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The map label for this gene is msmR [H]

Identifier: 157371343

GI number: 157371343

Start: 3415694

End: 3416542

Strand: Direct

Name: msmR [H]

Synonym: Spro_3104

Alternate gene names: 157371343

Gene position: 3415694-3416542 (Clockwise)

Preceding gene: 157371340

Following gene: 157371344

Centisome position: 62.69

GC content: 53.47

Gene sequence:

>849_bases
ATGCATAAGAGTTTCACCCTAAACCGCACCGACAATATTGAGCTGAATCTGTACCAATATGGTGAGGAGAACTGCGACAA
AGGGCACAGCTTCGGCCCGGCGGTGCGGCAGCACTATCTATTTCATTATGTGATAAGCGGAACCGGCGTACTGCACAGCG
AATACGGTGCATTTCCAGTCGTTGCTGGTGAAGGTTTTTTGATCCATCCGCACGACGTAACCACCTATCGCGCCGATAAA
AAAGATCCCTGGCATTACATGTGGCTGGAGGTCGACGGACTGGTGGCCGGCAAGATTTTCGAAGAGTGCCGCCTGAGCCG
CCAGTTCCCGATTTATCGCCCCCGCAAGACTGACGAGACTCCTCAGGCCCTGAGCTACCTGCGACAGCTCGTTAGCCATG
ATGATGAACATCGATTGAAGACCCTCGGCCTGAGCTATCTGTTTTTTTCTGCGTTGATCGACAATGCGCTACAGGGCAGC
GATGAACACCCCAGCGACAAGACGCAACATCTGCACAAAGCGGTCAAACTGATTGAAAACCGTTACCACGAACACCTGAC
CATTGAGCGCCTGGCCGCCTACTGCAATATCAACCGCAGTTACCTGTGCCGATTGTTCAAGGGGGCTTACGGTATCGGGC
CAAAGGAGTACTTGCTTAACTTTCGCATGACGCTCGCCACCAGCCTGCTGCGTAACAGCCGGACGGCGATAAAAGTGGTG
GGGATCTCGGTCGGCTATGAAAACCAACTGCATTTTTCCAAAGCCTTCAAACAGGTCCACGGCGTATCACCGGCCCAATG
GCGGCAGGAAAATCAACCGGACAACGCCTCGCCTTGCCACAAAGGTTAA

Upstream 100 bases:

>100_bases
CAGCGCAAAAACTGTGAGCCAGGTCTGGATTTGGCGTTTACCCACCTAACGCATGGCCGCTACACTGTTAGCGTGAACAA
GAAAACCAGGACATCGCCTG

Downstream 100 bases:

>100_bases
GCCATCACATCGTTGACCCTTCCCCCCACTCGCTATCGGTCTCTGAGAGCGATGTTCAGAGAAGAAACTTTTCTCTTCAC
CTTGTGAAATATTCAATAAG

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MHKSFTLNRTDNIELNLYQYGEENCDKGHSFGPAVRQHYLFHYVISGTGVLHSEYGAFPVVAGEGFLIHPHDVTTYRADK
KDPWHYMWLEVDGLVAGKIFEECRLSRQFPIYRPRKTDETPQALSYLRQLVSHDDEHRLKTLGLSYLFFSALIDNALQGS
DEHPSDKTQHLHKAVKLIENRYHEHLTIERLAAYCNINRSYLCRLFKGAYGIGPKEYLLNFRMTLATSLLRNSRTAIKVV
GISVGYENQLHFSKAFKQVHGVSPAQWRQENQPDNASPCHKG

Sequences:

>Translated_282_residues
MHKSFTLNRTDNIELNLYQYGEENCDKGHSFGPAVRQHYLFHYVISGTGVLHSEYGAFPVVAGEGFLIHPHDVTTYRADK
KDPWHYMWLEVDGLVAGKIFEECRLSRQFPIYRPRKTDETPQALSYLRQLVSHDDEHRLKTLGLSYLFFSALIDNALQGS
DEHPSDKTQHLHKAVKLIENRYHEHLTIERLAAYCNINRSYLCRLFKGAYGIGPKEYLLNFRMTLATSLLRNSRTAIKVV
GISVGYENQLHFSKAFKQVHGVSPAQWRQENQPDNASPCHKG
>Mature_282_residues
MHKSFTLNRTDNIELNLYQYGEENCDKGHSFGPAVRQHYLFHYVISGTGVLHSEYGAFPVVAGEGFLIHPHDVTTYRADK
KDPWHYMWLEVDGLVAGKIFEECRLSRQFPIYRPRKTDETPQALSYLRQLVSHDDEHRLKTLGLSYLFFSALIDNALQGS
DEHPSDKTQHLHKAVKLIENRYHEHLTIERLAAYCNINRSYLCRLFKGAYGIGPKEYLLNFRMTLATSLLRNSRTAIKVV
GISVGYENQLHFSKAFKQVHGVSPAQWRQENQPDNASPCHKG

Specific function: Regulatory protein for the msm operon for multiple sugar metabolism. Activates the transcription of the msmEFGK, aga, dexB and gftA genes [H]

COG id: COG2207

COG function: function code K; AraC-type DNA-binding domain-containing proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI226510985, Length=251, Percent_Identity=23.1075697211155, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787987, Length=93, Percent_Identity=35.4838709677419, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI87082197, Length=96, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003313
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060 [H]

Pfam domain/function: PF02311 AraC_binding; PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 32476; Mature: 32476

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKSFTLNRTDNIELNLYQYGEENCDKGHSFGPAVRQHYLFHYVISGTGVLHSEYGAFPV
CCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHEEECCCEEECCCCCCEE
VAGEGFLIHPHDVTTYRADKKDPWHYMWLEVDGLVAGKIFEECRLSRQFPIYRPRKTDET
EECCCEEECCCCCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCC
PQALSYLRQLVSHDDEHRLKTLGLSYLFFSALIDNALQGSDEHPSDKTQHLHKAVKLIEN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
RYHEHLTIERLAAYCNINRSYLCRLFKGAYGIGPKEYLLNFRMTLATSLLRNSRTAIKVV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
GISVGYENQLHFSKAFKQVHGVSPAQWRQENQPDNASPCHKG
EEEECCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MHKSFTLNRTDNIELNLYQYGEENCDKGHSFGPAVRQHYLFHYVISGTGVLHSEYGAFPV
CCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHEEECCCEEECCCCCCEE
VAGEGFLIHPHDVTTYRADKKDPWHYMWLEVDGLVAGKIFEECRLSRQFPIYRPRKTDET
EECCCEEECCCCCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCC
PQALSYLRQLVSHDDEHRLKTLGLSYLFFSALIDNALQGSDEHPSDKTQHLHKAVKLIEN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
RYHEHLTIERLAAYCNINRSYLCRLFKGAYGIGPKEYLLNFRMTLATSLLRNSRTAIKVV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
GISVGYENQLHFSKAFKQVHGVSPAQWRQENQPDNASPCHKG
EEEECCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1537846; 12397186 [H]