGAAACCGCCGAAATGCCA
GGTATGTATCATGGCGAAGATTACGACGTGGCCGGCTTTTGCGTCGGCGTGGTCGAGAAATCCGAAATCATCGACGGCAG
CAAGGTGCAGTCAGGCGATGCCCTGATCGCCCTCGGCGCTTCCGGCCCGCACTCCAACGGCTACTCGCTGGTGCGCAAAA
TTCTGGAAGTCAGCAACACCGACCCAACCACTACCGATCTGGACGGCCAACCACTGGCTGACCATCTGCTGGCACCAACC
AAAATTTATGTGAAATCCGTGCTGGAGCTGATCGAGAAAATCGACGTGCACGCTATCGCTCACCTGACCGGCGGCGGCTT
CTGGGAAAACATCCCACGCGTACTGCCGGAAGGCATGCAGGCGGTGATCGACGAATCCAGCTGGCAGTGGCCGGCCGTCT
TCAACTGGCTGCAGCAAACCGGTAACGTCAGCCGTCACGAAATGTACCGCACCTTTAACTGTGGCGTGGGCATGGTGATC
GCTCTGCCGGAAGAATCGGTTGAATCCGCCATCGCATTGTTGACCGCAGCCGGTGAAAAAGCGTGGAAGATCGGTAAACT
GACCGCCTCTTCTGACGAACAACAAGTGGTCATCAACTGA

Upstream 100 bases:

>100_bases
CAGTATAGATGACGAAAAATCGGAGCTGGTTCACAAGCCACTCGCAAACGTTTGCCTGCGCTGTTAGAATTGCCGCGCCT
TAGTCCGGAATCAATGCCGG

Downstream 100 bases:

>100_bases
TGAAAAAGATCGTGGTGTTGGTCTCCGGCCAGGGGAGTAATCTCCAGGCGCTGATTGATGCCTGCCAGCAGGGCCGGATT
GCCGCCGAAATTGTGGCGGT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MHSFQTANRRGDRAVTDKTSLSYKDAGVDIDAGNALVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDG
VGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMP
GMYHGEDYDVAGFCVGVVEKSEIIDGSKVQSGDALIALGASGPHSNGYSLVRKILEVSNTDPTTTDLDGQPLADHLLAPT
KIYVKSVLELIEKIDVHAIAHLTGGGFWENIPRVLPEGMQAVIDESSWQWPAVFNWLQQTGNVSRHEMYRTFNCGVGMVI
ALPEESVESAIALLTAAGEKAWKIGKLTASSDEQQVVIN

Sequences:

>Translated_359_residues
MHSFQTANRRGDRAVTDKTSLSYKDAGVDIDAGNALVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDG
VGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMP
GMYHGEDYDVAGFCVGVVEKSEIIDGSKVQSGDALIALGASGPHSNGYSLVRKILEVSNTDPTTTDLDGQPLADHLLAPT
KIYVKSVLELIEKIDVHAIAHLTGGGFWENIPRVLPEGMQAVIDESSWQWPAVFNWLQQTGNVSRHEMYRTFNCGVGMVI
ALPEESVESAIALLTAAGEKAWKIGKLTASSDEQQVVIN
>Mature_359_residues
MHSFQTANRRGDRAVTDKTSLSYKDAGVDIDAGNALVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDG
VGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMP
GMYHGEDYDVAGFCVGVVEKSEIIDGSKVQSGDALIALGASGPHSNGYSLVRKILEVSNTDPTTTDLDGQPLADHLLAPT
KIYVKSVLELIEKIDVHAIAHLTGGGFWENIPRVLPEGMQAVIDESSWQWPAVFNWLQQTGNVSRHEMYRTFNCGVGMVI
ALPEESVESAIALLTAAGEKAWKIGKLTASSDEQQVVIN

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=360, Percent_Identity=48.3333333333333, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI209869995, Length=360, Percent_Identity=48.3333333333333, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI209869993, Length=360, Percent_Identity=48.3333333333333, Blast_Score=335, Evalue=5e-92,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=86.9186046511628, Blast_Score=622, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=41.6184971098266, Blast_Score=251, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6321203, Length=359, Percent_Identity=48.1894150417827, Blast_Score=323, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24582400, Length=314, Percent_Identity=43.9490445859873, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38362; Mature: 38362

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFQTANRRGDRAVTDKTSLSYKDAGVDIDAGNALVDRIKGVVKQTRRPEVMGGLGGFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHH
ALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFL
HHHCCCHHHCCCEEEECCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCEEEE
DYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEK
EECCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHEEEHHHH
SEIIDGSKVQSGDALIALGASGPHSNGYSLVRKILEVSNTDPTTTDLDGQPLADHLLAPT
HHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCH
KIYVKSVLELIEKIDVHAIAHLTGGGFWENIPRVLPEGMQAVIDESSWQWPAVFNWLQQT
HHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GNVSRHEMYRTFNCGVGMVIALPEESVESAIALLTAAGEKAWKIGKLTASSDEQQVVIN
CCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEC
>Mature Secondary Structure
MHSFQTANRRGDRAVTDKTSLSYKDAGVDIDAGNALVDRIKGVVKQTRRPEVMGGLGGFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHH
ALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFL
HHHCCCHHHCCCEEEECCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCEEEE
DYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEK
EECCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHEEEHHHH
SEIIDGSKVQSGDALIALGASGPHSNGYSLVRKILEVSNTDPTTTDLDGQPLADHLLAPT
HHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCH
KIYVKSVLELIEKIDVHAIAHLTGGGFWENIPRVLPEGMQAVIDESSWQWPAVFNWLQQT
HHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GNVSRHEMYRTFNCGVGMVIALPEESVESAIALLTAAGEKAWKIGKLTASSDEQQVVIN
CCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA