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The map label for this gene is ddc [H]

Identifier: 157371289

GI number: 157371289

Start: 3360421

End: 3361836

Strand: Direct

Name: ddc [H]

Synonym: Spro_3049

Alternate gene names: 157371289

Gene position: 3360421-3361836 (Clockwise)

Preceding gene: 157371287

Following gene: 157371290

Centisome position: 61.67

GC content: 59.11

Gene sequence:

>1416_bases
ATGCACCCACGTTTACAGCAGGACCTTGAGCAATTTCCACAGATACTCGACCGCACCCGGCAGTTGGCCGAAGGCTTCCT
GACGGGCCTGCAACAGCGCCCGGTTTGCCCTCCTCTGGCTGCTCAACAGCTACAGCCGGGTGACAATTTACTGGCTGACA
GCGGTGATGGCGCACTGGCGGCACTGGACGATTTCTGGCGGCGTTATGCCGAGGGTCTTTCTGCCAGCGCCGGGCCGCGT
TATTTTGGCTTTGTTACCGGCGGCTCGACTCCTGCCGCATTGGCAGCAGACTGGTTGGTTAGCGCTGTCGACCAAAACAG
CCAGCTGAGCCACGATACCGTGGCCGCGGCAATTGAACTGGCGACCATTGTGCAGCTAAAAGACTTGTTGGGTCTGCCAG
AGGCATTCAACGGCAGTTTTGTTAGCGGGGCAACCATGGCCAACTTTGTCGGCATGGCCATCGGCCGCCAGTGGCTGGGG
CAGCAGCGCGGCATCAATGTTGCGGAACAGGGGTTGGCAGCGTTGGGGGCCATACAGGTTTTGTCAGCGAATGCGCACTC
CAGCAGCGAAAAAGCACTCAGCATGCTCGGCATGGGTCGCGACGCATTAAAAATTATCGACAGCCTGCCGAACTCCGAAG
CTATCGACCCTACTGCGTTGGAACGGCATCTGGCCGCCAGTGTTGGTGTACCGACCATGGTGCTGGCCAGTGCCGGAACG
GTGAATACCGTGGTCTTCGACGACCTGCAGCAGCTGCTGGCGTTGCGCGAGCGCTACCCGTTCTGGTTACACGTTGATGC
GGCCTTTGGCGGCGTGGCGGCCTGTTCACCGCACTATGCGCCACGCTTAGCCGGTTGGGAGCAGGCTGACTCGATTACCG
TTGATGCACATAAATGGTTGAACGTGCCCTACGACAGCGCGATCCAATTTAGCCGTCATCTGGCATTGCAGATGCAGGTC
TTCCAAAACCATTCGGCTTATCTGGAAGCGCCGACGCAGCGGCCAGACAACTACCTGCACCTGACTCCGGAAAACTCGCG
GCGTTTTCGCGCCCTGCCGTTGTGGATGGCGTTGAAAGCTTATGGCCGCAGCGGTATGCAAGATATGGTTGAACGCAATG
TTCGACTGGCGCAGTTGCTGGGGGCAGAGCTGACGGCCAGCGCGGGTTTCCACCTGCTGGCGCCAGTCAATCTGAACGTA
GTGTGCTTTGCGCTCAAAAATGTCGCAGGCGATGCTACTGCTGCACGCGATCGCTTTATAGCCCGTCTCGATCGGCACGG
CGTAGTGCGCTGCACCCCTACCCGTTATAACGGACAGCCGGGGGTCCGTGCTGCGTTGGTCAACTGGATGACCGAGGAAA
GCGATATCCATCTGGCGTTGGAATCGATACGTCACTGCCTGGCAGAGACTGGCTGA

Upstream 100 bases:

>100_bases
TGGTTAGCCAGACTATCCAAAAAGGCCATTTTTCATCGATTTTCGCCACAAAGCAAATGTTCTAGGCTGTCACTCATGCC
CCTTACATCTGGAGTCAGCG

Downstream 100 bases:

>100_bases
TAGGACAAGTCAAGGTAACGCCACACTATTGATTGCTGTCGGTGATTATTCTACGGCAGCATTACCCCCCCTGCCGATCA
ACGGATATTGGTACCCTGGG

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MHPRLQQDLEQFPQILDRTRQLAEGFLTGLQQRPVCPPLAAQQLQPGDNLLADSGDGALAALDDFWRRYAEGLSASAGPR
YFGFVTGGSTPAALAADWLVSAVDQNSQLSHDTVAAAIELATIVQLKDLLGLPEAFNGSFVSGATMANFVGMAIGRQWLG
QQRGINVAEQGLAALGAIQVLSANAHSSSEKALSMLGMGRDALKIIDSLPNSEAIDPTALERHLAASVGVPTMVLASAGT
VNTVVFDDLQQLLALRERYPFWLHVDAAFGGVAACSPHYAPRLAGWEQADSITVDAHKWLNVPYDSAIQFSRHLALQMQV
FQNHSAYLEAPTQRPDNYLHLTPENSRRFRALPLWMALKAYGRSGMQDMVERNVRLAQLLGAELTASAGFHLLAPVNLNV
VCFALKNVAGDATAARDRFIARLDRHGVVRCTPTRYNGQPGVRAALVNWMTEESDIHLALESIRHCLAETG

Sequences:

>Translated_471_residues
MHPRLQQDLEQFPQILDRTRQLAEGFLTGLQQRPVCPPLAAQQLQPGDNLLADSGDGALAALDDFWRRYAEGLSASAGPR
YFGFVTGGSTPAALAADWLVSAVDQNSQLSHDTVAAAIELATIVQLKDLLGLPEAFNGSFVSGATMANFVGMAIGRQWLG
QQRGINVAEQGLAALGAIQVLSANAHSSSEKALSMLGMGRDALKIIDSLPNSEAIDPTALERHLAASVGVPTMVLASAGT
VNTVVFDDLQQLLALRERYPFWLHVDAAFGGVAACSPHYAPRLAGWEQADSITVDAHKWLNVPYDSAIQFSRHLALQMQV
FQNHSAYLEAPTQRPDNYLHLTPENSRRFRALPLWMALKAYGRSGMQDMVERNVRLAQLLGAELTASAGFHLLAPVNLNV
VCFALKNVAGDATAARDRFIARLDRHGVVRCTPTRYNGQPGVRAALVNWMTEESDIHLALESIRHCLAETG
>Mature_471_residues
MHPRLQQDLEQFPQILDRTRQLAEGFLTGLQQRPVCPPLAAQQLQPGDNLLADSGDGALAALDDFWRRYAEGLSASAGPR
YFGFVTGGSTPAALAADWLVSAVDQNSQLSHDTVAAAIELATIVQLKDLLGLPEAFNGSFVSGATMANFVGMAIGRQWLG
QQRGINVAEQGLAALGAIQVLSANAHSSSEKALSMLGMGRDALKIIDSLPNSEAIDPTALERHLAASVGVPTMVLASAGT
VNTVVFDDLQQLLALRERYPFWLHVDAAFGGVAACSPHYAPRLAGWEQADSITVDAHKWLNVPYDSAIQFSRHLALQMQV
FQNHSAYLEAPTQRPDNYLHLTPENSRRFRALPLWMALKAYGRSGMQDMVERNVRLAQLLGAELTASAGFHLLAPVNLNV
VCFALKNVAGDATAARDRFIARLDRHGVVRCTPTRYNGQPGVRAALVNWMTEESDIHLALESIRHCLAETG

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=342, Percent_Identity=29.8245614035088, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4503875, Length=342, Percent_Identity=29.8245614035088, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4503281, Length=461, Percent_Identity=25.3796095444685, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI132814448, Length=461, Percent_Identity=25.3796095444685, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI194294551, Length=335, Percent_Identity=27.4626865671642, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI197383062, Length=339, Percent_Identity=27.4336283185841, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI58331246, Length=338, Percent_Identity=26.6272189349112, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI92110055, Length=465, Percent_Identity=23.2258064516129, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17534817, Length=476, Percent_Identity=26.4705882352941, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17534819, Length=476, Percent_Identity=26.4705882352941, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71993062, Length=378, Percent_Identity=25.6613756613757, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17555682, Length=378, Percent_Identity=25.6613756613757, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71993058, Length=324, Percent_Identity=25.6172839506173, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI133931025, Length=402, Percent_Identity=23.134328358209, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71981211, Length=290, Percent_Identity=24.1379310344828, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71981217, Length=290, Percent_Identity=24.1379310344828, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17551992, Length=300, Percent_Identity=22.6666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573972, Length=481, Percent_Identity=26.6112266112266, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24652373, Length=466, Percent_Identity=27.4678111587983, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585139, Length=492, Percent_Identity=24.1869918699187, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI221476190, Length=480, Percent_Identity=24.1666666666667, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24585143, Length=480, Percent_Identity=24.1666666666667, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24586044, Length=448, Percent_Identity=25.4464285714286, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136594, Length=412, Percent_Identity=26.2135922330097, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585135, Length=488, Percent_Identity=24.7950819672131, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136190, Length=255, Percent_Identity=28.6274509803922, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356415, Length=386, Percent_Identity=24.6113989637306, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24657193, Length=338, Percent_Identity=23.9644970414201, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24657185, Length=338, Percent_Identity=23.9644970414201, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24657188, Length=338, Percent_Identity=23.9644970414201, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 50999; Mature: 50999

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPRLQQDLEQFPQILDRTRQLAEGFLTGLQQRPVCPPLAAQQLQPGDNLLADSGDGALA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEECCCCCCCHH
ALDDFWRRYAEGLSASAGPRYFGFVTGGSTPAALAADWLVSAVDQNSQLSHDTVAAAIEL
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ATIVQLKDLLGLPEAFNGSFVSGATMANFVGMAIGRQWLGQQRGINVAEQGLAALGAIQV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LSANAHSSSEKALSMLGMGRDALKIIDSLPNSEAIDPTALERHLAASVGVPTMVLASAGT
HCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCC
VNTVVFDDLQQLLALRERYPFWLHVDAAFGGVAACSPHYAPRLAGWEQADSITVDAHKWL
CHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCEEEEHHHHC
NVPYDSAIQFSRHLALQMQVFQNHSAYLEAPTQRPDNYLHLTPENSRRFRALPLWMALKA
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEECCCCCCCEEEHHHHHHHHH
YGRSGMQDMVERNVRLAQLLGAELTASAGFHLLAPVNLNVVCFALKNVAGDATAARDRFI
HCCCCHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCEEEEEHHHHCCCHHHHHHHHH
ARLDRHGVVRCTPTRYNGQPGVRAALVNWMTEESDIHLALESIRHCLAETG
HHHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHPRLQQDLEQFPQILDRTRQLAEGFLTGLQQRPVCPPLAAQQLQPGDNLLADSGDGALA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEECCCCCCCHH
ALDDFWRRYAEGLSASAGPRYFGFVTGGSTPAALAADWLVSAVDQNSQLSHDTVAAAIEL
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ATIVQLKDLLGLPEAFNGSFVSGATMANFVGMAIGRQWLGQQRGINVAEQGLAALGAIQV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LSANAHSSSEKALSMLGMGRDALKIIDSLPNSEAIDPTALERHLAASVGVPTMVLASAGT
HCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCC
VNTVVFDDLQQLLALRERYPFWLHVDAAFGGVAACSPHYAPRLAGWEQADSITVDAHKWL
CHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCEEEEHHHHC
NVPYDSAIQFSRHLALQMQVFQNHSAYLEAPTQRPDNYLHLTPENSRRFRALPLWMALKA
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEECCCCCCCEEEHHHHHHHHH
YGRSGMQDMVERNVRLAQLLGAELTASAGFHLLAPVNLNVVCFALKNVAGDATAARDRFI
HCCCCHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCEEEEEHHHHCCCHHHHHHHHH
ARLDRHGVVRCTPTRYNGQPGVRAALVNWMTEESDIHLALESIRHCLAETG
HHHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]