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The map label for this gene is dsdC [H]

Identifier: 157371631

GI number: 157371631

Start: 3753702

End: 3754631

Strand: Direct

Name: dsdC [H]

Synonym: Spro_3394

Alternate gene names: 157371631

Gene position: 3753702-3754631 (Clockwise)

Preceding gene: 157371630

Following gene: 157371635

Centisome position: 68.89

GC content: 49.68

Gene sequence:

>930_bases
ATGTTCCCCAACAAGAAATATTCACAACGGGCCAATCCGTTAACCAGCTATCAATTTTCACGGTTGCATACTTTTGAATG
CGTCGCTCGTCACCTCTCCTTTTCATTGGCGGCGGAAGAACTGTCAATTACCCCCAGCGCTGTAAGTCACAGAATCAACC
TGCTGGAAAAAGAGCTGGGCTTTCTTTTATTTCAGCGTTTTCACCGCAGAATTACGCTCACACCGGAAGGAGAGCGGATG
CAATGGTCGTTAAGCAACTCCTTCGATGCCCTGACTCAGGAAATTCTTGATATTAAAAACCGTGAGCTGACGGGCACCCT
GACCATTTATTCCCACCCCTCCATCGTCCAATGCTTGCTGATTCCGCGGATCGGCGAATTTATTGCCCAGTATCCCACCA
TTCATTTGAACATTCTCACCGGGCAAGAGAATATCAACCTGGCCAACCGCGGCGTTGATTTAGCACTGTACTTTGGGCTT
CTGCCGTCAGGTAAACAGCTGGACGAAACCTTTATGTCGGAGTCCATGGTGCCGATCTGCACTGCGCAATACGCCAAAAC
GCATAACCTCTACAATGCTCCTGAAAACCTGGCGCACTGCACACTGTTGCATGACCGGTATAATTCGGGTGAAGACGAAT
GGCTGACCTGGGCACAACATTTTGATTTAGGGCTGGATACCGACAGCAAAAGCATGGAGTTCGATCGCTCAGATTTGGCG
GTGCTGGCGGCGACACAGCATCTTGGCGTCGCCATGGGCCGACTCAATCTGGTGCAAGACTGGATCAAAAGCGGTGAACT
GATTATCCCCTTTACCAACATGACCCTGCCCTGCGAACACTGCTATTTTGTTTCGACCATATCCGAACGTCAGTGGCCGA
AAATTATCGCGTTCAAACAGTGGATGATGAAAATAGAGCCTCTGGTCTGA

Upstream 100 bases:

>100_bases
TCAAAAGACCCTATTATCACAGTCATCCAAGAATAAATCGTATTTTAGTTCCACTGATTAAAATGTTAATATTGCTCTGT
GTCGCGAATGGAGTAATAGC

Downstream 100 bases:

>100_bases
TTGCCAGAGGCATTGGCCGGTGGTTTAAAAATGATTACCAAGTCTTGGGAGTATAAGAAAAATCGAGTGCGCAGCTGTAT
AACTGCCCGGCCTTTGAGTA

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MFPNKKYSQRANPLTSYQFSRLHTFECVARHLSFSLAAEELSITPSAVSHRINLLEKELGFLLFQRFHRRITLTPEGERM
QWSLSNSFDALTQEILDIKNRELTGTLTIYSHPSIVQCLLIPRIGEFIAQYPTIHLNILTGQENINLANRGVDLALYFGL
LPSGKQLDETFMSESMVPICTAQYAKTHNLYNAPENLAHCTLLHDRYNSGEDEWLTWAQHFDLGLDTDSKSMEFDRSDLA
VLAATQHLGVAMGRLNLVQDWIKSGELIIPFTNMTLPCEHCYFVSTISERQWPKIIAFKQWMMKIEPLV

Sequences:

>Translated_309_residues
MFPNKKYSQRANPLTSYQFSRLHTFECVARHLSFSLAAEELSITPSAVSHRINLLEKELGFLLFQRFHRRITLTPEGERM
QWSLSNSFDALTQEILDIKNRELTGTLTIYSHPSIVQCLLIPRIGEFIAQYPTIHLNILTGQENINLANRGVDLALYFGL
LPSGKQLDETFMSESMVPICTAQYAKTHNLYNAPENLAHCTLLHDRYNSGEDEWLTWAQHFDLGLDTDSKSMEFDRSDLA
VLAATQHLGVAMGRLNLVQDWIKSGELIIPFTNMTLPCEHCYFVSTISERQWPKIIAFKQWMMKIEPLV
>Mature_309_residues
MFPNKKYSQRANPLTSYQFSRLHTFECVARHLSFSLAAEELSITPSAVSHRINLLEKELGFLLFQRFHRRITLTPEGERM
QWSLSNSFDALTQEILDIKNRELTGTLTIYSHPSIVQCLLIPRIGEFIAQYPTIHLNILTGQENINLANRGVDLALYFGL
LPSGKQLDETFMSESMVPICTAQYAKTHNLYNAPENLAHCTLLHDRYNSGEDEWLTWAQHFDLGLDTDSKSMEFDRSDLA
VLAATQHLGVAMGRLNLVQDWIKSGELIIPFTNMTLPCEHCYFVSTISERQWPKIIAFKQWMMKIEPLV

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=297, Percent_Identity=54.8821548821549, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1789173, Length=296, Percent_Identity=31.7567567567568, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1786448, Length=284, Percent_Identity=30.2816901408451, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI145693193, Length=182, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787128, Length=257, Percent_Identity=24.5136186770428, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786401, Length=143, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081978, Length=141, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35468; Mature: 35468

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50931 HTH_LYSR ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPNKKYSQRANPLTSYQFSRLHTFECVARHLSFSLAAEELSITPSAVSHRINLLEKELG
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FLLFQRFHRRITLTPEGERMQWSLSNSFDALTQEILDIKNRELTGTLTIYSHPSIVQCLL
HHHHHHHCCEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHH
IPRIGEFIAQYPTIHLNILTGQENINLANRGVDLALYFGLLPSGKQLDETFMSESMVPIC
HHHHHHHHHHCCEEEEEEEECCCCCCHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCHHH
TAQYAKTHNLYNAPENLAHCTLLHDRYNSGEDEWLTWAQHFDLGLDTDSKSMEFDRSDLA
HHHHHHHCCCCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
VLAATQHLGVAMGRLNLVQDWIKSGELIIPFTNMTLPCEHCYFVSTISERQWPKIIAFKQ
EEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEHHCCCCCCHHHHHHH
WMMKIEPLV
HHHHHCCCC
>Mature Secondary Structure
MFPNKKYSQRANPLTSYQFSRLHTFECVARHLSFSLAAEELSITPSAVSHRINLLEKELG
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FLLFQRFHRRITLTPEGERMQWSLSNSFDALTQEILDIKNRELTGTLTIYSHPSIVQCLL
HHHHHHHCCEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHH
IPRIGEFIAQYPTIHLNILTGQENINLANRGVDLALYFGLLPSGKQLDETFMSESMVPIC
HHHHHHHHHHCCEEEEEEEECCCCCCHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCHHH
TAQYAKTHNLYNAPENLAHCTLLHDRYNSGEDEWLTWAQHFDLGLDTDSKSMEFDRSDLA
HHHHHHHCCCCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
VLAATQHLGVAMGRLNLVQDWIKSGELIIPFTNMTLPCEHCYFVSTISERQWPKIIAFKQ
EEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEHHCCCCCCHHHHHHH
WMMKIEPLV
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]